2567 |
GAMMA-AMINOBUTYRIC ACID TYPE A RECEPTOR GAMMA3 SUBUNIT |
GABRG3 |
600233 |
4088 |
ENSG00000182256 |
OTTHUMG00000044462 |
Q99928 |
GBRG3_HUMAN |
Gamma-aminobutyric acid receptor subunit gamma-3 |
GABA(A) receptor subunit gamma-3 |
GAMMA-AMINOBUTYRIC-ACID RECEPTOR GAMMA-3 SUBUNIT PRECURSOR (GABA(A) RECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:Q99928] |
PA28502 |
GABA(A) receptor gamma-3 |
T28722 |
gamma-aminobutyric acid type A receptor subunit gamma3 |
Target Main Class | Receptors |
Target Subclass | Ligand_gated_ion_channels |
Transmembrane Helix Count | 4 |
Target Subclass | cys-loop |
Target Subclass | Channels |
Target Class | Receptors |
Target Subclass | TC:1.A.9 |
Interpro Type | Domain |
Interpro Acc | IPR006201 |
Interpro Type | Family |
Interpro Acc | IPR006202 |
Uniprot Evidence | 2: Evidence at transcript level |
Uniprot Status | Swiss-Prot |
Interpro Short Name | Neur_chan_lig-bd |
Interpro Name | Neurotransmitter-gated ion-channel ligand-binding |
Human Readable Name | DRUGGABLE GENOME |
Interpro Short Name | Neur_channel |
Interpro Name | Neurotransmitter-gated ion-channel |
Human Readable Name | ION CHANNEL |
Gene Biotype | PROTEIN_CODING |
ION CHANNEL |
DRUGGABLE GENOME |
positive modulator (activating) |
potentiator |
Novel drug target | Established target |
Trial Name | - |
Direct Interaction | yes |
positive modulator (activating) |
potentiator |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
Trial Name | - |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
potentiator |
Novel drug target | Established target |
Trial Name | - |
positive modulator (activating) |
potentiator |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Trial Name | - |
positive modulator (activating) |
potentiator |
Trial Name | - |
Novel drug target | Established target |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive modulator (activating) |
potentiator |
Trial Name | - |
Novel drug target | Established target |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
potentiator |
Trial Name | - |
Novel drug target | Established target |
potentiator |
Novel drug target | Established target |
Trial Name | - |
positive modulator (activating) |
potentiator |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
Trial Name | - |
potentiator |
Trial Name | - |
Novel drug target | Established target |
potentiator |
Trial Name | - |
Novel drug target | Established target |
potentiator |
Trial Name | - |
Novel drug target | Established target |
positive modulator (activating) |
potentiator |
Trial Name | NRL-01 |
Novel drug target | Established target |
Trial Name | diazepam rectal gel |
positive modulator (activating) |
potentiator |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Trial Name | ARX-03, sufentanil + triazolam NanoTab |
positive modulator (activating) |
Trial Name | Clobazam |
Novel drug target | Established target |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
potentiator |
Trial Name | - |
Novel drug target | Established target |
positive modulator (activating) |
Novel drug target | Established target |
Trial Name | - |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive modulator (activating) |
Trial Name | - |
Novel drug target | Established target |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive modulator (activating) |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Novel drug target | Established target |
inverse agonist (inhibitory) |
Mechanism of Interaction | GABA-A receptor; benzodiazepine site inverse agonist |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; benzodiazepine site positive allosteric modulator |
Direct Interaction | yes |
n/a |
Trial Name | CNS-7056 |
Novel drug target | Established target |
potentiator |
Trial Name | - |
Novel drug target | Established target |
partial agonist (activating) |
Mechanism of Interaction | GABA-A receptor; benzodiazepine site partial agonist |
Direct Interaction | yes |
Trial Name | NG2-73 |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel allosteric antagonist |
Direct Interaction | yes |
positive modulator (activating) |
Trial Name | alprazolam,Xanax, Xanax XR |
Novel drug target | Established target |
Trial Name | AZ-002, Staccato alprazolam |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
n/a |
Trial Name | - |
Novel drug target | Established target |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
agonist (activating) |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel agonist |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
n/a |
Trial Name | ocinaplon |
Novel drug target | Established target |
agonist (activating) |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel agonist |
positive modulator (activating) |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
positive modulator (activating) |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
n/a |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
GABRG3 | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
GABRG3 | Display Id |
ENSG00000182256 | Ensembl Gene Id |
GAMMA-AMINOBUTYRIC-ACID RECEPTOR GAMMA-3 SUBUNIT PRECURSOR (GABA(A) RECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:Q99928] | Description |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
Q99928 | Uniprot Accession |
2567 | Entrez Gene Id |
GABRG3 | Gene Symbol |
Target Main Class | Receptors |
Target Subclass | Ligand_gated_ion_channels |
Transmembrane Helix Count | 4 |
ENSG00000182256 | Ensembl Gene Id |
GBRG3_HUMAN | Uniprot Id |
GABRG3 | Uniprot Gene Name |
Interpro Type | Domain |
Interpro Acc | IPR006201 |
Interpro Type | Family |
ION CHANNEL, DRUGGABLE GENOME |
GABRG3 | Gene Symbol |
Target Class | Receptors |
Target Subclass | TC:1.A.9 |
PA28502 | PharmGKB ID |
GABRG3 | GENE_SYMBOL |
Gamma-aminobutyric acid receptor subunit gamma-3 | UNIPROT |
GABA(A) receptor subunit gamma-3 | UNIPROT |
ENSG00000182256 | Gene Symbol |
GABRG3 | Ensembl Id |
DRUGGABLE GENOME |
GABRG3 | TTD Gene Abbreviation |
T28722 | TTD Target ID |
Gamma-aminobutyric acid receptor subunit gamma-3 | Gene Name |
Q99928 | UniProt ID |
ION CHANNEL |