DGIdb - GGCX Gene Record

GGCX 2677 Druggable Genome

Alternate Names:

2677
GAMMA-GLUTAMYL CARBOXYLASE
GGCX
VKCFD1
137167
4247
ENSG00000115486
OTTHUMG00000130173
P38435
VKGC_HUMAN
VITAMIN K-DEPENDENT GAMMA-CARBOXYLASE
VITAMIN K-DEPENDENT GAMMA-CARBOXYLASE (EC 6.4.-.-) (GAMMA-GLUTAMYL CARBOXYLASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P38435]
PA28660
T88182

Gene Info:

Target Class	Enzymes
Target Subclass	EC:4.1.1.90
Target Subclass	EC:6.4.-.-
Transmembrane Helix Count	6
Target Main Class	Enzymes
Target Subclass	6.4.-.-
Human Readable Name	DRUGGABLE GENOME
Gene Biotype	PROTEIN_CODING

(4 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
ENZYME

Publications:

Tuan, 1979, Vitamin K-dependent gamma-glutamyl carboxylase activity in the chick embryonic chorioallantoic membrane., J. Biol. Chem.
Reedstrom et al., 1995, Comparative distribution, metabolism, and utilization of phylloquinone and menaquinone-9 in rat liver., Proc. Soc. Exp. Biol. Med.
Morris et al., 1993, Characterization of the purified vitamin K-dependent gamma-glutamyl carboxylase., J. Biol. Chem.
Olson, 1984, The function and metabolism of vitamin K., Annu. Rev. Nutr.
Tasatargil et al., Effects of vitamin K1 supplementation on vascular responsiveness and oxidative stress in a rat femoral osteotomy model., Cell Biochem. Funct.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Stafford, 2005, The vitamin K cycle., J. Thromb. Haemost.
Wang et al., 1995, The growth inhibitory effects of vitamins K and their actions on gene expression., Hepatology
Presnell et al., 2002, The vitamin K-dependent carboxylase., Thromb. Haemost.
Bryk AH et al., 2018, Bleeding predictors in patients following venous thromboembolism treated with vitamin K antagonists: Association with increased number of single nucleotide polymorphisms., Vascul Pharmacol
Krishna Kumar D et al., 2015, An acenocoumarol dosing algorithm exploiting clinical and genetic factors in South Indian (Dravidian) population., Eur J Clin Pharmacol
Wypasek E et al., 2014, Genetic determinants of acenocoumarol and warfarin maintenance dose requirements in Slavic population: a potential role of CYP4F2 and GGCX polymorphisms., Thromb Res
Rathore SS et al., 2014, CYP4F2 1347 G > A & GGCX 12970 C > G polymorphisms: frequency in north Indians & their effect on dosing of acenocoumarol oral anticoagulant., Indian J Med Res

PHYTONADIONE GGCX

Interaction Score: 139.12

Interaction Types & Directionality:

inducer (activating)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
105006 7638250 8473318 6380538 16929463 11752352

Sources:
TdgClinicalTrial TEND TTD
ACENOCOUMAROL GGCX

Interaction Score: 12.88

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29432897 25519826 25042728 24927344

Sources:
PharmGKB
ANISINDIONE GGCX

Interaction Score: 12.88

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 11752352

Sources:
TdgClinicalTrial TEND
MENADIONE GGCX

Interaction Score: 2.76

Interaction Types & Directionality:

cofactor (activating)

Interaction Info:

Trial Name topical menadione lotion

Novel drug target Established target

PMIDs:
16102054 7657295 12083499

Sources:
TdgClinicalTrial TEND

Ensembl: ENSG00000115486
- Version: 101_38
Alternate Names:

GGCX Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
RussLampel: ENSG00000115486
- Version: 26-July-2011
Alternate Names:

GGCX Display Id

ENSG00000115486 Ensembl Gene Id

VITAMIN K-DEPENDENT GAMMA-CARBOXYLASE (EC 6.4.-.-) (GAMMA-GLUTAMYL CARBOXYLASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P38435] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
TEND: P38435
- Version: 01-August-2011
Alternate Names:

2677 Entrez Gene Id

ENSG00000115486 Ensembl Gene Id

P38435 Uniprot Accession

Gene Info:

Transmembrane Helix Count 6

Target Main Class Enzymes

Target Subclass 6.4.-.-

Publications:
TdgClinicalTrial: P38435
- Version: January-2014
Alternate Names:

GGCX Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:4.1.1.90

Target Subclass EC:6.4.-.-

Publications:

PharmGKB: GGCX

Version: 18-August-2020

Alternate Names:

PA28660 PharmGKB ID

Gene Info:

Publications:

Wypasek E et al., 2014, Genetic determinants of acenocoumarol and warfarin maintenance dose requirements in Slavic population: a potential role of CYP4F2 and GGCX polymorphisms., Thromb Res

Krishna Kumar D et al., 2015, An acenocoumarol dosing algorithm exploiting clinical and genetic factors in South Indian (Dravidian) population., Eur J Clin Pharmacol

Rathore SS et al., 2014, CYP4F2 1347 G > A & GGCX 12970 C > G polymorphisms: frequency in north Indians & their effect on dosing of acenocoumarol oral anticoagulant., Indian J Med Res

HingoraniCasas: ENSG00000115486
- Version: 31-May-2017
Alternate Names:

ENSG00000115486 Gene Symbol

GGCX Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
TTD: Vitamin K-dependent gamma-carboxylase
- Version: 2020.06.01
Alternate Names:

GGCX TTD Gene Abbreviation

T88182 TTD Target ID

Gene Info:

Publications:
Pharos: GGCX
- Version: 01-February-2022
Alternate Names:

Vitamin K-dependent gamma-carboxylase Gene Name

P38435 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:

Trial Name	topical menadione lotion
Novel drug target	Established target

GGCX	Display Id
ENSG00000115486	Ensembl Gene Id
VITAMIN K-DEPENDENT GAMMA-CARBOXYLASE (EC 6.4.-.-) (GAMMA-GLUTAMYL CARBOXYLASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P38435]	Description

2677	Entrez Gene Id
ENSG00000115486	Ensembl Gene Id
P38435	Uniprot Accession

Vitamin K-dependent gamma-carboxylase	Gene Name
P38435	UniProt ID

GGCX Gene Record

GGCX 2677 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

PHYTONADIONE GGCX

Interaction Types & Directionality: inducer (activating)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 105006 7638250 8473318 6380538 16929463 11752352

Sources: TdgClinicalTrial TEND TTD

ACENOCOUMAROL GGCX

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29432897 25519826 25042728 24927344

Sources: PharmGKB

ANISINDIONE GGCX

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 17016423 17139284 11752352

Sources: TdgClinicalTrial TEND

MENADIONE GGCX

Interaction Types & Directionality: cofactor (activating)

Interaction Info: Trial Name topical menadione lotion Novel drug target Established target

PMIDs: 16102054 7657295 12083499

Sources: TdgClinicalTrial TEND

Ensembl: ENSG00000115486

Alternate Names: GGCX Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000115486

Alternate Names: GGCX Display Id ENSG00000115486 Ensembl Gene Id VITAMIN K-DEPENDENT GAMMA-CARBOXYLASE (EC 6.4.-.-) (GAMMA-GLUTAMYL CARBOXYLASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P38435] Description

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

TEND: P38435

Alternate Names: 2677 Entrez Gene Id ENSG00000115486 Ensembl Gene Id P38435 Uniprot Accession

Gene Info: Transmembrane Helix Count 6 Target Main Class Enzymes Target Subclass 6.4.-.-

Publications:

TdgClinicalTrial: P38435

Alternate Names: GGCX Gene Symbol

Gene Info: Target Class Enzymes Target Subclass EC:4.1.1.90 Target Subclass EC:6.4.-.-

Publications:

PharmGKB: GGCX

Alternate Names: PA28660 PharmGKB ID

Gene Info:

HingoraniCasas: ENSG00000115486

Alternate Names: ENSG00000115486 Gene Symbol GGCX Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

TTD: Vitamin K-dependent gamma-carboxylase

Alternate Names: GGCX TTD Gene Abbreviation T88182 TTD Target ID

Gene Info:

Publications:

Pharos: GGCX

Alternate Names: Vitamin K-dependent gamma-carboxylase Gene Name P38435 UniProt ID

Gene Info:

Gene Categories: ENZYME

Publications:

Interaction Types & Directionality:

inducer (activating)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
105006 7638250 8473318 6380538 16929463 11752352

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
29432897 25519826 25042728 24927344

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 11752352

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

cofactor (activating)

Interaction Info:

Trial Name topical menadione lotion

Novel drug target Established target

PMIDs:
16102054 7657295 12083499

Sources:
TdgClinicalTrial TEND

Alternate Names:

GGCX Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

GGCX Display Id

ENSG00000115486 Ensembl Gene Id

VITAMIN K-DEPENDENT GAMMA-CARBOXYLASE (EC 6.4.-.-) (GAMMA-GLUTAMYL CARBOXYLASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P38435] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

2677 Entrez Gene Id

ENSG00000115486 Ensembl Gene Id

P38435 Uniprot Accession

Gene Info:

Transmembrane Helix Count 6

Target Main Class Enzymes

Target Subclass 6.4.-.-

Alternate Names:

GGCX Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:4.1.1.90

Target Subclass EC:6.4.-.-

Alternate Names:

PA28660 PharmGKB ID

Alternate Names:

ENSG00000115486 Gene Symbol

GGCX Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

GGCX TTD Gene Abbreviation

T88182 TTD Target ID

Alternate Names:

Vitamin K-dependent gamma-carboxylase Gene Name

P38435 UniProt ID

Gene Categories:

ENZYME