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FOS Gene Record

  • Summary
  • Interactions
  • Claims
  • FOS 2353 Druggable Genome

    Alternate Names:

    2353
    FOS PROTO-ONCOGENE, AP-1 TRANSCRIPTION FACTOR SUBUNIT
    FOS
    AP-1
    C-FOS
    p55
    164810
    3796
    ENSG00000170345
    OTTHUMG00000171774
    Proto-oncogene c-Fos
    P01100

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (0 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    TRANSCRIPTION FACTOR

    Publications:

    Takemura et al., 2001, GABA B receptor-mediated effects on expression of c-Fos in rat trigeminal nucleus following high- and low-intensity afferent stimulation., Neuroscience
    Lampugnani et al., 1990, Thrombin induces c-fos expression in cultured human endothelial cells by a Ca2(+)-dependent mechanism., Blood
    Hui et al., 1998, Inhibition of activator protein 1 activity by paclitaxel suppresses interleukin-1-induced collagenase and stromelysin expression by bovine chondrocytes., Arthritis Rheum.
    Murphy et al., 2006, Lack of evidence of a role for the neurosteroid allopregnanolone in ethanol-induced reward and c-fos expression in DBA/2 mice., Brain Res.
    Kukushkin et al., [Effect of anisomycin on activation of early response genes c-fos, c-jun, Egr-1 in cells transformed by E1A and cHa-ras oncogenes]., Mol. Biol. (Mosk.)
    Bucci et al., Effects of age on pilocarpine-induced c-fos expression in rat hippocampus and cortex., Neurobiol. Aging
    Tanaka et al., 1997, Changes in glutamate receptors, c-fos mRNA expression and activator protein-1 (AP-1) DNA binding activity in the brain of phenobarbital-dependent and -withdrawn rats., Brain Res.
    Mäkelä et al., 1995, Phytoestrogens are partial estrogen agonists in the adult male mouse., Environ. Health Perspect.
    Ko et al., 1993, Action of dihydropyridine calcium antagonists on early growth response gene expression and cell growth in vascular smooth muscle cells., J. Hypertens.
    Burdman et al., 2001, Bromocriptine and the expression of c-myc and c-fos in human prolactinomas., Neurol. Res.
  • ANTIBIOTIC   FOS

    Interaction Score: 1.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15773551


    Sources:
    NCI

  • BACLOFEN   FOS

    Interaction Score: 1.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11301212


    Sources:
    NCI

  • PILOCARPINE   FOS

    Interaction Score: 0.95

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9661997


    Sources:
    NCI

  • NIMODIPINE   FOS

    Interaction Score: 0.82

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8301097


    Sources:
    NCI

  • BROMOCRIPTINE   FOS

    Interaction Score: 0.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11680511


    Sources:
    NCI

  • DAIDZEIN   FOS

    Interaction Score: 0.65

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8593857


    Sources:
    NCI

  • THROMBIN   FOS

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2119237


    Sources:
    NCI

  • PHENOBARBITAL   FOS

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9187311


    Sources:
    NCI

  • ALCOHOL   FOS

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16750178


    Sources:
    NCI

  • PACLITAXEL   FOS

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9588740


    Sources:
    NCI

  • Ensembl: ENSG00000170345

    • Version: 101_38

    Alternate Names:
    FOS Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • NCI: FOS

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Ko et al., 1993, Action of dihydropyridine calcium antagonists on early growth response gene expression and cell growth in vascular smooth muscle cells., J. Hypertens.
    Buritova et al., 2001, Urethane anaesthesia could partly mask antinociceptive effects of non-steroidal anti-inflammatory drugs: a spinal c-Fos protein study., Brain Res.
    Silvers et al., The role of JNK and p38 MAPK activities in UVA-induced signaling pathways leading to AP-1 activation and c-Fos expression., Neoplasia

  • HingoraniCasas: ENSG00000170345

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000170345 Gene Symbol
    FOS Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • Pharos: FOS

    • Version: 01-February-2022

    Alternate Names:
    Proto-oncogene c-Fos Gene Name
    P01100 UniProt ID

    Gene Info:

    Gene Categories:
    TRANSCRIPTION FACTOR

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21