DGIdb - GBA Gene Record

GBA 2629 Druggable Genome

Alternate Names:

2629
GLUCOSYLCERAMIDASE BETA
GBA
GBA1
GCB
GLUC
606463
4177
ENSG00000177628
OTTHUMG00000035841
D-glucosyl-N-acylsphingosine glucohydrolase
Beta-glucocerebrosidase
Alglucerase
Acid beta-glucosidase
Beta-GC
Imiglucerase
Glucosylceramidase
P04062
GC
GLUCOSYLCERAMIDASE PRECURSOR (EC 3.2.1.45) (BETA-GLUCOCEREBROSIDASE) (ACID BETA-GLUCOSIDASE) (D-GLUCOSYL-N-ACYLSPHINGOSINE GLUCOHYDROLASE) (ALGLUCERASE) (IMIGLUCERASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P04062]
BE0000978
PA28591
T84173
2978
NM_000157
NP_000148

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Target Class	Enzymes
Target Subclass	EC:3.2.1.45
Gene Biotype	PROTEIN_CODING
GuideToPharmacology Gene Category Name	3.2.1.- Glycosidases
GuideToPharmacology Gene Category ID	841

(6 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
ENZYME

Publications:

Marugan JJ et al., 2011, Evaluation of quinazoline analogues as glucocerebrosidase inhibitors with chaperone activity., J Med Chem
Castilla J et al., 2012, Conformationally-locked N-glycosides with selective β-glucosidase inhibitory activity: identification of a new non-iminosugar-type pharmacological chaperone for Gaucher disease., J Med Chem
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

CHEMBL408500 GBA

Interaction Score: 5.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DTC DrugBank
AMBROXOL GBA

Interaction Score: 5.33

Interaction Types & Directionality:

n/a

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Binding

PMIDs:
22762530

Sources:
DTC GuideToPharmacology
AFEGOSTAT GBA

Interaction Score: 5.33

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Novel Target

Trial Name isofagomine tartrate, AT2101,Plicera

PMIDs:
21250698

Sources:
DTC TdgClinicalTrial
SCYLLITOL GBA

Interaction Score: 1.78

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CHEMBL588327 GBA

Interaction Score: 1.78

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CIRSIMARITIN GBA

Interaction Score: 1.78

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL529939 GBA

Interaction Score: 1.78

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1234669 GBA

Interaction Score: 1.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CASTANOSPERMINE GBA

Interaction Score: 0.89

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1379900 GBA

Interaction Score: 0.89

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SULFANITRAN GBA

Interaction Score: 0.89

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
APTIGANEL HYDROCHLORIDE GBA

Interaction Score: 0.89

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL603154 GBA

Interaction Score: 0.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
L-755507 GBA

Interaction Score: 0.44

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MIGALASTAT GBA

Interaction Score: 0.44

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL578928 GBA

Interaction Score: 0.44

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
2,3-DIHYDROXY-6,7-DICHLOROQUINOXALINE GBA

Interaction Score: 0.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DNQX GBA

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL579837 GBA

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DOMIPHEN BROMIDE GBA

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL73711 GBA

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL528181 GBA

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1169388 GBA

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ISOLIQUIRITIGENIN GBA

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GENTIAN VIOLET GBA

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PHLORETIN GBA

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TRICHOSTATIN GBA

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHLORHEXIDINE GBA

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
METITEPINE GBA

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RALOXIFENE HYDROCHLORIDE GBA

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
EBSELEN GBA

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GENISTEIN GBA

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

Ensembl: ENSG00000177628
- Version: 101_38
Alternate Names:

GBA Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000177628

Version: 26-July-2011

Alternate Names:

ENSG00000177628 Ensembl Gene Id

GBA Display Id

GLUCOSYLCERAMIDASE PRECURSOR (EC 3.2.1.45) (BETA-GLUCOCEREBROSIDASE) (ACID BETA-GLUCOSIDASE) (D-GLUCOSYL-N-ACYLSPHINGOSINE GLUCOHYDROLASE) (ALGLUCERASE) (IMIGLUCERASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P04062] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

TdgClinicalTrial: P04062
- Version: January-2014
Alternate Names:

GBA Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.2.1.45

Publications:
GuideToPharmacology: 2629
- Version: 29-September-2020
Alternate Names:

4177 HUGO Gene ID

4177 HUGO Gene Symbol

glucosylceramidase beta HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name 3.2.1.- Glycosidases

GuideToPharmacology Gene Category ID 841

Gene Categories:

ENZYME

Publications:

DrugBank: BE0000978

Version: 5.1.7

Alternate Names:

GBA DrugBank Gene Name

P04062 UniProt Accession

2629 Entrez Gene Id

Gene Info:

Publications:

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

Pastores, 2010, Velaglucerase alfa, a human recombinant glucocerebrosidase enzyme replacement therapy for type 1 Gaucher disease., Curr Opin Investig Drugs

DTC: GBA

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Castilla J et al., 2012, Conformationally-locked N-glycosides with selective β-glucosidase inhibitory activity: identification of a new non-iminosugar-type pharmacological chaperone for Gaucher disease., J Med Chem

Marugan JJ et al., 2011, Evaluation of quinazoline analogues as glucocerebrosidase inhibitors with chaperone activity., J Med Chem

HingoraniCasas: ENSG00000177628
- Version: 31-May-2017
Alternate Names:

ENSG00000177628 Gene Symbol

GBA Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
PharmGKB: GBA
- Version: 18-August-2020
Alternate Names:

PA28591 PharmGKB ID

Gene Info:

Publications:
HumanProteinAtlas: GBA
- Version: 19.3
Alternate Names:

ENSG00000177628 Ensembl Gene ID

GBA1 Human Protein Atlas Gene Synonym

GLUC Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories:

ENZYME

Publications:
TTD: Glucosylceramidase
- Version: 2020.06.01
Alternate Names:

GBA TTD Gene Abbreviation

T84173 TTD Target ID

Gene Info:

Publications:

Direct Interaction?	False
Endogenous Drug?	False
Specific Action of the Ligand	Binding

Novel drug target	Novel Target
Trial Name	isofagomine tartrate, AT2101,Plicera

ENSG00000177628	Ensembl Gene Id
GBA	Display Id
GLUCOSYLCERAMIDASE PRECURSOR (EC 3.2.1.45) (BETA-GLUCOCEREBROSIDASE) (ACID BETA-GLUCOSIDASE) (D-GLUCOSYL-N-ACYLSPHINGOSINE GLUCOHYDROLASE) (ALGLUCERASE) (IMIGLUCERASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P04062]	Description

4177	HUGO Gene ID
4177	HUGO Gene Symbol
glucosylceramidase beta	HUGO Gene Name

GBA	DrugBank Gene Name
P04062	UniProt Accession
2629	Entrez Gene Id

GBA Gene Record

GBA 2629 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DTC DrugBank

Interaction Types & Directionality: n/a

Interaction Info: Direct Interaction? False Endogenous Drug? False Specific Action of the Ligand Binding

PMIDs: 22762530

Sources: DTC GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info: Novel drug target Novel Target Trial Name isofagomine tartrate, AT2101,Plicera

PMIDs: 21250698

Sources: DTC TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DTC DrugBank

Interaction Types & Directionality:

n/a

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Binding

PMIDs:
22762530

Sources:
DTC GuideToPharmacology

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Novel Target

Trial Name isofagomine tartrate, AT2101,Plicera

PMIDs:
21250698

Sources:
DTC TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC