2560 |
GAMMA-AMINOBUTYRIC ACID TYPE A RECEPTOR BETA1 SUBUNIT |
GABRB1 |
EIEE45 |
137190 |
4081 |
ENSG00000163288 |
OTTHUMG00000044269 |
P18505 |
GBRB1_HUMAN |
P18507 |
GABRG2 |
GABA(A) receptor subunit beta-1 |
Gamma-aminobutyric acid receptor subunit beta-1 |
GAMMA-AMINOBUTYRIC-ACID RECEPTOR BETA-1 SUBUNIT PRECURSOR (GABA(A) RECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:P18505] |
gamma-aminobutyric acid type A receptor subunit beta1 |
DEE45 |
Target Class | Receptors |
Target Subclass | TC:1.A.9 |
Human Readable Name | DRUGGABLE GENOME |
Uniprot Status | Swiss-Prot |
Interpro Type | Domain |
Interpro Acc | IPR006202 |
Interpro Name | Neurotransmitter-gated ion-channel ligand-binding |
Interpro Name | Neurotransmitter-gated ion-channel |
Uniprot Evidence | 1: Evidence at protein level |
Interpro Short Name | Neur_channel |
Interpro Short Name | Neur_chan_lig-bd |
Interpro Type | Family |
Human Readable Name | ION CHANNEL |
Interpro Acc | IPR006201 |
Target Subclass | Channels |
Target Subclass | cys-loop |
Transmembrane Helix Count | 4 |
Target Main Class | Receptors |
Target Subclass | Ligand_gated_ion_channels |
Gene Biotype | PROTEIN_CODING |
ION CHANNEL |
DRUGGABLE GENOME |
positive modulator (activating) |
Mechanism of Interaction | GABA A receptor alpha-1/beta-1/gamma-2 positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA A receptor alpha-1/beta-1/gamma-2 positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
potentiator |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Novel drug target | Established target |
positive modulator (activating) |
potentiator |
Trial Name | - |
Novel drug target | Established target |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
potentiator |
Novel drug target | Established target |
Trial Name | - |
positive modulator (activating) |
potentiator |
Trial Name | - |
Novel drug target | Established target |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive modulator (activating) |
potentiator |
Novel drug target | Established target |
Trial Name | - |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive modulator (activating) |
potentiator |
Novel drug target | Established target |
Trial Name | - |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
potentiator |
Trial Name | - |
Novel drug target | Established target |
potentiator |
Novel drug target | Established target |
Trial Name | - |
positive modulator (activating) |
potentiator |
Novel drug target | Established target |
Trial Name | - |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
potentiator |
Novel drug target | Established target |
Trial Name | - |
potentiator |
Novel drug target | Established target |
Trial Name | - |
potentiator |
Trial Name | - |
Novel drug target | Established target |
positive modulator (activating) |
potentiator |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Trial Name | diazepam rectal gel |
positive modulator (activating) |
potentiator |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Trial Name | ARX-03, sufentanil + triazolam NanoTab |
agonist (activating) |
Mechanism of Interaction | GABA-A receptor; agonist GABA site agonist |
Direct Interaction | yes |
Trial Name | gaboxadol |
potentiator |
Trial Name | - |
Novel drug target | Established target |
positive modulator (activating) |
Novel drug target | Established target |
Trial Name | - |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive modulator (activating) |
Trial Name | Clobazam |
Novel drug target | Established target |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive modulator (activating) |
Novel drug target | Established target |
Trial Name | - |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive modulator (activating) |
Trial Name | JZP-8 |
Novel drug target | Established target |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
potentiator |
Trial Name | - |
Novel drug target | Established target |
n/a |
Trial Name | - |
Novel drug target | Established target |
positive modulator (activating) |
Trial Name | alprazolam,Xanax, Xanax XR |
Novel drug target | Established target |
Trial Name | AZ-002, Staccato alprazolam |
agonist (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel agonist |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
n/a |
Trial Name | EHT 0202 |
Novel drug target | Established target |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
positive modulator (activating) |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive modulator (activating) |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive modulator (activating) |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive modulator (activating) |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel agonist |
Direct Interaction | yes |
n/a |
Novel drug target | Established target |
Trial Name | ocinaplon |
n/a |
Novel drug target | Established target |
Trial Name | CNS-7056 |
n/a |
Trial Name | NG2-73 |
Novel drug target | Established target |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel allosteric antagonist |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive modulator (activating) |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
GABRB1 | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
GABRB1 | Display Id |
ENSG00000163288 | Ensembl Gene Id |
GAMMA-AMINOBUTYRIC-ACID RECEPTOR BETA-1 SUBUNIT PRECURSOR (GABA(A) RECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:P18505] | Description |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
GABRB1 | Gene Symbol |
Target Class | Receptors |
Target Subclass | TC:1.A.9 |
2560 | Entrez Gene Id |
GABRB1 | Gene Symbol |
ENSG00000163288 | Ensembl Gene Id |
Target Subclass | Channels |
Target Subclass | cys-loop |
Transmembrane Helix Count | 4 |
GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-1 | Uniprot Protein Name |
2560 | Entrez Gene Id |
P18505 | Uniprot Accession |
Human Readable Name | DRUGGABLE GENOME |
Uniprot Status | Swiss-Prot |
Interpro Type | Domain |
ION CHANNEL, DRUGGABLE GENOME |
GABRG2 | Gene Symbol |
GABRB1 | Gene Symbol |
Target Class | Receptors |
Target Subclass | TC:1.A.9 |
ENSG00000163288 | Gene Symbol |
GABRB1 | Ensembl Id |
DRUGGABLE GENOME |
GABRB1 | GENE_SYMBOL |
Gamma-aminobutyric acid receptor subunit beta-1 | UNIPROT |
GABA(A) receptor subunit beta-1 | UNIPROT |
Gamma-aminobutyric acid receptor subunit beta-1 | Gene Name |
P18505 | UniProt ID |
ION CHANNEL |