2564 |
GAMMA-AMINOBUTYRIC ACID TYPE A RECEPTOR EPSILON SUBUNIT |
GABRE |
300093 |
4085 |
ENSG00000102287 |
OTTHUMG00000024176 |
P78334 |
GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT EPSILON |
GBRE_HUMAN |
GABA(A) receptor subunit epsilon |
GAMMA-AMINOBUTYRIC-ACID RECEPTOR EPSILON SUBUNIT PRECURSOR (GABA(A) RECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:P78334] |
gamma-aminobutyric acid type A receptor subunit epsilon |
Interpro Acc | IPR006202 |
Interpro Type | Family |
Interpro Type | Domain |
Uniprot Evidence | 2: Evidence at transcript level |
Interpro Name | Neurotransmitter-gated ion-channel ligand-binding |
Human Readable Name | DRUGGABLE GENOME |
Interpro Acc | IPR006201 |
Interpro Name | Neurotransmitter-gated ion-channel |
Human Readable Name | ION CHANNEL |
Interpro Short Name | Neur_chan_lig-bd |
Interpro Short Name | Neur_channel |
Uniprot Status | Swiss-Prot |
Target Main Class | Receptors |
Transmembrane Helix Count | 4 |
Target Subclass | Channels |
Target Subclass | Ligand_gated_ion_channels |
Target Subclass | cys-loop |
Target Class | Receptors |
Target Subclass | TC:1.A.9 |
Gene Biotype | PROTEIN_CODING |
ION CHANNEL |
DRUGGABLE GENOME |
positive modulator (activating) |
potentiator |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Trial Name | - |
positive modulator (activating) |
potentiator |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Trial Name | - |
potentiator |
Trial Name | - |
Novel drug target | Established target |
positive modulator (activating) |
potentiator |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
Trial Name | - |
positive modulator (activating) |
potentiator |
Novel drug target | Established target |
Trial Name | - |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive modulator (activating) |
potentiator |
Trial Name | - |
Novel drug target | Established target |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
potentiator |
Trial Name | - |
Novel drug target | Established target |
potentiator |
Trial Name | - |
Novel drug target | Established target |
positive modulator (activating) |
potentiator |
Trial Name | - |
Novel drug target | Established target |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
potentiator |
Trial Name | - |
Novel drug target | Established target |
potentiator |
Trial Name | - |
Novel drug target | Established target |
potentiator |
Trial Name | - |
Novel drug target | Established target |
positive modulator (activating) |
potentiator |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
Trial Name | diazepam rectal gel |
positive modulator (activating) |
potentiator |
Trial Name | ARX-03, sufentanil + triazolam NanoTab |
Novel drug target | Established target |
Direct Interaction | yes |
positive modulator (activating) |
Trial Name | Clobazam |
Novel drug target | Established target |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
potentiator |
Trial Name | - |
Novel drug target | Established target |
positive modulator (activating) |
Trial Name | - |
Novel drug target | Established target |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
Trial Name | - |
positive modulator (activating) |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Trial Name | JZP-8 |
potentiator |
Trial Name | - |
Novel drug target | Established target |
n/a |
Trial Name | - |
Novel drug target | Established target |
positive modulator (activating) |
Trial Name | alprazolam,Xanax, Xanax XR |
Novel drug target | Established target |
Trial Name | AZ-002, Staccato alprazolam |
n/a |
Trial Name | gaboxadol |
Novel drug target | Established target |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel agonist |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
n/a |
Trial Name | EHT 0202 |
Novel drug target | Established target |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
n/a |
Trial Name | CNS-7056 |
Novel drug target | Established target |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
n/a |
Trial Name | ocinaplon |
Novel drug target | Established target |
agonist (activating) |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel agonist |
n/a |
Trial Name | NG2-73 |
Novel drug target | Established target |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel allosteric antagonist |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
n/a |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
GABRE | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
ENSG00000102287 | Ensembl Gene Id |
P78334 | Uniprot Accession |
GABRE | Gene Symbol |
Target Main Class | Receptors |
Transmembrane Helix Count | 4 |
Target Subclass | Channels |
GABRE | Display Id |
GAMMA-AMINOBUTYRIC-ACID RECEPTOR EPSILON SUBUNIT PRECURSOR (GABA(A) RECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:P78334] | Description |
ENSG00000102287 | Ensembl Gene Id |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
GABRE | Gene Symbol |
Target Class | Receptors |
Target Subclass | TC:1.A.9 |
GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT EPSILON | Uniprot Protein Name |
GBRE_HUMAN | Uniprot Id |
ENSG00000102287 | Ensembl Gene Id |
Interpro Acc | IPR006202 |
Interpro Type | Family |
Interpro Type | Domain |
ION CHANNEL, DRUGGABLE GENOME |
ENSG00000102287 | Gene Symbol |
GABRE | Ensembl Id |
DRUGGABLE GENOME |
GABRE | GENE_SYMBOL |
Gamma-aminobutyric acid receptor subunit epsilon | UNIPROT |
GABA(A) receptor subunit epsilon | UNIPROT |
Gamma-aminobutyric acid receptor subunit epsilon | Gene Name |
P78334 | UniProt ID |
ION CHANNEL |