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GSTM1 Gene Record

  • Summary
  • Interactions
  • Claims
  • GSTM1 2944 Druggable Genome

    Alternate Names:

    2944
    GLUTATHIONE S-TRANSFERASE MU 1
    GSTM1
    GST1
    GSTM1-1
    GSTM1a-1a
    GSTM1b-1b
    GTH4
    GTM1
    H-B
    MU
    MU-1
    138350
    4632
    ENSG00000134184
    OTTHUMG00000011635
    PA182
    P09488

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (1 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    ENZYME

    Publications:

    Altés A et al., 2013, Pharmacogenetic analysis in the treatment of Hodgkin lymphoma., Leuk Lymphoma
    Yee SW et al., 2013, Impact of polymorphisms in drug pathway genes on disease-free survival in adults with acute myeloid leukemia., J Hum Genet
    Tsuchida et al., 1990, Purification and characterization of glutathione transferases with an activity toward nitroglycerin from human aorta and heart. Multiplicity of the human class Mu forms., J. Biol. Chem.
    Anderer et al., 2000, Polymorphisms within glutathione S-transferase genes and initial response to glucocorticoids in childhood acute lymphoblastic leukaemia., Pharmacogenetics
    Pereira D et al., 2016, Improvement of a predictive model in ovarian cancer patients submitted to platinum-based chemotherapy: implications of a GST activity profile., Eur J Clin Pharmacol
    Depeille et al., 2004, Glutathione S-transferase M1 and multidrug resistance protein 1 act in synergy to protect melanoma cells from vincristine effects., Mol. Pharmacol.
    Watanabe et al., 2003, A study to survey susceptible genetic factors responsible for troglitazone-associated hepatotoxicity in Japanese patients with type 2 diabetes mellitus., Clin. Pharmacol. Ther.
    Kong X et al., 2016, GSTP1, GSTM1, and GSTT1 polymorphisms as predictors of response to chemotherapy in patients with breast cancer: a meta-analysis., Cancer Chemother Pharmacol
    Gasper et al., 2005, Glutathione S-transferase M1 polymorphism and metabolism of sulforaphane from standard and high-glucosinolate broccoli., Am. J. Clin. Nutr.
    Imanishi et al., 2007, Genetic polymorphisms associated with adverse events and elimination of methotrexate in childhood acute lymphoblastic leukemia and malignant lymphoma., J. Hum. Genet.
    Tran et al., 2006, Pharmacokinetics and toxicity of docetaxel: role of CYP3A, MDR1, and GST polymorphisms., Clin. Pharmacol. Ther.
    Stocco G et al., 2014, Deletion of glutathione-s-transferase m1 reduces azathioprine metabolite concentrations in young patients with inflammatory bowel disease., J Clin Gastroenterol
    Wolkenstein P et al., 2000, Prospective evaluation of detoxification pathways as markers of cutaneous adverse reactions to sulphonamides in AIDS., Pharmacogenetics
    van der Weide K et al., 2017, Genetic risk factors for clozapine-induced neutropenia and agranulocytosis in a Dutch psychiatric population., Pharmacogenomics J
    Romero et al., 2006, Potential application of GSTT1-null genotype in predicting toxicity associated to 5-fluouracil irinotecan and leucovorin regimen in advanced stage colorectal cancer patients., Oncol. Rep.
  • SULFAMETHOXAZOLE   GSTM1

    Interaction Score: 1.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11191886


    Sources:
    PharmGKB

  • IRINOTECAN HYDROCHLORIDE   GSTM1

    Interaction Score: 0.84

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16865249


    Sources:
    NCI

  • SULFORAPHANE   GSTM1

    Interaction Score: 0.84

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16332662


    Sources:
    NCI

  • DICUMAROL   GSTM1

    Interaction Score: 0.84

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15044619


    Sources:
    NCI

  • NITROGLYCERIN   GSTM1

    Interaction Score: 0.59

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2110160


    Sources:
    NCI

  • TRIMETHOPRIM   GSTM1

    Interaction Score: 0.54

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11191886


    Sources:
    PharmGKB

  • CHLORAMBUCIL   GSTM1

    Interaction Score: 0.49

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15044619


    Sources:
    NCI

  • DACARBAZINE   GSTM1

    Interaction Score: 0.45

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23323945


    Sources:
    PharmGKB

  • BUSULFAN   GSTM1

    Interaction Score: 0.35

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23677058


    Sources:
    PharmGKB

  • BLEOMYCIN   GSTM1

    Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23323945


    Sources:
    PharmGKB

  • AZATHIOPRINE   GSTM1

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23787247


    Sources:
    PharmGKB

  • TROGLITAZONE   GSTM1

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12732844


    Sources:
    NCI

  • VINBLASTINE   GSTM1

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23323945


    Sources:
    PharmGKB

  • PREDNISONE   GSTM1

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11186134


    Sources:
    NCI

  • CLOZAPINE   GSTM1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27168101


    Sources:
    PharmGKB

  • CURCUMIN   GSTM1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15044619


    Sources:
    NCI

  • DOCETAXEL   GSTM1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16765145


    Sources:
    NCI

  • CYCLOPHOSPHAMIDE   GSTM1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27785604


    Sources:
    PharmGKB

  • DOXORUBICIN   GSTM1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23323945


    Sources:
    PharmGKB

  • PACLITAXEL   GSTM1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26803611


    Sources:
    PharmGKB

  • METHOTREXATE   GSTM1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17180579


    Sources:
    NCI

  • Ensembl: ENSG00000134184

    • Version: 101_38

    Alternate Names:
    GSTM1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: GSTM1

    • Version: 18-August-2020

    Alternate Names:
    PA182 PharmGKB ID

    Gene Info:

    Publications:
    Altés A et al., 2013, Pharmacogenetic analysis in the treatment of Hodgkin lymphoma., Leuk Lymphoma
    Kong X et al., 2016, GSTP1, GSTM1, and GSTT1 polymorphisms as predictors of response to chemotherapy in patients with breast cancer: a meta-analysis., Cancer Chemother Pharmacol
    Yee SW et al., 2013, Impact of polymorphisms in drug pathway genes on disease-free survival in adults with acute myeloid leukemia., J Hum Genet

  • NCI: GSTM1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Tran et al., 2006, Pharmacokinetics and toxicity of docetaxel: role of CYP3A, MDR1, and GST polymorphisms., Clin. Pharmacol. Ther.
    Liu et al., 2002, Enhanced lipid peroxidation in epileptics with null genotype of glutathione S-transferase M1 and intractable seizure., Jpn. J. Pharmacol.
    Roy et al., 2001, Increased risk of antituberculosis drug-induced hepatotoxicity in individuals with glutathione S-transferase M1 'null' mutation., J. Gastroenterol. Hepatol.

  • HingoraniCasas: ENSG00000134184

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000134184 Gene Symbol
    GSTM1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • Pharos: GSTM1

    • Version: 01-February-2022

    Alternate Names:
    Glutathione S-transferase Mu 1 Gene Name
    P09488 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21