8841 |
HISTONE DEACETYLASE 3 |
HDAC3 |
HD3 |
RPD3 |
RPD3-2 |
605166 |
4854 |
ENSG00000171720 |
OTTHUMG00000129629 |
SMAP45 |
O15379 |
HDAC3_HUMAN |
2617 |
BE0002367 |
T05090 |
NM_003883 |
NP_003874 |
Target Main Class | Enzymes |
Target Subclass | 3.5.1.98 |
Target Class | Enzymes |
Target Subclass | EC:3.5.1.98 |
Gene Biotype | PROTEIN_CODING |
GuideToPharmacology Gene Category Name | 3.5.1.- Histone deacetylases (HDACs) |
GuideToPharmacology Gene Category ID | 848 |
TRANSCRIPTION FACTOR BINDING |
DRUGGABLE GENOME |
ENZYME |
TRANSCRIPTION FACTOR |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Histone deacetylase 3 |
Direct Interaction? | False |
inhibitor (inhibitory) |
Notes | |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
inhibitor (inhibitory) |
Mechanism of Interaction | Histone deacetylase inhibitor |
Direct Interaction | yes |
Specific Action of the Ligand | Inhibition |
inhibitor (inhibitory) |
Direct Interaction? | False |
Endogenous Drug? | False |
Specific Action of the Ligand | Inhibition |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | False |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | False |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | False |
inhibitor (inhibitory) |
Trial Name | Panobinostat |
Novel drug target | Established target |
Direct Interaction? | False |
inhibitor (inhibitory) |
Notes | |
Direct Interaction? | False |
Endogenous Drug? | False |
inhibitor (inhibitory) |
Trial Name | PCI-27483, CRA-024781 |
Novel drug target | Established target |
Notes |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | False |
n/a |
Trial Name | Chidamide, HBI-8000 |
Novel drug target | Established target |
inhibitor (inhibitory) |
Novel drug target | Established target |
Trial Name | ITF2357,Givinostat |
Notes |
inhibitor (inhibitory) |
Direct Interaction? | False |
Endogenous Drug? | False |
Specific Action of the Ligand | Inhibition |
inhibitor (inhibitory) |
Direct Interaction? | False |
Endogenous Drug? | False |
Specific Action of the Ligand | Inhibition |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | False |
inhibitor (inhibitory) |
Trial Name | Resminostat |
Novel drug target | Established target |
Specific Action of the Ligand | Inhibition |
n/a |
Trial Name | 4SC-202 |
Novel drug target | Established target |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | False |
inhibitor (inhibitory) |
Notes |
inhibitor (inhibitory) |
Notes |
inhibitor (inhibitory) |
Direct Interaction? | False |
Endogenous Drug? | False |
Specific Action of the Ligand | Inhibition |
inhibitor (inhibitory) |
Mechanism of Interaction | Histone deacetylase inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Direct Interaction? | False |
Endogenous Drug? | False |
Specific Action of the Ligand | Inhibition |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | False |
n/a |
Trial Name | AR-42 |
Novel drug target | Established target |
HDAC3 | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
8841 | Entrez Gene Id |
O15379 | Uniprot Accession |
ENSG00000171720 | Ensembl Gene Id |
Target Main Class | Enzymes |
Target Subclass | 3.5.1.98 |
HDAC3 | Gene Symbol |
Target Class | Enzymes |
Target Subclass | EC:3.5.1.98 |
4854 | HUGO Gene ID |
4854 | HUGO Gene Symbol |
histone deacetylase 3 | HUGO Gene Name |
GuideToPharmacology Gene Category Name | 3.5.1.- Histone deacetylases (HDACs) |
GuideToPharmacology Gene Category ID | 848 |
ENZYME |
HDAC3 | DrugBank Gene Name |
O15379 | UniProt Accession |
8841 | Entrez Gene Id |
ENSG00000171720 | Gene Symbol |
HDAC3 | Ensembl Id |
DRUGGABLE GENOME |
HDAC3 | Gene Symbol |
HDAC3 | GENE_SYMBOL |
Histone deacetylase 3 | UNIPROT |
RPD3-2 | UNIPROT |
Histone deacetylase 3 | Gene Name |
O15379 | UniProt ID |
TRANSCRIPTION FACTOR |
HDAC3 | TTD Gene Abbreviation |
T05090 | TTD Target ID |
TRANSCRIPTION FACTOR BINDING |