• Interaction Score: 13.43

    Interaction Types & Directionality:
    allosteric modulator
    modulator

    Interaction Info:
    Details of the Assay for Interaction Reduction of antagonist MPEP binding to mGlu<sub>5</sub> receptors <i>in vitro</i>
    Specific Action of the Ligand Negative
    Endogenous Drug? False

  • Interaction Score: 13.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Metabotropic glutamate receptor 5 negative allosteric modulator
    Trial Name STX107

  • Interaction Score: 10.07

    Interaction Types & Directionality:
    allosteric modulator
    modulator

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Negative
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 10.07

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Metabotropic glutamate receptor 5 modulator
    Trial Name ADX10059

    PMIDs:
    None found


  • Interaction Score: 6.71

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Metabotropic glutamate receptor 5 antagonist

    PMIDs:
    None found


  • Interaction Score: 6.71

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Metabotropic glutamate receptor 5 modulator
    Direct Interaction yes
    Trial Name AZD2066

    PMIDs:
    None found


  • Interaction Score: 6.71

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Metabotropic glutamate receptor 5 modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 6.71

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23046966


    Sources:
    DTC

  • Interaction Score: 6.71

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23046966


    Sources:
    DTC

  • Interaction Score: 3.36

    Interaction Types & Directionality:
    allosteric modulator

    Interaction Info:
    Specific Action of the Ligand Negative
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 3.36

    Interaction Types & Directionality:
    allosteric modulator

    Interaction Info:
    Specific Action of the Ligand Negative
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 3.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction Metabotropic glutamate receptor 5 negative allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 3.36

    Interaction Types & Directionality:
    allosteric modulator

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Positive

    PMIDs:
    None found


  • Interaction Score: 3.36

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Metabotropic glutamate receptor 5 antagonist

    PMIDs:
    None found


  • Interaction Score: 3.36

    Interaction Types & Directionality:
    allosteric modulator

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Negative

    PMIDs:
    None found


  • Interaction Score: 2.24

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name acamprosate,Campral
    Novel drug target Established target

    PMIDs:
    15963001


    Sources:
    TdgClinicalTrial

  • Interaction Score: 0.67

    Interaction Types & Directionality:
    allosteric modulator

    Interaction Info:
    Specific Action of the Ligand Negative
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


  • Interaction Score: 0.48

    Interaction Types & Directionality:
    allosteric modulator

    Interaction Info:
    Specific Action of the Ligand Negative
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


  • Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15717208


    Sources:
    NCI