DGIdb - GSTA1 Gene Record

GSTA1 2938 Druggable Genome

Alternate Names:

2938
GLUTATHIONE S-TRANSFERASE ALPHA 1
GSTA1
GST-epsilon
GST2
GSTA1-1
GTH1
138359
4626
ENSG00000243955
OTTHUMG00000014861
BE0002281
P08263
PA29016
Glutathione S-transferase A1
BE0010006

Gene Info:

Gene Biotype	PROTEIN_CODING

(4 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
ENZYME

Publications:

Kalra S et al., 2018, Association of CYP2C192 and ALDH1A11/*2 variants with disease outcome in breast cancer patients: results of a global screening array., Eur J Clin Pharmacol
Rossi D et al., 2009, Analysis of the host pharmacogenetic background for prediction of outcome and toxicity in diffuse large B-cell lymphoma treated with R-CHOP21., Leukemia
Kim et al., Glutathione S-transferase A1 polymorphisms and acute graft-vs.-host disease in HLA-matched sibling allogeneic hematopoietic stem cell transplantation., Clin Transplant
Jönsson et al., 2007, Levels of 2-thiothiazolidine-4-carboxylic acid (TTCA) and effect modification of polymorphisms of glutathione-related genes in vulcanization workers in the southern Sweden rubber industries., Int Arch Occup Environ Health
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Söderdahl et al., 2007, Glutathione transferases in hepatocyte-like cells derived from human embryonic stem cells., Toxicol In Vitro
Khrunin A et al., 2012, Pharmacogenomics of cisplatin-based chemotherapy in ovarian cancer patients of different ethnic origins., Pharmacogenomics
Wang HN et al., 2015, The GSTA1 polymorphism and cyclophosphamide therapy outcomes in lupus nephritis patients., Clin Immunol
Koutsoumpli GE et al., 2012, Synthesis and study of 2-(pyrrolesulfonylmethyl)-N-arylimines: a new class of inhibitors for human glutathione transferase A1-1., J Med Chem
ten Brink MH et al., 2013, Effect of genetic variants GSTA1 and CYP39A1 and age on busulfan clearance in pediatric patients undergoing hematopoietic stem cell transplantation., Pharmacogenomics
Gelderblom H et al., 2014, Brostallicin versus doxorubicin as first-line chemotherapy in patients with advanced or metastatic soft tissue sarcoma: an European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group randomised phase II and pharmacogenetic study., Eur J Cancer
Romero et al., 2006, Chemical inducers of rodent glutathione s-transferases down-regulate human GSTA1 transcription through a mechanism involving variant hepatic nuclear factor 1-C., Mol. Pharmacol.
Aniya Y et al., 1989, Activation of rat liver microsomal glutathione S-transferase by reduced oxygen species., J Biol Chem
Lu WD et al., 2004, A novel antioxidant role for ligandin behavior of glutathione S-transferases: attenuation of the photodynamic effects of hypericin., Biochemistry
Achilonu I et al., 2010, The role of a topologically conserved isoleucine in glutathione transferase structure, stability and function., Acta Crystallogr Sect F Struct Biol Cryst Commun

SULFOBROMOPHTHALEIN SODIUM GSTA1

Interaction Score: 8.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22849615

Sources:
DTC
CHEMBL1233278 GSTA1

Interaction Score: 4.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DrugBank
CHEMBL345292 GSTA1

Interaction Score: 2.43

Interaction Types & Directionality:

ligand

Interaction Info:

PMIDs:
20606271 10592235

Sources:
DrugBank
OXIGLUTATIONE GSTA1

Interaction Score: 1.62

Interaction Types & Directionality:

activator (activating)

Interaction Info:

PMIDs:
2492517

Sources:
DrugBank
RITUXIMAB GSTA1

Interaction Score: 0.87

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29938344 19448608

Sources:
PharmGKB
HYPERICIN GSTA1

Interaction Score: 0.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15461448

Sources:
DrugBank
GLUTATHIONE GSTA1

Interaction Score: 0.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17425746 17333241 10592235 17346923

Sources:
DrugBank
BUSULFAN GSTA1

Interaction Score: 0.48

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24192117

Sources:
PharmGKB
PREDNISONE GSTA1

Interaction Score: 0.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29938344 19448608

Sources:
PharmGKB
CYCLOPHOSPHAMIDE GSTA1

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22188361 29938344 19448608 26222310

Sources:
PharmGKB
PHENOBARBITAL GSTA1

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16608922

Sources:
NCI
VINCRISTINE GSTA1

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29938344 19448608

Sources:
PharmGKB
DOXORUBICIN GSTA1

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29938344 24215845 19448608

Sources:
PharmGKB
CISPLATIN GSTA1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22188361

Sources:
PharmGKB

Ensembl: ENSG00000243955
- Version: 101_38
Alternate Names:

GSTA1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

PharmGKB: GSTA1

Version: 18-August-2020

Alternate Names:

PA29016 PharmGKB ID

Gene Info:

Publications:

Kalra S et al., 2018, Association of CYP2C192 and ALDH1A11/*2 variants with disease outcome in breast cancer patients: results of a global screening array., Eur J Clin Pharmacol

Rossi D et al., 2009, Analysis of the host pharmacogenetic background for prediction of outcome and toxicity in diffuse large B-cell lymphoma treated with R-CHOP21., Leukemia

Khrunin A et al., 2012, Pharmacogenomics of cisplatin-based chemotherapy in ovarian cancer patients of different ethnic origins., Pharmacogenomics

DrugBank: BE0002281

Version: 5.1.7

Alternate Names:

GSTA1 DrugBank Gene Name

P08263 UniProt Accession

2938 Entrez Gene Id

Gene Info:

Publications:

Kim et al., Glutathione S-transferase A1 polymorphisms and acute graft-vs.-host disease in HLA-matched sibling allogeneic hematopoietic stem cell transplantation., Clin Transplant

Jönsson et al., 2007, Levels of 2-thiothiazolidine-4-carboxylic acid (TTCA) and effect modification of polymorphisms of glutathione-related genes in vulcanization workers in the southern Sweden rubber industries., Int Arch Occup Environ Health

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

DrugBank: BE0010006
- Version: 5.1.7
Alternate Names:

GSTA1 DrugBank Gene Name

P08263 UniProt Accession

2938 Entrez Gene Id

Gene Info:

Publications:

Aniya Y et al., 1989, Activation of rat liver microsomal glutathione S-transferase by reduced oxygen species., J Biol Chem

NCI: GSTA1

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Gross-Steinmeyer et al., 2004, Phytochemical-induced changes in gene expression of carcinogen-metabolizing enzymes in cultured human primary hepatocytes., Xenobiotica

Kakizaki et al., 2000, Induction of apoptosis and cell cycle arrest in mouse colon 26 cells by benastatin A., Jpn. J. Cancer Res.

Romero et al., 2006, Chemical inducers of rodent glutathione s-transferases down-regulate human GSTA1 transcription through a mechanism involving variant hepatic nuclear factor 1-C., Mol. Pharmacol.

DTC: GSTA1
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Koutsoumpli GE et al., 2012, Synthesis and study of 2-(pyrrolesulfonylmethyl)-N-arylimines: a new class of inhibitors for human glutathione transferase A1-1., J Med Chem
HingoraniCasas: ENSG00000243955
- Version: 31-May-2017
Alternate Names:

ENSG00000243955 Gene Symbol

GSTA1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
Pharos: GSTA1
- Version: 03-September-2020
Alternate Names:

Glutathione S-transferase A1 Gene Name

P08263 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:

GSTA1	DrugBank Gene Name
P08263	UniProt Accession
2938	Entrez Gene Id

GSTA1 Gene Record

GSTA1 2938 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22849615

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DrugBank

Interaction Types & Directionality: ligand

Interaction Info:

PMIDs: 20606271 10592235

Sources: DrugBank

Interaction Types & Directionality: activator (activating)

Interaction Info:

PMIDs: 2492517

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29938344 19448608

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15461448

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17425746 17333241 10592235 17346923

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24192117

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29938344 19448608

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22188361 29938344 19448608 26222310

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16608922

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29938344 19448608

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29938344 24215845 19448608

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22188361

Sources: PharmGKB

Ensembl: ENSG00000243955

Alternate Names: GSTA1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

PharmGKB: GSTA1

Alternate Names: PA29016 PharmGKB ID

Gene Info:

DrugBank: BE0002281

Alternate Names: GSTA1 DrugBank Gene Name P08263 UniProt Accession 2938 Entrez Gene Id

Gene Info:

DrugBank: BE0010006

Alternate Names: GSTA1 DrugBank Gene Name P08263 UniProt Accession 2938 Entrez Gene Id

Gene Info:

Publications: Aniya Y et al., 1989, Activation of rat liver microsomal glutathione S-transferase by reduced oxygen species., J Biol Chem

NCI: GSTA1

Alternate Names:

Gene Info:

DTC: GSTA1

Interaction Types & Directionality:

n/a

PMIDs:
22849615

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DrugBank

Interaction Types & Directionality:

ligand

PMIDs:
20606271 10592235

Sources:
DrugBank

Interaction Types & Directionality:

activator (activating)

PMIDs:
2492517

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
29938344 19448608

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
15461448

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17425746 17333241 10592235 17346923

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
24192117

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
29938344 19448608

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22188361 29938344 19448608 26222310

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
16608922

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
29938344 19448608

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
29938344 24215845 19448608

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22188361

Sources:
PharmGKB

Alternate Names:

GSTA1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

PA29016 PharmGKB ID

Alternate Names:

GSTA1 DrugBank Gene Name

P08263 UniProt Accession

2938 Entrez Gene Id

Alternate Names:

GSTA1 DrugBank Gene Name

P08263 UniProt Accession

2938 Entrez Gene Id

Publications:

Aniya Y et al., 1989, Activation of rat liver microsomal glutathione S-transferase by reduced oxygen species., J Biol Chem

Publications:

Koutsoumpli GE et al., 2012, Synthesis and study of 2-(pyrrolesulfonylmethyl)-N-arylimines: a new class of inhibitors for human glutathione transferase A1-1., J Med Chem

Alternate Names:

ENSG00000243955 Gene Symbol

GSTA1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

Glutathione S-transferase A1 Gene Name

P08263 UniProt ID

Gene Categories:

ENZYME