2561 |
GAMMA-AMINOBUTYRIC ACID TYPE A RECEPTOR BETA2 SUBUNIT |
GABRB2 |
600232 |
4082 |
ENSG00000145864 |
OTTHUMG00000130349 |
P47870 |
GBRB2_HUMAN |
GAMMA-AMINOBUTYRIC-ACID RECEPTOR BETA-2 SUBUNIT PRECURSOR (GABA(A) RECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:P47870] |
GABA(A) receptor subunit beta-2 |
Gamma-aminobutyric acid receptor subunit beta-2 |
GABA(A) receptor beta-2 |
T80387 |
gamma-aminobutyric acid type A receptor subunit beta2 |
DEE92 |
ICEE2 |
Target Subclass | cys-loop |
Target Main Class | Receptors |
Target Subclass | Ligand_gated_ion_channels |
Target Subclass | Channels |
Transmembrane Helix Count | 4 |
Human Readable Name | DRUGGABLE GENOME |
Target Class | Receptors |
Target Subclass | TC:1.A.9.5.2 |
Interpro Acc | IPR006202 |
Uniprot Status | Swiss-Prot |
Interpro Name | Neurotransmitter-gated ion-channel ligand-binding |
Interpro Short Name | Neur_chan_lig-bd |
Interpro Type | Family |
Uniprot Evidence | 1: Evidence at protein level |
Interpro Type | Domain |
Interpro Short Name | Neur_channel |
Human Readable Name | ION CHANNEL |
Interpro Name | Neurotransmitter-gated ion-channel |
Interpro Acc | IPR006201 |
Gene Biotype | PROTEIN_CODING |
ION CHANNEL |
DRUGGABLE GENOME |
potentiator |
Trial Name | fospropofol disodium, GPI-15715,Lusedra, Aquavan |
Novel drug target | Established target |
n/a |
Trial Name | pagoclone |
Novel drug target | Established target |
positive modulator (activating) |
potentiator |
Trial Name | - |
Novel drug target | Established target |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
potentiator |
Trial Name | - |
Novel drug target | Established target |
n/a |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
positive modulator (activating) |
potentiator |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
Trial Name | - |
positive modulator (activating) |
potentiator |
Novel drug target | Established target |
Trial Name | - |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive modulator (activating) |
potentiator |
Novel drug target | Established target |
Trial Name | - |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
potentiator |
Trial Name | - |
Novel drug target | Established target |
potentiator |
Novel drug target | Established target |
Trial Name | - |
positive modulator (activating) |
potentiator |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
Novel drug target | Established target |
potentiator |
Trial Name | - |
Novel drug target | Established target |
potentiator |
Novel drug target | Established target |
Trial Name | - |
potentiator |
Novel drug target | Established target |
Trial Name | - |
positive modulator (activating) |
potentiator |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
Trial Name | diazepam rectal gel |
positive modulator (activating) |
potentiator |
Novel drug target | Established target |
Trial Name | ARX-03, sufentanil + triazolam NanoTab |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
agonist (activating) |
Trial Name | gaboxadol |
Novel drug target | Established target |
Mechanism of Interaction | GABA-A receptor; agonist GABA site agonist |
potentiator |
Trial Name | - |
Novel drug target | Established target |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
Trial Name | - |
positive modulator (activating) |
Trial Name | Clobazam |
Novel drug target | Established target |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive modulator (activating) |
potentiator |
Trial Name | propofol,Diprivan |
Novel drug target | Established target |
Trial Name | propofol lingual spray |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
Trial Name | - |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
Trial Name | JZP-8 |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
potentiator |
Trial Name | - |
Novel drug target | Established target |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
Trial Name | alprazolam,Xanax, Xanax XR |
n/a |
Trial Name | - |
Novel drug target | Established target |
n/a |
Trial Name | EHT 0202 |
Novel drug target | Established target |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
n/a |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
agonist (activating) |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel agonist |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
positive modulator (activating) |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel agonist |
Direct Interaction | yes |
n/a |
Trial Name | CNS-7056 |
Novel drug target | Established target |
n/a |
Trial Name | ocinaplon |
Novel drug target | Established target |
n/a |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel allosteric antagonist |
n/a |
Trial Name | NG2-73 |
Novel drug target | Established target |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
n/a |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
positive modulator (activating) |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
GABRB2 | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
GABRB2 | Gene Symbol |
ENSG00000145864 | Ensembl Gene Id |
P47870 | Uniprot Accession |
Target Subclass | cys-loop |
Target Main Class | Receptors |
Target Subclass | Ligand_gated_ion_channels |
GAMMA-AMINOBUTYRIC-ACID RECEPTOR BETA-2 SUBUNIT PRECURSOR (GABA(A) RECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:P47870] | Description |
ENSG00000145864 | Ensembl Gene Id |
GABRB2 | Display Id |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
ENSG00000145864 | Ensembl Gene Id |
GABRB2 | Uniprot Gene Name |
GBRB2_HUMAN | Uniprot Id |
Human Readable Name | DRUGGABLE GENOME |
Interpro Acc | IPR006202 |
Uniprot Status | Swiss-Prot |
ION CHANNEL, DRUGGABLE GENOME |
GABRB2 | Gene Symbol |
Target Class | Receptors |
Target Subclass | TC:1.A.9.5.2 |
GABRB2 | GENE_SYMBOL |
Gamma-aminobutyric acid receptor subunit beta-2 | UNIPROT |
GABA(A) receptor subunit beta-2 | UNIPROT |
ENSG00000145864 | Gene Symbol |
GABRB2 | Ensembl Id |
DRUGGABLE GENOME |
GABRB2 | TTD Gene Abbreviation |
T80387 | TTD Target ID |
Gamma-aminobutyric acid receptor subunit beta-2 | Gene Name |
P47870 | UniProt ID |
ION CHANNEL |