• Interaction Score: 2.66

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

  • Interaction Score: 0.76

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Trial Name AZD-6765
    Novel drug target Established target
    Mechanism of Interaction Glutamate [NMDA] receptor blocker

    PMIDs:
    None found


  • Interaction Score: 0.76

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Trial Name CNS-5161
    Novel drug target Established target
    Mechanism of Interaction Glutamate [NMDA] receptor blocker

    PMIDs:
    None found


  • Interaction Score: 0.76

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name AM-101
    Novel drug target Established target
    Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

    PMIDs:
    None found


  • Interaction Score: 0.59

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes
    Trial Name V3381

    PMIDs:
    None found


  • Interaction Score: 0.38

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.38

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.38

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name Dimebon
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • Interaction Score: 0.38

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist

    PMIDs:
    None found


  • Interaction Score: 0.38

    Interaction Types & Directionality:
    partial agonist (activating)

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor partial agonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.38

    Interaction Types & Directionality:
    partial agonist (activating)

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor partial agonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.38

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Glutamate [NMDA] receptor positive allosteric modulator

    PMIDs:
    None found


  • Interaction Score: 0.33

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.3

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name dexanabinol, HU-211
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • Interaction Score: 0.22

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist

    PMIDs:
    None found


  • Interaction Score: 0.14

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist

    PMIDs:
    None found


  • Interaction Score: 0.13

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist

    PMIDs:
    None found


  • Interaction Score: 0.13

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.11

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    • Version: 101_38

    Alternate Names:
    GRIN3B Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

    • Version: 11-September-2012

    Alternate Names:
    116444 Entrez Gene Id
    O60391 Uniprot Accession
    GLUTAMATE [NMDA] RECEPTOR SUBUNIT 3B Uniprot Protein Name

    Gene Info:
    Interpro Short Name Iontro_glu_rcpt
    Interpro Acc IPR001320
    Interpro Name Ionotropic glutamate receptor

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: January-2014

    Alternate Names:
    GRIN3B Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass TC:1.A.10.1

    Publications:

    • Version: 26-July-2011

    Alternate Names:
    GRIN3B Display Id
    ENSG00000116032 Ensembl Gene Id
    GLUTAMATE [NMDA] RECEPTOR SUBUNIT 3B PRECURSOR (N-METHYL-D-ASPARTATE RECEPTOR SUBTYPE NR3B) (NR3B) (NMDAR3B) (FRAGMENT). [SOURCE:UNIPROT/SWISSPROT;ACC:O60391] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: 01-August-2011

    Alternate Names:
    ENSG00000116032 Ensembl Gene Id
    116444 Entrez Gene Id
    GRIN3B Gene Symbol

    Gene Info:
    Transmembrane Helix Count 5
    Target Subclass Glutamate
    Target Main Class Receptors

    Publications:

    • Version: 29-September-2020

    Alternate Names:
    16768 HUGO Gene ID
    16768 HUGO Gene Symbol
    glutamate ionotropic receptor NMDA type subunit 3B HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Ionotropic glutamate receptors
    GuideToPharmacology Gene Category ID 75

    Gene Categories:
    ION CHANNEL

    Publications:

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000116032 Gene Symbol
    GRIN3B Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: chembl_23

    Alternate Names:
    GRIN3B GENE_SYMBOL
    Glutamate receptor ionotropic, NMDA 3B UNIPROT
    N-methyl-D-aspartate receptor subtype 3B UNIPROT

    Gene Info:

    Publications:

    • Version: 01-May-2021

    Alternate Names:
    Glutamate receptor ionotropic, NMDA 3B Gene Name
    O60391 UniProt ID

    Gene Info:

    Gene Categories:
    ION CHANNEL

    Publications: