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GGCX Gene Record

  • Summary
  • Interactions
  • Claims
  • GGCX 2677 Druggable Genome

    Alternate Names:

    2677
    GAMMA-GLUTAMYL CARBOXYLASE
    GGCX
    VKCFD1
    137167
    4247
    ENSG00000115486
    OTTHUMG00000130173
    P38435
    VKGC_HUMAN
    VITAMIN K-DEPENDENT GAMMA-CARBOXYLASE
    VITAMIN K-DEPENDENT GAMMA-CARBOXYLASE (EC 6.4.-.-) (GAMMA-GLUTAMYL CARBOXYLASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P38435]
    PA28660
    T88182

    Gene Info:

    Target Class Enzymes
    Target Subclass EC:4.1.1.90
    Target Subclass EC:6.4.-.-
    Transmembrane Helix Count 6
    Target Main Class Enzymes
    Target Subclass 6.4.-.-
    Human Readable Name DRUGGABLE GENOME
    Gene Biotype PROTEIN_CODING
    (4 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    ENZYME

    Publications:

    Tuan, 1979, Vitamin K-dependent gamma-glutamyl carboxylase activity in the chick embryonic chorioallantoic membrane., J. Biol. Chem.
    Reedstrom et al., 1995, Comparative distribution, metabolism, and utilization of phylloquinone and menaquinone-9 in rat liver., Proc. Soc. Exp. Biol. Med.
    Morris et al., 1993, Characterization of the purified vitamin K-dependent gamma-glutamyl carboxylase., J. Biol. Chem.
    Olson, 1984, The function and metabolism of vitamin K., Annu. Rev. Nutr.
    Tasatargil et al., Effects of vitamin K1 supplementation on vascular responsiveness and oxidative stress in a rat femoral osteotomy model., Cell Biochem. Funct.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Stafford, 2005, The vitamin K cycle., J. Thromb. Haemost.
    Wang et al., 1995, The growth inhibitory effects of vitamins K and their actions on gene expression., Hepatology
    Presnell et al., 2002, The vitamin K-dependent carboxylase., Thromb. Haemost.
    Bryk AH et al., 2018, Bleeding predictors in patients following venous thromboembolism treated with vitamin K antagonists: Association with increased number of single nucleotide polymorphisms., Vascul Pharmacol
    Krishna Kumar D et al., 2015, An acenocoumarol dosing algorithm exploiting clinical and genetic factors in South Indian (Dravidian) population., Eur J Clin Pharmacol
    Wypasek E et al., 2014, Genetic determinants of acenocoumarol and warfarin maintenance dose requirements in Slavic population: a potential role of CYP4F2 and GGCX polymorphisms., Thromb Res
    Rathore SS et al., 2014, CYP4F2 1347 G > A & GGCX 12970 C > G polymorphisms: frequency in north Indians & their effect on dosing of acenocoumarol oral anticoagulant., Indian J Med Res
  • PHYTONADIONE   GGCX

    Interaction Score: 139.12

    Interaction Types & Directionality:
    inducer (activating)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    105006 7638250 8473318 6380538 16929463 11752352


    Sources:
    TdgClinicalTrial TEND TTD

  • ACENOCOUMAROL   GGCX

    Interaction Score: 12.88

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29432897 25519826 25042728 24927344


    Sources:
    PharmGKB

  • ANISINDIONE   GGCX

    Interaction Score: 12.88

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    17016423 17139284 11752352


    Sources:
    TdgClinicalTrial TEND

  • MENADIONE   GGCX

    Interaction Score: 2.76

    Interaction Types & Directionality:
    cofactor (activating)

    Interaction Info:
    Trial Name topical menadione lotion
    Novel drug target Established target

    PMIDs:
    16102054 7657295 12083499


    Sources:
    TdgClinicalTrial TEND

  • Ensembl: ENSG00000115486

    • Version: 101_38

    Alternate Names:
    GGCX Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000115486

    • Version: 26-July-2011

    Alternate Names:
    GGCX Display Id
    ENSG00000115486 Ensembl Gene Id
    VITAMIN K-DEPENDENT GAMMA-CARBOXYLASE (EC 6.4.-.-) (GAMMA-GLUTAMYL CARBOXYLASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P38435] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TEND: P38435

    • Version: 01-August-2011

    Alternate Names:
    2677 Entrez Gene Id
    ENSG00000115486 Ensembl Gene Id
    P38435 Uniprot Accession

    Gene Info:
    Transmembrane Helix Count 6
    Target Main Class Enzymes
    Target Subclass 6.4.-.-

    Publications:

  • TdgClinicalTrial: P38435

    • Version: January-2014

    Alternate Names:
    GGCX Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:4.1.1.90
    Target Subclass EC:6.4.-.-

    Publications:

  • PharmGKB: GGCX

    • Version: 18-August-2020

    Alternate Names:
    PA28660 PharmGKB ID

    Gene Info:

    Publications:
    Wypasek E et al., 2014, Genetic determinants of acenocoumarol and warfarin maintenance dose requirements in Slavic population: a potential role of CYP4F2 and GGCX polymorphisms., Thromb Res
    Krishna Kumar D et al., 2015, An acenocoumarol dosing algorithm exploiting clinical and genetic factors in South Indian (Dravidian) population., Eur J Clin Pharmacol
    Rathore SS et al., 2014, CYP4F2 1347 G > A & GGCX 12970 C > G polymorphisms: frequency in north Indians & their effect on dosing of acenocoumarol oral anticoagulant., Indian J Med Res

  • HingoraniCasas: ENSG00000115486

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000115486 Gene Symbol
    GGCX Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TTD: Vitamin K-dependent gamma-carboxylase

    • Version: 2020.06.01

    Alternate Names:
    GGCX TTD Gene Abbreviation
    T88182 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: GGCX

    • Version: 01-February-2022

    Alternate Names:
    Vitamin K-dependent gamma-carboxylase Gene Name
    P38435 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21