DGIdb - HDAC3 Gene Record

HDAC3 8841 Druggable Genome

Alternate Names:

8841
HISTONE DEACETYLASE 3
HDAC3
HD3
RPD3
RPD3-2
605166
4854
ENSG00000171720
OTTHUMG00000129629
SMAP45
O15379
HDAC3_HUMAN
2617
BE0002367
T05090
NM_003883
NP_003874

Gene Info:

Target Main Class	Enzymes
Target Subclass	3.5.1.98
Target Class	Enzymes
Target Subclass	EC:3.5.1.98
Gene Biotype	PROTEIN_CODING
GuideToPharmacology Gene Category Name	3.5.1.- Histone deacetylases (HDACs)
GuideToPharmacology Gene Category ID	848

(8 More Sources)

Gene Categories: Category Details

TRANSCRIPTION FACTOR BINDING
DRUGGABLE GENOME
ENZYME
TRANSCRIPTION FACTOR

Publications:

Kozlov MV et al., 2015, Pyridine hydroxamic acids are specific anti-HCV agents affecting HDAC6., Bioorg Med Chem Lett
Li X et al., 2014, Discovery of the first N-hydroxycinnamamide-based histone deacetylase 1/3 dual inhibitors with potent oral antitumor activity., J Med Chem
Xu et al., 2007, Histone deacetylase inhibitors: molecular mechanisms of action., Oncogene
Grolla AA et al., 2009, Synthesis, biological evaluation, and molecular docking of Ugi products containing a zinc-chelating moiety as novel inhibitors of histone deacetylases., J Med Chem
Hutt DM et al., 2010, Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis., Nat Chem Biol
Yang W et al., 2015, Design, synthesis and biological evaluation of isoquinoline-based derivatives as novel histone deacetylase inhibitors., Bioorg Med Chem
Guerrant W et al., 2013, Dual-acting histone deacetylase-topoisomerase I inhibitors., Bioorg Med Chem Lett
Guerrant W et al., 2012, Dual targeting of histone deacetylase and topoisomerase II with novel bifunctional inhibitors., J Med Chem
Pérez-Balado C et al., 2007, Bispyridinium dienes: histone deacetylase inhibitors with selective activities., J Med Chem
Souto JA et al., 2010, Synthesis and biological characterization of the histone deacetylase inhibitor largazole and C7- modified analogues., J Med Chem
Neelarapu R et al., 2011, Design, synthesis, docking, and biological evaluation of novel diazide-containing isoxazole- and pyrazole-based histone deacetylase probes., J Med Chem
Olson DE et al., 2013, Discovery of the first histone deacetylase 6/8 dual inhibitors., J Med Chem
Dallavalle S et al., 2009, Design, synthesis, and evaluation of biphenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors., Eur J Med Chem
Perrino E et al., 2008, New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity., Bioorg Med Chem Lett
Herman D et al., 2006, Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia., Nat Chem Biol
Petrelli R et al., 2014, From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase: synthesis and biological evaluation of valproic esters of 3'-C-methyladenosine., Bioorg Med Chem Lett
Shi Y et al., 2007, Induction of GRP78 by valproic acid is dependent upon histone deacetylase inhibition., Bioorg Med Chem Lett
Campbell CT et al., 2008, Targeting pro-invasive oncogenes with short chain fatty acid-hexosamine analogues inhibits the mobility of metastatic MDA-MB-231 breast cancer cells., J Med Chem
Beckers et al., 2007, Distinct pharmacological properties of second generation HDAC inhibitors with the benzamide or hydroxamate head group., Int. J. Cancer
Marson CM et al., 2013, Discovery of potent, isoform-selective inhibitors of histone deacetylase containing chiral heterocyclic capping groups and a N-(2-aminophenyl)benzamide binding unit., J Med Chem
Marson CM et al., 2015, Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit., J Med Chem
Fass et al., 2010, Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin., ACS Med Chem Lett
Hong S et al., 2015, Efficient synthesis and biological activity of Psammaplin A and its analogues as antitumor agents., Eur J Med Chem
Mimori S et al., 2013, 4-Phenylbutyric acid protects against neuronal cell death by primarily acting as a chemical chaperone rather than histone deacetylase inhibitor., Bioorg Med Chem Lett
Thomas M et al., 2008, Synthesis and biological evaluation of glucuronide prodrugs of the histone deacetylase inhibitor CI-994 for application in selective cancer chemotherapy., Bioorg Med Chem
Marrazzo A et al., 2011, Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(±)-MRJF4] in prostate cancer cells., Eur J Med Chem
Charrier C et al., 2009, Synthesis and modeling of new benzofuranone histone deacetylase inhibitors that stimulate tumor suppressor gene expression., J Med Chem
Olsen CA et al., 2009, Discovery of potent and selective histone deacetylase inhibitors via focused combinatorial libraries of cyclic alpha3beta-tetrapeptides., J Med Chem
Lahm A et al., 2007, Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases., Proc Natl Acad Sci U S A
Chen IH et al., 2009, Cytotoxic triterpenoids from the stems of Microtropis japonica., J Nat Prod
Benelkebir H et al., 2011, Total synthesis of largazole and analogues: HDAC inhibition, antiproliferative activity and metabolic stability., Bioorg Med Chem
Bhansali P et al., 2014, Synthesis and biological evaluation of largazole analogues with modified surface recognition cap groups., Eur J Med Chem

MOCETINOSTAT HDAC3

Interaction Score: 0.83

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Histone deacetylase 3

Direct Interaction? False

PMIDs:
17455259 23829483 26287310

Sources:
DTC TdgClinicalTrial DrugBank GuideToPharmacology ChemblInteractions
NANATINOSTAT HDAC3

Interaction Score: 0.68

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
TTD TALC GuideToPharmacology
BELINOSTAT HDAC3

Interaction Score: 0.58

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes

Specific Action of the Ligand Inhibition

PMIDs:
25937017

Sources:
DTC TdgClinicalTrial TALC GuideToPharmacology ChemblInteractions
VORINOSTAT HDAC3

Interaction Score: 0.55

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
24694055 17694093 19344175 19966789 26211462 23622981 22260166 17447750 20491440 21548582 23672185 19084294

Sources:
TEND DTC TdgClinicalTrial DrugBank TALC GuideToPharmacology ChemblInteractions
ENTINOSTAT HDAC3

Interaction Score: 0.53

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
19966789 20491440

Sources:
DTC TdgClinicalTrial TALC GuideToPharmacology ChemblInteractions
APICIDIN HDAC3

Interaction Score: 0.49

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
19705846 17956988

Sources:
DTC GuideToPharmacology
TACEDINALINE HDAC3

Interaction Score: 0.49

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
18692397

Sources:
DTC GuideToPharmacology ChemblInteractions
PANOBINOSTAT HDAC3

Interaction Score: 0.4

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Panobinostat

Novel drug target Established target

Direct Interaction? False

PMIDs:
24694055

Sources:
DTC TdgClinicalTrial TALC GuideToPharmacology
CUDC-101 HDAC3

Interaction Score: 0.39

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Direct Interaction? False

Endogenous Drug? False

PMIDs:
None found

Sources:
TdgClinicalTrial TALC GuideToPharmacology ChemblInteractions
ABEXINOSTAT HDAC3

Interaction Score: 0.37

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name PCI-27483, CRA-024781

Novel drug target Established target

Notes

PMIDs:
None found

Sources:
TdgClinicalTrial TALC GuideToPharmacology
TRICHOSTATIN HDAC3

Interaction Score: 0.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21055848 16921367 19966789 19385600

Sources:
DTC
PRACINOSTAT HDAC3

Interaction Score: 0.34

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
TdgClinicalTrial DrugBank GuideToPharmacology
CHIDAMIDE HDAC3

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Chidamide, HBI-8000

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
GIVINOSTAT HDAC3

Interaction Score: 0.34

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name ITF2357,Givinostat

Notes

PMIDs:
None found

Sources:
TdgClinicalTrial TALC GuideToPharmacology
SCRIPTAID HDAC3

Interaction Score: 0.34

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
19966789

Sources:
DTC GuideToPharmacology
ROMIDEPSIN HDAC3

Interaction Score: 0.34

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
TEND TdgClinicalTrial TALC GuideToPharmacology ChemblInteractions
VALPROIC ACID HDAC3

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18294844 16921367 25304896

Sources:
DTC
CITARINOSTAT HDAC3

Interaction Score: 0.27

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
CHEMBL1650245 HDAC3

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24044874

Sources:
DTC
PHENYLBUTYRYLHYDROXAMIC ACID HDAC3

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21874153

Sources:
DTC
RESMINOSTAT HDAC3

Interaction Score: 0.25

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Resminostat

Novel drug target Established target

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
TdgClinicalTrial GuideToPharmacology
SUBEROHYDROXAMIC ACID HDAC3

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16921367

Sources:
DTC
BUTYRYLHYDROXAMIC ACID HDAC3

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21874153

Sources:
DTC
CHEMBL324053 HDAC3

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16921367

Sources:
DTC
CHEMBL117487 HDAC3

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17566732

Sources:
DTC
URSOLIC ACID HDAC3

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19534471

Sources:
DTC
DOMATINOSTAT HDAC3

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name 4SC-202

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
RICOLINOSTAT HDAC3

Interaction Score: 0.23

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
BUTANOIC ACID HDAC3

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19053749

Sources:
DTC
PSAMMAPLIN A HDAC3

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25884112

Sources:
DTC
PHENYLBUTANOIC ACID HDAC3

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24044874

Sources:
DTC
LARGAZOLE HDAC3

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21420302 25203782 20491440

Sources:
DTC
DEPAKOTE HDAC3

Interaction Score: 0.17

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

PMIDs:
None found

Sources:
TALC
AN-9 HDAC3

Interaction Score: 0.15

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

PMIDs:
None found

Sources:
TALC
FIMEPINOSTAT HDAC3

Interaction Score: 0.15

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology ChemblInteractions
PANOBINOSTAT LACTATE HDAC3

Interaction Score: 0.14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DACINOSTAT HDAC3

Interaction Score: 0.12

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology
QUISINOSTAT HDAC3

Interaction Score: 0.11

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
AR-42 HDAC3

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name AR-42

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
7-ETHYL-10-HYDROXYCAMPTOTHECIN HDAC3

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23622981

Sources:
DTC
HINOKITIOL HDAC3

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DAUNORUBICIN HDAC3

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22260166

Sources:
DTC

Ensembl: ENSG00000171720
- Version: 101_38
Alternate Names:

HDAC3 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TEND: O15379
- Version: 01-August-2011
Alternate Names:

8841 Entrez Gene Id

O15379 Uniprot Accession

ENSG00000171720 Ensembl Gene Id

Gene Info:

Target Main Class Enzymes

Target Subclass 3.5.1.98

Publications:
TdgClinicalTrial: O15379
- Version: January-2014
Alternate Names:

HDAC3 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.5.1.98

Publications:
GuideToPharmacology: 8841
- Version: 29-September-2020
Alternate Names:

4854 HUGO Gene ID

4854 HUGO Gene Symbol

histone deacetylase 3 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name 3.5.1.- Histone deacetylases (HDACs)

GuideToPharmacology Gene Category ID 848

Gene Categories:

ENZYME

Publications:

DrugBank: BE0002367

Version: 5.1.7

Alternate Names:

HDAC3 DrugBank Gene Name

O15379 UniProt Accession

8841 Entrez Gene Id

Gene Info:

Publications:

Xu et al., 2007, Histone deacetylase inhibitors: molecular mechanisms of action., Oncogene

Beckers et al., 2007, Distinct pharmacological properties of second generation HDAC inhibitors with the benzamide or hydroxamate head group., Int. J. Cancer

DTC: HDAC3

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Guerrant W et al., 2013, Dual-acting histone deacetylase-topoisomerase I inhibitors., Bioorg Med Chem Lett

Hutt DM et al., 2010, Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis., Nat Chem Biol

Souto JA et al., 2010, Synthesis and biological characterization of the histone deacetylase inhibitor largazole and C7- modified analogues., J Med Chem

HingoraniCasas: ENSG00000171720
- Version: 31-May-2017
Alternate Names:

ENSG00000171720 Gene Symbol

HDAC3 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
TALC: HDAC3
- Version: 12-May-2016
Alternate Names:

HDAC3 Gene Symbol

Gene Info:

Publications:
ChemblInteractions: HDAC3
- Version: chembl_23
Alternate Names:

HDAC3 GENE_SYMBOL

Histone deacetylase 3 UNIPROT

RPD3-2 UNIPROT

Gene Info:

Publications:
Pharos: HDAC3
- Version: 03-September-2020
Alternate Names:

Histone deacetylase 3 Gene Name

O15379 UniProt ID

Gene Info:

Gene Categories:

TRANSCRIPTION FACTOR

Publications:
TTD: Histone deacetylase 3
- Version: 2020.06.01
Alternate Names:

HDAC3 TTD Gene Abbreviation

T05090 TTD Target ID

Gene Info:

Publications:
GO: HDAC3
- Version: 05-September-2020
Alternate Names:

Gene Info:

Gene Categories:

TRANSCRIPTION FACTOR BINDING

Publications:

Direct Interaction	yes
Mechanism of Interaction	Histone deacetylase 3
Direct Interaction?	False

Notes
Specific Action of the Ligand	Inhibition
Endogenous Drug?	False

Mechanism of Interaction	Histone deacetylase inhibitor
Direct Interaction	yes
Specific Action of the Ligand	Inhibition

Trial Name	Panobinostat
Novel drug target	Established target
Direct Interaction?	False

Trial Name	PCI-27483, CRA-024781
Novel drug target	Established target
Notes

Trial Name	Chidamide, HBI-8000
Novel drug target	Established target

Trial Name	Resminostat
Novel drug target	Established target
Specific Action of the Ligand	Inhibition

8841	Entrez Gene Id
O15379	Uniprot Accession
ENSG00000171720	Ensembl Gene Id

4854	HUGO Gene ID
4854	HUGO Gene Symbol
histone deacetylase 3	HUGO Gene Name

HDAC3	DrugBank Gene Name
O15379	UniProt Accession
8841	Entrez Gene Id

HDAC3 Gene Record

HDAC3 8841 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Histone deacetylase 3 Direct Interaction? False

PMIDs: 17455259 23829483 26287310

Sources: DTC TdgClinicalTrial DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Notes Specific Action of the Ligand Inhibition Endogenous Drug? False

PMIDs: None found

Sources: TTD TALC GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Histone deacetylase inhibitor Direct Interaction yes Specific Action of the Ligand Inhibition

PMIDs: 25937017

Sources: DTC TdgClinicalTrial TALC GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction? False Endogenous Drug? False Specific Action of the Ligand Inhibition

PMIDs: 24694055 17694093 19344175 19966789 26211462 23622981 22260166 17447750 20491440 21548582 23672185 19084294

Sources: TEND DTC TdgClinicalTrial DrugBank TALC GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: 19966789 20491440

Sources: DTC TdgClinicalTrial TALC GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: 19705846 17956988

Sources: DTC GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: 18692397

Sources: DTC GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name Panobinostat Novel drug target Established target Direct Interaction? False

PMIDs: 24694055

Sources: DTC TdgClinicalTrial TALC GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Notes Direct Interaction? False Endogenous Drug? False

PMIDs: None found

Sources: TdgClinicalTrial TALC GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name PCI-27483, CRA-024781 Novel drug target Established target Notes

PMIDs: None found

Sources: TdgClinicalTrial TALC GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21055848 16921367 19966789 19385600

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: TdgClinicalTrial DrugBank GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info: Trial Name Chidamide, HBI-8000 Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name ITF2357,Givinostat Notes

PMIDs: None found

Sources: TdgClinicalTrial TALC GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction? False Endogenous Drug? False Specific Action of the Ligand Inhibition

PMIDs: 19966789

Sources: DTC GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction? False Endogenous Drug? False Specific Action of the Ligand Inhibition

PMIDs: None found

Sources: TEND TdgClinicalTrial TALC GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18294844 16921367 25304896

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Histone deacetylase 3

Direct Interaction? False

PMIDs:
17455259 23829483 26287310

Sources:
DTC TdgClinicalTrial DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
TTD TALC GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes

Specific Action of the Ligand Inhibition

PMIDs:
25937017

Sources:
DTC TdgClinicalTrial TALC GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
24694055 17694093 19344175 19966789 26211462 23622981 22260166 17447750 20491440 21548582 23672185 19084294

Sources:
TEND DTC TdgClinicalTrial DrugBank TALC GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
19966789 20491440

Sources:
DTC TdgClinicalTrial TALC GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
19705846 17956988

Sources:
DTC GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
18692397

Sources:
DTC GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Panobinostat

Novel drug target Established target

Direct Interaction? False

PMIDs:
24694055

Sources:
DTC TdgClinicalTrial TALC GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Direct Interaction? False

Endogenous Drug? False

PMIDs:
None found

Sources:
TdgClinicalTrial TALC GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name PCI-27483, CRA-024781

Novel drug target Established target

Notes

PMIDs:
None found

Sources:
TdgClinicalTrial TALC GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
21055848 16921367 19966789 19385600

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
TdgClinicalTrial DrugBank GuideToPharmacology

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Chidamide, HBI-8000

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name ITF2357,Givinostat

Notes

PMIDs:
None found

Sources:
TdgClinicalTrial TALC GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
19966789

Sources:
DTC GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
TEND TdgClinicalTrial TALC GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
18294844 16921367 25304896

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
24044874

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21874153

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Resminostat

Novel drug target Established target

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
TdgClinicalTrial GuideToPharmacology