• GUCY1A2 2977 Druggable Genome

    Alternate Names:

    601244
    2977
    GUANYLATE CYCLASE 1 SOLUBLE SUBUNIT ALPHA 2
    GUCY1A2
    GC-SA2
    GUC1A2
    4684
    ENSG00000152402
    OTTHUMG00000166296
    GUANYLATE CYCLASE SOLUBLE, ALPHA-2 CHAIN (EC 4.6.1.2) (GCS-ALPHA-2). [SOURCE:UNIPROT/SWISSPROT;ACC:P33402]
    GUCSA2
    Guanylate cyclase soluble subunit alpha-2
    GCS-alpha-2
    P33402
    GCYA2_HUMAN
    1289
    Guanylyl cyclase &alpha;<sub>2</sub> subunit

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Interpro Type Domain
    Interpro Acc IPR001054
    Uniprot Status Swiss-Prot
    Uniprot Evidence 1: Evidence at protein level
    Interpro Short Name A/G_cyclase
    Interpro Name Adenylyl cyclase class-3/4/guanylyl cyclase
    Target Class Enzymes
    Target Subclass EC:4.6.1.2
    Gene Biotype PROTEIN_CODING
    GuideToPharmacology Gene Category Name Nitric oxide (NO)-sensitive (soluble) guanylyl cyclase
    GuideToPharmacology Gene Category ID 939
    (4 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    ENZYME
  • Interaction Score: 7.29

    Interaction Types & Directionality:
    activator (activating)
    positive modulator (activating)
    agonist (activating)
    stimulator (activating)

    Interaction Info:
    Novel drug target Established target
    Trial Name riociguat, BAY-63-2521
    Mechanism of Interaction Soluble guanylate cyclase positive allosteric modulator

  • Interaction Score: 3.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name Naproxcinod
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • Interaction Score: 2.28

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Mechanism of Interaction Soluble guanylate cyclase activator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 2.28

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Mechanism of Interaction Soluble guanylate cyclase activator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 1.82

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Mechanism of Interaction Soluble guanylate cyclase activator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 1.52

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Soluble guanylate cyclase activator

    PMIDs:
    None found


  • Interaction Score: 0.91

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Mechanism of Interaction Soluble guanylate cyclase activator
    Direct Interaction yes

    PMIDs:
    None found


    • Version: 101_38

    Alternate Names:
    GUCY1A2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

    • Version: 26-July-2011

    Alternate Names:
    GUCY1A2 Display Id
    ENSG00000152402 Ensembl Gene Id
    GUANYLATE CYCLASE SOLUBLE, ALPHA-2 CHAIN (EC 4.6.1.2) (GCS-ALPHA-2). [SOURCE:UNIPROT/SWISSPROT;ACC:P33402] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: January-2014

    Alternate Names:
    GUCY1A2 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:4.6.1.2

    Publications:

    • Version: 11-September-2012

    Alternate Names:
    ENSG00000152402 Ensembl Gene Id
    GCYA2_HUMAN Uniprot Id
    P33402 Uniprot Accession

    Gene Info:
    Interpro Type Domain
    Interpro Acc IPR001054
    Uniprot Status Swiss-Prot

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: 29-September-2020

    Alternate Names:
    4684 HUGO Gene ID
    4684 HUGO Gene Symbol
    guanylate cyclase 1 soluble subunit alpha 2 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Nitric oxide (NO)-sensitive (soluble) guanylyl cyclase
    GuideToPharmacology Gene Category ID 939

    Publications:

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000152402 Gene Symbol
    GUCY1A2 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: chembl_23

    Alternate Names:
    GUCSA2 GENE_SYMBOL
    GUCY1A2 GENE_SYMBOL
    Guanylate cyclase soluble subunit alpha-2 UNIPROT

    Gene Info:

    Publications:

    • Version: 01-May-2021

    Alternate Names:
    Guanylate cyclase soluble subunit alpha-2 Gene Name
    P33402 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications: