GUCY1B2 Gene Record

  • GUCY1B2 2974 Druggable Genome

    Alternate Names:

    2974
    GUANYLATE CYCLASE 1 SOLUBLE SUBUNIT BETA 2 (PSEUDOGENE)
    GUCY1B2
    GC-SB2
    603695
    4686
    ENSG00000123201
    O75343
    GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2
    GCYB2_HUMAN
    GUANYLATE CYCLASE SOLUBLE, BETA-2 CHAIN (EC 4.6.1.2) (GCS-BETA-2). [SOURCE:UNIPROT/SWISSPROT;ACC:O75343]
    GCS-beta-2

    Gene Info:

    Interpro Name Adenylyl cyclase class-3/4/guanylyl cyclase
    Interpro Acc IPR001054
    Uniprot Evidence 2: Evidence at transcript level
    Human Readable Name DRUGGABLE GENOME
    Interpro Short Name A/G_cyclase
    Uniprot Status Swiss-Prot
    Interpro Type Domain
    Target Class Enzymes
    Target Subclass EC:4.6.1.2
    Gene Biotype TRANSCRIBED_UNITARY_PSEUDOGENE
    (2 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME

    Publications:

  • RIOCIGUAT   GUCY1B2

    Interaction Score: 4.12

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Novel drug target Novel Target
    Trial Name riociguat, BAY-63-2521
    Mechanism of Interaction Soluble guanylate cyclase positive allosteric modulator

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions

  • NITRIC OXIDE   GUCY1B2

    Interaction Score: 2.58

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Mechanism of Interaction Soluble guanylate cyclase activator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • SODIUM NITROPRUSSIDE   GUCY1B2

    Interaction Score: 2.58

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Soluble guanylate cyclase activator

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ISOSORBIDE DINITRATE   GUCY1B2

    Interaction Score: 2.58

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Mechanism of Interaction Soluble guanylate cyclase activator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ISOSORBIDE MONONITRATE   GUCY1B2

    Interaction Score: 2.06

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Mechanism of Interaction Soluble guanylate cyclase activator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • NITROGLYCERIN   GUCY1B2

    Interaction Score: 1.03

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Mechanism of Interaction Soluble guanylate cyclase activator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • Ensembl: ENSG00000123201

    • Version: 101_38

    Alternate Names:
    GUCY1B2 Ensembl Gene Name

    Gene Info:
    Gene Biotype TRANSCRIBED_UNITARY_PSEUDOGENE

    Publications:

  • HopkinsGroom: O75343

    • Version: 11-September-2012

    Alternate Names:
    GUCY1B2 Uniprot Gene Name
    GCYB2_HUMAN Uniprot Id
    GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2 Uniprot Protein Name

    Gene Info:
    Interpro Name Adenylyl cyclase class-3/4/guanylyl cyclase
    Interpro Acc IPR001054
    Uniprot Evidence 2: Evidence at transcript level

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • RussLampel: ENSG00000123201

    • Version: 26-July-2011

    Alternate Names:
    GUCY1B2 Display Id
    GUANYLATE CYCLASE SOLUBLE, BETA-2 CHAIN (EC 4.6.1.2) (GCS-BETA-2). [SOURCE:UNIPROT/SWISSPROT;ACC:O75343] Description
    ENSG00000123201 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: O75343

    • Version: January-2014

    Alternate Names:
    GUCY1B2 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:4.6.1.2

    Publications:

  • HingoraniCasas: ENSG00000123201

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000123201 Gene Symbol
    GUCY1B2 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: GUCY1B2

    • Version: chembl_23

    Alternate Names:
    GUCY1B2 GENE_SYMBOL
    Guanylate cyclase soluble subunit beta-2 UNIPROT
    GCS-beta-2 UNIPROT

    Gene Info:

    Publications: