• GRIK4 2900 Druggable Genome

    Alternate Names:

    2900
    GLUTAMATE IONOTROPIC RECEPTOR KAINATE TYPE SUBUNIT 4
    GRIK4
    EAA1
    GRIK
    GluK4
    KA1
    600282
    4582
    ENSG00000149403
    OTTHUMG00000048255
    Q16099
    GRIK4_HUMAN
    GLUTAMATE RECEPTOR, IONOTROPIC KAINATE 4
    453
    NM_014619
    NP_055434
    PA28976
    Glutamate receptor KA-1
    Excitatory amino acid receptor 1
    Glutamate receptor ionotropic, kainate 4
    GLUTAMATE RECEPTOR, IONOTROPIC KAINATE 4 PRECURSOR (GLUTAMATE RECEPTOR KA-1) (KA1) (EXCITATORY AMINO ACID RECEPTOR 1) (EAA1). [SOURCE:UNIPROT/SWISSPROT;ACC:Q16099]

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Interpro Short Name Iontro_glu_rcpt
    Uniprot Evidence 2: Evidence at transcript level
    Interpro Acc IPR001320
    Interpro Name Ionotropic glutamate receptor
    Uniprot Status Swiss-Prot
    Interpro Type Domain
    GuideToPharmacology Gene Category Name Ionotropic glutamate receptors
    GuideToPharmacology Gene Category ID 75
    Target Class Receptors
    Target Subclass TC:1.A.10.1.9
    Gene Biotype PROTEIN_CODING
    (5 More Sources)

    Gene Categories: Category Details

    ION CHANNEL
    DRUGGABLE GENOME
  • Interaction Score: 4.25

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand Full agonist

    PMIDs:
    None found


  • Interaction Score: 2.84

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glutamate receptor ionotropic kainate antagonist
    Direct Interaction yes
    Trial Name tezampanel, NGX424,NGX426

    PMIDs:
    None found


  • Interaction Score: 1.59

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glutamate receptor ionotropic kainate antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27023437


    Sources:
    PharmGKB

  • Interaction Score: 0.3

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Glutamate receptor ionotropic kainate antagonist

    PMIDs:
    None found