2562 |
GAMMA-AMINOBUTYRIC ACID TYPE A RECEPTOR BETA3 SUBUNIT |
GABRB3 |
ECA5 |
EIEE43 |
137192 |
4083 |
ENSG00000166206 |
OTTHUMG00000129231 |
P28472 |
GAMMA-AMINOBUTYRIC-ACID RECEPTOR BETA-3 SUBUNIT PRECURSOR (GABA(A) RECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:P28472] |
GBRB3_HUMAN |
GABA(A) receptor subunit beta-3 |
Gamma-aminobutyric acid receptor subunit beta-3 |
gamma-aminobutyric acid type A receptor subunit beta3 |
DEE43 |
Target Class | Receptors |
Target Subclass | TC:1.A.9 |
Human Readable Name | DRUGGABLE GENOME |
Interpro Acc | IPR006201 |
Interpro Short Name | Neur_chan_lig-bd |
Uniprot Status | Swiss-Prot |
Interpro Acc | IPR006202 |
Interpro Type | Family |
Interpro Type | Domain |
Interpro Name | Neurotransmitter-gated ion-channel ligand-binding |
Human Readable Name | ION CHANNEL |
Interpro Name | Neurotransmitter-gated ion-channel |
Uniprot Evidence | 1: Evidence at protein level |
Interpro Short Name | Neur_channel |
Target Subclass | Ligand_gated_ion_channels |
Transmembrane Helix Count | 4 |
Target Subclass | Channels |
Target Subclass | cys-loop |
Target Main Class | Receptors |
Gene Biotype | PROTEIN_CODING |
ION CHANNEL |
DRUGGABLE GENOME |
potentiator |
Trial Name | fospropofol disodium, GPI-15715,Lusedra, Aquavan |
Novel drug target | Established target |
positive modulator (activating) |
potentiator |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
Trial Name | - |
positive modulator (activating) |
potentiator |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
Trial Name | - |
potentiator |
Trial Name | - |
Novel drug target | Established target |
positive modulator (activating) |
potentiator |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
Trial Name | - |
positive modulator (activating) |
potentiator |
Novel drug target | Established target |
Trial Name | - |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive modulator (activating) |
potentiator |
Novel drug target | Established target |
Trial Name | - |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
potentiator |
Trial Name | - |
Novel drug target | Established target |
potentiator |
Trial Name | - |
Novel drug target | Established target |
positive modulator (activating) |
potentiator |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
Trial Name | - |
potentiator |
Trial Name | - |
Novel drug target | Established target |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
potentiator |
Novel drug target | Established target |
Trial Name | - |
potentiator |
Novel drug target | Established target |
Trial Name | - |
positive modulator (activating) |
potentiator |
Trial Name | diazepam rectal gel |
Novel drug target | Established target |
Trial Name | NRL-01 |
positive modulator (activating) |
potentiator |
Trial Name | ARX-03, sufentanil + triazolam NanoTab |
Novel drug target | Established target |
Direct Interaction | yes |
agonist (activating) |
Trial Name | gaboxadol |
Novel drug target | Established target |
Mechanism of Interaction | GABA-A receptor; agonist GABA site agonist |
potentiator |
Trial Name | - |
Novel drug target | Established target |
positive modulator (activating) |
Novel drug target | Established target |
Trial Name | Clobazam |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive modulator (activating) |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Trial Name | - |
positive modulator (activating) |
potentiator |
Trial Name | propofol lingual spray |
Novel drug target | Established target |
Trial Name | propofol,Diprivan |
positive modulator (activating) |
Trial Name | - |
Novel drug target | Established target |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
Trial Name | JZP-8 |
potentiator |
Trial Name | - |
Novel drug target | Established target |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
Trial Name | AZ-002, Staccato alprazolam |
n/a |
Trial Name | - |
Novel drug target | Established target |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
positive modulator (activating) |
allosteric modulator |
Mechanism of Interaction | GABA receptor beta-3 subunit positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel agonist |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
n/a |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
n/a |
Trial Name | CNS-7056 |
Novel drug target | Established target |
agonist (activating) |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel agonist |
n/a |
Trial Name | ocinaplon |
Novel drug target | Established target |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel allosteric antagonist |
Direct Interaction | yes |
n/a |
Trial Name | NG2-73 |
Novel drug target | Established target |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
n/a |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
n/a |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
GABRB3 | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
GABRB3 | Display Id |
GAMMA-AMINOBUTYRIC-ACID RECEPTOR BETA-3 SUBUNIT PRECURSOR (GABA(A) RECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:P28472] | Description |
ENSG00000166206 | Ensembl Gene Id |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
GBRB3_HUMAN | Uniprot Id |
ENSG00000166206 | Ensembl Gene Id |
P28472 | Uniprot Accession |
Interpro Acc | IPR006201 |
Interpro Short Name | Neur_chan_lig-bd |
Uniprot Status | Swiss-Prot |
ION CHANNEL, DRUGGABLE GENOME |
GABRB3 | Gene Symbol |
Target Class | Receptors |
Target Subclass | TC:1.A.9 |
2562 | Entrez Gene Id |
ENSG00000166206 | Ensembl Gene Id |
P28472 | Uniprot Accession |
Target Subclass | Ligand_gated_ion_channels |
Transmembrane Helix Count | 4 |
Target Subclass | Channels |
GABRB3 | GENE_SYMBOL |
Gamma-aminobutyric acid receptor subunit beta-3 | UNIPROT |
GABA(A) receptor subunit beta-3 | UNIPROT |
ENSG00000166206 | Gene Symbol |
GABRB3 | Ensembl Id |
DRUGGABLE GENOME |
Gamma-aminobutyric acid receptor subunit beta-3 | Gene Name |
P28472 | UniProt ID |
ION CHANNEL |