DGIdb - GSTM1 Gene Record

GSTM1 2944 Druggable Genome

Alternate Names:

2944
GLUTATHIONE S-TRANSFERASE MU 1
GSTM1
GST1
GSTM1-1
GSTM1a-1a
GSTM1b-1b
GTH4
GTM1
H-B
MU
MU-1
138350
4632
ENSG00000134184
OTTHUMG00000011635
BE0000807
P09488
PA182

Gene Info:

Gene Biotype	PROTEIN_CODING

(2 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
ENZYME

Publications:

Altés A et al., 2013, Pharmacogenetic analysis in the treatment of Hodgkin lymphoma., Leuk Lymphoma
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Yee SW et al., 2013, Impact of polymorphisms in drug pathway genes on disease-free survival in adults with acute myeloid leukemia., J Hum Genet
Tsuchida et al., 1990, Purification and characterization of glutathione transferases with an activity toward nitroglycerin from human aorta and heart. Multiplicity of the human class Mu forms., J. Biol. Chem.
Anderer et al., 2000, Polymorphisms within glutathione S-transferase genes and initial response to glucocorticoids in childhood acute lymphoblastic leukaemia., Pharmacogenetics
Pereira D et al., 2016, Improvement of a predictive model in ovarian cancer patients submitted to platinum-based chemotherapy: implications of a GST activity profile., Eur J Clin Pharmacol
Depeille et al., 2004, Glutathione S-transferase M1 and multidrug resistance protein 1 act in synergy to protect melanoma cells from vincristine effects., Mol. Pharmacol.
Watanabe et al., 2003, A study to survey susceptible genetic factors responsible for troglitazone-associated hepatotoxicity in Japanese patients with type 2 diabetes mellitus., Clin. Pharmacol. Ther.
Kong X et al., 2016, GSTP1, GSTM1, and GSTT1 polymorphisms as predictors of response to chemotherapy in patients with breast cancer: a meta-analysis., Cancer Chemother Pharmacol
Gasper et al., 2005, Glutathione S-transferase M1 polymorphism and metabolism of sulforaphane from standard and high-glucosinolate broccoli., Am. J. Clin. Nutr.
Imanishi et al., 2007, Genetic polymorphisms associated with adverse events and elimination of methotrexate in childhood acute lymphoblastic leukemia and malignant lymphoma., J. Hum. Genet.
Tran et al., 2006, Pharmacokinetics and toxicity of docetaxel: role of CYP3A, MDR1, and GST polymorphisms., Clin. Pharmacol. Ther.
Schwartzbaum et al., 2007, An international case-control study of glutathione transferase and functionally related polymorphisms and risk of primary adult brain tumors., Cancer Epidemiol. Biomarkers Prev.
Sakoda et al., 2008, Glutathione S-transferase M1 and P1 polymorphisms and risk of breast cancer and fibrocystic breast conditions in Chinese women., Breast Cancer Res. Treat.
Contreras-Vergara et al., 2007, A Mu-class glutathione S-transferase from gills of the marine shrimp Litopenaeus vannamei: purification and characterization., J. Biochem. Mol. Toxicol.
Ouerhani et al., The role of glutathione transferases M1 and T1 in individual susceptibility to bladder cancer in a Tunisian population., Ann. Hum. Biol.
Moore et al., 2007, Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer., Int. J. Cancer
Stocco G et al., 2014, Deletion of glutathione-s-transferase m1 reduces azathioprine metabolite concentrations in young patients with inflammatory bowel disease., J Clin Gastroenterol
Wolkenstein P et al., 2000, Prospective evaluation of detoxification pathways as markers of cutaneous adverse reactions to sulphonamides in AIDS., Pharmacogenetics
van der Weide K et al., 2017, Genetic risk factors for clozapine-induced neutropenia and agranulocytosis in a Dutch psychiatric population., Pharmacogenomics J
Romero et al., 2006, Potential application of GSTT1-null genotype in predicting toxicity associated to 5-fluouracil irinotecan and leucovorin regimen in advanced stage colorectal cancer patients., Oncol. Rep.
Mukanganyama S et al., 1997, Phenotyping of the glutathione S-transferase M1 polymorphism in Zimbabweans and the effects of chloroquine on blood glutathione S-transferases M1 and A., Clin Chim Acta

FLUOROTRYPTOPHANE GSTM1

Interaction Score: 4.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17016423 17139284

Sources:
DrugBank
CHEMBL1232997 GSTM1

Interaction Score: 3.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
SULFAMETHOXAZOLE GSTM1

Interaction Score: 0.91

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11191886

Sources:
PharmGKB
IRINOTECAN HYDROCHLORIDE GSTM1

Interaction Score: 0.65

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16865249

Sources:
NCI
SULFORAPHANE GSTM1

Interaction Score: 0.65

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16332662

Sources:
NCI
DICUMAROL GSTM1

Interaction Score: 0.57

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15044619

Sources:
NCI
NITROGLYCERIN GSTM1

Interaction Score: 0.45

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2110160

Sources:
NCI
TRIMETHOPRIM GSTM1

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11191886

Sources:
PharmGKB
CHLORAMBUCIL GSTM1

Interaction Score: 0.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15044619

Sources:
NCI
GLUTATHIONE GSTM1

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17372252 17624589 17427177 17381051 17311259

Sources:
DrugBank
DACARBAZINE GSTM1

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23323945

Sources:
PharmGKB
CHLOROQUINE GSTM1

Interaction Score: 0.27

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
9385457

Sources:
DrugBank
BUSULFAN GSTM1

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23677058

Sources:
PharmGKB
BLEOMYCIN GSTM1

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23323945

Sources:
PharmGKB
AZATHIOPRINE GSTM1

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23787247

Sources:
PharmGKB
PREDNISONE GSTM1

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11186134

Sources:
NCI
TROGLITAZONE GSTM1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12732844

Sources:
NCI
VINBLASTINE GSTM1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23323945

Sources:
PharmGKB
CURCUMIN GSTM1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15044619

Sources:
NCI
CYCLOPHOSPHAMIDE GSTM1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27785604

Sources:
PharmGKB
CLOZAPINE GSTM1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27168101

Sources:
PharmGKB
DOCETAXEL GSTM1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16765145

Sources:
NCI
DOXORUBICIN GSTM1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23323945

Sources:
PharmGKB
PACLITAXEL GSTM1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26803611

Sources:
PharmGKB
METHOTREXATE GSTM1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17180579

Sources:
NCI

Ensembl: ENSG00000134184
- Version: 101_38
Alternate Names:

GSTM1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

PharmGKB: GSTM1

Version: 18-August-2020

Alternate Names:

PA182 PharmGKB ID

Gene Info:

Publications:

Altés A et al., 2013, Pharmacogenetic analysis in the treatment of Hodgkin lymphoma., Leuk Lymphoma

Kong X et al., 2016, GSTP1, GSTM1, and GSTT1 polymorphisms as predictors of response to chemotherapy in patients with breast cancer: a meta-analysis., Cancer Chemother Pharmacol

Yee SW et al., 2013, Impact of polymorphisms in drug pathway genes on disease-free survival in adults with acute myeloid leukemia., J Hum Genet

DrugBank: BE0000807

Version: 5.1.7

Alternate Names:

GSTM1 DrugBank Gene Name

P09488 UniProt Accession

2944 Entrez Gene Id

Gene Info:

Publications:

Contreras-Vergara et al., 2007, A Mu-class glutathione S-transferase from gills of the marine shrimp Litopenaeus vannamei: purification and characterization., J. Biochem. Mol. Toxicol.

Moore et al., 2007, Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer., Int. J. Cancer

Ouerhani et al., The role of glutathione transferases M1 and T1 in individual susceptibility to bladder cancer in a Tunisian population., Ann. Hum. Biol.

NCI: GSTM1

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Tran et al., 2006, Pharmacokinetics and toxicity of docetaxel: role of CYP3A, MDR1, and GST polymorphisms., Clin. Pharmacol. Ther.

Liu et al., 2002, Enhanced lipid peroxidation in epileptics with null genotype of glutathione S-transferase M1 and intractable seizure., Jpn. J. Pharmacol.

Roy et al., 2001, Increased risk of antituberculosis drug-induced hepatotoxicity in individuals with glutathione S-transferase M1 'null' mutation., J. Gastroenterol. Hepatol.

HingoraniCasas: ENSG00000134184
- Version: 31-May-2017
Alternate Names:

ENSG00000134184 Gene Symbol

GSTM1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
Pharos: GSTM1
- Version: 03-September-2020
Alternate Names:

Glutathione S-transferase Mu 1 Gene Name

P09488 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:

GSTM1	DrugBank Gene Name
P09488	UniProt Accession
2944	Entrez Gene Id

GSTM1 Gene Record

GSTM1 2944 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235 17016423 17139284

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11191886

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16865249

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16332662

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15044619

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2110160

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11191886

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15044619

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17372252 17624589 17427177 17381051 17311259

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23323945

Sources: PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 9385457

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23677058

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23323945

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23787247

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11186134

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12732844

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23323945

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
10592235 17016423 17139284

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
11191886

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
16865249

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16332662

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15044619

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
2110160

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11191886

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
15044619

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17372252 17624589 17427177 17381051 17311259

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
23323945

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
9385457

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
23677058

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
23323945

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
23787247

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
11186134

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12732844

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
23323945

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
15044619

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
27785604

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
27168101

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
16765145

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
23323945

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
26803611

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
17180579

Sources:
NCI

Alternate Names:

GSTM1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

PA182 PharmGKB ID

Alternate Names:

GSTM1 DrugBank Gene Name

P09488 UniProt Accession

2944 Entrez Gene Id

Alternate Names:

ENSG00000134184 Gene Symbol

GSTM1 Ensembl Id