DGIdb - HDAC7 Gene Record

HDAC7 51564 Druggable GenomeClinically Actionable

Alternate Names:

51564
HISTONE DEACETYLASE 7
HDAC7
HD7
HD7A
HDAC7A
606542
14067
ENSG00000061273
OTTHUMG00000152968
Q8WUI4
MEF2-interacting transcription repressor MITR
HD7b
HDAC7B
HDRP
KIAA0744
MITR
HDAC9
Histone deacetylase 9
Histone deacetylase 7B
Histone deacetylase-related protein
HD9
Histone deacetylase 7A
HDAC
T98698

Gene Info:

Target Class	Enzymes
Target Subclass	EC:3.5.1.98
Gene Biotype	PROTEIN_CODING

(8 More Sources)

Gene Categories: Category Details

TRANSCRIPTION FACTOR BINDING
DRUGGABLE GENOME
CLINICALLY ACTIONABLE
TRANSCRIPTION FACTOR

Publications:

Thomas M et al., 2008, Synthesis and biological evaluation of glucuronide prodrugs of the histone deacetylase inhibitor CI-994 for application in selective cancer chemotherapy., Bioorg Med Chem
Hutt DM et al., 2010, Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis., Nat Chem Biol
Campbell CT et al., 2008, Targeting pro-invasive oncogenes with short chain fatty acid-hexosamine analogues inhibits the mobility of metastatic MDA-MB-231 breast cancer cells., J Med Chem
Guerrant W et al., 2013, Dual-acting histone deacetylase-topoisomerase I inhibitors., Bioorg Med Chem Lett
Yang W et al., 2015, Design, synthesis and biological evaluation of isoquinoline-based derivatives as novel histone deacetylase inhibitors., Bioorg Med Chem
Neelarapu R et al., 2011, Design, synthesis, docking, and biological evaluation of novel diazide-containing isoxazole- and pyrazole-based histone deacetylase probes., J Med Chem
Souto JA et al., 2010, Synthesis and biological characterization of the histone deacetylase inhibitor largazole and C7- modified analogues., J Med Chem
Dallavalle S et al., 2009, Design, synthesis, and evaluation of biphenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors., Eur J Med Chem
Guerrant W et al., 2012, Dual targeting of histone deacetylase and topoisomerase II with novel bifunctional inhibitors., J Med Chem
Grolla AA et al., 2009, Synthesis, biological evaluation, and molecular docking of Ugi products containing a zinc-chelating moiety as novel inhibitors of histone deacetylases., J Med Chem
Charrier C et al., 2009, Synthesis and modeling of new benzofuranone histone deacetylase inhibitors that stimulate tumor suppressor gene expression., J Med Chem
Marrazzo A et al., 2011, Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(±)-MRJF4] in prostate cancer cells., Eur J Med Chem
Herman D et al., 2006, Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia., Nat Chem Biol
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Marson CM et al., 2015, Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit., J Med Chem
Marson CM et al., 2013, Discovery of potent, isoform-selective inhibitors of histone deacetylase containing chiral heterocyclic capping groups and a N-(2-aminophenyl)benzamide binding unit., J Med Chem
Kozlov MV et al., 2015, Pyridine hydroxamic acids are specific anti-HCV agents affecting HDAC6., Bioorg Med Chem Lett
Petrelli R et al., 2014, From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase: synthesis and biological evaluation of valproic esters of 3'-C-methyladenosine., Bioorg Med Chem Lett
Perrino E et al., 2008, New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity., Bioorg Med Chem Lett
Mimori S et al., 2013, 4-Phenylbutyric acid protects against neuronal cell death by primarily acting as a chemical chaperone rather than histone deacetylase inhibitor., Bioorg Med Chem Lett
Olsen CA et al., 2009, Discovery of potent and selective histone deacetylase inhibitors via focused combinatorial libraries of cyclic alpha3beta-tetrapeptides., J Med Chem
Hong S et al., 2015, Efficient synthesis and biological activity of Psammaplin A and its analogues as antitumor agents., Eur J Med Chem
Shi Y et al., 2007, Induction of GRP78 by valproic acid is dependent upon histone deacetylase inhibition., Bioorg Med Chem Lett
Fass et al., 2010, Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin., ACS Med Chem Lett
Benelkebir H et al., 2011, Total synthesis of largazole and analogues: HDAC inhibition, antiproliferative activity and metabolic stability., Bioorg Med Chem
Bhansali P et al., 2014, Synthesis and biological evaluation of largazole analogues with modified surface recognition cap groups., Eur J Med Chem

BELINOSTAT HDAC7

Interaction Score: 0.82

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes

PMIDs:
25937017

Sources:
TALC DTC MyCancerGenome TdgClinicalTrial ChemblInteractions
TRICHOSTATIN HDAC7

Interaction Score: 0.56

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19385600 21055848 19966789 16921367 10592235

Sources:
DTC
MOCETINOSTAT HDAC7

Interaction Score: 0.54

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name MGCD-0103

Novel drug target Established target

PMIDs:
26287310 23829483

Sources:
DTC TdgClinicalTrial
TACEDINALINE HDAC7

Interaction Score: 0.48

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes

PMIDs:
18692397

Sources:
DTC ChemblInteractions
COLFORSIN HDAC7

Interaction Score: 0.44

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19966789

Sources:
DTC
VORINOSTAT HDAC7

Interaction Score: 0.42

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

PMIDs:
23622981 19966789 26211462 21548582 20491440 19084294 22260166 19344175

Sources:
TALC DTC MyCancerGenome
VALPROIC ACID HDAC7

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16921367 25304896 18294844

Sources:
DTC
ENTINOSTAT HDAC7

Interaction Score: 0.39

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes

PMIDs:
20491440 19966789

Sources:
DTC ChemblInteractions
CUDC-101 HDAC7

Interaction Score: 0.38

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Direct Interaction yes

Mechanism of Interaction Histone deacetylase inhibitor

PMIDs:
None found

Sources:
TALC TdgClinicalTrial ChemblInteractions
PHENYLBUTYRYLHYDROXAMIC ACID HDAC7

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21874153

Sources:
DTC
BUTYRYLHYDROXAMIC ACID HDAC7

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21874153

Sources:
DTC
CHEMBL1650245 HDAC7

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24044874

Sources:
DTC
CHEMBL117487 HDAC7

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17566732

Sources:
DTC
SUBEROHYDROXAMIC ACID HDAC7

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16921367

Sources:
DTC
APICIDIN HDAC7

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19705846

Sources:
DTC
CHEMBL324053 HDAC7

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16921367

Sources:
DTC
BUTANOIC ACID HDAC7

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19053749

Sources:
DTC
PANOBINOSTAT HDAC7

Interaction Score: 0.31

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Panobinostat

Novel drug target Established target

Notes

PMIDs:
None found

Sources:
TALC MyCancerGenome TdgClinicalTrial
GIVINOSTAT HDAC7

Interaction Score: 0.29

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name ITF2357,Givinostat

Novel drug target Established target

Notes

PMIDs:
None found

Sources:
TALC TdgClinicalTrial
SCRIPTAID HDAC7

Interaction Score: 0.29

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
19966789

Sources:
DTC
ROMIDEPSIN HDAC7

Interaction Score: 0.28

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes

Trial Name Depsipeptide

PMIDs:
None found

Sources:
MyCancerGenome TdgClinicalTrial ChemblInteractions
PSAMMAPLIN A HDAC7

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25884112

Sources:
DTC
PHENYLBUTANOIC ACID HDAC7

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24044874

Sources:
DTC
LARGAZOLE HDAC7

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21420302 25203782 20491440

Sources:
DTC
DEPAKOTE HDAC7

Interaction Score: 0.22

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

PMIDs:
None found

Sources:
TALC
AN-9 HDAC7

Interaction Score: 0.2

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

PMIDs:
None found

Sources:
TALC
PANOBINOSTAT LACTATE HDAC7

Interaction Score: 0.18

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
RESMINOSTAT HDAC7

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Resminostat

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
ABEXINOSTAT HDAC7

Interaction Score: 0.16

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

PMIDs:
None found

Sources:
TALC
PRACINOSTAT HDAC7

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name SB939

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
AR-42 HDAC7

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name AR-42

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
7-ETHYL-10-HYDROXYCAMPTOTHECIN HDAC7

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23622981

Sources:
DTC
HINOKITIOL HDAC7

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FIMEPINOSTAT HDAC7

Interaction Score: 0.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Histone deacetylase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
DAUNORUBICIN HDAC7

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22260166

Sources:
DTC

Ensembl: ENSG00000061273
- Version: 101_38
Alternate Names:

HDAC7 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: Q8WUI4
- Version: January-2014
Alternate Names:

HDAC7A Gene Symbol

HDAC7 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.5.1.98

Publications:

DTC: HDAC7

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Campbell CT et al., 2008, Targeting pro-invasive oncogenes with short chain fatty acid-hexosamine analogues inhibits the mobility of metastatic MDA-MB-231 breast cancer cells., J Med Chem

Guerrant W et al., 2012, Dual targeting of histone deacetylase and topoisomerase II with novel bifunctional inhibitors., J Med Chem

Mimori S et al., 2013, 4-Phenylbutyric acid protects against neuronal cell death by primarily acting as a chemical chaperone rather than histone deacetylase inhibitor., Bioorg Med Chem Lett

MyCancerGenome: HDAC7
- Version: 20-Jun-2017
Alternate Names:

51564 Entrez Gene Id

HDAC7 MyCancerGenome Gene Symbol

HDAC MyCancerGenome Reported Gene Name

Gene Info:

Publications:
HingoraniCasas: ENSG00000061273
- Version: 31-May-2017
Alternate Names:

ENSG00000061273 Gene Symbol

HDAC7 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: HDAC7A
- Version: chembl_23
Alternate Names:

HDAC7A GENE_SYMBOL

HDAC7 GENE_SYMBOL

Histone deacetylase 7 UNIPROT

Gene Info:

Publications:
TALC: HDAC7
- Version: 12-May-2016
Alternate Names:

HDAC7 Gene Symbol

Gene Info:

Publications:
ChemblInteractions: HDAC7
- Version: chembl_23
Alternate Names:

HDAC7B GENE_SYMBOL

HDRP GENE_SYMBOL

KIAA0744 GENE_SYMBOL

Gene Info:

Publications:
GO: HDAC7
- Version: 01-February-2022
Alternate Names:

HDAC7A GO Gene Synonym

Gene Info:

Gene Categories:

TRANSCRIPTION FACTOR BINDING

Publications:
TTD: Histone deacetylase 7
- Version: 2020.06.01
Alternate Names:

HDAC7 TTD Gene Abbreviation

T98698 TTD Target ID

Gene Info:

Publications:
Pharos: HDAC7
- Version: 01-February-2022
Alternate Names:

Histone deacetylase 7 Gene Name

Q8WUI4 UniProt ID

Gene Info:

Gene Categories:

TRANSCRIPTION FACTOR

Publications:
FoundationOneGenes: HDAC7
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Notes
Mechanism of Interaction	Histone deacetylase inhibitor
Direct Interaction	yes

Trial Name	Panobinostat
Novel drug target	Established target
Notes

Trial Name	ITF2357,Givinostat
Novel drug target	Established target
Notes

51564	Entrez Gene Id
HDAC7	MyCancerGenome Gene Symbol
HDAC	MyCancerGenome Reported Gene Name

HDAC7A	GENE_SYMBOL
HDAC7	GENE_SYMBOL
Histone deacetylase 7	UNIPROT

HDAC7 Gene Record

HDAC7 51564 Druggable GenomeClinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Notes Mechanism of Interaction Histone deacetylase inhibitor Direct Interaction yes

PMIDs: 25937017

Sources: TALC DTC MyCancerGenome TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19385600 21055848 19966789 16921367 10592235

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info: Trial Name MGCD-0103 Novel drug target Established target

PMIDs: 26287310 23829483

Sources: DTC TdgClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Histone deacetylase inhibitor Direct Interaction yes

PMIDs: 18692397

Sources: DTC ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19966789

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Notes

PMIDs: 23622981 19966789 26211462 21548582 20491440 19084294 22260166 19344175

Sources: TALC DTC MyCancerGenome

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16921367 25304896 18294844

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Histone deacetylase inhibitor Direct Interaction yes

PMIDs: 20491440 19966789

Sources: DTC ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Notes Direct Interaction yes Mechanism of Interaction Histone deacetylase inhibitor

PMIDs: None found

Sources: TALC TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21874153

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21874153

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24044874

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17566732

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16921367

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19705846

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16921367

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19053749

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name Panobinostat Novel drug target Established target Notes

PMIDs: None found

Sources: TALC MyCancerGenome TdgClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name ITF2357,Givinostat Novel drug target Established target Notes

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes

PMIDs:
25937017

Sources:
TALC DTC MyCancerGenome TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
19385600 21055848 19966789 16921367 10592235

Sources:
DTC

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name MGCD-0103

Novel drug target Established target

PMIDs:
26287310 23829483

Sources:
DTC TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes

PMIDs:
18692397

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
19966789

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

PMIDs:
23622981 19966789 26211462 21548582 20491440 19084294 22260166 19344175

Sources:
TALC DTC MyCancerGenome

Interaction Types & Directionality:

n/a

PMIDs:
16921367 25304896 18294844

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes

PMIDs:
20491440 19966789

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Direct Interaction yes

Mechanism of Interaction Histone deacetylase inhibitor

PMIDs:
None found

Sources:
TALC TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
21874153

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21874153

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
24044874

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
17566732

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16921367

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19705846

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16921367

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19053749

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Panobinostat

Novel drug target Established target

Notes

PMIDs:
None found

Sources:
TALC MyCancerGenome TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name ITF2357,Givinostat

Novel drug target Established target

Notes

PMIDs:
None found

Sources:
TALC TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
19966789

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes

Trial Name Depsipeptide

PMIDs:
None found

Sources:
MyCancerGenome TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
25884112

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
24044874

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21420302 25203782 20491440