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FMO3 Gene Record

  • Summary
  • Interactions
  • Claims
  • FMO3 2328 Druggable Genome

    Alternate Names:

    2328
    FLAVIN CONTAINING MONOOXYGENASE 3
    FMO3
    FMOII
    TMAU
    dJ127D3.1
    136132
    3771
    ENSG00000007933
    OTTHUMG00000035505
    PA166
    P31513
    FLAVIN CONTAINING DIMETHYLANILINE MONOXYGENASE 3
    Dimethylaniline monooxygenase [N-oxide-forming] 3

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (1 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    ENZYME

    Publications:

    Ren L et al., 2017, Donors FMO3 polymorphisms affect tacrolimus elimination in Chinese liver transplant patients., Pharmacogenomics
    Teitelbaum AM et al., 2018, Nicotine dependence is associated with functional variation in FMO3, an enzyme that metabolizes nicotine in the brain., Pharmacogenomics J
    Klein DJ et al., 2013, PharmGKB summary: tamoxifen pathway, pharmacokinetics., Pharmacogenet Genomics
    Thompson P et al., 2014, Pharmacokinetics and pharmacogenomics of daunorubicin in children: a report from the Children's Oncology Group., Cancer Chemother Pharmacol
    Hu M et al., 2010, Pharmacogenetic analysis of lipid responses to rosuvastatin in Chinese patients., Pharmacogenet Genomics
    Zhou LP et al., 2014, Effect of two-linked mutations of the FMO3 gene on itopride metabolism in Chinese healthy volunteers., Eur J Clin Pharmacol
    Söderberg MM et al., 2013, Influence of FMO1 and 3 polymorphisms on serum olanzapine and its N-oxide metabolite in psychiatric patients., Pharmacogenomics J
  • ITOPRIDE   FMO3

    Interaction Score: 5.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25224784


    Sources:
    PharmGKB

  • ROSUVASTATIN   FMO3

    Interaction Score: 1.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20679960


    Sources:
    PharmGKB

  • TACROLIMUS   FMO3

    Interaction Score: 0.45

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28084894


    Sources:
    PharmGKB

  • SULINDAC   FMO3

    Interaction Score: 0.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • NICOTINE   FMO3

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28290528


    Sources:
    PharmGKB

  • TAMOXIFEN   FMO3

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23962908


    Sources:
    PharmGKB

  • DAUNORUBICIN   FMO3

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25119182


    Sources:
    PharmGKB

  • OLANZAPINE   FMO3

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23147717


    Sources:
    PharmGKB

  • Ensembl: ENSG00000007933

    • Version: 101_38

    Alternate Names:
    FMO3 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: FMO3

    • Version: 18-August-2020

    Alternate Names:
    PA166 PharmGKB ID

    Gene Info:

    Publications:
    Ren L et al., 2017, Donors FMO3 polymorphisms affect tacrolimus elimination in Chinese liver transplant patients., Pharmacogenomics
    Teitelbaum AM et al., 2018, Nicotine dependence is associated with functional variation in FMO3, an enzyme that metabolizes nicotine in the brain., Pharmacogenomics J
    Klein DJ et al., 2013, PharmGKB summary: tamoxifen pathway, pharmacokinetics., Pharmacogenet Genomics

  • HingoraniCasas: ENSG00000007933

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000007933 Gene Symbol
    FMO3 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HumanProteinAtlas: FMO3

    • Version: 19.3

    Alternate Names:
    ENSG00000007933 Ensembl Gene ID
    Flavin containing monooxygenase 3 Human Protein Atlas Gene Description
    P31513 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • Pharos: FMO3

    • Version: 01-February-2022

    Alternate Names:
    Dimethylaniline monooxygenase [N-oxide-forming] 3 Gene Name
    P31513 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21