DGIdb - HDAC6 Gene Record

HDAC6 10013 Druggable Genome

Alternate Names:

10013
HISTONE DEACETYLASE 6
HDAC6
CPBHM
HD6
JM21
PPP1R90
300272
14064
ENSG00000094631
OTTHUMG00000034496
Q9UBN7
KIAA0901
HDAC6_HUMAN
2618
T22274
NM_006044
NP_006035

Gene Info:

Target Class	Enzymes
Target Subclass	EC:3.5.1.98
Target Main Class	Enzymes
Target Subclass	3.5.1.98
Gene Biotype	PROTEIN_CODING
GuideToPharmacology Gene Category Name	3.5.1.- Histone deacetylases (HDACs)
GuideToPharmacology Gene Category ID	848

(6 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
ENZYME
TRANSCRIPTION FACTOR

Publications:

Kozlov MV et al., 2015, Pyridine hydroxamic acids are specific anti-HCV agents affecting HDAC6., Bioorg Med Chem Lett
VanderMolen et al., 2011, Romidepsin (Istodax, NSC 630176, FR901228, FK228, depsipeptide): a natural product recently approved for cutaneous T-cell lymphoma., J. Antibiot.
Yao Y et al., 2015, Discovery of Novel Class I Histone Deacetylase Inhibitors with Promising in Vitro and in Vivo Antitumor Activities., J Med Chem
Souto JA et al., 2010, Synthesis and biological characterization of the histone deacetylase inhibitor largazole and C7- modified analogues., J Med Chem
Hutt DM et al., 2010, Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis., Nat Chem Biol
Kemp MM et al., 2011, A novel HDAC inhibitor with a hydroxy-pyrimidine scaffold., Bioorg Med Chem Lett
Fass et al., 2010, Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin., ACS Med Chem Lett
Li X et al., 2014, Discovery of the first N-hydroxycinnamamide-based histone deacetylase 1/3 dual inhibitors with potent oral antitumor activity., J Med Chem
Olsen CA et al., 2009, Discovery of potent and selective histone deacetylase inhibitors via focused combinatorial libraries of cyclic alpha3beta-tetrapeptides., J Med Chem
Herman D et al., 2006, Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia., Nat Chem Biol
Petrelli R et al., 2014, From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase: synthesis and biological evaluation of valproic esters of 3'-C-methyladenosine., Bioorg Med Chem Lett
Perrino E et al., 2008, New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity., Bioorg Med Chem Lett
Guerrant W et al., 2012, Dual targeting of histone deacetylase and topoisomerase II with novel bifunctional inhibitors., J Med Chem
Benelkebir H et al., 2011, Total synthesis of largazole and analogues: HDAC inhibition, antiproliferative activity and metabolic stability., Bioorg Med Chem
Bhansali P et al., 2011, Largazole and analogues with modified metal-binding motifs targeting histone deacetylases: synthesis and biological evaluation., J Med Chem
Bhansali P et al., 2014, Synthesis and biological evaluation of largazole analogues with modified surface recognition cap groups., Eur J Med Chem
Mimori S et al., 2013, 4-Phenylbutyric acid protects against neuronal cell death by primarily acting as a chemical chaperone rather than histone deacetylase inhibitor., Bioorg Med Chem Lett
Bianchi G et al., 2015, Promising therapies in multiple myeloma., Blood
Marson CM et al., 2015, Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit., J Med Chem
Marson CM et al., 2013, Discovery of potent, isoform-selective inhibitors of histone deacetylase containing chiral heterocyclic capping groups and a N-(2-aminophenyl)benzamide binding unit., J Med Chem
Wagner FF et al., 2013, Potent and selective inhibition of histone deacetylase 6 (HDAC6) does not require a surface-binding motif., J Med Chem
Guerrant W et al., 2013, Dual-acting histone deacetylase-topoisomerase I inhibitors., Bioorg Med Chem Lett
Lee HY et al., 2014, Azaindolylsulfonamides, with a more selective inhibitory effect on histone deacetylase 6 activity, exhibit antitumor activity in colorectal cancer HCT116 cells., J Med Chem
Yang W et al., 2015, Design, synthesis and biological evaluation of isoquinoline-based derivatives as novel histone deacetylase inhibitors., Bioorg Med Chem
Moffat D et al., 2010, Discovery of 2-(6-{[(6-fluoroquinolin-2-yl)methyl]amino}bicyclo[3.1.0]hex-3-yl)-N-hydroxypyrimidine-5-carboxamide (CHR-3996), a class I selective orally active histone deacetylase inhibitor., J Med Chem
Neelarapu R et al., 2011, Design, synthesis, docking, and biological evaluation of novel diazide-containing isoxazole- and pyrazole-based histone deacetylase probes., J Med Chem
Sodji QH et al., 2013, Synthesis and structure-activity relationship of 3-hydroxypyridine-2-thione-based histone deacetylase inhibitors., J Med Chem
Dallavalle S et al., 2009, Design, synthesis, and evaluation of biphenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors., Eur J Med Chem
Olson DE et al., 2013, Discovery of the first histone deacetylase 6/8 dual inhibitors., J Med Chem
Grolla AA et al., 2009, Synthesis, biological evaluation, and molecular docking of Ugi products containing a zinc-chelating moiety as novel inhibitors of histone deacetylases., J Med Chem
Xu et al., 2007, Histone deacetylase inhibitors: molecular mechanisms of action., Oncogene
Chen IH et al., 2009, Cytotoxic triterpenoids from the stems of Microtropis japonica., J Nat Prod
Schäfer S et al., 2008, Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs)., Bioorg Med Chem
Baud MG et al., 2012, Defining the mechanism of action and enzymatic selectivity of psammaplin A against its epigenetic targets., J Med Chem
Charrier C et al., 2009, Synthesis and modeling of new benzofuranone histone deacetylase inhibitors that stimulate tumor suppressor gene expression., J Med Chem
Marrazzo A et al., 2011, Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(±)-MRJF4] in prostate cancer cells., Eur J Med Chem
Thomas M et al., 2008, Synthesis and biological evaluation of glucuronide prodrugs of the histone deacetylase inhibitor CI-994 for application in selective cancer chemotherapy., Bioorg Med Chem
Pereira R et al., 2012, Indole-derived psammaplin A analogues as epigenetic modulators with multiple inhibitory activities., J Med Chem
Hong S et al., 2015, Efficient synthesis and biological activity of Psammaplin A and its analogues as antitumor agents., Eur J Med Chem
Bantscheff et al., 2011, Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes., Nat. Biotechnol.
Shi Y et al., 2007, Induction of GRP78 by valproic acid is dependent upon histone deacetylase inhibition., Bioorg Med Chem Lett
Campbell CT et al., 2008, Targeting pro-invasive oncogenes with short chain fatty acid-hexosamine analogues inhibits the mobility of metastatic MDA-MB-231 breast cancer cells., J Med Chem

BENZOHYDROXAMATE HDAC6

Interaction Score: 4.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25937017 23368884

Sources:
DTC
VALPROPYLHYDROXAMIC ACID HDAC6

Interaction Score: 2.9

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21874153

Sources:
DTC
CHEMBL569419 HDAC6

Interaction Score: 2.9

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25937017

Sources:
DTC
NICOXAMAT HDAC6

Interaction Score: 2.9

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25937017

Sources:
DTC
TUBACIN HDAC6

Interaction Score: 1.45

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
RICOLINOSTAT HDAC6

Interaction Score: 0.97

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name ACY-1215

Novel drug target Established target

Direct Interaction? False

PMIDs:
26031917

Sources:
TdgClinicalTrial GuideToPharmacology TTD
BUFEXAMAC HDAC6

Interaction Score: 0.72

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
21258344

Sources:
GuideToPharmacology
VORINOSTAT HDAC6

Interaction Score: 0.65

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Merck

Novel drug target Established target

Mechanism of Interaction Histone deacetylase 6 inhibitor

PMIDs:
23622981 19966789 24766560 26211462 21696956 21080647 21548582 20491440 24304348 26331334 19084294 23672185 22260166 19344175 17694093

Sources:
TALC DTC TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology
BELINOSTAT HDAC6

Interaction Score: 0.62

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes

PMIDs:
25937017

Sources:
TALC DTC TdgClinicalTrial ChemblInteractions GuideToPharmacology
CITARINOSTAT HDAC6

Interaction Score: 0.58

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
GuideToPharmacology TTD
TRICHOSTATIN HDAC6

Interaction Score: 0.53

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19966789 18054239 22280363 19385600 21055848 16921367

Sources:
DTC
ROMIDEPSIN HDAC6

Interaction Score: 0.53

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name Depsipeptide

Mechanism of Interaction Histone deacetylase inhibitor

PMIDs:
21587264 26331334

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology
MOCETINOSTAT HDAC6

Interaction Score: 0.45

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name MGCD-0103

Novel drug target Established target

PMIDs:
26287310 23829483

Sources:
DTC TdgClinicalTrial
PANOBINOSTAT HDAC6

Interaction Score: 0.43

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Trial Name Panobinostat

Novel drug target Established target

PMIDs:
24694055

Sources:
TALC DTC TdgClinicalTrial GuideToPharmacology
CUDC-101 HDAC6

Interaction Score: 0.41

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
TALC TdgClinicalTrial ChemblInteractions GuideToPharmacology
ENTINOSTAT HDAC6

Interaction Score: 0.4

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Histone deacetylase inhibitor

PMIDs:
20491440 19966789 21696956

Sources:
DTC ChemblInteractions
TACEDINALINE HDAC6

Interaction Score: 0.4

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes

PMIDs:
18692397

Sources:
DTC ChemblInteractions
GIVINOSTAT HDAC6

Interaction Score: 0.36

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Direct Interaction? False

Endogenous Drug? False

PMIDs:
None found

Sources:
TALC TdgClinicalTrial GuideToPharmacology
SCRIPTAID HDAC6

Interaction Score: 0.36

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
19966789

Sources:
DTC GuideToPharmacology
PSAMMAPLIN A HDAC6

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23030799 25884112

Sources:
DTC
VALPROIC ACID HDAC6

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16921367 25304896 18294844

Sources:
DTC
BUTANOIC ACID HDAC6

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19053749

Sources:
DTC
CHEMBL117487 HDAC6

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17566732

Sources:
DTC
ABEXINOSTAT HDAC6

Interaction Score: 0.26

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Trial Name PCI-27483, CRA-024781

Novel drug target Established target

PMIDs:
None found

Sources:
TALC TdgClinicalTrial
RESMINOSTAT HDAC6

Interaction Score: 0.26

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
TdgClinicalTrial GuideToPharmacology
SUBEROHYDROXAMIC ACID HDAC6

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16921367

Sources:
DTC
CHEMBL1650245 HDAC6

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24044874

Sources:
DTC
PHENYLBUTYRYLHYDROXAMIC ACID HDAC6

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21874153

Sources:
DTC
CHEMBL324053 HDAC6

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16921367

Sources:
DTC
APICIDIN HDAC6

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19705846

Sources:
DTC
BUTYRYLHYDROXAMIC ACID HDAC6

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21874153

Sources:
DTC
LARGAZOLE HDAC6

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21420302 20491440 21936551 25203782

Sources:
DTC
NANATINOSTAT HDAC6

Interaction Score: 0.24

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
URSOLIC ACID HDAC6

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19534471

Sources:
DTC
PHENYLBUTANOIC ACID HDAC6

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24044874

Sources:
DTC
FIMEPINOSTAT HDAC6

Interaction Score: 0.16

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Histone deacetylase inhibitor

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
ChemblInteractions GuideToPharmacology
PANOBINOSTAT LACTATE HDAC6

Interaction Score: 0.14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DACINOSTAT HDAC6

Interaction Score: 0.13

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
QUISINOSTAT HDAC6

Interaction Score: 0.12

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
PRACINOSTAT HDAC6

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name SB939

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
AR-42 HDAC6

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name AR-42

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
7-ETHYL-10-HYDROXYCAMPTOTHECIN HDAC6

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23622981

Sources:
DTC
HINOKITIOL HDAC6

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DAUNORUBICIN HDAC6

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22260166

Sources:
DTC

Ensembl: ENSG00000094631
- Version: 101_38
Alternate Names:

HDAC6 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TEND: Q9UBN7
- Version: 01-August-2011
Alternate Names:

HDAC6_HUMAN Uniprot Id

Q9UBN7 Uniprot Accession

ENSG00000094631 Ensembl Gene Id

Gene Info:

Target Main Class Enzymes

Target Subclass 3.5.1.98

Publications:
TdgClinicalTrial: Q9UBN7
- Version: January-2014
Alternate Names:

HDAC6 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.5.1.98

Publications:
GuideToPharmacology: 10013
- Version: 29-September-2020
Alternate Names:

14064 HUGO Gene ID

14064 HUGO Gene Symbol

histone deacetylase 6 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name 3.5.1.- Histone deacetylases (HDACs)

GuideToPharmacology Gene Category ID 848

Gene Categories:

ENZYME

Publications:
TTD: Histone deacetylase 6
- Version: 2020.06.01
Alternate Names:

HDAC6 TTD Gene Abbreviation

T22274 TTD Target ID

Gene Info:

Publications:

Bianchi G et al., 2015, Promising therapies in multiple myeloma., Blood

DTC: HDAC6

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Kozlov MV et al., 2015, Pyridine hydroxamic acids are specific anti-HCV agents affecting HDAC6., Bioorg Med Chem Lett

Olsen CA et al., 2009, Discovery of potent and selective histone deacetylase inhibitors via focused combinatorial libraries of cyclic alpha3beta-tetrapeptides., J Med Chem

Perrino E et al., 2008, New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity., Bioorg Med Chem Lett

ChemblInteractions: KIAA0901
- Version: chembl_23
Alternate Names:

KIAA0901 GENE_SYMBOL

HDAC6 GENE_SYMBOL

Histone deacetylase 6 UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000094631
- Version: 31-May-2017
Alternate Names:

ENSG00000094631 Gene Symbol

HDAC6 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
TALC: HDAC6
- Version: 12-May-2016
Alternate Names:

HDAC6 Gene Symbol

Gene Info:

Publications:
Pharos: HDAC6
- Version: 01-May-2021
Alternate Names:

Histone deacetylase 6 Gene Name

Q9UBN7 UniProt ID

Gene Info:

Gene Categories:

TRANSCRIPTION FACTOR

Publications:

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	False

Trial Name	ACY-1215
Novel drug target	Established target
Direct Interaction?	False

Trial Name	Merck
Novel drug target	Established target
Mechanism of Interaction	Histone deacetylase 6 inhibitor

Notes
Mechanism of Interaction	Histone deacetylase inhibitor
Direct Interaction	yes

Notes
Trial Name	Panobinostat
Novel drug target	Established target

Notes
Trial Name	PCI-27483, CRA-024781
Novel drug target	Established target

HDAC6_HUMAN	Uniprot Id
Q9UBN7	Uniprot Accession
ENSG00000094631	Ensembl Gene Id

14064	HUGO Gene ID
14064	HUGO Gene Symbol
histone deacetylase 6	HUGO Gene Name

KIAA0901	GENE_SYMBOL
HDAC6	GENE_SYMBOL
Histone deacetylase 6	UNIPROT

HDAC6 Gene Record

HDAC6 10013 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25937017 23368884

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21874153

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25937017

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25937017

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name ACY-1215 Novel drug target Established target Direct Interaction? False

PMIDs: 26031917

Sources: TdgClinicalTrial GuideToPharmacology TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: 21258344

Sources: GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name Merck Novel drug target Established target Mechanism of Interaction Histone deacetylase 6 inhibitor

PMIDs: 23622981 19966789 24766560 26211462 21696956 21080647 21548582 20491440 24304348 26331334 19084294 23672185 22260166 19344175 17694093

Sources: TALC DTC TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Notes Mechanism of Interaction Histone deacetylase inhibitor Direct Interaction yes

PMIDs: 25937017

Sources: TALC DTC TdgClinicalTrial ChemblInteractions GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? True

PMIDs: None found

Sources: GuideToPharmacology TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19966789 18054239 22280363 19385600 21055848 16921367

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name Depsipeptide Mechanism of Interaction Histone deacetylase inhibitor

PMIDs: 21587264 26331334

Sources: DTC TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info: Trial Name MGCD-0103 Novel drug target Established target

PMIDs: 26287310 23829483

Sources: DTC TdgClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Notes Trial Name Panobinostat Novel drug target Established target

PMIDs: 24694055

Sources: TALC DTC TdgClinicalTrial GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction? False Endogenous Drug? False Specific Action of the Ligand Inhibition

PMIDs: None found

Sources: TALC TdgClinicalTrial ChemblInteractions GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Histone deacetylase inhibitor

PMIDs: 20491440 19966789 21696956

Sources: DTC ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Histone deacetylase inhibitor Direct Interaction yes

PMIDs: 18692397

Sources: DTC ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Notes Direct Interaction? False Endogenous Drug? False

PMIDs: None found

Sources: TALC TdgClinicalTrial GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

Interaction Types & Directionality:

n/a

PMIDs:
25937017 23368884

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21874153

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
25937017

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
25937017

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name ACY-1215

Novel drug target Established target

Direct Interaction? False

PMIDs:
26031917

Sources:
TdgClinicalTrial GuideToPharmacology TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
21258344

Sources:
GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Merck

Novel drug target Established target

Mechanism of Interaction Histone deacetylase 6 inhibitor

PMIDs:
23622981 19966789 24766560 26211462 21696956 21080647 21548582 20491440 24304348 26331334 19084294 23672185 22260166 19344175 17694093

Sources:
TALC DTC TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes

PMIDs:
25937017

Sources:
TALC DTC TdgClinicalTrial ChemblInteractions GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
GuideToPharmacology TTD

Interaction Types & Directionality:

n/a

PMIDs:
19966789 18054239 22280363 19385600 21055848 16921367

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name Depsipeptide

Mechanism of Interaction Histone deacetylase inhibitor

PMIDs:
21587264 26331334

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name MGCD-0103

Novel drug target Established target

PMIDs:
26287310 23829483

Sources:
DTC TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Trial Name Panobinostat

Novel drug target Established target

PMIDs:
24694055

Sources:
TALC DTC TdgClinicalTrial GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
TALC TdgClinicalTrial ChemblInteractions GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Histone deacetylase inhibitor

PMIDs:
20491440 19966789 21696956

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes

PMIDs:
18692397

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Direct Interaction? False

Endogenous Drug? False

PMIDs:
None found

Sources:
TALC TdgClinicalTrial GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
19966789

Sources:
DTC GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
23030799 25884112

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16921367 25304896 18294844

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19053749

Sources:
DTC