DGIdb - HDAC10 Gene Record

HDAC10 83933 Druggable Genome

Alternate Names:

83933
HISTONE DEACETYLASE 10
HDAC10
HD10
608544
18128
ENSG00000100429
OTTHUMG00000044647
Q969S8
2614
T94324
NM_032019
NP_114408

Gene Info:

Target Subclass	EC:3.5.1.98
Target Class	Enzymes
Gene Biotype	PROTEIN_CODING
GuideToPharmacology Gene Category Name	3.5.1.- Histone deacetylases (HDACs)
GuideToPharmacology Gene Category ID	848

(6 More Sources)

Gene Categories: Category Details

DNA REPAIR
DRUGGABLE GENOME
ENZYME

Publications:

Olsen CA et al., 2009, Discovery of potent and selective histone deacetylase inhibitors via focused combinatorial libraries of cyclic alpha3beta-tetrapeptides., J Med Chem
Fass et al., 2010, Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin., ACS Med Chem Lett
Kozlov MV et al., 2015, Pyridine hydroxamic acids are specific anti-HCV agents affecting HDAC6., Bioorg Med Chem Lett
Souto JA et al., 2010, Synthesis and biological characterization of the histone deacetylase inhibitor largazole and C7- modified analogues., J Med Chem
Hutt DM et al., 2010, Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis., Nat Chem Biol
Marson CM et al., 2015, Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit., J Med Chem
Marson CM et al., 2013, Discovery of potent, isoform-selective inhibitors of histone deacetylase containing chiral heterocyclic capping groups and a N-(2-aminophenyl)benzamide binding unit., J Med Chem
Neelarapu R et al., 2011, Design, synthesis, docking, and biological evaluation of novel diazide-containing isoxazole- and pyrazole-based histone deacetylase probes., J Med Chem
Dallavalle S et al., 2009, Design, synthesis, and evaluation of biphenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors., Eur J Med Chem
Guerrant W et al., 2012, Dual targeting of histone deacetylase and topoisomerase II with novel bifunctional inhibitors., J Med Chem
Grolla AA et al., 2009, Synthesis, biological evaluation, and molecular docking of Ugi products containing a zinc-chelating moiety as novel inhibitors of histone deacetylases., J Med Chem
Guerrant W et al., 2013, Dual-acting histone deacetylase-topoisomerase I inhibitors., Bioorg Med Chem Lett
Yang W et al., 2015, Design, synthesis and biological evaluation of isoquinoline-based derivatives as novel histone deacetylase inhibitors., Bioorg Med Chem
Campbell CT et al., 2008, Targeting pro-invasive oncogenes with short chain fatty acid-hexosamine analogues inhibits the mobility of metastatic MDA-MB-231 breast cancer cells., J Med Chem
Hong S et al., 2015, Efficient synthesis and biological activity of Psammaplin A and its analogues as antitumor agents., Eur J Med Chem
Herman D et al., 2006, Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia., Nat Chem Biol
Mimori S et al., 2013, 4-Phenylbutyric acid protects against neuronal cell death by primarily acting as a chemical chaperone rather than histone deacetylase inhibitor., Bioorg Med Chem Lett
Benelkebir H et al., 2011, Total synthesis of largazole and analogues: HDAC inhibition, antiproliferative activity and metabolic stability., Bioorg Med Chem
Bhansali P et al., 2014, Synthesis and biological evaluation of largazole analogues with modified surface recognition cap groups., Eur J Med Chem
Shi Y et al., 2007, Induction of GRP78 by valproic acid is dependent upon histone deacetylase inhibition., Bioorg Med Chem Lett
Charrier C et al., 2009, Synthesis and modeling of new benzofuranone histone deacetylase inhibitors that stimulate tumor suppressor gene expression., J Med Chem
Marrazzo A et al., 2011, Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(±)-MRJF4] in prostate cancer cells., Eur J Med Chem
Bantscheff et al., 2011, Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes., Nat. Biotechnol.
Petrelli R et al., 2014, From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase: synthesis and biological evaluation of valproic esters of 3'-C-methyladenosine., Bioorg Med Chem Lett
Perrino E et al., 2008, New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity., Bioorg Med Chem Lett
Thomas M et al., 2008, Synthesis and biological evaluation of glucuronide prodrugs of the histone deacetylase inhibitor CI-994 for application in selective cancer chemotherapy., Bioorg Med Chem

BUFEXAMAC HDAC10

Interaction Score: 0.91

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
21258344

Sources:
GuideToPharmacology
BELINOSTAT HDAC10

Interaction Score: 0.65

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name PXD101

Novel drug target Established target

Direct Interaction yes

PMIDs:
25937017

Sources:
TALC DTC TdgClinicalTrial ChemblInteractions
MOCETINOSTAT HDAC10

Interaction Score: 0.56

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name MGCD-0103

Novel drug target Established target

PMIDs:
26287310 23829483

Sources:
DTC TdgClinicalTrial
CUDC-101 HDAC10

Interaction Score: 0.52

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name CUDC-101

Novel drug target Established target

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
TALC TdgClinicalTrial ChemblInteractions GuideToPharmacology
TACEDINALINE HDAC10

Interaction Score: 0.5

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes

PMIDs:
18692397

Sources:
DTC ChemblInteractions
TRICHOSTATIN HDAC10

Interaction Score: 0.48

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19966789 19385600 21055848 16921367

Sources:
DTC
VORINOSTAT HDAC10

Interaction Score: 0.47

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
21548582 20491440 19084294 22260166 19344175 23622981 19966789 26211462

Sources:
TALC DTC ClearityFoundationClinicalTrial GuideToPharmacology
CHIDAMIDE HDAC10

Interaction Score: 0.46

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Chidamide, HBI-8000

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
VALPROIC ACID HDAC10

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16921367 25304896 18294844

Sources:
DTC
ENTINOSTAT HDAC10

Interaction Score: 0.41

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes

PMIDs:
20491440 19966789

Sources:
DTC ChemblInteractions
SUBEROHYDROXAMIC ACID HDAC10

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16921367

Sources:
DTC
CHEMBL117487 HDAC10

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17566732

Sources:
DTC
CHEMBL1650245 HDAC10

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24044874

Sources:
DTC
PHENYLBUTYRYLHYDROXAMIC ACID HDAC10

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21874153

Sources:
DTC
CHEMBL324053 HDAC10

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16921367

Sources:
DTC
BUTANOIC ACID HDAC10

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19053749

Sources:
DTC
ABEXINOSTAT HDAC10

Interaction Score: 0.33

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Trial Name PCI-27483, CRA-024781

Novel drug target Established target

PMIDs:
None found

Sources:
TALC TdgClinicalTrial
BUTYRYLHYDROXAMIC ACID HDAC10

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21874153

Sources:
DTC
APICIDIN HDAC10

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19705846

Sources:
DTC
SCRIPTAID HDAC10

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19966789

Sources:
DTC
GIVINOSTAT HDAC10

Interaction Score: 0.3

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Trial Name ITF2357,Givinostat

Novel drug target Established target

PMIDs:
None found

Sources:
TALC TdgClinicalTrial
PRACINOSTAT HDAC10

Interaction Score: 0.3

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
TdgClinicalTrial GuideToPharmacology
PSAMMAPLIN A HDAC10

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25884112

Sources:
DTC
PHENYLBUTANOIC ACID HDAC10

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24044874

Sources:
DTC
LARGAZOLE HDAC10

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21420302 25203782 20491440

Sources:
DTC
PANOBINOSTAT HDAC10

Interaction Score: 0.21

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Panobinostat

Novel drug target Established target

Notes

PMIDs:
None found

Sources:
TALC TdgClinicalTrial
FIMEPINOSTAT HDAC10

Interaction Score: 0.2

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
ChemblInteractions GuideToPharmacology
ROMIDEPSIN HDAC10

Interaction Score: 0.19

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes

Trial Name Depsipeptide

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
PANOBINOSTAT LACTATE HDAC10

Interaction Score: 0.18

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
RESMINOSTAT HDAC10

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name Resminostat

PMIDs:
None found

Sources:
TdgClinicalTrial
QUISINOSTAT HDAC10

Interaction Score: 0.15

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
AR-42 HDAC10

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name AR-42

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
7-ETHYL-10-HYDROXYCAMPTOTHECIN HDAC10

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23622981

Sources:
DTC
HINOKITIOL HDAC10

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DAUNORUBICIN HDAC10

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22260166

Sources:
DTC

Ensembl: ENSG00000100429
- Version: 101_38
Alternate Names:

HDAC10 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: Q969S8
- Version: January-2014
Alternate Names:

HDAC10 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.5.1.98

Publications:
GuideToPharmacology: 83933
- Version: 29-September-2020
Alternate Names:

18128 HUGO Gene ID

18128 HUGO Gene Symbol

histone deacetylase 10 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name 3.5.1.- Histone deacetylases (HDACs)

GuideToPharmacology Gene Category ID 848

Gene Categories:

ENZYME

Publications:

DTC: HDAC10

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Olsen CA et al., 2009, Discovery of potent and selective histone deacetylase inhibitors via focused combinatorial libraries of cyclic alpha3beta-tetrapeptides., J Med Chem

Marson CM et al., 2013, Discovery of potent, isoform-selective inhibitors of histone deacetylase containing chiral heterocyclic capping groups and a N-(2-aminophenyl)benzamide binding unit., J Med Chem

Marson CM et al., 2015, Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit., J Med Chem

TALC: HDAC10
- Version: 12-May-2016
Alternate Names:

HDAC10 Gene Symbol

Gene Info:

Publications:
HingoraniCasas: ENSG00000100429
- Version: 31-May-2017
Alternate Names:

ENSG00000100429 Gene Symbol

HDAC10 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: HDAC10
- Version: chembl_23
Alternate Names:

HDAC10 GENE_SYMBOL

Histone deacetylase 10 UNIPROT

HD10 UNIPROT

Gene Info:

Publications:
TTD: Histone deacetylase 10
- Version: 2020.06.01
Alternate Names:

HDAC10 TTD Gene Abbreviation

T94324 TTD Target ID

Gene Info:

Publications:
ClearityFoundationClinicalTrial: HDAC10
- Version: 15-June-2013
Alternate Names:

Gene Info:

Publications:
GO: HDAC10
- Version: 01-May-2021
Alternate Names:

Gene Info:

Gene Categories:

DNA REPAIR

Publications:

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	False

Trial Name	PXD101
Novel drug target	Established target
Direct Interaction	yes

Trial Name	CUDC-101
Novel drug target	Established target
Specific Action of the Ligand	Inhibition

Mechanism of Interaction	Histone deacetylase inhibitor
Direct Interaction	yes

Notes
Specific Action of the Ligand	Inhibition
Endogenous Drug?	False

Trial Name	Chidamide, HBI-8000
Novel drug target	Established target

Notes
Trial Name	PCI-27483, CRA-024781
Novel drug target	Established target

Notes
Trial Name	ITF2357,Givinostat
Novel drug target	Established target

Direct Interaction?	True
Endogenous Drug?	False
Specific Action of the Ligand	Inhibition

Trial Name	Panobinostat
Novel drug target	Established target
Notes

18128	HUGO Gene ID
18128	HUGO Gene Symbol
histone deacetylase 10	HUGO Gene Name

HDAC10 Gene Record

HDAC10 83933 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: 21258344

Sources: GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name PXD101 Novel drug target Established target Direct Interaction yes

PMIDs: 25937017

Sources: TALC DTC TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Trial Name MGCD-0103 Novel drug target Established target

PMIDs: 26287310 23829483

Sources: DTC TdgClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name CUDC-101 Novel drug target Established target Specific Action of the Ligand Inhibition

PMIDs: None found

Sources: TALC TdgClinicalTrial ChemblInteractions GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Histone deacetylase inhibitor Direct Interaction yes

PMIDs: 18692397

Sources: DTC ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19966789 19385600 21055848 16921367

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Notes Specific Action of the Ligand Inhibition Endogenous Drug? False

PMIDs: 21548582 20491440 19084294 22260166 19344175 23622981 19966789 26211462

Sources: TALC DTC ClearityFoundationClinicalTrial GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info: Trial Name Chidamide, HBI-8000 Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16921367 25304896 18294844

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Histone deacetylase inhibitor Direct Interaction yes

PMIDs: 20491440 19966789

Sources: DTC ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16921367

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17566732

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24044874

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21874153

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16921367

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19053749

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Notes Trial Name PCI-27483, CRA-024781 Novel drug target Established target

PMIDs: None found

Sources: TALC TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21874153

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
21258344

Sources:
GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name PXD101

Novel drug target Established target

Direct Interaction yes

PMIDs:
25937017

Sources:
TALC DTC TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name MGCD-0103

Novel drug target Established target

PMIDs:
26287310 23829483

Sources:
DTC TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name CUDC-101

Novel drug target Established target

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
TALC TdgClinicalTrial ChemblInteractions GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes

PMIDs:
18692397

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
19966789 19385600 21055848 16921367

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
21548582 20491440 19084294 22260166 19344175 23622981 19966789 26211462

Sources:
TALC DTC ClearityFoundationClinicalTrial GuideToPharmacology

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Chidamide, HBI-8000

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
16921367 25304896 18294844

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes

PMIDs:
20491440 19966789

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
16921367

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
17566732

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
24044874

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21874153

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16921367

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19053749

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Trial Name PCI-27483, CRA-024781

Novel drug target Established target

PMIDs:
None found

Sources:
TALC TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
21874153

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19705846

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19966789

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Trial Name ITF2357,Givinostat

Novel drug target Established target

PMIDs:
None found

Sources:
TALC TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
TdgClinicalTrial GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
25884112

Sources:
DTC