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GSR Gene Record

  • Summary
  • Interactions
  • Claims
  • GSR 2936 Druggable Genome

    Alternate Names:

    2936
    GLUTATHIONE-DISULFIDE REDUCTASE
    GSR
    HEL-75
    HEL-S-122m
    138300
    4623
    ENSG00000104687
    OTTHUMG00000163946
    P00390
    GSHR_HUMAN
    GLUTATHIONE REDUCTASE, MITOCHONDRIAL
    GLUR
    GRase
    GRD1
    GR
    GLUTATHIONE REDUCTASE, MITOCHONDRIAL PRECURSOR (EC 1.8.1.7) (GR) (GRASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P00390]
    PA29014
    Glutamine receptor
    T21447
    GSRD

    Gene Info:

    Target Class Enzymes
    Target Subclass EC:1.8.1.7
    Uniprot Evidence 1: Evidence at protein level
    Interpro Name Pyridine nucleotide-disulphide oxidoreductase, NAD-binding domain
    Interpro Acc IPR001327
    Interpro Type Domain
    Human Readable Name DRUGGABLE GENOME
    Uniprot Status Swiss-Prot
    Interpro Short Name Pyr_OxRdtase_NAD-bd_dom
    Target Subclass 1.8.1.7
    Target Main Class Enzymes
    Gene Biotype PROTEIN_CODING
    (8 More Sources)

    Gene Categories: Category Details

    EXTERNAL SIDE OF PLASMA MEMBRANE
    DRUGGABLE GENOME
    ENZYME

    Publications:

    Babych et al., 2000, [The effect of thyroxine on the enzymatic activity of the energy metabolism and antioxidant system in the neutrophilic granulocytes of piglets]., Fiziol Zh
    de Cavanagh et al., 2000, Enalapril and captopril enhance glutathione-dependent antioxidant defenses in mouse tissues., Am. J. Physiol. Regul. Integr. Comp. Physiol.
    Kurata et al., 1992, Effects of phenol compounds, glutathione analogues and a diuretic drug on glutathione S-transferase, glutathione reductase and glutathione peroxidase from canine erythrocytes., Comp. Biochem. Physiol., B
    He YJ et al., 2016, Carboplatin/taxane-induced gastrointestinal toxicity: a pharmacogenomics study on the SCOTROC1 trial., Pharmacogenomics J
    Erat et al., 2003, In vitro effects of some antibiotics on glutathione reductase from sheep liver., J Enzyme Inhib Med Chem
    Erat et al., 2005, Effects of some antibiotics on glutathione reductase activities from human erythrocytes in vitro and from rat erythrocytes in vivo., J Enzyme Inhib Med Chem
    Powell et al., 1987, Effect of inhibition of glutathione reductase by carmustine on central nervous system oxygen toxicity., J. Pharmacol. Exp. Ther.
    Doroshenko et al., 2004, The glutathione reductase inhibitor carmustine induces an influx of Ca2+ in PC12 cells., Eur. J. Pharmacol.
    Vallyathan et al., 1992, Enhanced generation of free radicals from phagocytes induced by mineral dusts., Am. J. Respir. Cell Mol. Biol.
    Jopperi-Davis et al., 2004, Compartmental inhibition of hepatic glutathione reductase activities by 1,3-bis(2-chloroethyl)-N-nitrosourea (BCNU) in Sprague-Dawley and Fischer-344 rats., Toxicol. Lett.
    Akella et al., Pyridine nucleotide flux and glutathione oxidation in the cultured rat conceptus., Reprod. Toxicol.
    Kirsch et al., 2002, Accumulation of glutathione disulfide mediates NF-kappaB activation during immune stimulation with CpG DNA., Antisense Nucleic Acid Drug Dev.
    Puglia et al., 1984, Inhibition of cellular antioxidants: a possible mechanism of toxic cell injury., Environ. Health Perspect.
    Brodie et al., 1992, Glutathione disulfide reduction in tumor mitochondria after t-butyl hydroperoxide treatment., Chem. Biol. Interact.
    Tamura T et al., 1996, Mitochondrial targeting of glutathione reductase requires a leader sequence., Biochem Biophys Res Commun
    Bajcetic et al., 2008, Effects of carvedilol on left ventricular function and oxidative stress in infants and children with idiopathic dilated cardiomyopathy: a 12-month, two-center, open-label study., Clin Ther
    Agnihotri et al., Role of oxidative stress in lansoprazole-mediated gastric and hepatic protection in Wistar rats., Indian J Gastroenterol
    Ozmen et al., 2004, Effects of antiemetic drugs on glucose 6-phosphate dehydrogenase and some antioxidant enzymes., Pharmacol. Res.
    Mulcahy, 1986, Carbamoylation, inhibition of glutathione reductase and chemopotentiation of nitrosoureas by misonidazole., Int. J. Radiat. Oncol. Biol. Phys.
    Stankiewicz et al., 2002, Effects of amifostine on liver oxidative stress caused by cyclophosphamide administration to rats., Drug Metabol Drug Interact
  • OXIGLUTATIONE   GSR

    Interaction Score: 4.12

    Interaction Types & Directionality:
    inhibitor (inhibitory)
    substrate

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Glutathione reductase

    PMIDs:
    8651901


    Sources:
    ChemblInteractions

  • CARMUSTINE   GSR

    Interaction Score: 4.12

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name polifeprosan 20/carmustine,Gliadel
    Novel drug target Established target
    Mechanism of Interaction Glutathione reductase inhibitor

    PMIDs:
    3806383 15321730 1312851 15104113 10378469 12477282 6094175 1394620


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • ALANYL GLUTAMINE   GSR

    Interaction Score: 4.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • MISONIDAZOLE   GSR

    Interaction Score: 2.75

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3759562


    Sources:
    NCI

  • LEVOFLOXACIN   GSR

    Interaction Score: 2.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15008519


    Sources:
    NCI

  • AMIFOSTINE   GSR

    Interaction Score: 1.65

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12751907


    Sources:
    NCI

  • CEFOTAXIME   GSR

    Interaction Score: 1.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15895687


    Sources:
    NCI

  • ONDANSETRON   GSR

    Interaction Score: 0.92

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15458770


    Sources:
    NCI

  • OFLOXACIN   GSR

    Interaction Score: 0.75

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15008519


    Sources:
    NCI

  • THYROXINE   GSR

    Interaction Score: 0.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11059392


    Sources:
    NCI

  • CARVEDILOL   GSR

    Interaction Score: 0.46

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18498919


    Sources:
    NCI

  • ENALAPRIL   GSR

    Interaction Score: 0.41

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10712274


    Sources:
    NCI

  • LANSOPRAZOLE   GSR

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17704577


    Sources:
    NCI

  • CARBOPLATIN   GSR

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26194361


    Sources:
    PharmGKB

  • QUERCETIN   GSR

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1478066


    Sources:
    NCI

  • Ensembl: ENSG00000104687

    • Version: 101_38

    Alternate Names:
    GSR Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P00390

    • Version: January-2014

    Alternate Names:
    GSR Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:1.8.1.7

    Publications:

  • TEND: P00390

    • Version: 01-August-2011

    Alternate Names:
    ENSG00000104687 Ensembl Gene Id
    P00390 Uniprot Accession
    GSHR_HUMAN Uniprot Id

    Gene Info:
    Target Subclass 1.8.1.7
    Target Main Class Enzymes

    Publications:

  • HopkinsGroom: P00390

    • Version: 11-September-2012

    Alternate Names:
    GLUTATHIONE REDUCTASE, MITOCHONDRIAL Uniprot Protein Name
    2936 Entrez Gene Id
    GSR Uniprot Gene Name

    Gene Info:
    Uniprot Evidence 1: Evidence at protein level
    Interpro Name Pyridine nucleotide-disulphide oxidoreductase, NAD-binding domain
    Interpro Acc IPR001327

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • RussLampel: ENSG00000104687

    • Version: 26-July-2011

    Alternate Names:
    GSR Display Id
    GLUTATHIONE REDUCTASE, MITOCHONDRIAL PRECURSOR (EC 1.8.1.7) (GR) (GRASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P00390] Description
    ENSG00000104687 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • PharmGKB: GSR

    • Version: 18-August-2020

    Alternate Names:
    PA29014 PharmGKB ID

    Gene Info:

    Publications:
    He YJ et al., 2016, Carboplatin/taxane-induced gastrointestinal toxicity: a pharmacogenomics study on the SCOTROC1 trial., Pharmacogenomics J

  • NCI: GSR

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Babych et al., 2000, [The effect of thyroxine on the enzymatic activity of the energy metabolism and antioxidant system in the neutrophilic granulocytes of piglets]., Fiziol Zh
    de Cavanagh et al., 2000, Enalapril and captopril enhance glutathione-dependent antioxidant defenses in mouse tissues., Am. J. Physiol. Regul. Integr. Comp. Physiol.
    Bajcetic et al., 2008, Effects of carvedilol on left ventricular function and oxidative stress in infants and children with idiopathic dilated cardiomyopathy: a 12-month, two-center, open-label study., Clin Ther

  • HingoraniCasas: ENSG00000104687

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000104687 Gene Symbol
    GSR Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: GLUR

    • Version: chembl_23

    Alternate Names:
    GRD1 GENE_SYMBOL
    GSR GENE_SYMBOL
    Glutathione reductase, mitochondrial UNIPROT

    Gene Info:

    Publications:

  • GO: GSR

    • Version: 01-February-2022

    Alternate Names:
    GLUR GO Gene Synonym
    GRD1 GO Gene Synonym

    Gene Info:

    Gene Categories:
    EXTERNAL SIDE OF PLASMA MEMBRANE

    Publications:

  • TTD: Glutamine receptor

    • Version: 2020.06.01

    Alternate Names:
    GluR TTD Gene Abbreviation
    T21447 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: GSR

    • Version: 01-February-2022

    Alternate Names:
    Glutathione reductase, mitochondrial Gene Name
    P00390 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21