DGIdb - FLT4 Gene Record

FLT4 2324 Druggable GenomeClinically Actionable

Alternate Names:

2324
FMS RELATED TYROSINE KINASE 4
FLT4
FLT-4
FLT41
LMPH1A
PCL
VEGFR-3
VEGFR3
136352
3767
ENSG00000037280
OTTHUMG00000130931
VEGFR1/2/3
VEGFR
VEGFR2/3
P35916
VGFR3_HUMAN
PA28183
VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 3 PRECURSOR (EC 2.7.1.112) (VEGFR-3) (TYROSINE-PROTEIN KINASE RECEPTOR FLT4). [SOURCE:UNIPROT/SWISSPROT;ACC:P35916]
Tyrosine-protein kinase receptor FLT4
Fms-like tyrosine kinase 4
Vascular endothelial growth factor receptor 3
fms related receptor tyrosine kinase 4
T07303
1938
CHTD7
LMPHM1

Gene Info:

Transmembrane Helix Count	1
Target Subclass	Other
Target Subclass	Kinase
Target Main Class	Receptors
Human Readable Name	DRUGGABLE GENOME
CancerCommons Reported Gene Name	VEGF, PDGF
Uniprot Status	Swiss-Prot
Human Readable Name	KINASE
Interpro Acc	IPR001245
Interpro Short Name	Ser-Thr/Tyr_kinase_cat_dom
Interpro Name	Serine-threonine/tyrosine-protein kinase catalytic domain
Interpro Type	Domain
Uniprot Evidence	1: Evidence at protein level
Target Class	Receptors
Target Subclass	EC:2.7.10.1
Gene Biotype	PROTEIN_CODING

(18 More Sources)

Gene Categories: Category Details

KINASE
TYROSINE KINASE
DRUGGABLE GENOME
CLINICALLY ACTIONABLE

Publications:

Gingrich DE et al., 2003, A new class of potent vascular endothelial growth factor receptor tyrosine kinase inhibitors: structure-activity relationships for a series of 9-alkoxymethyl-12-(3-hydroxypropyl)indeno[2,1-a]pyrrolo[3,4-c]carbazole-5-ones and the identification of CEP-5214 and its dimethylglycine ester prodrug clinical candidate CEP-7055., J Med Chem
Sonpavde et al., 2007, Pazopanib: a novel multitargeted tyrosine kinase inhibitor., Curr Oncol Rep
Subbiah V et al., 2017, Phase Ib/II Study of the Safety and Efficacy of Combination Therapy with Multikinase VEGF Inhibitor Pazopanib and MEK Inhibitor Trametinib In Advanced Soft Tissue Sarcoma., Clin Cancer Res
Ravi V et al., 2016, Antitumor Response of VEGFR2- and VEGFR3-Amplified Angiosarcoma to Pazopanib., J Natl Compr Canc Netw
Hilberg et al., 2008, BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy., Cancer Res.
Wind S et al., 2019, Clinical Pharmacokinetics and Pharmacodynamics of Nintedanib., Clin Pharmacokinet
Matsui et al., 2008, E7080, a novel inhibitor that targets multiple kinases, has potent antitumor activities against stem cell factor producing human small cell lung cancer H146, based on angiogenesis inhibition., Int. J. Cancer
Roskoski, 2007, Sunitinib: a VEGF and PDGF receptor protein kinase and angiogenesis inhibitor., Biochem. Biophys. Res. Commun.
Gridelli et al., 2007, Sorafenib and sunitinib in the treatment of advanced non-small cell lung cancer., Oncologist
Ahmed et al., 2004, Vascular endothelial growth factor (VEGF) inhibition by small molecules., J Chemother
Katoh et al., 2006, Comparative integromics on VEGF family members., Int. J. Oncol.
Deprimo et al., 2007, Circulating protein biomarkers of pharmacodynamic activity of sunitinib in patients with metastatic renal cell carcinoma: modulation of VEGF and VEGF-related proteins., J Transl Med
Garcia-Donas J et al., 2011, Single nucleotide polymorphism associations with response and toxic effects in patients with advanced renal-cell carcinoma treated with first-line sunitinib: a multicentre, observational, prospective study., Lancet Oncol
Quek R et al., 2009, Gastrointestinal stromal tumor: a clinical overview., Hematol Oncol Clin North Am
Reddy et al., 2006, Sorafenib: recent update on activity as a single agent and in combination with interferon-alpha2 in patients with advanced-stage renal cell carcinoma., Clin Genitourin Cancer
Lathia et al., 2006, Lack of effect of ketoconazole-mediated CYP3A inhibition on sorafenib clinical pharmacokinetics., Cancer Chemother. Pharmacol.
Strumberg, 2005, Preclinical and clinical development of the oral multikinase inhibitor sorafenib in cancer treatment., Drugs Today
Adnane et al., 2006, Sorafenib (BAY 43-9006, Nexavar), a dual-action inhibitor that targets RAF/MEK/ERK pathway in tumor cells and tyrosine kinases VEGFR/PDGFR in tumor vasculature., Meth. Enzymol.
Gong L et al., 2017, PharmGKB summary: sorafenib pathways., Pharmacogenet Genomics
Cohen et al., 2008, Axitinib is an active treatment for all histologic subtypes of advanced thyroid cancer: results from a phase II study., J. Clin. Oncol.
Kurenova et al., 2009, Small molecule chloropyramine hydrochloride (C4) targets the binding site of focal adhesion kinase and vascular endothelial growth factor receptor 3 and suppresses breast cancer growth in vivo., J. Med. Chem.
Yamamoto et al., 2007, Vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK 222584 inhibits both the induction and elicitation phases of contact hypersensitivity., J. Dermatol.
Stevenson CE et al., 2012, Bevacizumab and breast cancer: what does the future hold?, Future Oncol

IMC-3C5 FLT4

Interaction Score: 2.23

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name IMC-3C5

Novel drug target Established target

PMIDs:
22515444

Sources:
TdgClinicalTrial TTD
CHLORPYRAMIN HYDROCHLORIDE FLT4

Interaction Score: 0.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19610651

Sources:
DTC
TIVOZANIB FLT4

Interaction Score: 0.74

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Trial Name AV-951

Novel drug target Established target

PMIDs:
None found

Sources:
TALC MyCancerGenome TdgClinicalTrial ClearityFoundationClinicalTrial ChemblInteractions TTD
FRUQUINTINIB FLT4

Interaction Score: 0.74

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name fruquintinib

Novel drug target Established target

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD
CEP-5214 FLT4

Interaction Score: 0.74

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
14640546

Sources:
DTC ChemblInteractions
TELATINIB FLT4

Interaction Score: 0.5

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Mechanism of Interaction Vascular endothelial growth factor receptor 3 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
TALC MyCancerGenome TdgClinicalTrial ChemblInteractions
AXITINIB FLT4

Interaction Score: 0.43

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Reported Cancer Type Prostate

Direct Interaction yes

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

PMIDs:
18541897

Sources:
TALC MyCancerGenome TdgClinicalTrial ChemblInteractions CancerCommons MyCancerGenomeClinicalTrial
MOTESANIB FLT4

Interaction Score: 0.37

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

Notes

PMIDs:
None found

Sources:
TALC MyCancerGenome TdgClinicalTrial ChemblInteractions
VATALANIB FLT4

Interaction Score: 0.34

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Vatalanib

Novel drug target Established target

Trial Name vatalanib, PTK 787

PMIDs:
17584317

Sources:
DTC MyCancerGenome TdgClinicalTrial ChemblInteractions TTD
X-82 FLT4

Interaction Score: 0.3

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
MyCancerGenome ChemblInteractions
SURUFATINIB FLT4

Interaction Score: 0.3

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
GLESATINIB FLT4

Interaction Score: 0.28

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Novel drug target Established target

Trial Name MGCD265

PMIDs:
None found

Sources:
TALC MyCancerGenome TdgClinicalTrial
LUCITANIB FLT4

Interaction Score: 0.25

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions MyCancerGenomeClinicalTrial
LENVATINIB MESYLATE FLT4

Interaction Score: 0.25

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
AG-13958 FLT4

Interaction Score: 0.25

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CEP-7055 FLT4

Interaction Score: 0.25

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
KRN-633 FLT4

Interaction Score: 0.25

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
L-21649 FLT4

Interaction Score: 0.25

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
LENVATINIB FLT4

Interaction Score: 0.25

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Trial Name E7080

Novel drug target Established target

PMIDs:
17943726

Sources:
TALC MyCancerGenome TdgClinicalTrial
SUNITINIB FLT4

Interaction Score: 0.23

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name Sutent

Notes

PMIDs:
17367763 17296815 15688612 16685460 17605814 22015057 19248971

Sources:
TALC TdgClinicalTrial TEND MyCancerGenomeClinicalTrial PharmGKB
FAMITINIB FLT4

Interaction Score: 0.21

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor 3 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
TESEVATINIB FLT4

Interaction Score: 0.21

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name XL647

Novel drug target Established target

PMIDs:
None found

Sources:
MyCancerGenome TdgClinicalTrial
NINTEDANIB FLT4

Interaction Score: 0.21

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name BIBF-1120,Vargatef

Novel drug target Established target

Notes

PMIDs:
18559524 31016670

Sources:
TALC MyCancerGenome TdgClinicalTrial ClearityFoundationClinicalTrial
4SC-203 FLT4

Interaction Score: 0.19

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CHIAURANIB FLT4

Interaction Score: 0.19

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
JNJ-26483327 FLT4

Interaction Score: 0.17

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor 3 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
ANLOTINIB FLT4

Interaction Score: 0.15

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Vascular endothelial growth factor receptor 3 inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
TAK-593 FLT4

Interaction Score: 0.15

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MUPARFOSTAT FLT4

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Muparfostat

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TTD
OSI-930 FLT4

Interaction Score: 0.15

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
PAZOPANIB FLT4

Interaction Score: 0.15

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name Pazopanib

Notes

PMIDs:
17288876 28377484 27160228

Sources:
TALC MyCancerGenome TdgClinicalTrial CIViC MyCancerGenomeClinicalTrial
MGCD-265 FLT4

Interaction Score: 0.12

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PEGPLERANIB SODIUM FLT4

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name E-10030

PMIDs:
None found

Sources:
TdgClinicalTrial
FORETINIB FLT4

Interaction Score: 0.12

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
MyCancerGenome ChemblInteractions
XL-820 FLT4

Interaction Score: 0.12

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
SORAFENIB FLT4

Interaction Score: 0.11

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name Nexavar

Novel drug target Established target

Notes

PMIDs:
16729906 16133532 16474853 16757355 17296815 28362716

Sources:
TALC DTC TdgClinicalTrial TEND MyCancerGenomeClinicalTrial PharmGKB
SU-014813 FLT4

Interaction Score: 0.11

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
BMS-690514 FLT4

Interaction Score: 0.11

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
REGORAFENIB FLT4

Interaction Score: 0.11

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Notes

PMIDs:
None found

Sources:
TALC MyCancerGenome ChemblInteractions MyCancerGenomeClinicalTrial
BRIVANIB ALANINATE FLT4

Interaction Score: 0.11

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CP-459632 FLT4

Interaction Score: 0.09

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
RABEPRAZOLE SODIUM FLT4

Interaction Score: 0.09

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome TTD
SUNITINIB MALATE FLT4

Interaction Score: 0.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
NINTEDANIB ESYLATE FLT4

Interaction Score: 0.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ORANTINIB FLT4

Interaction Score: 0.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
CEDIRANIB FLT4

Interaction Score: 0.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name cediranib, AZD2171,Recentin

Notes

PMIDs:
None found

Sources:
TALC DTC TdgClinicalTrial ClearityFoundationClinicalTrial ChemblInteractions
AZAKENPAULLONE FLT4

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TANDUTINIB FLT4

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
VANDETANIB FLT4

Interaction Score: 0.07

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Trial Name Zactima

Novel drug target Established target

PMIDs:
None found

Sources:
TALC TdgClinicalTrial ClearityFoundationClinicalTrial ChemblInteractions MyCancerGenomeClinicalTrial
CEP-11981 FLT4

Interaction Score: 0.07

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
BRIVANIB FLT4

Interaction Score: 0.07

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
XL-999 FLT4

Interaction Score: 0.07

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PAZOPANIB HYDROCHLORIDE FLT4

Interaction Score: 0.07

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ENMD-2076 FLT4

Interaction Score: 0.06

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name ENMD-2076

PMIDs:
None found

Sources:
MyCancerGenome TdgClinicalTrial
MK-2461 FLT4

Interaction Score: 0.06

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
TTD
LINIFANIB FLT4

Interaction Score: 0.05

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

Trial Name ABT-869, Linifanib

PMIDs:
None found

Sources:
DTC MyCancerGenome TdgClinicalTrial ChemblInteractions TTD
SEMAXANIB FLT4

Interaction Score: 0.05

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
SORAFENIB TOSYLATE FLT4

Interaction Score: 0.05

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DORAMAPIMOD FLT4

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DOVITINIB FLT4

Interaction Score: 0.03

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

Trial Name dovitinib, TKI-258, CHIR-258

PMIDs:
None found

Sources:
DTC TdgClinicalTrial ClearityFoundationClinicalTrial ChemblInteractions
AZD-1152-HQPA FLT4

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TAK-715 FLT4

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SB-203580 FLT4

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MLN-8054 FLT4

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SB-220025 FLT4

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GW843682X FLT4

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
OSI-632 FLT4

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GO-6976 FLT4

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GSK-269962A FLT4

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
KENPAULLONE FLT4

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ERLOTINIB FLT4

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ALSTERPAULLONE FLT4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ILORASERTIB FLT4

Interaction Score: 0.01

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
DTC ChemblInteractions
SOTRASTAURIN FLT4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ENTRECTINIB FLT4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GW441756X FLT4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GEFITINIB FLT4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TOZASERTIB FLT4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RG-1530 FLT4

Interaction Score: 0.01

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
SP-600125 FLT4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TAE-684 FLT4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PF-00562271 FLT4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CENISERTIB FLT4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

Ensembl: ENSG00000037280
- Version: 101_38
Alternate Names:

FLT4 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: P35916
- Version: 11-September-2012
Alternate Names:

2324 Entrez Gene Id

FLT4 Uniprot Gene Name

VGFR3_HUMAN Uniprot Id

Gene Info:

Uniprot Status Swiss-Prot

Human Readable Name KINASE

Interpro Acc IPR001245

Gene Categories:

KINASE, DRUGGABLE GENOME

Publications:
TEND: P35916
- Version: 01-August-2011
Alternate Names:

ENSG00000037280 Ensembl Gene Id

FLT4 Gene Symbol

P35916 Uniprot Accession

Gene Info:

Transmembrane Helix Count 1

Target Subclass Other

Target Subclass Kinase

Publications:

RussLampel: ENSG00000037280

Version: 26-July-2011

Alternate Names:

ENSG00000037280 Ensembl Gene Id

FLT4 Display Id

VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 3 PRECURSOR (EC 2.7.1.112) (VEGFR-3) (TYROSINE-PROTEIN KINASE RECEPTOR FLT4). [SOURCE:UNIPROT/SWISSPROT;ACC:P35916] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

CancerCommons: FLT4
- Version: 25-July-2013
Alternate Names:

2324 Entrez Gene ID

Gene Info:

CancerCommons Reported Gene Name VEGF, PDGF

Publications:
TdgClinicalTrial: P35916
- Version: January-2014
Alternate Names:

FLT4 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass EC:2.7.10.1

Publications:

PharmGKB: FLT4

Version: 18-August-2020

Alternate Names:

PA28183 PharmGKB ID

Gene Info:

Publications:

Garcia-Donas J et al., 2011, Single nucleotide polymorphism associations with response and toxic effects in patients with advanced renal-cell carcinoma treated with first-line sunitinib: a multicentre, observational, prospective study., Lancet Oncol

Quek R et al., 2009, Gastrointestinal stromal tumor: a clinical overview., Hematol Oncol Clin North Am

Gong L et al., 2017, PharmGKB summary: sorafenib pathways., Pharmacogenet Genomics

CIViC: FLT4

Version: 14-September-2020

Alternate Names:

2324 Entrez Gene ID

1938 CIViC Gene ID

Gene Info:

Publications:

Ravi V et al., 2016, Antitumor Response of VEGFR2- and VEGFR3-Amplified Angiosarcoma to Pazopanib., J Natl Compr Canc Netw

Subbiah V et al., 2017, Phase Ib/II Study of the Safety and Efficacy of Combination Therapy with Multikinase VEGF Inhibitor Pazopanib and MEK Inhibitor Trametinib In Advanced Soft Tissue Sarcoma., Clin Cancer Res

TTD: Vascular endothelial growth factor receptor 3
- Version: 2020.06.01
Alternate Names:

FLT-4 TTD Gene Abbreviation

T07303 TTD Target ID

Gene Info:

Publications:

Stevenson CE et al., 2012, Bevacizumab and breast cancer: what does the future hold?, Future Oncol

DTC: FLT4

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Kurenova et al., 2009, Small molecule chloropyramine hydrochloride (C4) targets the binding site of focal adhesion kinase and vascular endothelial growth factor receptor 3 and suppresses breast cancer growth in vivo., J. Med. Chem.

Gingrich DE et al., 2003, A new class of potent vascular endothelial growth factor receptor tyrosine kinase inhibitors: structure-activity relationships for a series of 9-alkoxymethyl-12-(3-hydroxypropyl)indeno[2,1-a]pyrrolo[3,4-c]carbazole-5-ones and the identification of CEP-5214 and its dimethylglycine ester prodrug clinical candidate CEP-7055., J Med Chem

HingoraniCasas: ENSG00000037280
- Version: 31-May-2017
Alternate Names:

ENSG00000037280 Gene Symbol

FLT4 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
MyCancerGenome: FLT4
- Version: 20-Jun-2017
Alternate Names:

2324 Entrez Gene Id

FLT4 MyCancerGenome Gene Symbol

VEGFR1/2/3 MyCancerGenome Reported Gene Name

Gene Info:

Publications:
TALC: VEGFR-3
- Version: 12-May-2016
Alternate Names:

VEGFR-3 Gene Symbol

Gene Info:

Publications:
ChemblInteractions: VEGFR3
- Version: chembl_23
Alternate Names:

VEGFR3 GENE_SYMBOL

FLT4 GENE_SYMBOL

Vascular endothelial growth factor receptor 3 UNIPROT

Gene Info:

Publications:
Tempus: FLT4
- Version: 11-November-2018
Alternate Names:

FLT4 Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
dGene: FLT4
- Version: 27-Jun-2013
Alternate Names:

2324 Gene ID

FLT41 dGene Synonym

LMPH1A dGene Synonym

Gene Info:

Gene Categories:

KINASE, TYROSINE KINASE

Publications:
Pharos: FLT4
- Version: 01-February-2022
Alternate Names:

Vascular endothelial growth factor receptor 3 Gene Name

P35916 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:
MyCancerGenomeClinicalTrial: FLT4
- Version: 30-February-2014
Alternate Names:

Gene Info:

Publications:
MskImpact: FLT4
- Version: May-2015
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
ClearityFoundationClinicalTrial: FLT4
- Version: 15-June-2013
Alternate Names:

Gene Info:

Publications:
FoundationOneGenes: FLT4
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
CarisMolecularIntelligence: FLT4
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Trial Name	fruquintinib
Novel drug target	Established target
Mechanism of Interaction	Vascular endothelial growth factor receptor inhibitor

Mechanism of Interaction	Vascular endothelial growth factor receptor inhibitor
Direct Interaction	yes

Notes
Mechanism of Interaction	Vascular endothelial growth factor receptor 3 inhibitor
Direct Interaction	yes

Reported Cancer Type	Prostate
Direct Interaction	yes
Mechanism of Interaction	Vascular endothelial growth factor receptor inhibitor

Trial Name	Vatalanib
Novel drug target	Established target
Trial Name	vatalanib, PTK 787

Trial Name	BIBF-1120,Vargatef
Novel drug target	Established target
Notes

2324	Entrez Gene Id
FLT4	Uniprot Gene Name
VGFR3_HUMAN	Uniprot Id

ENSG00000037280	Ensembl Gene Id
FLT4	Gene Symbol
P35916	Uniprot Accession

VEGFR3	GENE_SYMBOL
FLT4	GENE_SYMBOL
Vascular endothelial growth factor receptor 3	UNIPROT

Vascular endothelial growth factor receptor 3	Gene Name
P35916	UniProt ID

FLT4 Gene Record

FLT4 2324 Druggable GenomeClinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info: Trial Name IMC-3C5 Novel drug target Established target

PMIDs: 22515444

Sources: TdgClinicalTrial TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19610651

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Notes Trial Name AV-951 Novel drug target Established target

PMIDs: None found

Sources: TALC MyCancerGenome TdgClinicalTrial ClearityFoundationClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name fruquintinib Novel drug target Established target Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor Direct Interaction yes

PMIDs: 14640546

Sources: DTC ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Notes Mechanism of Interaction Vascular endothelial growth factor receptor 3 inhibitor Direct Interaction yes

PMIDs: None found

Sources: TALC MyCancerGenome TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Reported Cancer Type Prostate Direct Interaction yes Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

PMIDs: 18541897

Sources: TALC MyCancerGenome TdgClinicalTrial ChemblInteractions CancerCommons MyCancerGenomeClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor Direct Interaction yes Notes

PMIDs: None found

Sources: TALC MyCancerGenome TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name Vatalanib Novel drug target Established target Trial Name vatalanib, PTK 787

PMIDs: 17584317

Sources: DTC MyCancerGenome TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor Direct Interaction yes

PMIDs: None found

Sources: MyCancerGenome ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Notes Novel drug target Established target Trial Name MGCD265

PMIDs: None found

Sources: TALC MyCancerGenome TdgClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions MyCancerGenomeClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Notes Trial Name E7080 Novel drug target Established target

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name IMC-3C5

Novel drug target Established target

PMIDs:
22515444

Sources:
TdgClinicalTrial TTD

Interaction Types & Directionality:

n/a

PMIDs:
19610651

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Trial Name AV-951

Novel drug target Established target

PMIDs:
None found

Sources:
TALC MyCancerGenome TdgClinicalTrial ClearityFoundationClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name fruquintinib

Novel drug target Established target

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
14640546

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Mechanism of Interaction Vascular endothelial growth factor receptor 3 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
TALC MyCancerGenome TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Reported Cancer Type Prostate

Direct Interaction yes

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

PMIDs:
18541897

Sources:
TALC MyCancerGenome TdgClinicalTrial ChemblInteractions CancerCommons MyCancerGenomeClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

Notes

PMIDs:
None found

Sources:
TALC MyCancerGenome TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Vatalanib

Novel drug target Established target

Trial Name vatalanib, PTK 787

PMIDs:
17584317

Sources:
DTC MyCancerGenome TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
MyCancerGenome ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Novel drug target Established target

Trial Name MGCD265

PMIDs:
None found

Sources:
TALC MyCancerGenome TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions MyCancerGenomeClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Trial Name E7080

Novel drug target Established target

PMIDs:
17943726

Sources:
TALC MyCancerGenome TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name Sutent

Notes

PMIDs:
17367763 17296815 15688612 16685460 17605814 22015057 19248971

Sources:
TALC TdgClinicalTrial TEND MyCancerGenomeClinicalTrial PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)