• Interaction Score: 6.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20346682


    Sources:
    DTC

  • Interaction Score: 2.28

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Details of Interaction weak inhibition
    Endogenous Drug? False

    PMIDs:
    20346682


  • Interaction Score: 1.22

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    17234181


    Sources:
    TTD

  • Interaction Score: 1.01

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


  • Interaction Score: 0.87

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11752352


    Sources:
    TTD

  • Interaction Score: 0.83

    Interaction Types & Directionality:
    allosteric modulator

    Interaction Info:
    Specific Action of the Ligand Potentiation
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    20346682


  • Interaction Score: 0.76

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Specific Action of the Ligand None
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


  • Interaction Score: 0.76

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Specific Action of the Ligand None
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


  • Interaction Score: 0.63

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Novel drug target Established target
    Trial Name -
    Direct Interaction yes

  • Interaction Score: 0.61

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Mechanism of Interaction Glycine receptor (alpha-1/beta) positive modulator

  • Interaction Score: 0.59

    Interaction Types & Directionality:
    agonist (activating)
    potentiator

    Interaction Info:
    Mechanism of Interaction Glycine receptor (alpha-1/beta) positive modulator
    Direct Interaction yes
    Trial Name -

  • Interaction Score: 0.55

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Glycine receptor (alpha-1/beta) agonist
    Direct Interaction yes

  • Interaction Score: 0.55

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Mechanism of Interaction Glycine receptor (alpha-1/beta) positive modulator

  • Interaction Score: 0.39

    Interaction Types & Directionality:
    allosteric modulator

    Interaction Info:
    Mechanism of Interaction Glycine receptor (alpha-1/beta) positive modulator
    Direct Interaction yes

  • Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20346682


    Sources:
    DTC

  • Interaction Score: 0.3

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


  • Interaction Score: 0.3

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


  • Interaction Score: 0.26

    Interaction Types & Directionality:
    antagonist (inhibitory)
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand None

    PMIDs:
    15081878


  • Interaction Score: 0.19

    Interaction Types & Directionality:
    allosteric modulator

    Interaction Info:
    Specific Action of the Ligand Potentiation
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


  • Interaction Score: 0.06

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


  • Interaction Score: 0.06

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    • Version: 101_38

    Alternate Names:
    GLRA1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

    • Version: 26-July-2011

    Alternate Names:
    GLRA1 Display Id
    GLYCINE RECEPTOR ALPHA-1 CHAIN PRECURSOR (GLYCINE RECEPTOR 48 KDA SUBUNIT) (STRYCHNINE BINDING SUBUNIT). [SOURCE:UNIPROT/SWISSPROT;ACC:P23415] Description
    ENSG00000145888 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: 01-August-2011

    Alternate Names:
    GLRA1 Gene Symbol
    P23415 Uniprot Accession
    2741 Entrez Gene Id

    Gene Info:
    Transmembrane Helix Count 3
    Target Subclass Channels
    Target Subclass Ligand_gated_ion_channels

    Publications:

    • Version: January-2014

    Alternate Names:
    GLRA1 Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass TC:1.A.9.3.1

    Publications:

    • Version: 11-September-2012

    Alternate Names:
    GLRA1_HUMAN Uniprot Id
    ENSG00000145888 Ensembl Gene Id
    P23415 Uniprot Accession

    Gene Info:
    Uniprot Status Swiss-Prot
    Interpro Type Family
    Human Readable Name ION CHANNEL

    Gene Categories:
    ION CHANNEL, DRUGGABLE GENOME

    Publications:

    • Version: 29-September-2020

    Alternate Names:
    4326 HUGO Gene ID
    4326 HUGO Gene Symbol
    glycine receptor alpha 1 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Glycine receptors
    GuideToPharmacology Gene Category ID 73

    Gene Categories:
    ION CHANNEL

    Publications:

    • Version: 02-September-2020
    • Version: chembl_23

    Alternate Names:
    GLRA1 GENE_SYMBOL
    Glycine receptor subunit alpha-1 UNIPROT
    Glycine receptor 48 kDa subunit UNIPROT

    Gene Info:

    Publications:

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000145888 Gene Symbol
    GLRA1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • Alternate Names:
    GLRA1 TTD Gene Abbreviation
    T50269 TTD Target ID

    Gene Info:

    Publications:

    • Version: 01-May-2021

    Alternate Names:
    Glycine receptor subunit alpha-1 Gene Name
    P23415 UniProt ID

    Gene Info:

    Gene Categories:
    ION CHANNEL

    Publications:

    • Version: 01-May-2021

    Alternate Names:

    Gene Info:

    Gene Categories:
    EXTERNAL SIDE OF PLASMA MEMBRANE

    Publications: