• Interaction Score: 3.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name talampanel
    Novel drug target Established target

  • Interaction Score: 2.52

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name E2007
    Novel drug target Established target
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 1.12

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

  • Interaction Score: 0.84

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction Glutamate receptor ionotropic AMPA positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.84

    Interaction Types & Directionality:
    allosteric modulator

    Interaction Info:
    Specific Action of the Ligand Positive
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


  • Interaction Score: 0.84

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.84

    Interaction Types & Directionality:
    allosteric modulator

    Interaction Info:
    Specific Action of the Ligand Positive
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


  • Interaction Score: 0.84

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist
    Direct Interaction yes
    Trial Name BGG-492

    PMIDs:
    None found


  • Interaction Score: 0.84

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.84

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Glutamate receptor ionotropic AMPA positive allosteric modulator

    PMIDs:
    None found


  • Interaction Score: 0.84

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction Glutamate receptor ionotropic AMPA positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.84

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Glutamate receptor ionotropic AMPA positive allosteric modulator

    PMIDs:
    None found


  • Interaction Score: 0.84

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Glutamate receptor ionotropic AMPA positive allosteric modulator

    PMIDs:
    None found


  • Interaction Score: 0.67

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist

    PMIDs:
    None found


  • Interaction Score: 0.42

    Interaction Types & Directionality:
    allosteric modulator

    Interaction Info:
    Specific Action of the Ligand Positive
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


  • Interaction Score: 0.37

    Interaction Types & Directionality:
    allosteric modulator

    Interaction Info:
    Specific Action of the Ligand Positive
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


  • Interaction Score: 0.24

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.22

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


  • Interaction Score: 0.08

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist
    Direct Interaction yes

    PMIDs:
    None found