• Interaction Score: 23.2

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name TZP-101
    Novel drug target Novel Target
    Mechanism of Interaction Ghrelin receptor agonist

  • Interaction Score: 17.4

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Details of the Assay for Interaction Measuring ghrelin-induced GHSR activation detected by β-arrestin recruitment in cells stably expressing hGHSR.
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    23816043


  • Interaction Score: 11.6

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction Measured <i>in vitro</i> in recombinant receptor over-expressing cells.
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 11.6

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False
    Details of Interaction Calcium release, IP<sub>3</sub> accumulation.

    PMIDs:
    None found


  • Interaction Score: 8.7

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Details of the Assay for Interaction In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.
    Specific Action of the Ligand Agonist
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 5.8

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 5.8

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Interaction Score: 5.8

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Ghrelin receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 5.8

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Novel Target
    Trial Name anamorelin, RC-1291

    PMIDs:
    None found


  • Interaction Score: 3.87

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Ghrelin receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18828808


    Sources:
    PharmGKB