• Interaction Score: 1.06

    Interaction Types & Directionality:
    positive modulator (activating)
    allosteric modulator

    Interaction Info:
    Direct Interaction? True
    Endogenous Drug? False
    Specific Action of the Ligand Positive

  • Interaction Score: 0.77

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

  • Interaction Score: 0.64

    Interaction Types & Directionality:
    allosteric modulator
    potentiator

    Interaction Info:
    Novel drug target Established target
    Trial Name -
    Specific Binding Site for Interaction benzodiazepine site

  • Interaction Score: 0.57

    Interaction Types & Directionality:
    agonist (activating)
    allosteric modulator

    Interaction Info:
    Details of the Assay for Interaction Assay using recombinant GABA<sub>A</sub> channels with subunit composition; &alpha;2&beta;1&gamma;2.
    Specific Action of the Ligand Positive
    Endogenous Drug? False

  • Interaction Score: 0.48

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Established target
    Trial Name pagoclone

  • Interaction Score: 0.32

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA receptor alpha-2 subunit positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.32

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

  • Interaction Score: 0.32

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

  • Interaction Score: 0.29

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Novel drug target Established target
    Trial Name -

  • Interaction Score: 0.29

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

  • Interaction Score: 0.27

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Novel drug target Established target
    Trial Name -

  • Interaction Score: 0.21

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Mechanism of Interaction GABA-A receptor; anion channel agonist

  • Interaction Score: 0.19

    Interaction Types & Directionality:
    potentiator

    Interaction Info:


    Sources:
    DrugBank

  • Interaction Score: 0.19

    Interaction Types & Directionality:
    potentiator

    Interaction Info:


    Sources:
    DrugBank

  • Interaction Score: 0.19

    Interaction Types & Directionality:
    positive modulator (activating)
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

  • Interaction Score: 0.19

    Interaction Types & Directionality:
    potentiator

    Interaction Info:


    Sources:
    DrugBank

  • Interaction Score: 0.19

    Interaction Types & Directionality:
    positive modulator (activating)
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

  • Interaction Score: 0.19

    Interaction Types & Directionality:
    potentiator

    Interaction Info:


    Sources:
    DrugBank

  • Interaction Score: 0.19

    Interaction Types & Directionality:
    positive modulator (activating)
    potentiator

    Interaction Info:
    Novel drug target Established target
    Trial Name -
    Direct Interaction yes

  • Interaction Score: 0.18

    Interaction Types & Directionality:
    positive modulator (activating)
    agonist (activating)

    Interaction Info:
    Trial Name Lunesta
    Novel drug target Established target
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

  • Interaction Score: 0.17

    Interaction Types & Directionality:
    positive modulator (activating)
    potentiator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes
    Trial Name -

  • Interaction Score: 0.17

    Interaction Types & Directionality:
    allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel allosteric antagonist
    Direct Interaction yes
    Specific Binding Site for Interaction benzodiazepine site

  • Interaction Score: 0.16

    Interaction Types & Directionality:
    allosteric modulator

    Interaction Info:
    Specific Binding Site for Interaction benzodiazepine site
    Specific Action of the Ligand Partial agonist
    Details of Interaction low efficacy

    PMIDs:
    None found


  • Interaction Score: 0.16

    Interaction Types & Directionality:
    positive modulator (activating)
    potentiator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes
    Trial Name -

  • Interaction Score: 0.16

    Interaction Types & Directionality:
    positive modulator (activating)
    potentiator

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Trial Name -

  • Interaction Score: 0.15

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

  • Interaction Score: 0.15

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Novel drug target Established target
    Trial Name -

  • Interaction Score: 0.15

    Interaction Types & Directionality:
    positive modulator (activating)
    allosteric modulator
    potentiator

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Trial Name diazepam rectal gel

  • Interaction Score: 0.15

    Interaction Types & Directionality:
    positive modulator (activating)
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

  • Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name Ganaxolone
    Novel drug target Established target

    PMIDs:
    None found


  • Interaction Score: 0.14

    Interaction Types & Directionality:
    positive modulator (activating)
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

  • Interaction Score: 0.13

    Interaction Types & Directionality:
    positive modulator (activating)
    allosteric modulator
    potentiator

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Trial Name ARX-03, sufentanil + triazolam NanoTab

  • Interaction Score: 0.12

    Interaction Types & Directionality:
    positive modulator (activating)
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

  • Interaction Score: 0.12

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

  • Interaction Score: 0.12

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

  • Interaction Score: 0.12

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; agonist GABA site agonist
    Direct Interaction yes
    Specific Binding Site for Interaction GABA site

  • Interaction Score: 0.12

    Interaction Types & Directionality:
    positive modulator (activating)
    potentiator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes
    Trial Name -

  • Interaction Score: 0.12

    Interaction Types & Directionality:
    positive modulator (activating)
    potentiator

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Trial Name -

  • Interaction Score: 0.11

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    18855614


  • Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive modulator
    Direct Interaction yes

    PMIDs:
    16884293


  • Interaction Score: 0.11

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    7849137


  • Interaction Score: 0.11

    Interaction Types & Directionality:
    allosteric modulator

    Interaction Info:
    Specific Binding Site for Interaction benzodiazepine site
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.11

    Interaction Types & Directionality:
    positive modulator (activating)
    allosteric modulator

    Interaction Info:
    Trial Name JZP-8
    Novel drug target Established target
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

  • Interaction Score: 0.09

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Binding Site for Interaction GABA site
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.09

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Novel drug target Established target
    Trial Name Clobazam
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

    PMIDs:
    None found


  • Interaction Score: 0.09

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

    PMIDs:
    None found


  • Interaction Score: 0.09

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    18384456


  • Interaction Score: 0.09

    Interaction Types & Directionality:
    positive modulator (activating)
    allosteric modulator

    Interaction Info:
    Trial Name AZ-002, Staccato alprazolam
    Novel drug target Established target
    Trial Name alprazolam,Xanax, Xanax XR

  • Interaction Score: 0.08

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes
    Trial Name -

    PMIDs:
    None found


  • Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16884293


    Sources:
    DTC

  • Interaction Score: 0.08

    Interaction Types & Directionality:
    agonist (activating)
    allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel agonist
    Direct Interaction yes
    Details of the Assay for Interaction Determined in a radioligand competition binding assay using [<sup>3</sup>H]flumazenil and recombinant human GABA<sub>A</sub> receptor with the &alpha;2/&beta;2/&gamma;3 configuration.

    PMIDs:
    None found


  • Interaction Score: 0.07

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; benzodiazepine site positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.07

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Binding Site for Interaction GABA site
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    None found


  • Interaction Score: 0.07

    Interaction Types & Directionality:
    allosteric modulator

    Interaction Info:
    Trial Name ocinaplon
    Novel drug target Established target
    Direct Interaction? False

    PMIDs:
    None found


  • Interaction Score: 0.07

    Interaction Types & Directionality:
    inverse agonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; benzodiazepine site inverse agonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.07

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand Full agonist

    PMIDs:
    None found


  • Interaction Score: 0.07

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Novel drug target Established target
    Trial Name -

  • Interaction Score: 0.07

    Interaction Types & Directionality:
    partial agonist (activating)

    Interaction Info:
    Novel drug target Established target
    Trial Name NG2-73
    Mechanism of Interaction GABA-A receptor; benzodiazepine site partial agonist

    PMIDs:
    None found


  • Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    None found


  • Interaction Score: 0.06

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Binding Site for Interaction GABA site
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.04

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.04

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

    PMIDs:
    None found


  • Interaction Score: 0.04

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name EHT 0202
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • Interaction Score: 0.04

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.04

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.04

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction GABA-A receptor; anion channel positive modulator

    PMIDs:
    None found


  • Interaction Score: 0.04

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.04

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.04

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name CNS-7056
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    None found


  • Interaction Score: 0.03

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Specific Action of the Ligand None
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    None found


  • Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • Interaction Score: 0.02

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

    PMIDs:
    None found


  • Interaction Score: 0.02

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.02

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.02

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction GABA-A receptor; anion channel positive modulator

    PMIDs:
    None found


  • Interaction Score: 0.01

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:


    Sources:
    DrugBank

  • Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive modulator
    Direct Interaction yes

    PMIDs:
    None found