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GRIA2 Gene Record

  • Summary
  • Interactions
  • Claims
  • GRIA2 2891 Druggable Genome

    Alternate Names:

    2891
    GLUTAMATE IONOTROPIC RECEPTOR AMPA TYPE SUBUNIT 2
    GRIA2
    GLUR2
    GLURB
    GluA2
    GluR-K2
    HBGR2
    138247
    4572
    ENSG00000120251
    OTTHUMG00000133836
    BE0000829
    P42262
    GluR-B
    Glutamate receptor 2
    AMPA-selective glutamate receptor 2
    GluR-2
    Glutamate receptor ionotropic, AMPA 2
    445
    NP_000817|NP_001077088
    NM_000826|NM_001083619
    GLUTAMATE RECEPTOR 2 PRECURSOR (GLUR-2) (GLUR-B) (GLUR-K2) (GLUTAMATE RECEPTOR IONOTROPIC, AMPA 2). [SOURCE:UNIPROT/SWISSPROT;ACC:P42262]
    GRIA2_HUMAN
    Glutamate receptor AMPA 2
    T42392

    Gene Info:

    GuideToPharmacology Gene Category Name Ionotropic glutamate receptors
    GuideToPharmacology Gene Category ID 75
    Human Readable Name DRUGGABLE GENOME
    Target Subclass Glutamate
    Target Subclass Ligand_gated_ion_channels
    Transmembrane Helix Count 3
    Target Subclass Channels
    Target Main Class Receptors
    Target Class Receptors
    Target Subclass TC:1.A.10.1.13
    Interpro Short Name Iontro_glu_rcpt
    Interpro Name Ionotropic glutamate receptor
    Interpro Acc IPR001320
    Interpro Type Domain
    Uniprot Status Swiss-Prot
    Uniprot Evidence 1: Evidence at protein level
    Gene Biotype PROTEIN_CODING
    (9 More Sources)

    Gene Categories: Category Details

    ION CHANNEL
    EXTERNAL SIDE OF PLASMA MEMBRANE
    DRUGGABLE GENOME

    Publications:

    Yamakura et al., 2001, Anesthetics and ion channels: molecular models and sites of action., Annu. Rev. Pharmacol. Toxicol.
    Krasowski et al., 1999, General anaesthetic actions on ligand-gated ion channels., Cell. Mol. Life Sci.
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Jin et al., 2010, The interaction of the neuroprotective compounds riluzole and phenobarbital with AMPA-type glutamate receptors: a patch-clamp study., Pharmacology
    Langan et al., 2003, Talampanel, a new antiepileptic drug: single- and multiple-dose pharmacokinetics and initial 1-week experience in patients with chronic intractable epilepsy., Epilepsia
    Denes et al., 2006, Talampanel a non-competitive AMPA-antagonist attenuates caspase-3 dependent apoptosis in mouse brain after transient focal cerebral ischemia., Brain Res. Bull.
    Howes et al., 2007, Talampanel., Neurotherapeutics
    Cheng Q et al., 2005, Evolution of glutamate interactions during binding to a glutamate receptor., Nat Chem Biol
    Stein et al., 1992, Complex pharmacological properties of recombinant alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subtypes., Mol. Pharmacol.
    Henley et al., 1993, Localisation of glutamate receptor binding sites and mRNAs to the dorsal horn of the rat spinal cord., Neuropharmacology
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Li et al., 1995, Functional effects of mutations in the putative agonist binding region of recombinant alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors., Mol. Pharmacol.
    Dopico et al., 2009, Acute alcohol action and desensitization of ligand-gated ion channels., Pharmacol. Rev.
  • CHEMBL337577   GRIA2

    Interaction Score: 4.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • CHEMBL123132   GRIA2

    Interaction Score: 4.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • CHEMBL28472   GRIA2

    Interaction Score: 4.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • CHEMBL333964   GRIA2

    Interaction Score: 4.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • CHEMBL594840   GRIA2

    Interaction Score: 4.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • CHEMBL29024   GRIA2

    Interaction Score: 2.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • (S)-WILLARDIINE   GRIA2

    Interaction Score: 2.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • CHEMBL121915   GRIA2

    Interaction Score: 2.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • TALAMPANEL   GRIA2

    Interaction Score: 1.45

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name talampanel
    Novel drug target Established target

    PMIDs:
    12581229 16861112 17199027


    Sources:
    TdgClinicalTrial DrugBank

  • (S)-AMPA   GRIA2

    Interaction Score: 1.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • PALIRODEN   GRIA2

    Interaction Score: 1.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • PERAMPANEL   GRIA2

    Interaction Score: 0.87

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist
    Direct Interaction yes
    Trial Name E2007

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TTD ChemblInteractions

  • DNQX   GRIA2

    Interaction Score: 0.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • QUISQUALATE   GRIA2

    Interaction Score: 0.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • HEXOBARBITAL   GRIA2

    Interaction Score: 0.58

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11264449 10487207


    Sources:
    TEND TdgClinicalTrial DrugBank

  • BUTETHAL   GRIA2

    Interaction Score: 0.58

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11264449 10487207


    Sources:
    TEND TdgClinicalTrial DrugBank

  • SECOBARBITAL   GRIA2

    Interaction Score: 0.53

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    11264449 10487207


    Sources:
    TEND TdgClinicalTrial DrugBank

  • THIOPENTAL   GRIA2

    Interaction Score: 0.48

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    11264449 10487207


    Sources:
    TEND TdgClinicalTrial DrugBank

  • MEPHOBARBITAL   GRIA2

    Interaction Score: 0.45

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11264449 10487207


    Sources:
    TEND TdgClinicalTrial DrugBank

  • ANIRACETAM   GRIA2

    Interaction Score: 0.39

    Interaction Types & Directionality:
    allosteric modulator

    Interaction Info:
    Specific Action of the Ligand Positive
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    10592235


    Sources:
    DrugBank GuideToPharmacology

  • APROBARBITAL   GRIA2

    Interaction Score: 0.35

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    11264449 10487207


    Sources:
    DrugBank

  • BARBITAL   GRIA2

    Interaction Score: 0.35

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    11264449 10487207


    Sources:
    DrugBank

  • HEPTABARBITAL   GRIA2

    Interaction Score: 0.35

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    11264449 10487207


    Sources:
    DrugBank

  • AMOBARBITAL   GRIA2

    Interaction Score: 0.35

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    11264449 10487207


    Sources:
    DrugBank

  • TEZAMPANEL   GRIA2

    Interaction Score: 0.35

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name tezampanel, NGX424,NGX426
    Novel drug target Established target
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial GuideToPharmacology ChemblInteractions

  • BUTABARBITAL   GRIA2

    Interaction Score: 0.32

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11264449 10487207


    Sources:
    TEND TdgClinicalTrial DrugBank

  • PIRACETAM   GRIA2

    Interaction Score: 0.29

    Interaction Types & Directionality:
    allosteric modulator

    Interaction Info:
    Specific Action of the Ligand Positive
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • CX516   GRIA2

    Interaction Score: 0.29

    Interaction Types & Directionality:
    allosteric modulator

    Interaction Info:
    Specific Action of the Ligand Positive
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • MIBAMPATOR   GRIA2

    Interaction Score: 0.29

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction Glutamate receptor ionotropic AMPA positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ZONAMPANEL   GRIA2

    Interaction Score: 0.29

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CX1739   GRIA2

    Interaction Score: 0.29

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction Glutamate receptor ionotropic AMPA positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • MK-8777   GRIA2

    Interaction Score: 0.29

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction Glutamate receptor ionotropic AMPA positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • METHARBITAL   GRIA2

    Interaction Score: 0.29

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11264449 10487207


    Sources:
    TEND TdgClinicalTrial DrugBank

  • PF-04958242   GRIA2

    Interaction Score: 0.29

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction Glutamate receptor ionotropic AMPA positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TALBUTAL   GRIA2

    Interaction Score: 0.29

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11264449 10487207


    Sources:
    TEND TdgClinicalTrial DrugBank

  • FARAMPATOR   GRIA2

    Interaction Score: 0.29

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Glutamate receptor ionotropic AMPA positive allosteric modulator

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • BUTALBITAL   GRIA2

    Interaction Score: 0.29

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11264449 10487207


    Sources:
    TEND TdgClinicalTrial DrugBank

  • SELURAMPANEL   GRIA2

    Interaction Score: 0.29

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name BGG-492
    Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions

  • BECAMPANEL   GRIA2

    Interaction Score: 0.29

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PENTOBARBITAL   GRIA2

    Interaction Score: 0.26

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11264449 10487207


    Sources:
    TEND TdgClinicalTrial DrugBank

  • DASOLAMPANEL   GRIA2

    Interaction Score: 0.23

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PHENOBARBITAL   GRIA2

    Interaction Score: 0.18

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    11264449 10487207 20051697


    Sources:
    TEND TdgClinicalTrial DrugBank

  • PRIMIDONE   GRIA2

    Interaction Score: 0.18

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11264449 10487207


    Sources:
    TEND TdgClinicalTrial DrugBank

  • GLUTAMIC ACID   GRIA2

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16408071 1279377 7679210 17139284 17016423 7838123


    Sources:
    DTC DrugBank

  • CYCLOTHIAZIDE   GRIA2

    Interaction Score: 0.12

    Interaction Types & Directionality:
    allosteric modulator

    Interaction Info:
    Specific Action of the Ligand Positive
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • IRAMPANEL   GRIA2

    Interaction Score: 0.08

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • NBQX   GRIA2

    Interaction Score: 0.08

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • TOPIRAMATE   GRIA2

    Interaction Score: 0.03

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ALCOHOL   GRIA2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19270242


    Sources:
    DrugBank

  • Ensembl: ENSG00000120251

    • Version: 101_38

    Alternate Names:
    GRIA2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TEND: P42262

    • Version: 01-August-2011

    Alternate Names:
    GRIA2_HUMAN Uniprot Id
    GRIA2 Gene Symbol
    2891 Entrez Gene Id

    Gene Info:
    Target Subclass Glutamate
    Target Subclass Ligand_gated_ion_channels
    Transmembrane Helix Count 3

    Publications:

  • TdgClinicalTrial: P42262

    • Version: January-2014

    Alternate Names:
    GRIA2 Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass TC:1.A.10.1.13

    Publications:

  • RussLampel: ENSG00000120251

    • Version: 26-July-2011

    Alternate Names:
    GRIA2 Display Id
    ENSG00000120251 Ensembl Gene Id
    GLUTAMATE RECEPTOR 2 PRECURSOR (GLUR-2) (GLUR-B) (GLUR-K2) (GLUTAMATE RECEPTOR IONOTROPIC, AMPA 2). [SOURCE:UNIPROT/SWISSPROT;ACC:P42262] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: P42262

    • Version: 11-September-2012

    Alternate Names:
    2891 Entrez Gene Id
    GLUTAMATE RECEPTOR 2 Uniprot Protein Name
    GRIA2 Uniprot Gene Name

    Gene Info:
    Human Readable Name DRUGGABLE GENOME
    Interpro Short Name Iontro_glu_rcpt
    Interpro Name Ionotropic glutamate receptor

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GuideToPharmacology: 2891

    • Version: 29-September-2020

    Alternate Names:
    4572 HUGO Gene ID
    4572 HUGO Gene Symbol
    glutamate ionotropic receptor AMPA type subunit 2 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Ionotropic glutamate receptors
    GuideToPharmacology Gene Category ID 75

    Gene Categories:
    ION CHANNEL

    Publications:

  • DrugBank: BE0000829

    • Version: 5.1.7

    Alternate Names:
    GRIA2 DrugBank Gene Name
    P42262 UniProt Accession
    2891 Entrez Gene Id

    Gene Info:

    Publications:
    Stein et al., 1992, Complex pharmacological properties of recombinant alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subtypes., Mol. Pharmacol.
    Henley et al., 1993, Localisation of glutamate receptor binding sites and mRNAs to the dorsal horn of the rat spinal cord., Neuropharmacology
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

  • DTC: GRIA2

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Cheng Q et al., 2005, Evolution of glutamate interactions during binding to a glutamate receptor., Nat Chem Biol

  • ChemblInteractions: GLUR2

    • Version: chembl_23

    Alternate Names:
    GLUR2 GENE_SYMBOL
    GRIA2 GENE_SYMBOL
    Glutamate receptor 2 UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000120251

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000120251 Gene Symbol
    GRIA2 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • Pharos: GRIA2

    • Version: 03-September-2020

    Alternate Names:
    Glutamate receptor 2 Gene Name
    P42262 UniProt ID

    Gene Info:

    Gene Categories:
    ION CHANNEL

    Publications:

  • GO: GRIA2

    • Version: 05-September-2020

    Alternate Names:
    GLUR2 GO Gene Synonym

    Gene Info:

    Gene Categories:
    EXTERNAL SIDE OF PLASMA MEMBRANE

    Publications:

  • TTD: Glutamate receptor AMPA 2

    • Version: 2020.06.01

    Alternate Names:
    GRIA2 TTD Gene Abbreviation
    T42392 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21