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HDAC6 Gene Record

  • Summary
  • Interactions
  • Claims
  • HDAC6 10013 Druggable Genome

    Alternate Names:

    10013
    HISTONE DEACETYLASE 6
    HDAC6
    CPBHM
    HD6
    JM21
    PPP1R90
    300272
    14064
    ENSG00000094631
    OTTHUMG00000034496
    Q9UBN7
    KIAA0901
    HDAC6_HUMAN
    T22274

    Gene Info:

    Target Class Enzymes
    Target Subclass EC:3.5.1.98
    Target Main Class Enzymes
    Target Subclass 3.5.1.98
    Gene Biotype PROTEIN_CODING
    (6 More Sources)

    Gene Categories: Category Details

    TRANSCRIPTION FACTOR BINDING
    DRUGGABLE GENOME
    TRANSCRIPTION FACTOR

    Publications:

    Kozlov MV et al., 2015, Pyridine hydroxamic acids are specific anti-HCV agents affecting HDAC6., Bioorg Med Chem Lett
    VanderMolen et al., 2011, Romidepsin (Istodax, NSC 630176, FR901228, FK228, depsipeptide): a natural product recently approved for cutaneous T-cell lymphoma., J. Antibiot.
    Yao Y et al., 2015, Discovery of Novel Class I Histone Deacetylase Inhibitors with Promising in Vitro and in Vivo Antitumor Activities., J Med Chem
    Souto JA et al., 2010, Synthesis and biological characterization of the histone deacetylase inhibitor largazole and C7- modified analogues., J Med Chem
    Hutt DM et al., 2010, Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis., Nat Chem Biol
    Kemp MM et al., 2011, A novel HDAC inhibitor with a hydroxy-pyrimidine scaffold., Bioorg Med Chem Lett
    Fass et al., 2010, Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin., ACS Med Chem Lett
    Li X et al., 2014, Discovery of the first N-hydroxycinnamamide-based histone deacetylase 1/3 dual inhibitors with potent oral antitumor activity., J Med Chem
    Olsen CA et al., 2009, Discovery of potent and selective histone deacetylase inhibitors via focused combinatorial libraries of cyclic alpha3beta-tetrapeptides., J Med Chem
    Herman D et al., 2006, Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia., Nat Chem Biol
    Petrelli R et al., 2014, From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase: synthesis and biological evaluation of valproic esters of 3'-C-methyladenosine., Bioorg Med Chem Lett
    Perrino E et al., 2008, New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity., Bioorg Med Chem Lett
    Guerrant W et al., 2012, Dual targeting of histone deacetylase and topoisomerase II with novel bifunctional inhibitors., J Med Chem
    Benelkebir H et al., 2011, Total synthesis of largazole and analogues: HDAC inhibition, antiproliferative activity and metabolic stability., Bioorg Med Chem
    Bhansali P et al., 2011, Largazole and analogues with modified metal-binding motifs targeting histone deacetylases: synthesis and biological evaluation., J Med Chem
    Bhansali P et al., 2014, Synthesis and biological evaluation of largazole analogues with modified surface recognition cap groups., Eur J Med Chem
    Mimori S et al., 2013, 4-Phenylbutyric acid protects against neuronal cell death by primarily acting as a chemical chaperone rather than histone deacetylase inhibitor., Bioorg Med Chem Lett
    Bianchi G et al., 2015, Promising therapies in multiple myeloma., Blood
    Marson CM et al., 2015, Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit., J Med Chem
    Marson CM et al., 2013, Discovery of potent, isoform-selective inhibitors of histone deacetylase containing chiral heterocyclic capping groups and a N-(2-aminophenyl)benzamide binding unit., J Med Chem
    Wagner FF et al., 2013, Potent and selective inhibition of histone deacetylase 6 (HDAC6) does not require a surface-binding motif., J Med Chem
    Guerrant W et al., 2013, Dual-acting histone deacetylase-topoisomerase I inhibitors., Bioorg Med Chem Lett
    Lee HY et al., 2014, Azaindolylsulfonamides, with a more selective inhibitory effect on histone deacetylase 6 activity, exhibit antitumor activity in colorectal cancer HCT116 cells., J Med Chem
    Yang W et al., 2015, Design, synthesis and biological evaluation of isoquinoline-based derivatives as novel histone deacetylase inhibitors., Bioorg Med Chem
    Moffat D et al., 2010, Discovery of 2-(6-{[(6-fluoroquinolin-2-yl)methyl]amino}bicyclo[3.1.0]hex-3-yl)-N-hydroxypyrimidine-5-carboxamide (CHR-3996), a class I selective orally active histone deacetylase inhibitor., J Med Chem
    Neelarapu R et al., 2011, Design, synthesis, docking, and biological evaluation of novel diazide-containing isoxazole- and pyrazole-based histone deacetylase probes., J Med Chem
    Sodji QH et al., 2013, Synthesis and structure-activity relationship of 3-hydroxypyridine-2-thione-based histone deacetylase inhibitors., J Med Chem
    Dallavalle S et al., 2009, Design, synthesis, and evaluation of biphenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors., Eur J Med Chem
    Olson DE et al., 2013, Discovery of the first histone deacetylase 6/8 dual inhibitors., J Med Chem
    Grolla AA et al., 2009, Synthesis, biological evaluation, and molecular docking of Ugi products containing a zinc-chelating moiety as novel inhibitors of histone deacetylases., J Med Chem
    Xu et al., 2007, Histone deacetylase inhibitors: molecular mechanisms of action., Oncogene
    Chen IH et al., 2009, Cytotoxic triterpenoids from the stems of Microtropis japonica., J Nat Prod
    Schäfer S et al., 2008, Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs)., Bioorg Med Chem
    Baud MG et al., 2012, Defining the mechanism of action and enzymatic selectivity of psammaplin A against its epigenetic targets., J Med Chem
    Charrier C et al., 2009, Synthesis and modeling of new benzofuranone histone deacetylase inhibitors that stimulate tumor suppressor gene expression., J Med Chem
    Marrazzo A et al., 2011, Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(±)-MRJF4] in prostate cancer cells., Eur J Med Chem
    Thomas M et al., 2008, Synthesis and biological evaluation of glucuronide prodrugs of the histone deacetylase inhibitor CI-994 for application in selective cancer chemotherapy., Bioorg Med Chem
    Pereira R et al., 2012, Indole-derived psammaplin A analogues as epigenetic modulators with multiple inhibitory activities., J Med Chem
    Hong S et al., 2015, Efficient synthesis and biological activity of Psammaplin A and its analogues as antitumor agents., Eur J Med Chem
    Shi Y et al., 2007, Induction of GRP78 by valproic acid is dependent upon histone deacetylase inhibition., Bioorg Med Chem Lett
    Campbell CT et al., 2008, Targeting pro-invasive oncogenes with short chain fatty acid-hexosamine analogues inhibits the mobility of metastatic MDA-MB-231 breast cancer cells., J Med Chem
  • BENZOHYDROXAMATE   HDAC6

    Interaction Score: 4.76

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25937017 23368884


    Sources:
    DTC

  • VALPROPYLHYDROXAMIC ACID   HDAC6

    Interaction Score: 3.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21874153


    Sources:
    DTC

  • CHEMBL569419   HDAC6

    Interaction Score: 3.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25937017


    Sources:
    DTC

  • NICOXAMAT   HDAC6

    Interaction Score: 3.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25937017


    Sources:
    DTC

  • RICOLINOSTAT   HDAC6

    Interaction Score: 2.38

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name ACY-1215
    Novel drug target Established target

    PMIDs:
    26031917


    Sources:
    TdgClinicalTrial TTD

  • CITARINOSTAT   HDAC6

    Interaction Score: 1.59

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • VORINOSTAT   HDAC6

    Interaction Score: 0.69

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name Merck
    Novel drug target Established target
    Mechanism of Interaction Histone deacetylase 6 inhibitor

    PMIDs:
    23622981 19966789 24766560 26211462 21696956 21080647 21548582 20491440 24304348 26331334 19084294 23672185 22260166 19344175 17694093


    Sources:
    TALC DTC TdgClinicalTrial ChemblInteractions TEND

  • BELINOSTAT   HDAC6

    Interaction Score: 0.61

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Notes
    Mechanism of Interaction Histone deacetylase inhibitor
    Direct Interaction yes

    PMIDs:
    25937017


    Sources:
    TALC DTC TdgClinicalTrial ChemblInteractions

  • TRICHOSTATIN   HDAC6

    Interaction Score: 0.58

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19966789 18054239 22280363 19385600 21055848 16921367


    Sources:
    DTC

  • ROMIDEPSIN   HDAC6

    Interaction Score: 0.5

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name Depsipeptide
    Mechanism of Interaction Histone deacetylase inhibitor

    PMIDs:
    21587264 26331334


    Sources:
    DTC TdgClinicalTrial ChemblInteractions TEND

  • MOCETINOSTAT   HDAC6

    Interaction Score: 0.49

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name MGCD-0103
    Novel drug target Established target

    PMIDs:
    26287310 23829483


    Sources:
    DTC TdgClinicalTrial

  • ENTINOSTAT   HDAC6

    Interaction Score: 0.44

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Histone deacetylase inhibitor

    PMIDs:
    20491440 19966789 21696956


    Sources:
    DTC ChemblInteractions

  • TACEDINALINE   HDAC6

    Interaction Score: 0.43

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Histone deacetylase inhibitor
    Direct Interaction yes

    PMIDs:
    18692397


    Sources:
    DTC ChemblInteractions

  • PANOBINOSTAT   HDAC6

    Interaction Score: 0.37

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Notes
    Trial Name Panobinostat
    Novel drug target Established target

    PMIDs:
    24694055


    Sources:
    TALC DTC TdgClinicalTrial

  • PSAMMAPLIN A   HDAC6

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23030799 25884112


    Sources:
    DTC

  • VALPROIC ACID   HDAC6

    Interaction Score: 0.35

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16921367 25304896 18294844


    Sources:
    DTC

  • CUDC-101   HDAC6

    Interaction Score: 0.34

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name CUDC-101
    Novel drug target Established target
    Mechanism of Interaction Histone deacetylase inhibitor

    PMIDs:
    None found


    Sources:
    TALC TdgClinicalTrial ChemblInteractions

  • BUTANOIC ACID   HDAC6

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19053749


    Sources:
    DTC

  • CHEMBL117487   HDAC6

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17566732


    Sources:
    DTC

  • ABEXINOSTAT   HDAC6

    Interaction Score: 0.29

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Notes
    Trial Name PCI-27483, CRA-024781
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TALC TdgClinicalTrial

  • SUBEROHYDROXAMIC ACID   HDAC6

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16921367


    Sources:
    DTC

  • CHEMBL1650245   HDAC6

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24044874


    Sources:
    DTC

  • PHENYLBUTYRYLHYDROXAMIC ACID   HDAC6

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21874153


    Sources:
    DTC

  • CHEMBL324053   HDAC6

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16921367


    Sources:
    DTC

  • APICIDIN   HDAC6

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19705846


    Sources:
    DTC

  • BUTYRYLHYDROXAMIC ACID   HDAC6

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21874153


    Sources:
    DTC

  • LARGAZOLE   HDAC6

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21420302 20491440 21936551 25203782


    Sources:
    DTC

  • URSOLIC ACID   HDAC6

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19534471


    Sources:
    DTC

  • GIVINOSTAT   HDAC6

    Interaction Score: 0.26

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Notes
    Trial Name ITF2357,Givinostat
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TALC TdgClinicalTrial

  • SCRIPTAID   HDAC6

    Interaction Score: 0.26

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    19966789


    Sources:
    DTC

  • PHENYLBUTANOIC ACID   HDAC6

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24044874


    Sources:
    DTC

  • PANOBINOSTAT LACTATE   HDAC6

    Interaction Score: 0.16

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Histone deacetylase inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • RESMINOSTAT   HDAC6

    Interaction Score: 0.14

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name Resminostat
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • AR-42   HDAC6

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name AR-42
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • PRACINOSTAT   HDAC6

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name SB939
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • 7-ETHYL-10-HYDROXYCAMPTOTHECIN   HDAC6

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23622981


    Sources:
    DTC

  • HINOKITIOL   HDAC6

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • FIMEPINOSTAT   HDAC6

    Interaction Score: 0.09

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Histone deacetylase inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DAUNORUBICIN   HDAC6

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22260166


    Sources:
    DTC

  • Ensembl: ENSG00000094631

    • Version: 101_38

    Alternate Names:
    HDAC6 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TEND: Q9UBN7

    • Version: 01-August-2011

    Alternate Names:
    HDAC6_HUMAN Uniprot Id
    Q9UBN7 Uniprot Accession
    ENSG00000094631 Ensembl Gene Id

    Gene Info:
    Target Main Class Enzymes
    Target Subclass 3.5.1.98

    Publications:

  • TdgClinicalTrial: Q9UBN7

    • Version: January-2014

    Alternate Names:
    HDAC6 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:3.5.1.98

    Publications:

  • TTD: Histone deacetylase 6

    • Version: 2020.06.01

    Alternate Names:
    HDAC6 TTD Gene Abbreviation
    T22274 TTD Target ID

    Gene Info:

    Publications:
    Bianchi G et al., 2015, Promising therapies in multiple myeloma., Blood

  • DTC: HDAC6

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Kozlov MV et al., 2015, Pyridine hydroxamic acids are specific anti-HCV agents affecting HDAC6., Bioorg Med Chem Lett
    Olsen CA et al., 2009, Discovery of potent and selective histone deacetylase inhibitors via focused combinatorial libraries of cyclic alpha3beta-tetrapeptides., J Med Chem
    Perrino E et al., 2008, New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity., Bioorg Med Chem Lett

  • ChemblInteractions: KIAA0901

    • Version: chembl_23

    Alternate Names:
    KIAA0901 GENE_SYMBOL
    HDAC6 GENE_SYMBOL
    Histone deacetylase 6 UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000094631

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000094631 Gene Symbol
    HDAC6 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TALC: HDAC6

    • Version: 12-May-2016

    Alternate Names:
    HDAC6 Gene Symbol

    Gene Info:

    Publications:

  • GO: HDAC6

    • Version: 01-February-2022

    Alternate Names:
    KIAA0901 GO Gene Synonym
    JM21 GO Gene Synonym

    Gene Info:

    Gene Categories:
    TRANSCRIPTION FACTOR BINDING

    Publications:

  • Pharos: HDAC6

    • Version: 01-February-2022

    Alternate Names:
    Histone deacetylase 6 Gene Name
    Q9UBN7 UniProt ID

    Gene Info:

    Gene Categories:
    TRANSCRIPTION FACTOR

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21