• GRIK3 2899 Druggable Genome

    Alternate Names:

    2899
    GLUTAMATE IONOTROPIC RECEPTOR KAINATE TYPE SUBUNIT 3
    GRIK3
    EAA5
    GLR7
    GLUR7
    GluK3
    GluR7a
    138243
    4581
    ENSG00000163873
    OTTHUMG00000004189
    GLUTAMATE RECEPTOR, IONOTROPIC KAINATE 3 PRECURSOR (GLUTAMATE RECEPTOR 7) (GLUR-7) (GLUR7) (EXCITATORY AMINO ACID RECEPTOR 5) (EAA5). [SOURCE:UNIPROT/SWISSPROT;ACC:Q13003]
    Q13003
    Excitatory amino acid receptor 5
    Glutamate receptor ionotropic, kainate 3
    Glutamate receptor 7
    GluR-7
    GRIK3_HUMAN
    GLUTAMATE RECEPTOR, IONOTROPIC KAINATE 3
    452
    NP_000822
    NM_000831
    PA28975

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Interpro Acc IPR001320
    Uniprot Status Swiss-Prot
    Uniprot Evidence 1: Evidence at protein level
    Interpro Type Domain
    Interpro Short Name Iontro_glu_rcpt
    Interpro Name Ionotropic glutamate receptor
    GuideToPharmacology Gene Category Name Ionotropic glutamate receptors
    GuideToPharmacology Gene Category ID 75
    Target Class Receptors
    Target Subclass TC:1.A.10.1
    Gene Biotype PROTEIN_CODING
    (5 More Sources)

    Gene Categories: Category Details

    ION CHANNEL
    DRUGGABLE GENOME

    Publications:

  • Interaction Score: 5.32

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


  • Interaction Score: 3.54

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Novel Target
    Trial Name tezampanel, NGX424,NGX426
    Mechanism of Interaction Glutamate receptor ionotropic kainate antagonist

    PMIDs:
    None found


  • Interaction Score: 1.99

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Glutamate receptor ionotropic kainate antagonist

    PMIDs:
    None found


  • Interaction Score: 0.37

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glutamate receptor ionotropic kainate antagonist
    Direct Interaction yes

    PMIDs:
    None found


    • Version: 101_38

    Alternate Names:
    GRIK3 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

    • Version: 11-September-2012

    Alternate Names:
    Q13003 Uniprot Accession
    GRIK3_HUMAN Uniprot Id
    ENSG00000163873 Ensembl Gene Id

    Gene Info:
    Interpro Acc IPR001320
    Uniprot Status Swiss-Prot
    Uniprot Evidence 1: Evidence at protein level

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: January-2014

    Alternate Names:
    GRIK3 Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass TC:1.A.10.1

    Publications:

    • Version: 26-July-2011

    Alternate Names:
    GLUTAMATE RECEPTOR, IONOTROPIC KAINATE 3 PRECURSOR (GLUTAMATE RECEPTOR 7) (GLUR-7) (GLUR7) (EXCITATORY AMINO ACID RECEPTOR 5) (EAA5). [SOURCE:UNIPROT/SWISSPROT;ACC:Q13003] Description
    GRIK3 Display Id
    ENSG00000163873 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: 29-September-2020

    Alternate Names:
    4581 HUGO Gene ID
    4581 HUGO Gene Symbol
    glutamate ionotropic receptor kainate type subunit 3 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Ionotropic glutamate receptors
    GuideToPharmacology Gene Category ID 75

    Gene Categories:
    ION CHANNEL

    Publications:

    • Version: 18-August-2020
    • Version: 31-May-2017

    Alternate Names:
    ENSG00000163873 Gene Symbol
    GRIK3 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: chembl_23

    Alternate Names:
    GLUR7 GENE_SYMBOL
    GRIK3 GENE_SYMBOL
    Glutamate receptor ionotropic, kainate 3 UNIPROT

    Gene Info:

    Publications:

    • Version: 01-May-2021

    Alternate Names:
    Glutamate receptor ionotropic, kainate 3 Gene Name
    Q13003 UniProt ID

    Gene Info:

    Gene Categories:
    ION CHANNEL

    Publications: