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GDF15 Gene Record

  • Summary
  • Interactions
  • Claims
  • GDF15 9518 Druggable Genome

    Alternate Names:

    9518
    GROWTH DIFFERENTIATION FACTOR 15
    GDF15
    GDF-15
    MIC-1
    MIC1
    NAG-1
    PDF
    PLAB
    PTGFB
    605312
    30142
    ENSG00000130513
    OTTHUMG00000183360
    Q99988
    Growth/differentiation factor 15

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (1 More Sources)

    Gene Categories: Category Details

    GROWTH FACTOR
    DRUGGABLE GENOME
    TRANSCRIPTION FACTOR

    Publications:

    Nazarova et al., 2004, Calcitriol-induced prostate-derived factor: autocrine control of prostate cancer cell growth., Int. J. Cancer
    Baek et al., 2002, Resveratrol enhances the expression of non-steroidal anti-inflammatory drug-activated gene (NAG-1) by increasing the expression of p53., Carcinogenesis
    Tan et al., 2000, PTGF-beta, a type beta transforming growth factor (TGF-beta) superfamily member, is a p53 target gene that inhibits tumor cell growth via TGF-beta signaling pathway., Proc. Natl. Acad. Sci. U.S.A.
    Kim et al., 2004, Cyclooxygenase inhibitors induce apoptosis in oral cavity cancer cells by increased expression of nonsteroidal anti-inflammatory drug-activated gene., Biochem. Biophys. Res. Commun.
    Lee et al., 2005, Indole-3-carbinol and 3,3'-diindolylmethane induce expression of NAG-1 in a p53-independent manner., Biochem. Biophys. Res. Commun.
  • INDOLE-3-CARBINOL   GDF15

    Interaction Score: 4.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15670751


    Sources:
    NCI

  • CALCITRIOL   GDF15

    Interaction Score: 2.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15386353


    Sources:
    NCI

  • DICLOFENAC   GDF15

    Interaction Score: 1.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15555568


    Sources:
    NCI

  • RESVERATROL   GDF15

    Interaction Score: 0.54

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11895857


    Sources:
    NCI

  • ETOPOSIDE   GDF15

    Interaction Score: 0.48

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10618379


    Sources:
    NCI

  • Ensembl: ENSG00000130513

    • Version: 101_38

    Alternate Names:
    GDF15 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • NCI: GDF15

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Nazarova et al., 2004, Calcitriol-induced prostate-derived factor: autocrine control of prostate cancer cell growth., Int. J. Cancer
    Baek et al., 2005, Cyclooxygenase inhibitors induce the expression of the tumor suppressor gene EGR-1, which results in the up-regulation of NAG-1, an antitumorigenic protein., Mol. Pharmacol.
    Kim et al., 2004, Cyclooxygenase inhibitors induce apoptosis in oral cavity cancer cells by increased expression of nonsteroidal anti-inflammatory drug-activated gene., Biochem. Biophys. Res. Commun.

  • HingoraniCasas: ENSG00000130513

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000130513 Gene Symbol
    GDF15 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: GDF15

    • Version: 01-February-2022

    Alternate Names:
    MIC1 GO Gene Synonym
    PDF GO Gene Synonym
    PLAB GO Gene Synonym

    Gene Info:

    Gene Categories:
    GROWTH FACTOR

    Publications:

  • Pharos: GDF15

    • Version: 01-February-2022

    Alternate Names:
    Growth/differentiation factor 15 Gene Name
    Q99988 UniProt ID

    Gene Info:

    Gene Categories:
    TRANSCRIPTION FACTOR

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21