• Interaction Score: 1.22

    Interaction Types & Directionality:
    positive modulator (activating)
    allosteric modulator

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction GABA receptor alpha-3 subunit positive allosteric modulator

  • Interaction Score: 0.81

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Interaction Score: 0.81

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

  • Interaction Score: 0.63

    Interaction Types & Directionality:
    agonist (activating)
    allosteric modulator

    Interaction Info:
    Trial Name OX-22, zolpidem sublingual,Edluar, Sublinox
    Novel drug target Established target

  • Interaction Score: 0.51

    Interaction Types & Directionality:
    allosteric modulator
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

  • Interaction Score: 0.41

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA receptor alpha-3 subunit positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.34

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

  • Interaction Score: 0.33

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

  • Interaction Score: 0.33

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

  • Interaction Score: 0.33

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

  • Interaction Score: 0.3

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

  • Interaction Score: 0.23

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel agonist
    Direct Interaction yes
    Trial Name -

  • Interaction Score: 0.2

    Interaction Types & Directionality:
    positive modulator (activating)
    potentiator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes
    Trial Name -

  • Interaction Score: 0.2

    Interaction Types & Directionality:
    positive modulator (activating)
    potentiator

    Interaction Info:
    Novel drug target Established target
    Trial Name -
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

  • Interaction Score: 0.2

    Interaction Types & Directionality:
    positive modulator (activating)
    potentiator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes
    Trial Name -

  • Interaction Score: 0.2

    Interaction Types & Directionality:
    positive modulator (activating)
    potentiator

    Interaction Info:
    Novel drug target Established target
    Trial Name -
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

  • Interaction Score: 0.2

    Interaction Types & Directionality:
    positive modulator (activating)
    potentiator

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Trial Name -

  • Interaction Score: 0.2

    Interaction Types & Directionality:
    positive modulator (activating)
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Direct Interaction yes

  • Interaction Score: 0.19

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

  • Interaction Score: 0.18

    Interaction Types & Directionality:
    positive modulator (activating)
    potentiator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes
    Trial Name -

  • Interaction Score: 0.18

    Interaction Types & Directionality:
    positive modulator (activating)
    agonist (activating)

    Interaction Info:
    Novel drug target Established target
    Trial Name Lunesta
    Direct Interaction yes

  • Interaction Score: 0.18

    Interaction Types & Directionality:
    positive modulator (activating)
    potentiator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes
    Trial Name -

  • Interaction Score: 0.17

    Interaction Types & Directionality:
    allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel allosteric antagonist
    Direct Interaction yes
    Trial Name -

    PMIDs:
    None found


  • Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    None found


  • Interaction Score: 0.16

    Interaction Types & Directionality:
    positive modulator (activating)
    allosteric modulator
    potentiator

    Interaction Info:
    Trial Name diazepam rectal gel
    Novel drug target Established target
    Trial Name NRL-01

  • Interaction Score: 0.16

    Interaction Types & Directionality:
    positive modulator (activating)
    potentiator

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Trial Name -

  • Interaction Score: 0.15

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

  • Interaction Score: 0.15

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

  • Interaction Score: 0.15

    Interaction Types & Directionality:
    positive modulator (activating)
    potentiator

    Interaction Info:
    Novel drug target Established target
    Trial Name -
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

  • Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction GABA-A receptor; anion channel positive modulator

    PMIDs:
    16884293


  • Interaction Score: 0.14

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    2857046


  • Interaction Score: 0.14

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    7849137


  • Interaction Score: 0.14

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    18855614


  • Interaction Score: 0.14

    Interaction Types & Directionality:
    positive modulator (activating)
    allosteric modulator
    potentiator

    Interaction Info:
    Trial Name ARX-03, sufentanil + triazolam NanoTab
    Novel drug target Established target
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

  • Interaction Score: 0.13

    Interaction Types & Directionality:
    positive modulator (activating)
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

  • Interaction Score: 0.13

    Interaction Types & Directionality:
    partial agonist (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; benzodiazepine site partial agonist
    Direct Interaction yes
    Trial Name NG2-73

    PMIDs:
    None found


  • Interaction Score: 0.13

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Novel drug target Established target
    Trial Name gaboxadol
    Mechanism of Interaction GABA-A receptor; agonist GABA site agonist

    PMIDs:
    None found


  • Interaction Score: 0.12

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    18384456


  • Interaction Score: 0.12

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Trial Name -

    PMIDs:
    None found


  • Interaction Score: 0.12

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes
    Trial Name Clobazam

    PMIDs:
    None found


  • Interaction Score: 0.11

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes
    Trial Name -

    PMIDs:
    None found


  • Interaction Score: 0.11

    Interaction Types & Directionality:
    positive modulator (activating)
    allosteric modulator

    Interaction Info:
    Trial Name JZP-8
    Novel drug target Established target
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

    PMIDs:
    None found


  • Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16884293


    Sources:
    DTC

  • Interaction Score: 0.09

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; benzodiazepine site positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name Ganaxolone
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • Interaction Score: 0.09

    Interaction Types & Directionality:
    inverse agonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; benzodiazepine site inverse agonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.09

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

  • Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    None found


  • Interaction Score: 0.08

    Interaction Types & Directionality:
    positive modulator (activating)
    allosteric modulator

    Interaction Info:
    Trial Name alprazolam,Xanax, Xanax XR
    Novel drug target Established target
    Trial Name AZ-002, Staccato alprazolam

    PMIDs:
    None found


  • Interaction Score: 0.05

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.05

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.05

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.05

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction GABA-A receptor; anion channel positive modulator

    PMIDs:
    None found


  • Interaction Score: 0.05

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

    PMIDs:
    None found


  • Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name EHT 0202
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • Interaction Score: 0.05

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction GABA-A receptor; anion channel agonist

    PMIDs:
    None found


  • Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.05

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.05

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.05

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.05

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Established target
    Trial Name CNS-7056

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • Interaction Score: 0.05

    Interaction Types & Directionality:
    allosteric modulator

    Interaction Info:
    Novel drug target Established target
    Trial Name ocinaplon

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    None found


  • Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.03

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.03

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.03

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.03

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction GABA-A receptor; anion channel positive modulator

    PMIDs:
    None found


  • Interaction Score: 0.02

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive modulator
    Direct Interaction yes

    PMIDs:
    None found


    • Version: 101_38

    Alternate Names:
    GABRA3 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

    • Version: 11-September-2012

    Alternate Names:
    ENSG00000011677 Ensembl Gene Id
    2556 Entrez Gene Id
    GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-3 Uniprot Protein Name

    Gene Info:
    Interpro Acc IPR006201
    Interpro Name Neurotransmitter-gated ion-channel ligand-binding
    Interpro Short Name Neur_channel

    Gene Categories:
    ION CHANNEL, DRUGGABLE GENOME

    Publications:

    • Version: 01-August-2011

    Alternate Names:
    ENSG00000011677 Ensembl Gene Id
    GABRA3 Gene Symbol
    P34903 Uniprot Accession

    Gene Info:
    Transmembrane Helix Count 4
    Target Subclass Ligand_gated_ion_channels
    Target Subclass Channels

    Publications:

    • Version: 26-July-2011

    Alternate Names:
    GABRA3 Display Id
    GAMMA-AMINOBUTYRIC-ACID RECEPTOR ALPHA-3 SUBUNIT PRECURSOR (GABA(A) RECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:P34903] Description
    ENSG00000011677 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: January-2014

    Alternate Names:
    GABRA3 Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass TC:1.A.9

    Publications:

    • Version: 02-September-2020
    • Version: chembl_23

    Alternate Names:
    GABRA3 GENE_SYMBOL
    Gamma-aminobutyric acid receptor subunit alpha-3 UNIPROT
    GABA(A) receptor subunit alpha-3 UNIPROT

    Gene Info:

    Publications:

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000011677 Gene Symbol
    GABRA3 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: 2020.06.01

    Alternate Names:
    GABRA3 TTD Gene Abbreviation
    T62292 TTD Target ID

    Gene Info:

    Publications:

    • Version: 01-February-2022

    Alternate Names:
    Gamma-aminobutyric acid receptor subunit alpha-3 Gene Name
    P34903 UniProt ID

    Gene Info:

    Gene Categories:
    ION CHANNEL

    Publications: