• GRK4 2868 Druggable Genome

    Alternate Names:

    2868
    G PROTEIN-COUPLED RECEPTOR KINASE 4
    GRK4
    GPRK2L
    GPRK4
    GRK4a
    IT11
    137026
    4543
    ENSG00000125388
    OTTHUMG00000159914
    G PROTEIN-COUPLED RECEPTOR KINASE 4 (EC 2.7.1.-) (G PROTEIN-COUPLED RECEPTOR KINASE GRK4) (ITI1). [SOURCE:UNIPROT/SWISSPROT;ACC:P32298]
    1468
    P32298
    GRK4_HUMAN
    NP_001004056
    NM_001004056
    PA28941

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Uniprot Status Swiss-Prot
    Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain
    Interpro Type Domain
    Human Readable Name KINASE
    Uniprot Evidence 1: Evidence at protein level
    Interpro Acc IPR002290
    Interpro Short Name Ser/Thr_dual-sp_kinase_dom
    Gene Biotype PROTEIN_CODING
    GuideToPharmacology Gene Category Name GRK4 subfamily
    GuideToPharmacology Gene Category ID 937
    (4 More Sources)

    Gene Categories: Category Details

    KINASE
    SERINE THREONINE KINASE
    DRUGGABLE GENOME
    ENZYME
  • Interaction Score: 1.99

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • Interaction Score: 1.23

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction Measuring inhibition of human GRK-4-mediated phosphorylation of bovine tubulin dimers.
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.94

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22949529


    Sources:
    PharmGKB

  • Interaction Score: 0.78

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22949529


    Sources:
    PharmGKB

    • Version: 101_38

    Alternate Names:
    GRK4 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

    • Version: 11-September-2012

    Alternate Names:
    P32298 Uniprot Accession
    ENSG00000125388 Ensembl Gene Id
    GRK4 Uniprot Gene Name

    Gene Info:
    Human Readable Name DRUGGABLE GENOME
    Uniprot Status Swiss-Prot
    Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain

    Gene Categories:
    KINASE, DRUGGABLE GENOME

    Publications:

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000125388 Ensembl Gene Id
    GRK4 Display Id
    G PROTEIN-COUPLED RECEPTOR KINASE 4 (EC 2.7.1.-) (G PROTEIN-COUPLED RECEPTOR KINASE GRK4) (ITI1). [SOURCE:UNIPROT/SWISSPROT;ACC:P32298] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: 29-September-2020

    Alternate Names:
    4543 HUGO Gene ID
    4543 HUGO Gene Symbol
    G protein-coupled receptor kinase 4 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name GRK4 subfamily
    GuideToPharmacology Gene Category ID 937

    Gene Categories:
    ENZYME

    Publications:

    • Version: 18-August-2020
    • Version: 31-May-2017

    Alternate Names:
    ENSG00000125388 Gene Symbol
    GRK4 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: 27-Jun-2013

    Alternate Names:
    2868 Gene ID
    GPRK2L dGene Synonym
    GPRK4 dGene Synonym

    Gene Info:

    Gene Categories:
    KINASE, SERINE THREONINE KINASE

    Publications:

    • Version: 01-May-2021

    Alternate Names:
    G protein-coupled receptor kinase 4 Gene Name
    P32298 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications: