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GSTA1 Gene Record

  • Summary
  • Interactions
  • Claims
  • GSTA1 2938 Druggable Genome

    Alternate Names:

    2938
    GLUTATHIONE S-TRANSFERASE ALPHA 1
    GSTA1
    GST-epsilon
    GST2
    GSTA1-1
    GTH1
    138359
    4626
    ENSG00000243955
    OTTHUMG00000014861
    BE0002281
    P08263
    PA29016
    Glutathione S-transferase A1
    BE0010006

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (4 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    ENZYME

    Publications:

    Kalra S et al., 2018, Association of CYP2C19*2 and ALDH1A1*1/*2 variants with disease outcome in breast cancer patients: results of a global screening array., Eur J Clin Pharmacol
    Rossi D et al., 2009, Analysis of the host pharmacogenetic background for prediction of outcome and toxicity in diffuse large B-cell lymphoma treated with R-CHOP21., Leukemia
    Kim et al., Glutathione S-transferase A1 polymorphisms and acute graft-vs.-host disease in HLA-matched sibling allogeneic hematopoietic stem cell transplantation., Clin Transplant
    Jönsson et al., 2007, Levels of 2-thiothiazolidine-4-carboxylic acid (TTCA) and effect modification of polymorphisms of glutathione-related genes in vulcanization workers in the southern Sweden rubber industries., Int Arch Occup Environ Health
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Söderdahl et al., 2007, Glutathione transferases in hepatocyte-like cells derived from human embryonic stem cells., Toxicol In Vitro
    Khrunin A et al., 2012, Pharmacogenomics of cisplatin-based chemotherapy in ovarian cancer patients of different ethnic origins., Pharmacogenomics
    Wang HN et al., 2015, The GSTA1 polymorphism and cyclophosphamide therapy outcomes in lupus nephritis patients., Clin Immunol
    Koutsoumpli GE et al., 2012, Synthesis and study of 2-(pyrrolesulfonylmethyl)-N-arylimines: a new class of inhibitors for human glutathione transferase A1-1., J Med Chem
    ten Brink MH et al., 2013, Effect of genetic variants GSTA1 and CYP39A1 and age on busulfan clearance in pediatric patients undergoing hematopoietic stem cell transplantation., Pharmacogenomics
    Gelderblom H et al., 2014, Brostallicin versus doxorubicin as first-line chemotherapy in patients with advanced or metastatic soft tissue sarcoma: an European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group randomised phase II and pharmacogenetic study., Eur J Cancer
    Romero et al., 2006, Chemical inducers of rodent glutathione s-transferases down-regulate human GSTA1 transcription through a mechanism involving variant hepatic nuclear factor 1-C., Mol. Pharmacol.
    Aniya Y et al., 1989, Activation of rat liver microsomal glutathione S-transferase by reduced oxygen species., J Biol Chem
    Lu WD et al., 2004, A novel antioxidant role for ligandin behavior of glutathione S-transferases: attenuation of the photodynamic effects of hypericin., Biochemistry
    Achilonu I et al., 2010, The role of a topologically conserved isoleucine in glutathione transferase structure, stability and function., Acta Crystallogr Sect F Struct Biol Cryst Commun
  • SULFOBROMOPHTHALEIN SODIUM   GSTA1

    Interaction Score: 8.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22849615


    Sources:
    DTC

  • CHEMBL1233278   GSTA1

    Interaction Score: 4.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • CHEMBL345292   GSTA1

    Interaction Score: 2.43

    Interaction Types & Directionality:
    ligand

    Interaction Info:

    PMIDs:
    20606271 10592235


    Sources:
    DrugBank

  • OXIGLUTATIONE   GSTA1

    Interaction Score: 1.62

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:

    PMIDs:
    2492517


    Sources:
    DrugBank

  • RITUXIMAB   GSTA1

    Interaction Score: 0.87

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29938344 19448608


    Sources:
    PharmGKB

  • HYPERICIN   GSTA1

    Interaction Score: 0.54

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15461448


    Sources:
    DrugBank

  • GLUTATHIONE   GSTA1

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17425746 17333241 10592235 17346923


    Sources:
    DrugBank

  • BUSULFAN   GSTA1

    Interaction Score: 0.48

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24192117


    Sources:
    PharmGKB

  • PREDNISONE   GSTA1

    Interaction Score: 0.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29938344 19448608


    Sources:
    PharmGKB

  • CYCLOPHOSPHAMIDE   GSTA1

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22188361 29938344 19448608 26222310


    Sources:
    PharmGKB

  • PHENOBARBITAL   GSTA1

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16608922


    Sources:
    NCI

  • VINCRISTINE   GSTA1

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29938344 19448608


    Sources:
    PharmGKB

  • DOXORUBICIN   GSTA1

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29938344 24215845 19448608


    Sources:
    PharmGKB

  • CISPLATIN   GSTA1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22188361


    Sources:
    PharmGKB

  • Ensembl: ENSG00000243955

    • Version: 101_38

    Alternate Names:
    GSTA1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: GSTA1

    • Version: 18-August-2020

    Alternate Names:
    PA29016 PharmGKB ID

    Gene Info:

    Publications:
    Kalra S et al., 2018, Association of CYP2C19*2 and ALDH1A1*1/*2 variants with disease outcome in breast cancer patients: results of a global screening array., Eur J Clin Pharmacol
    Rossi D et al., 2009, Analysis of the host pharmacogenetic background for prediction of outcome and toxicity in diffuse large B-cell lymphoma treated with R-CHOP21., Leukemia
    Khrunin A et al., 2012, Pharmacogenomics of cisplatin-based chemotherapy in ovarian cancer patients of different ethnic origins., Pharmacogenomics

  • DrugBank: BE0002281

    • Version: 5.1.7

    Alternate Names:
    GSTA1 DrugBank Gene Name
    P08263 UniProt Accession
    2938 Entrez Gene Id

    Gene Info:

    Publications:
    Kim et al., Glutathione S-transferase A1 polymorphisms and acute graft-vs.-host disease in HLA-matched sibling allogeneic hematopoietic stem cell transplantation., Clin Transplant
    Jönsson et al., 2007, Levels of 2-thiothiazolidine-4-carboxylic acid (TTCA) and effect modification of polymorphisms of glutathione-related genes in vulcanization workers in the southern Sweden rubber industries., Int Arch Occup Environ Health
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

  • DrugBank: BE0010006

    • Version: 5.1.7

    Alternate Names:
    GSTA1 DrugBank Gene Name
    P08263 UniProt Accession
    2938 Entrez Gene Id

    Gene Info:

    Publications:
    Aniya Y et al., 1989, Activation of rat liver microsomal glutathione S-transferase by reduced oxygen species., J Biol Chem

  • NCI: GSTA1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Gross-Steinmeyer et al., 2004, Phytochemical-induced changes in gene expression of carcinogen-metabolizing enzymes in cultured human primary hepatocytes., Xenobiotica
    Kakizaki et al., 2000, Induction of apoptosis and cell cycle arrest in mouse colon 26 cells by benastatin A., Jpn. J. Cancer Res.
    Romero et al., 2006, Chemical inducers of rodent glutathione s-transferases down-regulate human GSTA1 transcription through a mechanism involving variant hepatic nuclear factor 1-C., Mol. Pharmacol.

  • DTC: GSTA1

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Koutsoumpli GE et al., 2012, Synthesis and study of 2-(pyrrolesulfonylmethyl)-N-arylimines: a new class of inhibitors for human glutathione transferase A1-1., J Med Chem

  • HingoraniCasas: ENSG00000243955

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000243955 Gene Symbol
    GSTA1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • Pharos: GSTA1

    • Version: 03-September-2020

    Alternate Names:
    Glutathione S-transferase A1 Gene Name
    P08263 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21