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GNB3 Gene Record

  • Summary
  • Interactions
  • Claims
  • GNB3 2784

    Alternate Names:

    2784
    G PROTEIN SUBUNIT BETA 3
    GNB3
    CSNB1H
    139130
    4400
    ENSG00000111664
    OTTHUMG00000168517
    PA176
    HG2D

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (0 More Sources)

    Gene Categories: Category Details

    Publications:

    Vormfelde SV et al., 2012, The genetics of loop diuretic effects., Pharmacogenomics J
    Firouzabadi D et al., 2019, Response to sertraline is influenced by GNβ3 gene G-350A variant in patients with major depressive disorder., Eur J Clin Pharmacol
    Filigheddu F et al., 2010, Haplotypes of the adrenergic system predict the blood pressure response to beta-blockers in women with essential hypertension., Pharmacogenomics
    Sperling H et al., 2003, Sildenafil response is influenced by the G protein beta 3 subunit GNB3 C825T polymorphism: a pilot study., J Urol
    Lieb B et al., 2009, Intensity of opiate withdrawal in relation to the 825C>T polymorphism of the G-protein beta 3 subunit gene., Prog Neuropsychopharmacol Biol Psychiatry
    Keers R et al., 2011, Variation in GNB3 predicts response and adverse reactions to antidepressants., J Psychopharmacol
    Schürks M et al., 2007, G protein beta3 polymorphism and triptan response in cluster headache., Clin Pharmacol Ther
    Hauner H et al., 2003, Prediction of successful weight reduction under sibutramine therapy through genotyping of the G-protein beta3 subunit gene (GNB3) C825T polymorphism., Pharmacogenetics
    Ujike H et al., 2008, Multiple genetic factors in olanzapine-induced weight gain in schizophrenia patients: a cohort study., J Clin Psychiatry
    Yang YY et al., 2010, Association of the G-protein and α2-adrenergic receptor gene and plasma norepinephrine level with clonidine improvement of the effects of diuretics in patients with cirrhosis with refractory ascites: a randomised clinical trial., Gut
    Nürnberger J et al., 2003, Effect of the C825T polymorphism of the G protein beta 3 subunit on the systolic blood pressure-lowering effect of clonidine in young, healthy male subjects., Clin Pharmacol Ther
  • SIBUTRAMINE   GNB3

    Interaction Score: 1.9

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12893983


    Sources:
    PharmGKB

  • CLONIDINE   GNB3

    Interaction Score: 1.59

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20833658 12844135


    Sources:
    PharmGKB

  • SILDENAFIL   GNB3

    Interaction Score: 1.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12576843


    Sources:
    PharmGKB

  • TORSEMIDE   GNB3

    Interaction Score: 0.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20877298


    Sources:
    PharmGKB

  • NORTRIPTYLINE   GNB3

    Interaction Score: 0.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20826553


    Sources:
    PharmGKB

  • FUROSEMIDE   GNB3

    Interaction Score: 0.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20877298


    Sources:
    PharmGKB

  • BUMETANIDE   GNB3

    Interaction Score: 0.73

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20877298


    Sources:
    PharmGKB

  • SUMATRIPTAN   GNB3

    Interaction Score: 0.68

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17361120


    Sources:
    PharmGKB

  • TELMISARTAN   GNB3

    Interaction Score: 0.68

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • SERTRALINE   GNB3

    Interaction Score: 0.45

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    30324302


    Sources:
    PharmGKB

  • METHADONE   GNB3

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19303909


    Sources:
    PharmGKB

  • ATENOLOL   GNB3

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20235788


    Sources:
    PharmGKB

  • OLANZAPINE   GNB3

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19193342


    Sources:
    PharmGKB

  • Ensembl: ENSG00000111664

    • Version: 101_38

    Alternate Names:
    GNB3 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: GNB3

    • Version: 18-August-2020

    Alternate Names:
    PA176 PharmGKB ID

    Gene Info:

    Publications:
    Vormfelde SV et al., 2012, The genetics of loop diuretic effects., Pharmacogenomics J
    Bozkurt O et al., 2009, Variation in Renin-Angiotensin system and salt-sensitivity genes and the risk of diabetes mellitus associated with the use of thiazide diuretics., Am J Hypertens
    Dörr M et al., 2010, β-blocker therapy and heart rate control during exercise testing in the general population: role of a common G-protein β-3 subunit variant., Pharmacogenomics

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21