DGIdb - HDAC9 Gene Record

HDAC9 9734 Druggable Genome

Alternate Names:

9734
HISTONE DEACETYLASE 9
HDAC9
HD7
HD7b
HD9
HDAC
HDAC7
HDAC7B
HDAC9B
HDAC9FL
HDRP
MITR
606543
14065
ENSG00000048052
OTTHUMG00000152487
Q9UKV0
KIAA0744
MEF2-interacting transcription repressor MITR
Histone deacetylase 7B
Histone deacetylase-related protein
PA38377
T03687

Gene Info:

Target Class	Enzymes
Target Subclass	EC:3.5.1.98
Gene Biotype	PROTEIN_CODING

(7 More Sources)

Gene Categories: Category Details

TRANSCRIPTION FACTOR COMPLEX
TRANSCRIPTION FACTOR BINDING
DRUGGABLE GENOME
TRANSCRIPTION FACTOR

Publications:

Marson CM et al., 2015, Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit., J Med Chem
Marson CM et al., 2013, Discovery of potent, isoform-selective inhibitors of histone deacetylase containing chiral heterocyclic capping groups and a N-(2-aminophenyl)benzamide binding unit., J Med Chem
Fass et al., 2010, Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin., ACS Med Chem Lett
Herman D et al., 2006, Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia., Nat Chem Biol
Guerrant W et al., 2013, Dual-acting histone deacetylase-topoisomerase I inhibitors., Bioorg Med Chem Lett
Hutt DM et al., 2010, Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis., Nat Chem Biol
Yang W et al., 2015, Design, synthesis and biological evaluation of isoquinoline-based derivatives as novel histone deacetylase inhibitors., Bioorg Med Chem
Neelarapu R et al., 2011, Design, synthesis, docking, and biological evaluation of novel diazide-containing isoxazole- and pyrazole-based histone deacetylase probes., J Med Chem
Souto JA et al., 2010, Synthesis and biological characterization of the histone deacetylase inhibitor largazole and C7- modified analogues., J Med Chem
Dallavalle S et al., 2009, Design, synthesis, and evaluation of biphenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors., Eur J Med Chem
Guerrant W et al., 2012, Dual targeting of histone deacetylase and topoisomerase II with novel bifunctional inhibitors., J Med Chem
Grolla AA et al., 2009, Synthesis, biological evaluation, and molecular docking of Ugi products containing a zinc-chelating moiety as novel inhibitors of histone deacetylases., J Med Chem
Kozlov MV et al., 2015, Pyridine hydroxamic acids are specific anti-HCV agents affecting HDAC6., Bioorg Med Chem Lett
Shi Y et al., 2007, Induction of GRP78 by valproic acid is dependent upon histone deacetylase inhibition., Bioorg Med Chem Lett
Mimori S et al., 2013, 4-Phenylbutyric acid protects against neuronal cell death by primarily acting as a chemical chaperone rather than histone deacetylase inhibitor., Bioorg Med Chem Lett
Campbell CT et al., 2008, Targeting pro-invasive oncogenes with short chain fatty acid-hexosamine analogues inhibits the mobility of metastatic MDA-MB-231 breast cancer cells., J Med Chem
Olsen CA et al., 2009, Discovery of potent and selective histone deacetylase inhibitors via focused combinatorial libraries of cyclic alpha3beta-tetrapeptides., J Med Chem
Charrier C et al., 2009, Synthesis and modeling of new benzofuranone histone deacetylase inhibitors that stimulate tumor suppressor gene expression., J Med Chem
Marrazzo A et al., 2011, Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(±)-MRJF4] in prostate cancer cells., Eur J Med Chem
Petrelli R et al., 2014, From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase: synthesis and biological evaluation of valproic esters of 3'-C-methyladenosine., Bioorg Med Chem Lett
Perrino E et al., 2008, New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity., Bioorg Med Chem Lett
Hong S et al., 2015, Efficient synthesis and biological activity of Psammaplin A and its analogues as antitumor agents., Eur J Med Chem
Benelkebir H et al., 2011, Total synthesis of largazole and analogues: HDAC inhibition, antiproliferative activity and metabolic stability., Bioorg Med Chem
Bhansali P et al., 2014, Synthesis and biological evaluation of largazole analogues with modified surface recognition cap groups., Eur J Med Chem
Thomas M et al., 2008, Synthesis and biological evaluation of glucuronide prodrugs of the histone deacetylase inhibitor CI-994 for application in selective cancer chemotherapy., Bioorg Med Chem

BELINOSTAT HDAC9

Interaction Score: 0.74

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Trial Name PXD101

Novel drug target Established target

PMIDs:
25937017

Sources:
TALC DTC MyCancerGenome TdgClinicalTrial
MOCETINOSTAT HDAC9

Interaction Score: 0.59

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name MGCD-0103

Novel drug target Established target

PMIDs:
26287310 23829483

Sources:
DTC TdgClinicalTrial
TRICHOSTATIN HDAC9

Interaction Score: 0.51

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19966789 19385600 21055848 16921367

Sources:
DTC
VORINOSTAT HDAC9

Interaction Score: 0.5

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

PMIDs:
23622981 19966789 26211462 21548582 20491440 19084294 22260166 19344175

Sources:
TALC DTC MyCancerGenome ClearityFoundationClinicalTrial
VALPROIC ACID HDAC9

Interaction Score: 0.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16921367 25304896 18294844

Sources:
DTC
TACEDINALINE HDAC9

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18692397

Sources:
DTC
PHENYLBUTYRYLHYDROXAMIC ACID HDAC9

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21874153

Sources:
DTC
APICIDIN HDAC9

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19705846

Sources:
DTC
BUTANOIC ACID HDAC9

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19053749

Sources:
DTC
CHEMBL1650245 HDAC9

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24044874

Sources:
DTC
CHEMBL117487 HDAC9

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17566732

Sources:
DTC
CHEMBL324053 HDAC9

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16921367

Sources:
DTC
SUBEROHYDROXAMIC ACID HDAC9

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16921367

Sources:
DTC
BUTYRYLHYDROXAMIC ACID HDAC9

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21874153

Sources:
DTC
PANOBINOSTAT HDAC9

Interaction Score: 0.34

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Panobinostat

Novel drug target Established target

Notes

PMIDs:
None found

Sources:
TALC MyCancerGenome TdgClinicalTrial
SCRIPTAID HDAC9

Interaction Score: 0.32

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
19966789

Sources:
DTC
ENTINOSTAT HDAC9

Interaction Score: 0.32

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
20491440 19966789

Sources:
DTC
GIVINOSTAT HDAC9

Interaction Score: 0.32

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Novel drug target Established target

Trial Name ITF2357,Givinostat

PMIDs:
None found

Sources:
TALC TdgClinicalTrial
PSAMMAPLIN A HDAC9

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25884112

Sources:
DTC
PHENYLBUTANOIC ACID HDAC9

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24044874

Sources:
DTC
CUDC-101 HDAC9

Interaction Score: 0.28

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Trial Name CUDC-101

Novel drug target Established target

PMIDs:
None found

Sources:
TALC TdgClinicalTrial
LARGAZOLE HDAC9

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20491440 21420302 25203782

Sources:
DTC
DEPAKOTE HDAC9

Interaction Score: 0.24

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

PMIDs:
None found

Sources:
TALC
AN-9 HDAC9

Interaction Score: 0.21

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

PMIDs:
None found

Sources:
TALC
ROMIDEPSIN HDAC9

Interaction Score: 0.2

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Depsipeptide

Novel drug target Established target

PMIDs:
None found

Sources:
MyCancerGenome TdgClinicalTrial
RESMINOSTAT HDAC9

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Resminostat

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
ABEXINOSTAT HDAC9

Interaction Score: 0.18

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

PMIDs:
None found

Sources:
TALC
AR-42 HDAC9

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name AR-42

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
PRACINOSTAT HDAC9

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name SB939

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
7-ETHYL-10-HYDROXYCAMPTOTHECIN HDAC9

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23622981

Sources:
DTC
HINOKITIOL HDAC9

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DAUNORUBICIN HDAC9

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22260166

Sources:
DTC

Ensembl: ENSG00000048052
- Version: 101_38
Alternate Names:

HDAC9 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: Q9UKV0
- Version: January-2014
Alternate Names:

HDAC9 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.5.1.98

Publications:
PharmGKB: HDAC9
- Version: 18-August-2020
Alternate Names:

PA38377 PharmGKB ID

Gene Info:

Publications:

Ghodke-Puranik Y et al., 2013, Valproic acid pathway: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics

DTC: HDAC9

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Fass et al., 2010, Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin., ACS Med Chem Lett

Herman D et al., 2006, Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia., Nat Chem Biol

Guerrant W et al., 2012, Dual targeting of histone deacetylase and topoisomerase II with novel bifunctional inhibitors., J Med Chem

TALC: HDAC9
- Version: 12-May-2016
Alternate Names:

HDAC9 Gene Symbol

Gene Info:

Publications:
MyCancerGenome: HDAC9
- Version: 20-Jun-2017
Alternate Names:

HDAC MyCancerGenome Reported Gene Name

9734 Entrez Gene Id

HDAC9 MyCancerGenome Gene Symbol

Gene Info:

Publications:
HingoraniCasas: ENSG00000048052
- Version: 31-May-2017
Alternate Names:

ENSG00000048052 Gene Symbol

HDAC9 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
GO: HDAC9
- Version: 01-February-2022
Alternate Names:

HDAC7 GO Gene Synonym

HDAC7B GO Gene Synonym

HDRP GO Gene Synonym

Gene Info:

Gene Categories:

TRANSCRIPTION FACTOR COMPLEX, TRANSCRIPTION FACTOR BINDING

Publications:
TTD: Histone deacetylase 9
- Version: 2020.06.01
Alternate Names:

HDAC9 TTD Gene Abbreviation

T03687 TTD Target ID

Gene Info:

Publications:
Pharos: HDAC9
- Version: 01-February-2022
Alternate Names:

Histone deacetylase 9 Gene Name

Q9UKV0 UniProt ID

Gene Info:

Gene Categories:

TRANSCRIPTION FACTOR

Publications:
ClearityFoundationClinicalTrial: HDAC9
- Version: 15-June-2013
Alternate Names:

Gene Info:

Publications:

Trial Name	Panobinostat
Novel drug target	Established target
Notes

HDAC	MyCancerGenome Reported Gene Name
9734	Entrez Gene Id
HDAC9	MyCancerGenome Gene Symbol

HDAC7	GO Gene Synonym
HDAC7B	GO Gene Synonym
HDRP	GO Gene Synonym

HDAC9 Gene Record

HDAC9 9734 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Notes Trial Name PXD101 Novel drug target Established target

PMIDs: 25937017

Sources: TALC DTC MyCancerGenome TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info: Trial Name MGCD-0103 Novel drug target Established target

PMIDs: 26287310 23829483

Sources: DTC TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19966789 19385600 21055848 16921367

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Notes

PMIDs: 23622981 19966789 26211462 21548582 20491440 19084294 22260166 19344175

Sources: TALC DTC MyCancerGenome ClearityFoundationClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16921367 25304896 18294844

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18692397

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21874153

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19705846

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19053749

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24044874

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17566732

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16921367

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16921367

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21874153

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name Panobinostat Novel drug target Established target Notes

PMIDs: None found

Sources: TALC MyCancerGenome TdgClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 19966789

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 20491440 19966789

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Notes Novel drug target Established target Trial Name ITF2357,Givinostat

PMIDs: None found

Sources: TALC TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Trial Name PXD101

Novel drug target Established target

PMIDs:
25937017

Sources:
TALC DTC MyCancerGenome TdgClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name MGCD-0103

Novel drug target Established target

PMIDs:
26287310 23829483

Sources:
DTC TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
19966789 19385600 21055848 16921367

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

PMIDs:
23622981 19966789 26211462 21548582 20491440 19084294 22260166 19344175

Sources:
TALC DTC MyCancerGenome ClearityFoundationClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
16921367 25304896 18294844

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
18692397

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21874153

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19705846

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19053749

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
24044874

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
17566732

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16921367

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16921367

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21874153

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Panobinostat

Novel drug target Established target

Notes

PMIDs:
None found

Sources:
TALC MyCancerGenome TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
19966789

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
20491440 19966789

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Novel drug target Established target

Trial Name ITF2357,Givinostat

PMIDs:
None found

Sources:
TALC TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
25884112

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
24044874

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Trial Name CUDC-101

Novel drug target Established target

PMIDs:
None found

Sources:
TALC TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
20491440 21420302 25203782

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

PMIDs:
None found

Sources:
TALC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

PMIDs:
None found

Sources:
TALC