DGIdb - GSTA1 Gene Record

GSTA1 2938 Druggable Genome

Alternate Names:

2938
GLUTATHIONE S-TRANSFERASE ALPHA 1
GSTA1
GST-epsilon
GST2
GSTA1-1
GTH1
138359
4626
ENSG00000243955
OTTHUMG00000014861
P08263
PA29016
Glutathione S-transferase A1

Gene Info:

Gene Biotype	PROTEIN_CODING

(2 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
ENZYME

Publications:

Kalra S et al., 2018, Association of CYP2C192 and ALDH1A11/*2 variants with disease outcome in breast cancer patients: results of a global screening array., Eur J Clin Pharmacol
Rossi D et al., 2009, Analysis of the host pharmacogenetic background for prediction of outcome and toxicity in diffuse large B-cell lymphoma treated with R-CHOP21., Leukemia
Wang HN et al., 2015, The GSTA1 polymorphism and cyclophosphamide therapy outcomes in lupus nephritis patients., Clin Immunol
Khrunin A et al., 2012, Pharmacogenomics of cisplatin-based chemotherapy in ovarian cancer patients of different ethnic origins., Pharmacogenomics
Koutsoumpli GE et al., 2012, Synthesis and study of 2-(pyrrolesulfonylmethyl)-N-arylimines: a new class of inhibitors for human glutathione transferase A1-1., J Med Chem
ten Brink MH et al., 2013, Effect of genetic variants GSTA1 and CYP39A1 and age on busulfan clearance in pediatric patients undergoing hematopoietic stem cell transplantation., Pharmacogenomics
Gelderblom H et al., 2014, Brostallicin versus doxorubicin as first-line chemotherapy in patients with advanced or metastatic soft tissue sarcoma: an European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group randomised phase II and pharmacogenetic study., Eur J Cancer
Romero et al., 2006, Chemical inducers of rodent glutathione s-transferases down-regulate human GSTA1 transcription through a mechanism involving variant hepatic nuclear factor 1-C., Mol. Pharmacol.

SULFOBROMOPHTHALEIN SODIUM GSTA1

Interaction Score: 14.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22849615

Sources:
DTC
RITUXIMAB GSTA1

Interaction Score: 1.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29938344 19448608

Sources:
PharmGKB
BUSULFAN GSTA1

Interaction Score: 0.83

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24192117

Sources:
PharmGKB
PREDNISONE GSTA1

Interaction Score: 0.66

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29938344 19448608

Sources:
PharmGKB
CYCLOPHOSPHAMIDE GSTA1

Interaction Score: 0.45

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29938344 26222310 22188361 19448608

Sources:
PharmGKB
PHENOBARBITAL GSTA1

Interaction Score: 0.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16608922

Sources:
NCI
VINCRISTINE GSTA1

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29938344 19448608

Sources:
PharmGKB
DOXORUBICIN GSTA1

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29938344 24215845 19448608

Sources:
PharmGKB
CISPLATIN GSTA1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22188361

Sources:
PharmGKB

Ensembl: ENSG00000243955
- Version: 101_38
Alternate Names:

GSTA1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

PharmGKB: GSTA1

Version: 18-August-2020

Alternate Names:

PA29016 PharmGKB ID

Gene Info:

Publications:

Kalra S et al., 2018, Association of CYP2C192 and ALDH1A11/*2 variants with disease outcome in breast cancer patients: results of a global screening array., Eur J Clin Pharmacol

Rossi D et al., 2009, Analysis of the host pharmacogenetic background for prediction of outcome and toxicity in diffuse large B-cell lymphoma treated with R-CHOP21., Leukemia

Khrunin A et al., 2012, Pharmacogenomics of cisplatin-based chemotherapy in ovarian cancer patients of different ethnic origins., Pharmacogenomics

NCI: GSTA1

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Gross-Steinmeyer et al., 2004, Phytochemical-induced changes in gene expression of carcinogen-metabolizing enzymes in cultured human primary hepatocytes., Xenobiotica

Kakizaki et al., 2000, Induction of apoptosis and cell cycle arrest in mouse colon 26 cells by benastatin A., Jpn. J. Cancer Res.

Romero et al., 2006, Chemical inducers of rodent glutathione s-transferases down-regulate human GSTA1 transcription through a mechanism involving variant hepatic nuclear factor 1-C., Mol. Pharmacol.

DTC: GSTA1
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Koutsoumpli GE et al., 2012, Synthesis and study of 2-(pyrrolesulfonylmethyl)-N-arylimines: a new class of inhibitors for human glutathione transferase A1-1., J Med Chem
HingoraniCasas: ENSG00000243955
- Version: 31-May-2017
Alternate Names:

ENSG00000243955 Gene Symbol

GSTA1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
Pharos: GSTA1
- Version: 01-May-2021
Alternate Names:

Glutathione S-transferase A1 Gene Name

P08263 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:

GSTA1 Gene Record

GSTA1 2938 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22849615

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29938344 19448608

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24192117

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29938344 19448608

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29938344 26222310 22188361 19448608

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16608922

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29938344 19448608

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29938344 24215845 19448608

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22188361

Sources: PharmGKB

Ensembl: ENSG00000243955

Alternate Names: GSTA1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

PharmGKB: GSTA1

Alternate Names: PA29016 PharmGKB ID

Gene Info:

NCI: GSTA1

Alternate Names:

Gene Info:

DTC: GSTA1

Alternate Names:

Gene Info:

Publications: Koutsoumpli GE et al., 2012, Synthesis and study of 2-(pyrrolesulfonylmethyl)-N-arylimines: a new class of inhibitors for human glutathione transferase A1-1., J Med Chem

HingoraniCasas: ENSG00000243955

Alternate Names: ENSG00000243955 Gene Symbol GSTA1 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

Pharos: GSTA1

Alternate Names: Glutathione S-transferase A1 Gene Name P08263 UniProt ID

Gene Info:

Gene Categories: ENZYME

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
22849615

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
29938344 19448608

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
24192117

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
29938344 19448608

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
29938344 26222310 22188361 19448608

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
16608922

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
29938344 19448608

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
29938344 24215845 19448608

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22188361

Sources:
PharmGKB

Alternate Names:

GSTA1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

PA29016 PharmGKB ID

Publications:

Koutsoumpli GE et al., 2012, Synthesis and study of 2-(pyrrolesulfonylmethyl)-N-arylimines: a new class of inhibitors for human glutathione transferase A1-1., J Med Chem

Alternate Names:

ENSG00000243955 Gene Symbol

GSTA1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

Glutathione S-transferase A1 Gene Name

P08263 UniProt ID

Gene Categories:

ENZYME