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HLA-DQB1 Gene Record

  • Summary
  • Interactions
  • Claims
  • HLA-DQB1 3119

    Alternate Names:

    3119
    MAJOR HISTOCOMPATIBILITY COMPLEX, CLASS II, DQ BETA 1
    HLA-DQB1
    CELIAC1
    HLA-DQB
    IDDM1
    604305
    4944
    ENSG00000179344
    OTTHUMG00000031124
    PA35068

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (0 More Sources)

    Gene Categories: Category Details

    Publications:

    Hirata K et al., 2008, Ticlopidine-induced hepatotoxicity is associated with specific human leukocyte antigen genomic subtypes in Japanese patients: a preliminary case-control study., Pharmacogenomics J
    He XJ et al., 2013, Association between the HLA-B*15:02 allele and carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis in Han individuals of northeastern China., Pharmacol Rep
    Cirulli ET et al., 2019, A Missense Variant in PTPN22 is a Risk Factor for Drug-induced Liver Injury., Gastroenterology
    Hautekeete ML et al., 1999, HLA association of amoxicillin-clavulanate--induced hepatitis., Gastroenterology
    Cristallo AF et al., 2011, A study of HLA class I and class II 4-digit allele level in Stevens-Johnson syndrome and toxic epidermal necrolysis., Int J Immunogenet
    Nicoletti P et al., 2016, HLA-DRB1*16: 01-DQB1*05: 02 is a novel genetic risk factor for flupirtine-induced liver injury., Pharmacogenet Genomics
    Kazeem GR et al., 2009, High-resolution HLA genotyping and severe cutaneous adverse reactions in lamotrigine-treated patients., Pharmacogenet Genomics
    Singer JB et al., 2010, A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injury., Nat Genet
    Esmaeilzadeh H et al., 2015, Pharmacogenetic tests to predict the efficacy of aspirin desensitization in patients with aspirin-exacerbated respiratory diseases; HLA-DQB302., Expert Rev Respir Med
    Lee HY et al., 2009, The HLA allele marker for differentiating ASA hypersensitivity phenotypes., Allergy
    Kim SH et al., 2005, The human leucocyte antigen-DRB1*1302-DQB1*0609-DPB1*0201 haplotype may be a strong genetic marker for aspirin-induced urticaria., Clin Exp Allergy
  • LUMIRACOXIB   HLA-DQB1

    Interaction Score: 2.58

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20639878


    Sources:
    PharmGKB

  • BUCILLAMINE   HLA-DQB1

    Interaction Score: 2.58

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • CLAVULANIC ACID   HLA-DQB1

    Interaction Score: 2.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    30664875 10535882


    Sources:
    PharmGKB

  • FLOXACILLIN   HLA-DQB1

    Interaction Score: 1.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    30664875


    Sources:
    PharmGKB

  • AMOXICILLIN   HLA-DQB1

    Interaction Score: 0.91

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    30664875 10535882


    Sources:
    PharmGKB

  • TICLOPIDINE   HLA-DQB1

    Interaction Score: 0.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17339877


    Sources:
    PharmGKB

  • FLUPIRTINE   HLA-DQB1

    Interaction Score: 0.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26959717


    Sources:
    PharmGKB

  • LAMOTRIGINE   HLA-DQB1

    Interaction Score: 0.4

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19668019


    Sources:
    PharmGKB

  • ASPIRIN   HLA-DQB1

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26366802 19392989 15784113


    Sources:
    PharmGKB

  • ACETAMINOPHEN   HLA-DQB1

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21545408


    Sources:
    PharmGKB

  • NEVIRAPINE   HLA-DQB1

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • CARBAMAZEPINE   HLA-DQB1

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24399721


    Sources:
    PharmGKB

  • Ensembl: ENSG00000179344

    • Version: 101_38

    Alternate Names:
    HLA-DQB1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: HLA-DQB1

    • Version: 18-August-2020

    Alternate Names:
    PA35068 PharmGKB ID

    Gene Info:

    Publications:
    Hautekeete ML et al., 1999, HLA association of amoxicillin-clavulanate--induced hepatitis., Gastroenterology
    Cirulli ET et al., 2019, A Missense Variant in PTPN22 is a Risk Factor for Drug-induced Liver Injury., Gastroenterology
    Chen R et al., 2015, The association between HLA-DQB1 polymorphism and antituberculosis drug-induced liver injury: a Case-Control Study., J Clin Pharm Ther

  • Tempus: HLA-DQB1

    • Version: 11-November-2018

    Alternate Names:
    HLA-DQB1 Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21