DGIdb - HLA-DRB1 Gene Record

HLA-DRB1 3123 Druggable Genome

Alternate Names:

3123
MAJOR HISTOCOMPATIBILITY COMPLEX, CLASS II, DR BETA 1
HLA-DRB1
DRB1
HLA-DR1B
HLA-DRB
SS1
142857
4948
ENSG00000196126
OTTHUMG00000031196
MHC class II antigen DRB1*10
DRw10
HLA class II histocompatibility antigen, DRB1-10 beta chain
PA35072
HLA class II antigen DR10
T99532
MHC class II antigen DRB1*1
T83611

Gene Info:

Gene Biotype	PROTEIN_CODING

(5 More Sources)

Gene Categories: Category Details

CELL SURFACE
EXTERNAL SIDE OF PLASMA MEMBRANE
DRUGGABLE GENOME

Publications:

Nicoletti P et al., 2016, HLA-DRB116: 01-DQB105: 02 is a novel genetic risk factor for flupirtine-induced liver injury., Pharmacogenet Genomics
Sai K et al., 2016, A possible role for HLA-DRB1*04:06 in statin-related myopathy in Japanese patients., Drug Metab Pharmacokinet
Lee HY et al., 2009, The HLA allele marker for differentiating ASA hypersensitivity phenotypes., Allergy
Kim SH et al., 2005, The human leucocyte antigen-DRB11302-DQB10609-DPB1*0201 haplotype may be a strong genetic marker for aspirin-induced urticaria., Clin Exp Allergy
Vitezica ZG et al., 2008, HLA-DRB1*01 associated with cutaneous hypersensitivity induced by nevirapine and efavirenz., AIDS
Spraggs CF et al., 2018, Characterisation of the HLA-DRB1*07:01 biomarker for lapatinib-induced liver toxicity during treatment of early-stage breast cancer patients with lapatinib in combination with trastuzumab and/or taxanes., Pharmacogenomics J
Schaid DJ et al., 2014, Prospective validation of HLA-DRB1*07:01 allele carriage as a predictive risk factor for lapatinib-induced liver injury., J Clin Oncol
Kulkarni D et al., 2016, Pyrexia in dabrafenib-treated melanoma patients is not associated with common genetic variation or HLA polymorphisms., Pharmacogenomics
Fernandez CA et al., 2015, Genome-wide analysis links NFATC2 with asparaginase hypersensitivity., Blood
Fernandez CA et al., 2014, HLA-DRB1*07:01 is associated with a higher risk of asparaginase allergies., Blood
Yue Z et al., 2018, Amino Acid Variants of HLA-DRB1 Confer Susceptibility to Dapsone Hypersensitivity Syndrome in Addition to HLA-B*13:01., J Invest Dermatol
Singer JB et al., 2010, A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injury., Nat Genet
He XJ et al., 2013, Association between the HLA-B*15:02 allele and carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis in Han individuals of northeastern China., Pharmacol Rep
Li LJ et al., 2013, Predictive markers for carbamazepine and lamotrigine-induced maculopapular exanthema in Han Chinese., Epilepsy Res
Cirulli ET et al., 2019, A Missense Variant in PTPN22 is a Risk Factor for Drug-induced Liver Injury., Gastroenterology
Donaldson PT et al., 2010, Human leucocyte antigen class II genotype in susceptibility and resistance to co-amoxiclav-induced liver injury., J Hepatol
Hautekeete ML et al., 1999, HLA association of amoxicillin-clavulanate--induced hepatitis., Gastroenterology
Moon J et al., 2016, HLA-B40:02 and DRB104:03 are risk factors for oxcarbazepine-induced maculopapular eruption., Epilepsia
Kazeem GR et al., 2009, High-resolution HLA genotyping and severe cutaneous adverse reactions in lamotrigine-treated patients., Pharmacogenet Genomics
Heap GA et al., 2014, HLA-DQA1-HLA-DRB1 variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants., Nat Genet
Hirata K et al., 2008, Ticlopidine-induced hepatotoxicity is associated with specific human leukocyte antigen genomic subtypes in Japanese patients: a preliminary case-control study., Pharmacogenomics J

LYM-1 HLA-DRB1

Interaction Score: 3.99

Interaction Types & Directionality:

n/a

Interaction Info:

Direct Interaction yes

Mechanism of Interaction HLA class II histocompatibility antigen, DRB1-10 beta chain other

PMIDs:
None found

Sources:
ChemblInteractions TTD
CLAVULANIC ACID HLA-DRB1

Interaction Score: 1.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
30664875 20800921 10535882

Sources:
PharmGKB
LUMIRACOXIB HLA-DRB1

Interaction Score: 1.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20639878

Sources:
PharmGKB
BUCILLAMINE HLA-DRB1

Interaction Score: 1.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
PITAVASTATIN HLA-DRB1

Interaction Score: 1.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27839692

Sources:
PharmGKB
FLOXACILLIN HLA-DRB1

Interaction Score: 0.57

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
30664875

Sources:
PharmGKB
AMOXICILLIN HLA-DRB1

Interaction Score: 0.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
30664875 20800921 10535882

Sources:
PharmGKB
DAPSONE HLA-DRB1

Interaction Score: 0.4

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29233746

Sources:
PharmGKB
ASPARAGINASE HLA-DRB1

Interaction Score: 0.4

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25987655 24970932

Sources:
PharmGKB
CARBIMAZOLE HLA-DRB1

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
TICLOPIDINE HLA-DRB1

Interaction Score: 0.31

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17339877

Sources:
PharmGKB
ROSUVASTATIN HLA-DRB1

Interaction Score: 0.31

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27839692

Sources:
PharmGKB
LAPATINIB HLA-DRB1

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
28786423 24687830

Sources:
PharmGKB FDA
FLUPIRTINE HLA-DRB1

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26959717

Sources:
PharmGKB
DABRAFENIB HLA-DRB1

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27023328

Sources:
PharmGKB
OXCARBAZEPINE HLA-DRB1

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27666425

Sources:
PharmGKB
EFAVIRENZ HLA-DRB1

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18301070

Sources:
PharmGKB
FLUVASTATIN HLA-DRB1

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27839692

Sources:
PharmGKB
AZATHIOPRINE HLA-DRB1

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25217962

Sources:
PharmGKB
LAMOTRIGINE HLA-DRB1

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19668019

Sources:
PharmGKB
CARBAMAZEPINE HLA-DRB1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24399721 23830818

Sources:
PharmGKB
PROPYLTHIOURACIL HLA-DRB1

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
ADALIMUMAB HLA-DRB1

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
PRAVASTATIN HLA-DRB1

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27839692

Sources:
PharmGKB
MERCAPTOPURINE HLA-DRB1

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25217962

Sources:
PharmGKB
METHIMAZOLE HLA-DRB1

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
ETANERCEPT HLA-DRB1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
INFLIXIMAB HLA-DRB1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
ASPIRIN HLA-DRB1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19392989 15784113

Sources:
PharmGKB
SIMVASTATIN HLA-DRB1

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27839692

Sources:
PharmGKB
ATORVASTATIN HLA-DRB1

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27839692

Sources:
PharmGKB

Ensembl: ENSG00000196126
- Version: 101_38
Alternate Names:

HLA-DRB1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

PharmGKB: HLA-DRB1

Version: 18-August-2020

Alternate Names:

PA35072 PharmGKB ID

Gene Info:

Publications:

Nicoletti P et al., 2016, HLA-DRB116: 01-DQB105: 02 is a novel genetic risk factor for flupirtine-induced liver injury., Pharmacogenet Genomics

Sai K et al., 2016, A possible role for HLA-DRB104:06 in statin-related myopathy in Japanese patients., Drug Metab Pharmacokinet

Schaid DJ et al., 2014, Prospective validation of HLA-DRB107:01 allele carriage as a predictive risk factor for lapatinib-induced liver injury., J Clin Oncol

HingoraniCasas: ENSG00000196126
- Version: 31-May-2017
Alternate Names:

ENSG00000196126 Gene Symbol

HLA-DRB1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: HLA-DRB1
- Version: chembl_23
Alternate Names:

HLA-DRB1 GENE_SYMBOL

HLA class II histocompatibility antigen, DRB1-10 beta chain UNIPROT

DRw10 UNIPROT

Gene Info:

Publications:
Tempus: HLA-DRB1
- Version: 11-November-2018
Alternate Names:

HLA-DRB1 Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
TTD: MHC class II antigen DRB1*1
- Version: 2020.06.01
Alternate Names:

HLA-DRB1 TTD Gene Abbreviation

T83611 TTD Target ID

Gene Info:

Publications:
TTD: HLA class II antigen DR10
- Version: 2020.06.01
Alternate Names:

HLA-DRB1 TTD Gene Abbreviation

T99532 TTD Target ID

Gene Info:

Publications:
FDA: HLA-DRB1
- Version: 04-September-2020
Alternate Names:

Gene Info:

Publications:
GO: HLA-DRB1
- Version: 01-February-2022
Alternate Names:

Gene Info:

Gene Categories:

CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:

Direct Interaction	yes
Mechanism of Interaction	HLA class II histocompatibility antigen, DRB1-10 beta chain other

HLA-DRB1	GENE_SYMBOL
HLA class II histocompatibility antigen, DRB1-10 beta chain	UNIPROT
DRw10	UNIPROT

HLA-DRB1 Gene Record

HLA-DRB1 3123 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info: Direct Interaction yes Mechanism of Interaction HLA class II histocompatibility antigen, DRB1-10 beta chain other

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 30664875 20800921 10535882

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20639878

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27839692

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 30664875

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 30664875 20800921 10535882

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29233746

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25987655 24970932

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17339877

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27839692

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 28786423 24687830

Sources: PharmGKB FDA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26959717

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27023328

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27666425

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18301070

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27839692

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

Interaction Info:

Direct Interaction yes

Mechanism of Interaction HLA class II histocompatibility antigen, DRB1-10 beta chain other

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
30664875 20800921 10535882

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
20639878

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
27839692

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
30664875

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
30664875 20800921 10535882

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
29233746

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
25987655 24970932

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
17339877

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
27839692

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
28786423 24687830

Sources:
PharmGKB FDA

Interaction Types & Directionality:

n/a

PMIDs:
26959717

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
27023328

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
27666425

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
18301070

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
27839692

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
25217962

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
19668019

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
24399721 23830818

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
27839692

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
25217962

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a