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GFAP Gene Record

  • Summary
  • Interactions
  • Claims
  • GFAP 2670

    Alternate Names:

    2670
    GLIAL FIBRILLARY ACIDIC PROTEIN
    GFAP
    ALXDRD
    137780
    4235
    ENSG00000131095
    OTTHUMG00000179866

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (0 More Sources)

    Gene Categories: Category Details

    Publications:

    Levi et al., 1993, Human immunodeficiency virus coat protein gp120 inhibits the beta-adrenergic regulation of astroglial and microglial functions., Proc. Natl. Acad. Sci. U.S.A.
    Woiciechowsky et al., 2004, Brain-IL-1 beta triggers astrogliosis through induction of IL-6: inhibition by propranolol and IL-10., Med. Sci. Monit.
    Whitehead et al., 2007, Effects of triflusal and aspirin in a rat model of cerebral ischemia., Stroke
    Jean Harry et al., 2003, Differential modulation of hippocampal chemical-induced injury response by ebselen, pentoxifylline, and TNFalpha-, IL-1alpha-, and IL-6-neutralizing antibodies., J. Neurosci. Res.
    Suárez et al., 2000, Neuronal and astroglial response to pre- and perinatal exposure to delta-9-tetra- hydrocannabinol in the rat substantia nigra., Dev. Neurosci.
    Mader et al., 2004, Dual mode of signalling of the axotomy reaction: retrograde electric stimulation or block of retrograde transport differently mimic the reaction of motoneurons to nerve transection in the rat brainstem., J. Neurotrauma
    Pozas et al., 1999, Fra-1 immunoreactivity in the rat brain during normal postnatal development and after injury in adulthood., Neurosci. Res.
    Luthman et al., 1991, Combined lead acetate and disulfiram treatment-induced alterations of glial fibrillary acidic protein (GFA) immunoreactive astrocytes in brain smears., Toxicology
    Oh et al., 1995, Acidic pH rapidly increases immunoreactivity of glial fibrillary acidic protein in cultured astrocytes., Glia
    Wofchuk et al., 1995, Age-dependent changes in the regulation by external calcium ions of the phosphorylation of glial fibrillary acidic protein in slices of rat hippocampus., Brain Res. Dev. Brain Res.
    Du et al., 1999, Calcium influx and activation of calpain I mediate acute reactive gliosis in injured spinal cord., Exp. Neurol.
    Guntinas-Lichius et al., 1997, Nimodipine maintains in vivo the increase in GFAP and enhances the astroglial ensheathment of surviving motoneurons in the rat following permanent target deprivation., J. Neurocytol.
    Seoane et al., 1999, Degeneration and gliosis in rat retina and central nervous system following 3,3'-iminodipropionitrile exposure., Brain Res.
    Sharma et al., 1991, Phorbol-12-myristate-13-acetate (PMA) and inhibitors of protein kinase C alter glial fibrillary acidic protein (GFAP) mRNA levels., Glia
    Pittman et al., Immunohistochemical changes in the mouse striatum induced by the pyrethroid insecticide permethrin., Int. J. Toxicol.
    Massengale et al., 2002, Carbohydrate source influences gelatinase production by mouse astrocytes in vitro., Glia
    Melcangi et al., 1997, Astrocyte-neuron interactions in vitro: role of growth factors and steroids on LHRH dynamics., Brain Res. Bull.
    Yanagisawa et al., 2000, Astrocyte differentiation of fetal neuroepithelial cells by interleukin-11 via activation of a common cytokine signal transducer, gp130, and a transcription factor, STAT3., J. Neurochem.
    Hoyk et al., 2004, Dehydroepiandrosterone regulates astroglia reaction to denervation of olfactory glomeruli., Glia
    Kim et al., 2004, Lithium selectively increases neuronal differentiation of hippocampal neural progenitor cells both in vitro and in vivo., J. Neurochem.
    Suzuki et al., 2004, Mitotic and neurogenic effects of dehydroepiandrosterone (DHEA) on human neural stem cell cultures derived from the fetal cortex., Proc. Natl. Acad. Sci. U.S.A.
    Borlongan et al., 2000, Glial cell survival is enhanced during melatonin-induced neuroprotection against cerebral ischemia., FASEB J.
    Oppelt et al., 2004, Role of intracellular calcium stores on the effect of metabotropic glutamate receptors on phosphorylation of glial fibrillary acidic protein in hippocampal slices from immature rats., Neurochem. Res.
    Ogawa et al., 1985, Transient expression of glial fibrillary acidic protein in developing oligodendrocytes in vitro., Brain Res.
    Okere et al., 2004, Capsaicin increases GFAP and glutamine synthetase immunoreactivity in rat arcuate nucleus and median eminence., Neuroreport
    Silva-Araújo et al., 1995, Expression of glial fibrillary acidic protein in the rat retina after exposure to psychostimulants., Retina (Philadelphia, Pa.)
    Armstrong et al., 2004, Repeated amphetamine treatment causes a persistent elevation of glial fibrillary acidic protein in the caudate-putamen., Eur. J. Pharmacol.
    Luo et al., 1999, Dopamine stimulates redox-tyrosine kinase signaling and p38 MAPK in activation of astrocytic C6-D2L cells., Brain Res.
    Kiaei et al., 2005, Peroxisome proliferator-activated receptor-gamma agonist extends survival in transgenic mouse model of amyotrophic lateral sclerosis., Exp. Neurol.
  • SORBITOL   GFAP

    Interaction Score: 1.65

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11968061


    Sources:
    NCI

  • PERMETHRIN   GFAP

    Interaction Score: 1.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14555407


    Sources:
    NCI

  • FADROZOLE   GFAP

    Interaction Score: 0.99

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15390121


    Sources:
    NCI

  • DEMECOLCINE   GFAP

    Interaction Score: 0.82

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3886082


    Sources:
    NCI

  • OPRELVEKIN   GFAP

    Interaction Score: 0.82

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10737606


    Sources:
    NCI

  • DRONABINOL   GFAP

    Interaction Score: 0.62

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10965147


    Sources:
    NCI

  • AMPHETAMINE   GFAP

    Interaction Score: 0.57

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7569352 15044042


    Sources:
    NCI

  • PIOGLITAZONE   GFAP

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15649489


    Sources:
    NCI

  • CAPSAICIN   GFAP

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15076747


    Sources:
    NCI

  • NIMODIPINE   GFAP

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9192289


    Sources:
    NCI

  • PROPRANOLOL   GFAP

    Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15328477


    Sources:
    NCI

  • PRASTERONE   GFAP

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14973190


    Sources:
    NCI

  • METHIMAZOLE   GFAP

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10375702


    Sources:
    NCI

  • NIFEDIPINE   GFAP

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7615340 7600665 10222112


    Sources:
    NCI

  • MELATONIN   GFAP

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10877823


    Sources:
    NCI

  • CAFFEINE   GFAP

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15260132


    Sources:
    NCI

  • STAUROSPORINE   GFAP

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1720762


    Sources:
    NCI

  • ISOPROTERENOL   GFAP

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8381971


    Sources:
    NCI

  • COLCHICINE   GFAP

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15307907 10211779


    Sources:
    NCI

  • PENTOXIFYLLINE   GFAP

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12898537


    Sources:
    NCI

  • DISULFIRAM   GFAP

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1992564


    Sources:
    NCI

  • LITHIUM   GFAP

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15056276


    Sources:
    NCI

  • GENISTEIN   GFAP

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10629745


    Sources:
    NCI

  • PROGESTERONE   GFAP

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9370212


    Sources:
    NCI

  • ASPIRIN   GFAP

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17194886


    Sources:
    NCI

  • Ensembl: ENSG00000131095

    • Version: 101_38

    Alternate Names:
    GFAP Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • NCI: GFAP

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Woiciechowsky et al., 2004, Brain-IL-1 beta triggers astrogliosis through induction of IL-6: inhibition by propranolol and IL-10., Med. Sci. Monit.
    Whitehead et al., 2007, Effects of triflusal and aspirin in a rat model of cerebral ischemia., Stroke
    Pittman et al., Immunohistochemical changes in the mouse striatum induced by the pyrethroid insecticide permethrin., Int. J. Toxicol.

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21