DGIdb - HLA-C Gene Record

HLA-C 3107 Druggable GenomeDrug Resistance

Alternate Names:

3107
MAJOR HISTOCOMPATIBILITY COMPLEX, CLASS I, C
HLA-C
D6S204
HLA-JY3
HLAC
HLC-C
MHC
PSORS1
142840
4933
ENSG00000204525
OTTHUMG00000031154
2608
PA35057

Gene Info:

Gene Biotype	PROTEIN_CODING

(2 More Sources)

Gene Categories: Category Details

CELL SURFACE
DRUG RESISTANCE
DRUGGABLE GENOME

Publications:

Cirulli ET et al., 2019, A Missense Variant in PTPN22 is a Risk Factor for Drug-induced Liver Injury., Gastroenterology
Indhumathi S et al., 2017, Pharmacogenetic markers to predict the clinical response to methotrexate in south Indian Tamil patients with psoriasis., Eur J Clin Pharmacol
Talamonti M et al., 2013, Pharmacogenetics of psoriasis: HLA-Cw6 but not LCE3B/3C deletion nor TNFAIP3 polymorphism predisposes to clinical response to interleukin 12/23 blocker ustekinumab., Br J Dermatol
Dettling M et al., 2001, Further evidence of human leukocyte antigen-encoded susceptibility to clozapine-induced agranulocytosis independent of ancestry., Pharmacogenetics
Tangamornsuksan W et al., 2019, Association between HLA-B*5901 and methazolamide-induced Stevens-Johnson syndrome/toxic epidermal necrolysis: a systematic review and meta-analysis., Pharmacogenomics J
Yang F et al., 2016, HLA-B*59:01: a marker for Stevens-Johnson syndrome/toxic epidermal necrolysis caused by methazolamide in Han Chinese., Pharmacogenomics J
Kim SH et al., 2010, HLA-B*5901 is strongly associated with methazolamide-induced Stevens-Johnson syndrome/toxic epidermal necrolysis., Pharmacogenomics
Kazeem GR et al., 2009, High-resolution HLA genotyping and severe cutaneous adverse reactions in lamotrigine-treated patients., Pharmacogenet Genomics
Björn N et al., 2020, Genes and variants in hematopoiesis-related pathways are associated with gemcitabine/carboplatin-induced thrombocytopenia., Pharmacogenomics J
Hirata K et al., 2008, Ticlopidine-induced hepatotoxicity is associated with specific human leukocyte antigen genomic subtypes in Japanese patients: a preliminary case-control study., Pharmacogenomics J

METHAZOLAMIDE HLA-C

Interaction Score: 2.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
30242287 25918017 20504258

Sources:
PharmGKB
CLAVULANIC ACID HLA-C

Interaction Score: 1.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
30664875

Sources:
PharmGKB
FLOXACILLIN HLA-C

Interaction Score: 1.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
30664875

Sources:
PharmGKB
USTEKINUMAB HLA-C

Interaction Score: 1.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23521149

Sources:
PharmGKB
TICLOPIDINE HLA-C

Interaction Score: 0.79

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17339877

Sources:
PharmGKB
AMOXICILLIN HLA-C

Interaction Score: 0.61

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
30664875

Sources:
PharmGKB
LAMOTRIGINE HLA-C

Interaction Score: 0.4

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19668019

Sources:
PharmGKB
CLOZAPINE HLA-C

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11266078

Sources:
PharmGKB
RIBAVIRIN HLA-C

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
CARBOPLATIN HLA-C

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
31616045

Sources:
PharmGKB
GEMCITABINE HLA-C

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
31616045

Sources:
PharmGKB
METHOTREXATE HLA-C

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
28444425

Sources:
PharmGKB

Ensembl: ENSG00000204525
- Version: 101_38
Alternate Names:

HLA-C Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

PharmGKB: HLA-C

Version: 18-August-2020

Alternate Names:

PA35057 PharmGKB ID

Gene Info:

Publications:

Dettling M et al., 2001, Further evidence of human leukocyte antigen-encoded susceptibility to clozapine-induced agranulocytosis independent of ancestry., Pharmacogenetics

Kim SH et al., 2013, Antituberculosis drug-induced hypersensitivity syndrome and its association with human leukocyte antigen., Tuberculosis (Edinb)

Prieto-Pérez R et al., 2018, New polymorphisms associated with response to anti-TNF drugs in patients with moderate-to-severe plaque psoriasis., Pharmacogenomics J

CIViC: HLA-C
- Version: 14-September-2020
Alternate Names:

3107 Entrez Gene ID

2608 CIViC Gene ID

Gene Info:

Gene Categories:

DRUG RESISTANCE

Publications:

Tran et al., 2016, T-Cell Transfer Therapy Targeting Mutant KRAS in Cancer., N. Engl. J. Med.
HingoraniCasas: ENSG00000204525
- Version: 31-May-2017
Alternate Names:

ENSG00000204525 Gene Symbol

HLA-C Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
GO: HLA-C
- Version: 01-February-2022
Alternate Names:

HLAC GO Gene Synonym

Gene Info:

Gene Categories:

CELL SURFACE

Publications:
Tempus: HLA-C
- Version: 11-November-2018
Alternate Names:

HLA-C Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

HLA-C Gene Record

HLA-C 3107 Druggable GenomeDrug Resistance

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 30242287 25918017 20504258

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 30664875

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 30664875

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23521149

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17339877

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 30664875

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19668019

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11266078

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 31616045

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 31616045

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 28444425

Sources: PharmGKB

Ensembl: ENSG00000204525

Alternate Names: HLA-C Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

PharmGKB: HLA-C

Alternate Names: PA35057 PharmGKB ID

Gene Info:

CIViC: HLA-C

Alternate Names: 3107 Entrez Gene ID 2608 CIViC Gene ID

Gene Info:

Gene Categories: DRUG RESISTANCE

Publications: Tran et al., 2016, T-Cell Transfer Therapy Targeting Mutant KRAS in Cancer., N. Engl. J. Med.

HingoraniCasas: ENSG00000204525

Alternate Names: ENSG00000204525 Gene Symbol HLA-C Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

GO: HLA-C

Alternate Names: HLAC GO Gene Synonym

Gene Info:

Gene Categories: CELL SURFACE

Publications:

Tempus: HLA-C

Alternate Names: HLA-C Gene Symbol

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Interaction Types & Directionality:

n/a

PMIDs:
30242287 25918017 20504258

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
30664875

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
30664875

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
23521149

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
17339877

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
30664875

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
19668019

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
11266078

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
31616045

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
31616045

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
28444425

Sources:
PharmGKB

Alternate Names:

HLA-C Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

PA35057 PharmGKB ID

Alternate Names:

3107 Entrez Gene ID

2608 CIViC Gene ID

Gene Categories:

DRUG RESISTANCE

Publications:

Tran et al., 2016, T-Cell Transfer Therapy Targeting Mutant KRAS in Cancer., N. Engl. J. Med.

Alternate Names:

ENSG00000204525 Gene Symbol

HLA-C Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

HLAC GO Gene Synonym

Gene Categories:

CELL SURFACE

Alternate Names:

HLA-C Gene Symbol

Gene Categories:

CLINICALLY ACTIONABLE