DGIdb - GRIN1 Gene Record

GRIN1 2902 Druggable Genome

Alternate Names:

2902
GLUTAMATE IONOTROPIC RECEPTOR NMDA TYPE SUBUNIT 1
GRIN1
GluN1
MRD8
NMD-R1
NMDA1
NMDAR1
NR1
138249
4584
ENSG00000176884
OTTHUMG00000020976
NMDZ1_HUMAN
Q05586
N-methyl-D-aspartate receptor subunit NR1
Glutamate [NMDA] receptor subunit zeta-1
Glutamate receptor ionotropic, NMDA 1
GLUTAMATE [NMDA] RECEPTOR SUBUNIT ZETA 1 PRECURSOR (N-METHYL-D- ASPARTATE RECEPTOR SUBUNIT NR1). [SOURCE:UNIPROT/SWISSPROT;ACC:Q05586]
455
NP_015566
NM_007327
Q12879
GRIN2A
PA28978
Glutamate receptor ionotropic NMDA 1
T62276
NDHMSD
NDHMSR

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Interpro Type	Domain
Uniprot Status	Swiss-Prot
Interpro Acc	IPR001320
Interpro Name	Ionotropic glutamate receptor
Uniprot Evidence	1: Evidence at protein level
Interpro Short Name	Iontro_glu_rcpt
Transmembrane Helix Count	3
Target Subclass	Ligand_gated_ion_channels
Target Subclass	Glutamate
Target Subclass	Channels
Target Main Class	Receptors
GuideToPharmacology Gene Category Name	Ionotropic glutamate receptors
GuideToPharmacology Gene Category ID	75
Target Class	Receptors
Target Subclass	TC:1.A.10.1
Target Subclass	TC:1.A.10.1.6
Gene Biotype	PROTEIN_CODING

(11 More Sources)

Gene Categories: Category Details

CELL SURFACE
ION CHANNEL
DRUGGABLE GENOME

Publications:

Rook Y et al., 2010, Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents., J Med Chem
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Chanasong R et al., 2013, Genetic variation of GRIN1 confers vulnerability to methamphetamine-dependent psychosis in a Thai population., Neurosci Lett
Frølund S et al., 2010, Assessment of structurally diverse philanthotoxin analogues for inhibitory activity on ionotropic glutamate receptor subtypes: discovery of nanomolar, nonselective, and use-dependent antagonists., J Med Chem
Kornhuber et al., 1995, Orphenadrine is an uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist: binding and patch clamp studies., J. Neural Transm. Gen. Sect.
Kotermanski et al., 2009, Memantine binding to a superficial site on NMDA receptors contributes to partial trapping., J. Physiol. (Lond.)
Cacabelos R et al., 1999, The glutamatergic system and neurodegeneration in dementia: preventive strategies in Alzheimer's disease., Int J Geriatr Psychiatry
Robinson DM et al., 2006, Memantine: a review of its use in Alzheimer's disease., Drugs
Rogawski et al., 2003, The neuropharmacological basis for the use of memantine in the treatment of Alzheimer's disease., CNS Drug Rev
Zhu et al., 2003, Region-specific changes in NMDA receptor mRNA induced by chronic morphine treatment are prevented by the co-administration of the competitive NMDA receptor antagonist LY274614., Brain Res. Mol. Brain Res.
Porcelli S et al., 2016, Possible biomarkers modulating haloperidol efficacy and/or tolerability., Pharmacogenomics
Morrison RL et al., 2018, Effect of intranasal esketamine on cognitive functioning in healthy participants: a randomized, double-blind, placebo-controlled study., Psychopharmacology (Berl)

MEMANTINE GRIN1

Interaction Score: 2.08

Interaction Types & Directionality:

binder

antagonist (inhibitory)

Interaction Info:

Trial Name memantine

Novel drug target Established target

Trial Name Namenda

PMIDs:
20361801 19687120 10029935 16906789 14530799

Sources:
DTC TdgClinicalTrial
ORPHENADRINE GRIN1

Interaction Score: 1.48

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
17016423 17139284 8788072

Sources:
TdgClinicalTrial TEND
(D)-SERINE GRIN1

Interaction Score: 1.06

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Binding Site for Interaction glycine site

Specific Action of the Ligand Agonist

Endogenous Drug? True

PMIDs:
10592235 17016423 17139284

Sources:
GuideToPharmacology TTD
PHILANTHOTOXIN 343 GRIN1

Interaction Score: 0.99

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20873775

Sources:
DTC
TRAXOPRODIL GRIN1

Interaction Score: 0.74

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate NMDA receptor; GRIN1/GRIN2B antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
RADIPRODIL GRIN1

Interaction Score: 0.74

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate NMDA receptor; GRIN1/GRIN2B antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
EVT-101 GRIN1

Interaction Score: 0.74

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate NMDA receptor; GRIN1/GRIN2B antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
RISLENEMDAZ GRIN1

Interaction Score: 0.74

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutamate NMDA receptor; GRIN1/GRIN2B antagonist

PMIDs:
None found

Sources:
ChemblInteractions
NERAMEXANE GRIN1

Interaction Score: 0.49

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name neramexane mesylate

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
CYCLOSERINE GRIN1

Interaction Score: 0.49

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
DIZOCILPINE GRIN1

Interaction Score: 0.49

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20361801

Sources:
DTC
ESKETAMINE GRIN1

Interaction Score: 0.42

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

PMIDs:
29392371

Sources:
ChemblInteractions
RAPASTINEL GRIN1

Interaction Score: 0.42

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name GLYX-13

Mechanism of Interaction Glutamate [NMDA] receptor partial agonist

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
LANICEMINE GRIN1

Interaction Score: 0.42

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor blocker

Direct Interaction yes

Trial Name AZD-6765

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
ESKETAMINE HYDROCHLORIDE GRIN1

Interaction Score: 0.42

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

Direct Interaction yes

Trial Name AM-101

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
KETAMINE GRIN1

Interaction Score: 0.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20361801

Sources:
DTC
CNS-5161 GRIN1

Interaction Score: 0.42

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Trial Name CNS-5161

Novel drug target Established target

Mechanism of Interaction Glutamate [NMDA] receptor blocker

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
ELIPRODIL GRIN1

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
DIMIRACETAM GRIN1

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name dimiracetam, NT-11624

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
INDANTADOL GRIN1

Interaction Score: 0.33

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name V3381

Direct Interaction yes

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
FELBAMATE GRIN1

Interaction Score: 0.25

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
GW468816 GRIN1

Interaction Score: 0.21

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
AZD8108 GRIN1

Interaction Score: 0.21

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DELUCEMINE GRIN1

Interaction Score: 0.21

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

PMIDs:
None found

Sources:
ChemblInteractions
MEMANTINE HYDROCHLORIDE GRIN1

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
KETAMINE HYDROCHLORIDE GRIN1

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

PMIDs:
None found

Sources:
ChemblInteractions
LATREPIRDINE GRIN1

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Dimebon

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
NEBOGLAMINE GRIN1

Interaction Score: 0.21

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor positive allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
APIMOSTINEL GRIN1

Interaction Score: 0.21

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor partial agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
AV-101 GRIN1

Interaction Score: 0.21

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
AMANTADINE HYDROCHLORIDE GRIN1

Interaction Score: 0.19

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

PMIDs:
None found

Sources:
ChemblInteractions
N-METHYL-D-ASPARTIC ACID (NMDA) GRIN1

Interaction Score: 0.16

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Binding Site for Interaction glutamate site

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
NERAMEXANE MESYLATE GRIN1

Interaction Score: 0.16

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DEXANABINOL GRIN1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name dexanabinol, HU-211

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
GLYCINE GRIN1

Interaction Score: 0.13

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Binding Site for Interaction glycine site

Specific Action of the Ligand Agonist

Endogenous Drug? True

PMIDs:
None found

Sources:
GuideToPharmacology
METHAMPHETAMINE GRIN1

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23880023

Sources:
PharmGKB
NBQX GRIN1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
MORPHINE GRIN1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12829326

Sources:
NCI
RALFINAMIDE GRIN1

Interaction Score: 0.08

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

PMIDs:
None found

Sources:
ChemblInteractions
ORPHENADRINE HYDROCHLORIDE GRIN1

Interaction Score: 0.07

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

PMIDs:
None found

Sources:
ChemblInteractions
ORPHENADRINE CITRATE GRIN1

Interaction Score: 0.07

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ACAMPROSATE CALCIUM GRIN1

Interaction Score: 0.06

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
HALOPERIDOL GRIN1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27023437

Sources:
PharmGKB

Ensembl: ENSG00000176884
- Version: 101_38
Alternate Names:

GRIN1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: Q05586
- Version: January-2014
Alternate Names:

GRIN1 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass TC:1.A.10.1.6

Publications:
TEND: Q05586
- Version: 01-August-2011
Alternate Names:

Q05586 Uniprot Accession

GRIN1 Gene Symbol

2902 Entrez Gene Id

Gene Info:

Transmembrane Helix Count 3

Target Subclass Ligand_gated_ion_channels

Target Subclass Glutamate

Publications:

RussLampel: ENSG00000176884

Version: 26-July-2011

Alternate Names:

ENSG00000176884 Ensembl Gene Id

GLUTAMATE [NMDA] RECEPTOR SUBUNIT ZETA 1 PRECURSOR (N-METHYL-D- ASPARTATE RECEPTOR SUBUNIT NR1). [SOURCE:UNIPROT/SWISSPROT;ACC:Q05586] Description

GRIN1 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

HopkinsGroom: Q05586
- Version: 11-September-2012
Alternate Names:

GRIN1 Uniprot Gene Name

GLUTAMATE [NMDA] RECEPTOR SUBUNIT ZETA-1 Uniprot Protein Name

2902 Entrez Gene Id

Gene Info:

Interpro Type Domain

Uniprot Status Swiss-Prot

Interpro Acc IPR001320

Gene Categories:

DRUGGABLE GENOME

Publications:
TdgClinicalTrial: Q12879
- Version: January-2014
Alternate Names:

GRIN2A Gene Symbol

GRIN1 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass TC:1.A.10.1

Publications:
GuideToPharmacology: 2902
- Version: 29-September-2020
Alternate Names:

4584 HUGO Gene ID

4584 HUGO Gene Symbol

glutamate ionotropic receptor NMDA type subunit 1 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Ionotropic glutamate receptors

GuideToPharmacology Gene Category ID 75

Gene Categories:

ION CHANNEL

Publications:

PharmGKB: GRIN1

Version: 18-August-2020

Alternate Names:

PA28978 PharmGKB ID

Gene Info:

Publications:

Porcelli S et al., 2016, Possible biomarkers modulating haloperidol efficacy and/or tolerability., Pharmacogenomics

Chanasong R et al., 2013, Genetic variation of GRIN1 confers vulnerability to methamphetamine-dependent psychosis in a Thai population., Neurosci Lett

NCI: GRIN1

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Zhu et al., 2003, Region-specific changes in NMDA receptor mRNA induced by chronic morphine treatment are prevented by the co-administration of the competitive NMDA receptor antagonist LY274614., Brain Res. Mol. Brain Res.

DTC: GRIN1

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Frølund S et al., 2010, Assessment of structurally diverse philanthotoxin analogues for inhibitory activity on ionotropic glutamate receptor subtypes: discovery of nanomolar, nonselective, and use-dependent antagonists., J Med Chem

Rook Y et al., 2010, Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents., J Med Chem

ChemblInteractions: NMDAR1
- Version: chembl_23
Alternate Names:

NMDAR1 GENE_SYMBOL

GRIN1 GENE_SYMBOL

Glutamate receptor ionotropic, NMDA 1 UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000176884
- Version: 31-May-2017
Alternate Names:

ENSG00000176884 Gene Symbol

GRIN1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
TTD: Glutamate receptor ionotropic NMDA 1
- Version: 2020.06.01
Alternate Names:

NMDAR1 TTD Gene Abbreviation

T62276 TTD Target ID

Gene Info:

Publications:
GO: GRIN1
- Version: 01-May-2021
Alternate Names:

NMDAR1 GO Gene Synonym

Gene Info:

Gene Categories:

CELL SURFACE

Publications:
Pharos: GRIN1
- Version: 01-May-2021
Alternate Names:

Glutamate receptor ionotropic, NMDA 1 Gene Name

Q05586 UniProt ID

Gene Info:

Gene Categories:

ION CHANNEL

Publications:

Trial Name	memantine
Novel drug target	Established target
Trial Name	Namenda

Specific Binding Site for Interaction	glycine site
Specific Action of the Ligand	Agonist
Endogenous Drug?	True

Mechanism of Interaction	Glutamate NMDA receptor; GRIN1/GRIN2B antagonist
Direct Interaction	yes

Trial Name	neramexane mesylate
Novel drug target	Established target

Direct Interaction	yes
Mechanism of Interaction	Glutamate [NMDA] receptor negative allosteric modulator

Mechanism of Interaction	Glutamate [NMDA] receptor blocker
Direct Interaction	yes
Trial Name	AZD-6765

Trial Name	CNS-5161
Novel drug target	Established target
Mechanism of Interaction	Glutamate [NMDA] receptor blocker

Trial Name	dimiracetam, NT-11624
Novel drug target	Established target

Mechanism of Interaction	Glutamate [NMDA] receptor antagonist
Direct Interaction	yes

Mechanism of Interaction	Glutamate [NMDA] receptor positive allosteric modulator
Direct Interaction	yes

binder
antagonist (inhibitory)

Mechanism of Interaction	Glutamate [NMDA] receptor partial agonist
Direct Interaction	yes

Specific Binding Site for Interaction	glutamate site
Specific Action of the Ligand	Full agonist
Endogenous Drug?	False

Trial Name	dexanabinol, HU-211
Novel drug target	Established target

ENSG00000176884	Ensembl Gene Id
GLUTAMATE [NMDA] RECEPTOR SUBUNIT ZETA 1 PRECURSOR (N-METHYL-D- ASPARTATE RECEPTOR SUBUNIT NR1). [SOURCE:UNIPROT/SWISSPROT;ACC:Q05586]	Description
GRIN1	Display Id

GRIN1	Uniprot Gene Name
GLUTAMATE [NMDA] RECEPTOR SUBUNIT ZETA-1	Uniprot Protein Name
2902	Entrez Gene Id

4584	HUGO Gene ID
4584	HUGO Gene Symbol
glutamate ionotropic receptor NMDA type subunit 1	HUGO Gene Name

NMDAR1	GENE_SYMBOL
GRIN1	GENE_SYMBOL
Glutamate receptor ionotropic, NMDA 1	UNIPROT

Glutamate receptor ionotropic, NMDA 1	Gene Name
Q05586	UniProt ID

GRIN1 Gene Record

GRIN1 2902 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: binder antagonist (inhibitory)

Interaction Info: Trial Name memantine Novel drug target Established target Trial Name Namenda

PMIDs: 20361801 19687120 10029935 16906789 14530799

Sources: DTC TdgClinicalTrial

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 17016423 17139284 8788072

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Binding Site for Interaction glycine site Specific Action of the Ligand Agonist Endogenous Drug? True

PMIDs: 10592235 17016423 17139284

Sources: GuideToPharmacology TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20873775

Sources: DTC

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Glutamate NMDA receptor; GRIN1/GRIN2B antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Glutamate NMDA receptor; GRIN1/GRIN2B antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Glutamate NMDA receptor; GRIN1/GRIN2B antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Glutamate NMDA receptor; GRIN1/GRIN2B antagonist

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Trial Name neramexane mesylate Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20361801

Sources: DTC

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

PMIDs: 29392371

Sources: ChemblInteractions

Interaction Types & Directionality: partial agonist (activating)

Interaction Info: Novel drug target Established target Trial Name GLYX-13 Mechanism of Interaction Glutamate [NMDA] receptor partial agonist

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Glutamate [NMDA] receptor blocker Direct Interaction yes Trial Name AZD-6765

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator Direct Interaction yes Trial Name AM-101

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20361801

Sources: DTC

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Trial Name CNS-5161 Novel drug target Established target Mechanism of Interaction Glutamate [NMDA] receptor blocker

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info: Trial Name dimiracetam, NT-11624 Novel drug target Established target

Interaction Types & Directionality:

binder

antagonist (inhibitory)

Interaction Info:

Trial Name memantine

Novel drug target Established target

Trial Name Namenda

PMIDs:
20361801 19687120 10029935 16906789 14530799

Sources:
DTC TdgClinicalTrial

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
17016423 17139284 8788072

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Binding Site for Interaction glycine site

Specific Action of the Ligand Agonist

Endogenous Drug? True

PMIDs:
10592235 17016423 17139284

Sources:
GuideToPharmacology TTD

Interaction Types & Directionality:

n/a

PMIDs:
20873775

Sources:
DTC

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate NMDA receptor; GRIN1/GRIN2B antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate NMDA receptor; GRIN1/GRIN2B antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate NMDA receptor; GRIN1/GRIN2B antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutamate NMDA receptor; GRIN1/GRIN2B antagonist

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name neramexane mesylate

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
20361801

Sources:
DTC

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

PMIDs:
29392371

Sources:
ChemblInteractions

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name GLYX-13

Mechanism of Interaction Glutamate [NMDA] receptor partial agonist

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor blocker

Direct Interaction yes

Trial Name AZD-6765

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

Direct Interaction yes

Trial Name AM-101

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
20361801

Sources:
DTC

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Trial Name CNS-5161

Novel drug target Established target

Mechanism of Interaction Glutamate [NMDA] receptor blocker

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name dimiracetam, NT-11624

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name V3381

Direct Interaction yes

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)