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HLA-C Gene Record

  • Summary
  • Interactions
  • Claims
  • HLA-C 3107 Druggable GenomeDrug Resistance

    Alternate Names:

    3107
    MAJOR HISTOCOMPATIBILITY COMPLEX, CLASS I, C
    HLA-C
    D6S204
    HLA-JY3
    HLAC
    HLC-C
    MHC
    PSORS1
    142840
    4933
    ENSG00000204525
    OTTHUMG00000031154
    2608
    PA35057

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (2 More Sources)

    Gene Categories: Category Details

    CELL SURFACE
    DRUG RESISTANCE
    DRUGGABLE GENOME

    Publications:

    Cirulli ET et al., 2019, A Missense Variant in PTPN22 is a Risk Factor for Drug-induced Liver Injury., Gastroenterology
    Indhumathi S et al., 2017, Pharmacogenetic markers to predict the clinical response to methotrexate in south Indian Tamil patients with psoriasis., Eur J Clin Pharmacol
    Talamonti M et al., 2013, Pharmacogenetics of psoriasis: HLA-Cw6 but not LCE3B/3C deletion nor TNFAIP3 polymorphism predisposes to clinical response to interleukin 12/23 blocker ustekinumab., Br J Dermatol
    Dettling M et al., 2001, Further evidence of human leukocyte antigen-encoded susceptibility to clozapine-induced agranulocytosis independent of ancestry., Pharmacogenetics
    Tangamornsuksan W et al., 2019, Association between HLA-B*5901 and methazolamide-induced Stevens-Johnson syndrome/toxic epidermal necrolysis: a systematic review and meta-analysis., Pharmacogenomics J
    Yang F et al., 2016, HLA-B*59:01: a marker for Stevens-Johnson syndrome/toxic epidermal necrolysis caused by methazolamide in Han Chinese., Pharmacogenomics J
    Kim SH et al., 2010, HLA-B*5901 is strongly associated with methazolamide-induced Stevens-Johnson syndrome/toxic epidermal necrolysis., Pharmacogenomics
    Kazeem GR et al., 2009, High-resolution HLA genotyping and severe cutaneous adverse reactions in lamotrigine-treated patients., Pharmacogenet Genomics
    Björn N et al., 2020, Genes and variants in hematopoiesis-related pathways are associated with gemcitabine/carboplatin-induced thrombocytopenia., Pharmacogenomics J
    Hirata K et al., 2008, Ticlopidine-induced hepatotoxicity is associated with specific human leukocyte antigen genomic subtypes in Japanese patients: a preliminary case-control study., Pharmacogenomics J
  • METHAZOLAMIDE   HLA-C

    Interaction Score: 2.58

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    30242287 25918017 20504258


    Sources:
    PharmGKB

  • CLAVULANIC ACID   HLA-C

    Interaction Score: 1.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    30664875


    Sources:
    PharmGKB

  • FLOXACILLIN   HLA-C

    Interaction Score: 1.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    30664875


    Sources:
    PharmGKB

  • USTEKINUMAB   HLA-C

    Interaction Score: 1.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23521149


    Sources:
    PharmGKB

  • TICLOPIDINE   HLA-C

    Interaction Score: 0.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17339877


    Sources:
    PharmGKB

  • AMOXICILLIN   HLA-C

    Interaction Score: 0.61

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    30664875


    Sources:
    PharmGKB

  • LAMOTRIGINE   HLA-C

    Interaction Score: 0.4

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19668019


    Sources:
    PharmGKB

  • CLOZAPINE   HLA-C

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11266078


    Sources:
    PharmGKB

  • RIBAVIRIN   HLA-C

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • CARBOPLATIN   HLA-C

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    31616045


    Sources:
    PharmGKB

  • GEMCITABINE   HLA-C

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    31616045


    Sources:
    PharmGKB

  • METHOTREXATE   HLA-C

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28444425


    Sources:
    PharmGKB

  • Ensembl: ENSG00000204525

    • Version: 101_38

    Alternate Names:
    HLA-C Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: HLA-C

    • Version: 18-August-2020

    Alternate Names:
    PA35057 PharmGKB ID

    Gene Info:

    Publications:
    Dettling M et al., 2001, Further evidence of human leukocyte antigen-encoded susceptibility to clozapine-induced agranulocytosis independent of ancestry., Pharmacogenetics
    Kim SH et al., 2013, Antituberculosis drug-induced hypersensitivity syndrome and its association with human leukocyte antigen., Tuberculosis (Edinb)
    Prieto-Pérez R et al., 2018, New polymorphisms associated with response to anti-TNF drugs in patients with moderate-to-severe plaque psoriasis., Pharmacogenomics J

  • CIViC: HLA-C

    • Version: 14-September-2020

    Alternate Names:
    3107 Entrez Gene ID
    2608 CIViC Gene ID

    Gene Info:

    Gene Categories:
    DRUG RESISTANCE

    Publications:
    Tran et al., 2016, T-Cell Transfer Therapy Targeting Mutant KRAS in Cancer., N. Engl. J. Med.

  • HingoraniCasas: ENSG00000204525

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000204525 Gene Symbol
    HLA-C Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: HLA-C

    • Version: 01-February-2022

    Alternate Names:
    HLAC GO Gene Synonym

    Gene Info:

    Gene Categories:
    CELL SURFACE

    Publications:

  • Tempus: HLA-C

    • Version: 11-November-2018

    Alternate Names:
    HLA-C Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21