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HDAC7 Gene Record

  • Summary
  • Interactions
  • Claims
  • HDAC7 51564 Druggable GenomeClinically Actionable

    Alternate Names:

    51564
    HISTONE DEACETYLASE 7
    HDAC7
    HD7
    HD7A
    HDAC7A
    606542
    14067
    ENSG00000061273
    OTTHUMG00000152968
    Q8WUI4
    MEF2-interacting transcription repressor MITR
    HD7b
    HDAC7B
    HDRP
    KIAA0744
    MITR
    HDAC9
    Histone deacetylase 9
    Histone deacetylase 7B
    Histone deacetylase-related protein
    HD9
    Histone deacetylase 7A
    HDAC
    T98698

    Gene Info:

    Target Class Enzymes
    Target Subclass EC:3.5.1.98
    Gene Biotype PROTEIN_CODING
    (8 More Sources)

    Gene Categories: Category Details

    TRANSCRIPTION FACTOR BINDING
    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE
    TRANSCRIPTION FACTOR

    Publications:

    Thomas M et al., 2008, Synthesis and biological evaluation of glucuronide prodrugs of the histone deacetylase inhibitor CI-994 for application in selective cancer chemotherapy., Bioorg Med Chem
    Hutt DM et al., 2010, Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis., Nat Chem Biol
    Campbell CT et al., 2008, Targeting pro-invasive oncogenes with short chain fatty acid-hexosamine analogues inhibits the mobility of metastatic MDA-MB-231 breast cancer cells., J Med Chem
    Guerrant W et al., 2013, Dual-acting histone deacetylase-topoisomerase I inhibitors., Bioorg Med Chem Lett
    Yang W et al., 2015, Design, synthesis and biological evaluation of isoquinoline-based derivatives as novel histone deacetylase inhibitors., Bioorg Med Chem
    Neelarapu R et al., 2011, Design, synthesis, docking, and biological evaluation of novel diazide-containing isoxazole- and pyrazole-based histone deacetylase probes., J Med Chem
    Souto JA et al., 2010, Synthesis and biological characterization of the histone deacetylase inhibitor largazole and C7- modified analogues., J Med Chem
    Dallavalle S et al., 2009, Design, synthesis, and evaluation of biphenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors., Eur J Med Chem
    Guerrant W et al., 2012, Dual targeting of histone deacetylase and topoisomerase II with novel bifunctional inhibitors., J Med Chem
    Grolla AA et al., 2009, Synthesis, biological evaluation, and molecular docking of Ugi products containing a zinc-chelating moiety as novel inhibitors of histone deacetylases., J Med Chem
    Charrier C et al., 2009, Synthesis and modeling of new benzofuranone histone deacetylase inhibitors that stimulate tumor suppressor gene expression., J Med Chem
    Marrazzo A et al., 2011, Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(±)-MRJF4] in prostate cancer cells., Eur J Med Chem
    Herman D et al., 2006, Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia., Nat Chem Biol
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Marson CM et al., 2015, Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit., J Med Chem
    Marson CM et al., 2013, Discovery of potent, isoform-selective inhibitors of histone deacetylase containing chiral heterocyclic capping groups and a N-(2-aminophenyl)benzamide binding unit., J Med Chem
    Kozlov MV et al., 2015, Pyridine hydroxamic acids are specific anti-HCV agents affecting HDAC6., Bioorg Med Chem Lett
    Petrelli R et al., 2014, From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase: synthesis and biological evaluation of valproic esters of 3'-C-methyladenosine., Bioorg Med Chem Lett
    Perrino E et al., 2008, New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity., Bioorg Med Chem Lett
    Mimori S et al., 2013, 4-Phenylbutyric acid protects against neuronal cell death by primarily acting as a chemical chaperone rather than histone deacetylase inhibitor., Bioorg Med Chem Lett
    Olsen CA et al., 2009, Discovery of potent and selective histone deacetylase inhibitors via focused combinatorial libraries of cyclic alpha3beta-tetrapeptides., J Med Chem
    Hong S et al., 2015, Efficient synthesis and biological activity of Psammaplin A and its analogues as antitumor agents., Eur J Med Chem
    Shi Y et al., 2007, Induction of GRP78 by valproic acid is dependent upon histone deacetylase inhibition., Bioorg Med Chem Lett
    Fass et al., 2010, Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin., ACS Med Chem Lett
    Benelkebir H et al., 2011, Total synthesis of largazole and analogues: HDAC inhibition, antiproliferative activity and metabolic stability., Bioorg Med Chem
    Bhansali P et al., 2014, Synthesis and biological evaluation of largazole analogues with modified surface recognition cap groups., Eur J Med Chem
  • BELINOSTAT   HDAC7

    Interaction Score: 0.82

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Notes
    Mechanism of Interaction Histone deacetylase inhibitor
    Direct Interaction yes

    PMIDs:
    25937017


    Sources:
    TALC DTC MyCancerGenome TdgClinicalTrial ChemblInteractions

  • TRICHOSTATIN   HDAC7

    Interaction Score: 0.56

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19385600 21055848 19966789 16921367 10592235


    Sources:
    DTC

  • MOCETINOSTAT   HDAC7

    Interaction Score: 0.54

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name MGCD-0103
    Novel drug target Established target

    PMIDs:
    26287310 23829483


    Sources:
    DTC TdgClinicalTrial

  • TACEDINALINE   HDAC7

    Interaction Score: 0.48

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Histone deacetylase inhibitor
    Direct Interaction yes

    PMIDs:
    18692397


    Sources:
    DTC ChemblInteractions

  • COLFORSIN   HDAC7

    Interaction Score: 0.44

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19966789


    Sources:
    DTC

  • VORINOSTAT   HDAC7

    Interaction Score: 0.42

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Notes

    PMIDs:
    23622981 19966789 26211462 21548582 20491440 19084294 22260166 19344175


    Sources:
    TALC DTC MyCancerGenome

  • VALPROIC ACID   HDAC7

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16921367 25304896 18294844


    Sources:
    DTC

  • ENTINOSTAT   HDAC7

    Interaction Score: 0.39

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Histone deacetylase inhibitor
    Direct Interaction yes

    PMIDs:
    20491440 19966789


    Sources:
    DTC ChemblInteractions

  • CUDC-101   HDAC7

    Interaction Score: 0.38

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Notes
    Direct Interaction yes
    Mechanism of Interaction Histone deacetylase inhibitor

    PMIDs:
    None found


    Sources:
    TALC TdgClinicalTrial ChemblInteractions

  • PHENYLBUTYRYLHYDROXAMIC ACID   HDAC7

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21874153


    Sources:
    DTC

  • BUTYRYLHYDROXAMIC ACID   HDAC7

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21874153


    Sources:
    DTC

  • CHEMBL1650245   HDAC7

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24044874


    Sources:
    DTC

  • CHEMBL117487   HDAC7

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17566732


    Sources:
    DTC

  • SUBEROHYDROXAMIC ACID   HDAC7

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16921367


    Sources:
    DTC

  • APICIDIN   HDAC7

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19705846


    Sources:
    DTC

  • CHEMBL324053   HDAC7

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16921367


    Sources:
    DTC

  • BUTANOIC ACID   HDAC7

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19053749


    Sources:
    DTC

  • PANOBINOSTAT   HDAC7

    Interaction Score: 0.31

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name Panobinostat
    Novel drug target Established target
    Notes

    PMIDs:
    None found


    Sources:
    TALC MyCancerGenome TdgClinicalTrial

  • GIVINOSTAT   HDAC7

    Interaction Score: 0.29

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name ITF2357,Givinostat
    Novel drug target Established target
    Notes

    PMIDs:
    None found


    Sources:
    TALC TdgClinicalTrial

  • SCRIPTAID   HDAC7

    Interaction Score: 0.29

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    19966789


    Sources:
    DTC

  • ROMIDEPSIN   HDAC7

    Interaction Score: 0.28

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Histone deacetylase inhibitor
    Direct Interaction yes
    Trial Name Depsipeptide

    PMIDs:
    None found


    Sources:
    MyCancerGenome TdgClinicalTrial ChemblInteractions

  • PSAMMAPLIN A   HDAC7

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25884112


    Sources:
    DTC

  • PHENYLBUTANOIC ACID   HDAC7

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24044874


    Sources:
    DTC

  • LARGAZOLE   HDAC7

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21420302 25203782 20491440


    Sources:
    DTC

  • DEPAKOTE   HDAC7

    Interaction Score: 0.22

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Notes

    PMIDs:
    None found


    Sources:
    TALC

  • AN-9   HDAC7

    Interaction Score: 0.2

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Notes

    PMIDs:
    None found


    Sources:
    TALC

  • PANOBINOSTAT LACTATE   HDAC7

    Interaction Score: 0.18

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Histone deacetylase inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • RESMINOSTAT   HDAC7

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name Resminostat
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • ABEXINOSTAT   HDAC7

    Interaction Score: 0.16

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Notes

    PMIDs:
    None found


    Sources:
    TALC

  • PRACINOSTAT   HDAC7

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name SB939
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • AR-42   HDAC7

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name AR-42
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • 7-ETHYL-10-HYDROXYCAMPTOTHECIN   HDAC7

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23622981


    Sources:
    DTC

  • HINOKITIOL   HDAC7

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • FIMEPINOSTAT   HDAC7

    Interaction Score: 0.1

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Histone deacetylase inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DAUNORUBICIN   HDAC7

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22260166


    Sources:
    DTC

  • Ensembl: ENSG00000061273

    • Version: 101_38

    Alternate Names:
    HDAC7 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: Q8WUI4

    • Version: January-2014

    Alternate Names:
    HDAC7A Gene Symbol
    HDAC7 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:3.5.1.98

    Publications:

  • DTC: HDAC7

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Campbell CT et al., 2008, Targeting pro-invasive oncogenes with short chain fatty acid-hexosamine analogues inhibits the mobility of metastatic MDA-MB-231 breast cancer cells., J Med Chem
    Guerrant W et al., 2012, Dual targeting of histone deacetylase and topoisomerase II with novel bifunctional inhibitors., J Med Chem
    Mimori S et al., 2013, 4-Phenylbutyric acid protects against neuronal cell death by primarily acting as a chemical chaperone rather than histone deacetylase inhibitor., Bioorg Med Chem Lett

  • MyCancerGenome: HDAC7

    • Version: 20-Jun-2017

    Alternate Names:
    51564 Entrez Gene Id
    HDAC7 MyCancerGenome Gene Symbol
    HDAC MyCancerGenome Reported Gene Name

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000061273

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000061273 Gene Symbol
    HDAC7 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: HDAC7A

    • Version: chembl_23

    Alternate Names:
    HDAC7A GENE_SYMBOL
    HDAC7 GENE_SYMBOL
    Histone deacetylase 7 UNIPROT

    Gene Info:

    Publications:

  • TALC: HDAC7

    • Version: 12-May-2016

    Alternate Names:
    HDAC7 Gene Symbol

    Gene Info:

    Publications:

  • ChemblInteractions: HDAC7

    • Version: chembl_23

    Alternate Names:
    HDAC7B GENE_SYMBOL
    HDRP GENE_SYMBOL
    KIAA0744 GENE_SYMBOL

    Gene Info:

    Publications:

  • GO: HDAC7

    • Version: 01-February-2022

    Alternate Names:
    HDAC7A GO Gene Synonym

    Gene Info:

    Gene Categories:
    TRANSCRIPTION FACTOR BINDING

    Publications:

  • TTD: Histone deacetylase 7

    • Version: 2020.06.01

    Alternate Names:
    HDAC7 TTD Gene Abbreviation
    T98698 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: HDAC7

    • Version: 01-February-2022

    Alternate Names:
    Histone deacetylase 7 Gene Name
    Q8WUI4 UniProt ID

    Gene Info:

    Gene Categories:
    TRANSCRIPTION FACTOR

    Publications:

  • FoundationOneGenes: HDAC7

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21