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GRIK2 Gene Record

  • Summary
  • Interactions
  • Claims
  • GRIK2 2898 Druggable Genome

    Alternate Names:

    2898
    GLUTAMATE IONOTROPIC RECEPTOR KAINATE TYPE SUBUNIT 2
    GRIK2
    EAA4
    GLR6
    GLUK6
    GLUR6
    GluK2
    MRT6
    138244
    4580
    ENSG00000164418
    OTTHUMG00000016328
    GLUTAMATE RECEPTOR, IONOTROPIC KAINATE 2 PRECURSOR (GLUTAMATE RECEPTOR 6) (GLUR-6) (GLUR6) (EXCITATORY AMINO ACID RECEPTOR 4) (EAA4). [SOURCE:UNIPROT/SWISSPROT;ACC:Q13002]
    BE0000826
    Q13002
    451
    NM_021956
    NP_068775
    GRIK2_HUMAN
    KA2
    EAA2
    GRIK5
    Glutamate receptor ionotropic, kainate 5
    Excitatory amino acid receptor 2
    Glutamate receptor KA-2
    GluK5
    GluR-6
    Glutamate receptor 6
    Excitatory amino acid receptor 4
    Glutamate receptor ionotropic, kainate 2
    GLUTAMATE RECEPTOR, IONOTROPIC KAINATE 2

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    GuideToPharmacology Gene Category Name Ionotropic glutamate receptors
    GuideToPharmacology Gene Category ID 75
    Target Subclass Glutamate
    Target Subclass Ligand_gated_ion_channels
    Target Subclass Channels
    Transmembrane Helix Count 3
    Target Main Class Receptors
    Interpro Acc IPR001320
    Interpro Short Name Iontro_glu_rcpt
    Interpro Type Domain
    Interpro Name Ionotropic glutamate receptor
    Uniprot Evidence 1: Evidence at protein level
    Uniprot Status Swiss-Prot
    Target Class Receptors
    Target Subclass TC:1.A.10.1
    Gene Biotype PROTEIN_CODING
    (7 More Sources)

    Gene Categories: Category Details

    ION CHANNEL
    DRUGGABLE GENOME

    Publications:

    Yamakura et al., 2001, Anesthetics and ion channels: molecular models and sites of action., Annu. Rev. Pharmacol. Toxicol.
    Krasowski et al., 1999, General anaesthetic actions on ligand-gated ion channels., Cell. Mol. Life Sci.
    Wong et al., 2007, Na+/Cl- dipole couples agonist binding to kainate receptor activation., J. Neurosci.
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
  • DOMOIC ACID   GRIK2

    Interaction Score: 5.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • QUISQUALATE   GRIK2

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • BUTETHAL   GRIK2

    Interaction Score: 1.29

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11264449 10487207


    Sources:
    TEND TdgClinicalTrial DrugBank

  • HEXOBARBITAL   GRIK2

    Interaction Score: 1.29

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    11264449 10487207


    Sources:
    TEND TdgClinicalTrial DrugBank

  • SECOBARBITAL   GRIK2

    Interaction Score: 1.17

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11264449 10487207


    Sources:
    TEND TdgClinicalTrial DrugBank

  • THIOPENTAL   GRIK2

    Interaction Score: 1.08

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11264449 10487207


    Sources:
    TEND TdgClinicalTrial DrugBank

  • MEPHOBARBITAL   GRIK2

    Interaction Score: 0.99

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11264449 10487207


    Sources:
    TEND TdgClinicalTrial DrugBank

  • AMOBARBITAL   GRIK2

    Interaction Score: 0.77

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    11264449 10487207


    Sources:
    DrugBank

  • BARBITAL   GRIK2

    Interaction Score: 0.77

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    11264449 10487207


    Sources:
    DrugBank

  • APROBARBITAL   GRIK2

    Interaction Score: 0.77

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    11264449 10487207


    Sources:
    DrugBank

  • HEPTABARBITAL   GRIK2

    Interaction Score: 0.77

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    11264449 10487207


    Sources:
    DrugBank

  • BUTABARBITAL   GRIK2

    Interaction Score: 0.72

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11264449 10487207


    Sources:
    TEND TdgClinicalTrial DrugBank

  • METHARBITAL   GRIK2

    Interaction Score: 0.65

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11264449 10487207


    Sources:
    TEND TdgClinicalTrial DrugBank

  • BUTALBITAL   GRIK2

    Interaction Score: 0.65

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    11264449 10487207


    Sources:
    TEND TdgClinicalTrial DrugBank

  • TALBUTAL   GRIK2

    Interaction Score: 0.65

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11264449 10487207


    Sources:
    TEND TdgClinicalTrial DrugBank

  • PENTOBARBITAL   GRIK2

    Interaction Score: 0.59

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    11264449 10487207


    Sources:
    TEND TdgClinicalTrial DrugBank

  • TEZAMPANEL   GRIK2

    Interaction Score: 0.52

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glutamate receptor ionotropic kainate antagonist
    Direct Interaction yes
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions

  • PRIMIDONE   GRIK2

    Interaction Score: 0.4

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11264449 10487207


    Sources:
    TEND TdgClinicalTrial DrugBank

  • PHENOBARBITAL   GRIK2

    Interaction Score: 0.34

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    11264449 10487207


    Sources:
    TEND TdgClinicalTrial DrugBank

  • SELURAMPANEL   GRIK2

    Interaction Score: 0.32

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glutamate receptor ionotropic kainate antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • GLUTAMIC ACID   GRIK2

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17581967


    Sources:
    DrugBank

  • TOPIRAMATE   GRIK2

    Interaction Score: 0.06

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Glutamate receptor ionotropic kainate antagonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • Ensembl: ENSG00000164418

    • Version: 101_38

    Alternate Names:
    GRIK2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: Q13002

    • Version: 11-September-2012

    Alternate Names:
    GLUTAMATE RECEPTOR, IONOTROPIC KAINATE 2 Uniprot Protein Name
    GRIK2 Uniprot Gene Name
    ENSG00000164418 Ensembl Gene Id

    Gene Info:
    Interpro Acc IPR001320
    Interpro Short Name Iontro_glu_rcpt
    Interpro Type Domain

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • RussLampel: ENSG00000164418

    • Version: 26-July-2011

    Alternate Names:
    GLUTAMATE RECEPTOR, IONOTROPIC KAINATE 2 PRECURSOR (GLUTAMATE RECEPTOR 6) (GLUR-6) (GLUR6) (EXCITATORY AMINO ACID RECEPTOR 4) (EAA4). [SOURCE:UNIPROT/SWISSPROT;ACC:Q13002] Description
    GRIK2 Display Id
    ENSG00000164418 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TEND: Q13002

    • Version: 01-August-2011

    Alternate Names:
    GRIK2 Gene Symbol
    GRIK2_HUMAN Uniprot Id
    Q13002 Uniprot Accession

    Gene Info:
    Target Subclass Glutamate
    Target Subclass Ligand_gated_ion_channels
    Target Subclass Channels

    Publications:

  • TdgClinicalTrial: Q13002

    • Version: January-2014

    Alternate Names:
    GRIK2 Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass TC:1.A.10.1

    Publications:

  • GuideToPharmacology: 2898

    • Version: 29-September-2020

    Alternate Names:
    4580 HUGO Gene ID
    4580 HUGO Gene Symbol
    glutamate ionotropic receptor kainate type subunit 2 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Ionotropic glutamate receptors
    GuideToPharmacology Gene Category ID 75

    Gene Categories:
    ION CHANNEL

    Publications:

  • DrugBank: BE0000826

    • Version: 5.1.7

    Alternate Names:
    GRIK2 DrugBank Gene Name
    Q13002 UniProt Accession
    2898 Entrez Gene Id

    Gene Info:

    Publications:
    Wong et al., 2007, Na+/Cl- dipole couples agonist binding to kainate receptor activation., J. Neurosci.
    Yamakura et al., 2001, Anesthetics and ion channels: molecular models and sites of action., Annu. Rev. Pharmacol. Toxicol.
    Krasowski et al., 1999, General anaesthetic actions on ligand-gated ion channels., Cell. Mol. Life Sci.

  • ChemblInteractions: GLUR6

    • Version: chembl_23

    Alternate Names:
    GLUR6 GENE_SYMBOL
    GRIK2 GENE_SYMBOL
    Glutamate receptor ionotropic, kainate 2 UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000164418

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000164418 Gene Symbol
    GRIK2 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: GRIK2

    • Version: chembl_23

    Alternate Names:
    GRIK2 GENE_SYMBOL
    GRIK5 GENE_SYMBOL
    Glutamate receptor ionotropic, kainate 5 UNIPROT

    Gene Info:

    Publications:

  • Pharos: GRIK2

    • Version: 03-September-2020

    Alternate Names:
    Glutamate receptor ionotropic, kainate 2 Gene Name
    Q13002 UniProt ID

    Gene Info:

    Gene Categories:
    ION CHANNEL

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21