DGIdb - HDAC4 Gene Record

HDAC4 9759 Druggable GenomeClinically ActionableDrug Resistance

Alternate Names:

9759
HISTONE DEACETYLASE 4
HDAC4
AHO3
BDMR
HA6116
HD4
HDAC-4
HDAC-A
HDACA
605314
14063
ENSG00000068024
OTTHUMG00000133344
P56524
HDAC
KIAA0288
2659
BE0003523
PA29229
T63816
NM_006037
NP_006028

Gene Info:

Target Class	Enzymes
Target Subclass	EC:3.5.1.98
Gene Biotype	PROTEIN_CODING
GuideToPharmacology Gene Category Name	3.5.1.- Histone deacetylases (HDACs)
GuideToPharmacology Gene Category ID	848

(11 More Sources)

Gene Categories: Category Details

DRUG RESISTANCE
TRANSCRIPTION FACTOR BINDING
DRUGGABLE GENOME
CLINICALLY ACTIONABLE
ENZYME
TRANSCRIPTION FACTOR

Publications:

Olsen CA et al., 2009, Discovery of potent and selective histone deacetylase inhibitors via focused combinatorial libraries of cyclic alpha3beta-tetrapeptides., J Med Chem
Lahm A et al., 2007, Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases., Proc Natl Acad Sci U S A
Herman D et al., 2006, Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia., Nat Chem Biol
Kozlov MV et al., 2015, Pyridine hydroxamic acids are specific anti-HCV agents affecting HDAC6., Bioorg Med Chem Lett
VanderMolen et al., 2011, Romidepsin (Istodax, NSC 630176, FR901228, FK228, depsipeptide): a natural product recently approved for cutaneous T-cell lymphoma., J. Antibiot.
Grolla AA et al., 2009, Synthesis, biological evaluation, and molecular docking of Ugi products containing a zinc-chelating moiety as novel inhibitors of histone deacetylases., J Med Chem
Hutt DM et al., 2010, Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis., Nat Chem Biol
Yang W et al., 2015, Design, synthesis and biological evaluation of isoquinoline-based derivatives as novel histone deacetylase inhibitors., Bioorg Med Chem
Guerrant W et al., 2013, Dual-acting histone deacetylase-topoisomerase I inhibitors., Bioorg Med Chem Lett
Guerrant W et al., 2012, Dual targeting of histone deacetylase and topoisomerase II with novel bifunctional inhibitors., J Med Chem
Mai A et al., 2008, Novel uracil-based 2-aminoanilide and 2-aminoanilide-like derivatives: histone deacetylase inhibition and in-cell activities., Bioorg Med Chem Lett
Souto JA et al., 2010, Synthesis and biological characterization of the histone deacetylase inhibitor largazole and C7- modified analogues., J Med Chem
Neelarapu R et al., 2011, Design, synthesis, docking, and biological evaluation of novel diazide-containing isoxazole- and pyrazole-based histone deacetylase probes., J Med Chem
Dallavalle S et al., 2009, Design, synthesis, and evaluation of biphenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors., Eur J Med Chem
Mimori S et al., 2013, 4-Phenylbutyric acid protects against neuronal cell death by primarily acting as a chemical chaperone rather than histone deacetylase inhibitor., Bioorg Med Chem Lett
Chen IH et al., 2009, Cytotoxic triterpenoids from the stems of Microtropis japonica., J Nat Prod
Marrazzo A et al., 2011, Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(±)-MRJF4] in prostate cancer cells., Eur J Med Chem
Charrier C et al., 2009, Synthesis and modeling of new benzofuranone histone deacetylase inhibitors that stimulate tumor suppressor gene expression., J Med Chem
Marson CM et al., 2013, Discovery of potent, isoform-selective inhibitors of histone deacetylase containing chiral heterocyclic capping groups and a N-(2-aminophenyl)benzamide binding unit., J Med Chem
Marson CM et al., 2015, Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit., J Med Chem
Perrino E et al., 2008, New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity., Bioorg Med Chem Lett
Petrelli R et al., 2014, From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase: synthesis and biological evaluation of valproic esters of 3'-C-methyladenosine., Bioorg Med Chem Lett
Shi Y et al., 2007, Induction of GRP78 by valproic acid is dependent upon histone deacetylase inhibition., Bioorg Med Chem Lett
Benelkebir H et al., 2011, Total synthesis of largazole and analogues: HDAC inhibition, antiproliferative activity and metabolic stability., Bioorg Med Chem
Bhansali P et al., 2014, Synthesis and biological evaluation of largazole analogues with modified surface recognition cap groups., Eur J Med Chem
Campbell CT et al., 2008, Targeting pro-invasive oncogenes with short chain fatty acid-hexosamine analogues inhibits the mobility of metastatic MDA-MB-231 breast cancer cells., J Med Chem
Brown CC et al., 2014, Genome-wide association and pharmacological profiling of 29 anticancer agents using lymphoblastoid cell lines., Pharmacogenomics
Fass et al., 2010, Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin., ACS Med Chem Lett
Hong S et al., 2015, Efficient synthesis and biological activity of Psammaplin A and its analogues as antitumor agents., Eur J Med Chem
Thomas M et al., 2008, Synthesis and biological evaluation of glucuronide prodrugs of the histone deacetylase inhibitor CI-994 for application in selective cancer chemotherapy., Bioorg Med Chem
Klausmeyer P et al., 2011, Histone deacetylase inhibitors from Burkholderia thailandensis., J Nat Prod
Bhuiyan MP et al., 2006, Chlamydocin analogs bearing carbonyl group as possible ligand toward zinc atom in histone deacetylases., Bioorg Med Chem
Zhang L et al., 2018, Zinc binding groups for histone deacetylase inhibitors., J Enzyme Inhib Med Chem

SPIRUCHOSTATIN C HDAC4

Interaction Score: 0.9

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21967146

Sources:
DTC
TASQUINIMOD HDAC4

Interaction Score: 0.68

Interaction Types & Directionality:

allosteric modulator

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
BELINOSTAT HDAC4

Interaction Score: 0.68

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name PXD101

Notes

PMIDs:
25937017

Sources:
DTC TdgClinicalTrial TALC MyCancerGenome GuideToPharmacology ChemblInteractions
MOCETINOSTAT HDAC4

Interaction Score: 0.42

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name MGCD-0103

PMIDs:
23829483 26287310

Sources:
DTC TdgClinicalTrial
ROMIDEPSIN HDAC4

Interaction Score: 0.41

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Histone deacetylase inhibitor

Trial Name Depsipeptide

PMIDs:
21587264

Sources:
TdgClinicalTrial DrugBank MyCancerGenome GuideToPharmacology ChemblInteractions
CUDC-101 HDAC4

Interaction Score: 0.39

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Trial Name CUDC-101

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TALC GuideToPharmacology ChemblInteractions
ENTINOSTAT HDAC4

Interaction Score: 0.38

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes

PMIDs:
19966789 18381238 20491440

Sources:
DTC ChemblInteractions
TACEDINALINE HDAC4

Interaction Score: 0.37

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes

PMIDs:
18692397

Sources:
DTC ChemblInteractions
DACINOSTAT HDAC4

Interaction Score: 0.37

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
17956988

Sources:
DTC GuideToPharmacology
APICIDIN HDAC4

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19705846 17956988

Sources:
DTC
TRICHOSTATIN HDAC4

Interaction Score: 0.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21055848 16921367 19966789 19385600

Sources:
DTC
VORINOSTAT HDAC4

Interaction Score: 0.35

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

PMIDs:
19344175 19966789 26211462 23622981 22260166 18381238 20491440 21548582 19084294

Sources:
DTC TALC MyCancerGenome
GIVINOSTAT HDAC4

Interaction Score: 0.34

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name ITF2357,Givinostat

Novel drug target Established target

Notes

PMIDs:
None found

Sources:
TdgClinicalTrial TALC GuideToPharmacology
SCRIPTAID HDAC4

Interaction Score: 0.34

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
19966789

Sources:
DTC GuideToPharmacology
PANOBINOSTAT HDAC4

Interaction Score: 0.32

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name Panobinostat

Notes

PMIDs:
None found

Sources:
TdgClinicalTrial TALC MyCancerGenome GuideToPharmacology
VALPROIC ACID HDAC4

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18294844 16921367 25304896

Sources:
DTC
BUTYRYLHYDROXAMIC ACID HDAC4

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21874153

Sources:
DTC
PHENYLBUTYRYLHYDROXAMIC ACID HDAC4

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21874153

Sources:
DTC
CHEMBL117487 HDAC4

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17566732

Sources:
DTC
CHEMBL1650245 HDAC4

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24044874

Sources:
DTC
SUBEROHYDROXAMIC ACID HDAC4

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16921367

Sources:
DTC
CHEMBL324053 HDAC4

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16921367

Sources:
DTC
BUTANOIC ACID HDAC4

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19053749

Sources:
DTC
QUISINOSTAT HDAC4

Interaction Score: 0.23

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
TTD GuideToPharmacology
URSOLIC ACID HDAC4

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19534471

Sources:
DTC
PSAMMAPLIN A HDAC4

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25884112

Sources:
DTC
PHENYLBUTANOIC ACID HDAC4

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24044874

Sources:
DTC
LARGAZOLE HDAC4

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21420302 25203782 20491440

Sources:
DTC
DEPAKOTE HDAC4

Interaction Score: 0.17

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

PMIDs:
None found

Sources:
TALC
AN-9 HDAC4

Interaction Score: 0.15

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

PMIDs:
None found

Sources:
TALC
PANOBINOSTAT LACTATE HDAC4

Interaction Score: 0.14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TEMOZOLOMIDE HDAC4

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24444404

Sources:
PharmGKB
RESMINOSTAT HDAC4

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Resminostat

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
ABEXINOSTAT HDAC4

Interaction Score: 0.12

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

PMIDs:
None found

Sources:
TALC
PRACINOSTAT HDAC4

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name SB939

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
AR-42 HDAC4

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name AR-42

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
7-ETHYL-10-HYDROXYCAMPTOTHECIN HDAC4

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23622981

Sources:
DTC
HINOKITIOL HDAC4

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FIMEPINOSTAT HDAC4

Interaction Score: 0.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Histone deacetylase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
ZINC CHLORIDE HDAC4

Interaction Score: 0.04

Interaction Types & Directionality:

cofactor (activating)

Interaction Info:

PMIDs:
16439135 29616828

Sources:
DrugBank
DAUNORUBICIN HDAC4

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22260166

Sources:
DTC
METHYLDOPA HDAC4

Interaction Score: 0.02

Interaction Types & Directionality:

cofactor (activating)

Interaction Info:

PMIDs:
16439135

Sources:
DrugBank

Ensembl: ENSG00000068024
- Version: 101_38
Alternate Names:

HDAC4 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P56524
- Version: January-2014
Alternate Names:

HDAC4 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.5.1.98

Publications:
GuideToPharmacology: 9759
- Version: 29-September-2020
Alternate Names:

14063 HUGO Gene ID

14063 HUGO Gene Symbol

histone deacetylase 4 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name 3.5.1.- Histone deacetylases (HDACs)

GuideToPharmacology Gene Category ID 848

Gene Categories:

ENZYME

Publications:
PharmGKB: HDAC4
- Version: 18-August-2020
Alternate Names:

PA29229 PharmGKB ID

Gene Info:

Publications:

Brown CC et al., 2014, Genome-wide association and pharmacological profiling of 29 anticancer agents using lymphoblastoid cell lines., Pharmacogenomics

DrugBank: BE0003523

Version: 5.1.7

Alternate Names:

HDAC4 DrugBank Gene Name

P56524 UniProt Accession

9759 Entrez Gene Id

Gene Info:

Publications:

Bhuiyan MP et al., 2006, Chlamydocin analogs bearing carbonyl group as possible ligand toward zinc atom in histone deacetylases., Bioorg Med Chem

VanderMolen et al., 2011, Romidepsin (Istodax, NSC 630176, FR901228, FK228, depsipeptide): a natural product recently approved for cutaneous T-cell lymphoma., J. Antibiot.

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

DTC: HDAC4

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Olsen CA et al., 2009, Discovery of potent and selective histone deacetylase inhibitors via focused combinatorial libraries of cyclic alpha3beta-tetrapeptides., J Med Chem

Lahm A et al., 2007, Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases., Proc Natl Acad Sci U S A

Kozlov MV et al., 2015, Pyridine hydroxamic acids are specific anti-HCV agents affecting HDAC6., Bioorg Med Chem Lett

TALC: HDAC4
- Version: 12-May-2016
Alternate Names:

HDAC4 Gene Symbol

Gene Info:

Publications:
MyCancerGenome: HDAC4
- Version: 20-Jun-2017
Alternate Names:

9759 Entrez Gene Id

HDAC4 MyCancerGenome Gene Symbol

HDAC MyCancerGenome Reported Gene Name

Gene Info:

Publications:
HingoraniCasas: ENSG00000068024
- Version: 31-May-2017
Alternate Names:

ENSG00000068024 Gene Symbol

HDAC4 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: KIAA0288
- Version: chembl_23
Alternate Names:

KIAA0288 GENE_SYMBOL

HDAC4 GENE_SYMBOL

Histone deacetylase 4 UNIPROT

Gene Info:

Publications:
Pharos: HDAC4
- Version: 03-September-2020
Alternate Names:

Histone deacetylase 4 Gene Name

P56524 UniProt ID

Gene Info:

Gene Categories:

TRANSCRIPTION FACTOR

Publications:
GO: HDAC4
- Version: 05-September-2020
Alternate Names:

KIAA0288 GO Gene Synonym

Gene Info:

Gene Categories:

DRUG RESISTANCE, TRANSCRIPTION FACTOR BINDING

Publications:
Tempus: HDAC4
- Version: 11-November-2018
Alternate Names:

HDAC4 Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
TTD: Histone deacetylase 4
- Version: 2020.06.01
Alternate Names:

HDAC4 TTD Gene Abbreviation

T63816 TTD Target ID

Gene Info:

Publications:
FoundationOneGenes: HDAC4
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	False

Direct Interaction	yes
Mechanism of Interaction	Histone deacetylase inhibitor
Trial Name	Depsipeptide

Trial Name	ITF2357,Givinostat
Novel drug target	Established target
Notes

14063	HUGO Gene ID
14063	HUGO Gene Symbol
histone deacetylase 4	HUGO Gene Name

HDAC4	DrugBank Gene Name
P56524	UniProt Accession
9759	Entrez Gene Id

KIAA0288	GENE_SYMBOL
HDAC4	GENE_SYMBOL
Histone deacetylase 4	UNIPROT

HDAC4 Gene Record

HDAC4 9759 Druggable GenomeClinically ActionableDrug Resistance

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21967146

Sources: DTC

Interaction Types & Directionality: allosteric modulator

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name PXD101 Notes

PMIDs: 25937017

Sources: DTC TdgClinicalTrial TALC MyCancerGenome GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Novel drug target Established target Trial Name MGCD-0103

PMIDs: 23829483 26287310

Sources: DTC TdgClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Histone deacetylase inhibitor Trial Name Depsipeptide

PMIDs: 21587264

Sources: TdgClinicalTrial DrugBank MyCancerGenome GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Notes Trial Name CUDC-101 Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial TALC GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Histone deacetylase inhibitor Direct Interaction yes

PMIDs: 19966789 18381238 20491440

Sources: DTC ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Histone deacetylase inhibitor Direct Interaction yes

PMIDs: 18692397

Sources: DTC ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: 17956988

Sources: DTC GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19705846 17956988

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21055848 16921367 19966789 19385600

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Notes

PMIDs: 19344175 19966789 26211462 23622981 22260166 18381238 20491440 21548582 19084294

Sources: DTC TALC MyCancerGenome

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name ITF2357,Givinostat Novel drug target Established target Notes

PMIDs: None found

Sources: TdgClinicalTrial TALC GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: 19966789

Sources: DTC GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name Panobinostat Notes

PMIDs: None found

Sources: TdgClinicalTrial TALC MyCancerGenome GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18294844 16921367 25304896

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21874153

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21874153

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
21967146

Sources:
DTC

Interaction Types & Directionality:

allosteric modulator

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name PXD101

Notes

PMIDs:
25937017

Sources:
DTC TdgClinicalTrial TALC MyCancerGenome GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name MGCD-0103

PMIDs:
23829483 26287310

Sources:
DTC TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Histone deacetylase inhibitor

Trial Name Depsipeptide

PMIDs:
21587264

Sources:
TdgClinicalTrial DrugBank MyCancerGenome GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Trial Name CUDC-101

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TALC GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes

PMIDs:
19966789 18381238 20491440

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes

PMIDs:
18692397

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
17956988

Sources:
DTC GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
19705846 17956988

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21055848 16921367 19966789 19385600

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

PMIDs:
19344175 19966789 26211462 23622981 22260166 18381238 20491440 21548582 19084294

Sources:
DTC TALC MyCancerGenome

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name ITF2357,Givinostat

Novel drug target Established target

Notes

PMIDs:
None found

Sources:
TdgClinicalTrial TALC GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
19966789

Sources:
DTC GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name Panobinostat

Notes

PMIDs:
None found

Sources:
TdgClinicalTrial TALC MyCancerGenome GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
18294844 16921367 25304896

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21874153

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21874153

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
17566732

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
24044874

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16921367

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16921367

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19053749