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HLA-DRB1 Gene Record

  • Summary
  • Interactions
  • Claims
  • HLA-DRB1 3123 Druggable Genome

    Alternate Names:

    3123
    MAJOR HISTOCOMPATIBILITY COMPLEX, CLASS II, DR BETA 1
    HLA-DRB1
    DRB1
    HLA-DR1B
    HLA-DRB
    SS1
    142857
    4948
    ENSG00000196126
    OTTHUMG00000031196
    MHC class II antigen DRB1*10
    DRw10
    HLA class II histocompatibility antigen, DRB1-10 beta chain
    PA35072
    HLA class II antigen DR10
    T99532
    MHC class II antigen DRB1*1
    T83611

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (5 More Sources)

    Gene Categories: Category Details

    CELL SURFACE
    EXTERNAL SIDE OF PLASMA MEMBRANE
    DRUGGABLE GENOME

    Publications:

    Nicoletti P et al., 2016, HLA-DRB1*16: 01-DQB1*05: 02 is a novel genetic risk factor for flupirtine-induced liver injury., Pharmacogenet Genomics
    Sai K et al., 2016, A possible role for HLA-DRB1*04:06 in statin-related myopathy in Japanese patients., Drug Metab Pharmacokinet
    Lee HY et al., 2009, The HLA allele marker for differentiating ASA hypersensitivity phenotypes., Allergy
    Kim SH et al., 2005, The human leucocyte antigen-DRB1*1302-DQB1*0609-DPB1*0201 haplotype may be a strong genetic marker for aspirin-induced urticaria., Clin Exp Allergy
    Vitezica ZG et al., 2008, HLA-DRB1*01 associated with cutaneous hypersensitivity induced by nevirapine and efavirenz., AIDS
    Spraggs CF et al., 2018, Characterisation of the HLA-DRB1*07:01 biomarker for lapatinib-induced liver toxicity during treatment of early-stage breast cancer patients with lapatinib in combination with trastuzumab and/or taxanes., Pharmacogenomics J
    Schaid DJ et al., 2014, Prospective validation of HLA-DRB1*07:01 allele carriage as a predictive risk factor for lapatinib-induced liver injury., J Clin Oncol
    Kulkarni D et al., 2016, Pyrexia in dabrafenib-treated melanoma patients is not associated with common genetic variation or HLA polymorphisms., Pharmacogenomics
    Fernandez CA et al., 2015, Genome-wide analysis links NFATC2 with asparaginase hypersensitivity., Blood
    Fernandez CA et al., 2014, HLA-DRB1*07:01 is associated with a higher risk of asparaginase allergies., Blood
    Yue Z et al., 2018, Amino Acid Variants of HLA-DRB1 Confer Susceptibility to Dapsone Hypersensitivity Syndrome in Addition to HLA-B*13:01., J Invest Dermatol
    Singer JB et al., 2010, A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injury., Nat Genet
    He XJ et al., 2013, Association between the HLA-B*15:02 allele and carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis in Han individuals of northeastern China., Pharmacol Rep
    Li LJ et al., 2013, Predictive markers for carbamazepine and lamotrigine-induced maculopapular exanthema in Han Chinese., Epilepsy Res
    Cirulli ET et al., 2019, A Missense Variant in PTPN22 is a Risk Factor for Drug-induced Liver Injury., Gastroenterology
    Donaldson PT et al., 2010, Human leucocyte antigen class II genotype in susceptibility and resistance to co-amoxiclav-induced liver injury., J Hepatol
    Hautekeete ML et al., 1999, HLA association of amoxicillin-clavulanate--induced hepatitis., Gastroenterology
    Moon J et al., 2016, HLA-B*40:02 and DRB1*04:03 are risk factors for oxcarbazepine-induced maculopapular eruption., Epilepsia
    Kazeem GR et al., 2009, High-resolution HLA genotyping and severe cutaneous adverse reactions in lamotrigine-treated patients., Pharmacogenet Genomics
    Heap GA et al., 2014, HLA-DQA1-HLA-DRB1 variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants., Nat Genet
    Hirata K et al., 2008, Ticlopidine-induced hepatotoxicity is associated with specific human leukocyte antigen genomic subtypes in Japanese patients: a preliminary case-control study., Pharmacogenomics J
  • LYM-1   HLA-DRB1

    Interaction Score: 3.99

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction HLA class II histocompatibility antigen, DRB1-10 beta chain other

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • CLAVULANIC ACID   HLA-DRB1

    Interaction Score: 1.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    30664875 20800921 10535882


    Sources:
    PharmGKB

  • LUMIRACOXIB   HLA-DRB1

    Interaction Score: 1.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20639878


    Sources:
    PharmGKB

  • BUCILLAMINE   HLA-DRB1

    Interaction Score: 1.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • PITAVASTATIN   HLA-DRB1

    Interaction Score: 1.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27839692


    Sources:
    PharmGKB

  • FLOXACILLIN   HLA-DRB1

    Interaction Score: 0.57

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    30664875


    Sources:
    PharmGKB

  • AMOXICILLIN   HLA-DRB1

    Interaction Score: 0.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    30664875 20800921 10535882


    Sources:
    PharmGKB

  • DAPSONE   HLA-DRB1

    Interaction Score: 0.4

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29233746


    Sources:
    PharmGKB

  • ASPARAGINASE   HLA-DRB1

    Interaction Score: 0.4

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25987655 24970932


    Sources:
    PharmGKB

  • CARBIMAZOLE   HLA-DRB1

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • TICLOPIDINE   HLA-DRB1

    Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17339877


    Sources:
    PharmGKB

  • ROSUVASTATIN   HLA-DRB1

    Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27839692


    Sources:
    PharmGKB

  • LAPATINIB   HLA-DRB1

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28786423 24687830


    Sources:
    PharmGKB FDA

  • FLUPIRTINE   HLA-DRB1

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26959717


    Sources:
    PharmGKB

  • DABRAFENIB   HLA-DRB1

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27023328


    Sources:
    PharmGKB

  • OXCARBAZEPINE   HLA-DRB1

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27666425


    Sources:
    PharmGKB

  • EFAVIRENZ   HLA-DRB1

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18301070


    Sources:
    PharmGKB

  • FLUVASTATIN   HLA-DRB1

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27839692


    Sources:
    PharmGKB

  • AZATHIOPRINE   HLA-DRB1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25217962


    Sources:
    PharmGKB

  • LAMOTRIGINE   HLA-DRB1

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19668019


    Sources:
    PharmGKB

  • CARBAMAZEPINE   HLA-DRB1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24399721 23830818


    Sources:
    PharmGKB

  • PROPYLTHIOURACIL   HLA-DRB1

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ADALIMUMAB   HLA-DRB1

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • PRAVASTATIN   HLA-DRB1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27839692


    Sources:
    PharmGKB

  • MERCAPTOPURINE   HLA-DRB1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25217962


    Sources:
    PharmGKB

  • METHIMAZOLE   HLA-DRB1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ETANERCEPT   HLA-DRB1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • INFLIXIMAB   HLA-DRB1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ASPIRIN   HLA-DRB1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19392989 15784113


    Sources:
    PharmGKB

  • SIMVASTATIN   HLA-DRB1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27839692


    Sources:
    PharmGKB

  • ATORVASTATIN   HLA-DRB1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27839692


    Sources:
    PharmGKB

  • Ensembl: ENSG00000196126

    • Version: 101_38

    Alternate Names:
    HLA-DRB1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: HLA-DRB1

    • Version: 18-August-2020

    Alternate Names:
    PA35072 PharmGKB ID

    Gene Info:

    Publications:
    Nicoletti P et al., 2016, HLA-DRB1*16: 01-DQB1*05: 02 is a novel genetic risk factor for flupirtine-induced liver injury., Pharmacogenet Genomics
    Sai K et al., 2016, A possible role for HLA-DRB1*04:06 in statin-related myopathy in Japanese patients., Drug Metab Pharmacokinet
    Schaid DJ et al., 2014, Prospective validation of HLA-DRB1*07:01 allele carriage as a predictive risk factor for lapatinib-induced liver injury., J Clin Oncol

  • HingoraniCasas: ENSG00000196126

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000196126 Gene Symbol
    HLA-DRB1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: HLA-DRB1

    • Version: chembl_23

    Alternate Names:
    HLA-DRB1 GENE_SYMBOL
    HLA class II histocompatibility antigen, DRB1-10 beta chain UNIPROT
    DRw10 UNIPROT

    Gene Info:

    Publications:

  • Tempus: HLA-DRB1

    • Version: 11-November-2018

    Alternate Names:
    HLA-DRB1 Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • TTD: MHC class II antigen DRB1*1

    • Version: 2020.06.01

    Alternate Names:
    HLA-DRB1 TTD Gene Abbreviation
    T83611 TTD Target ID

    Gene Info:

    Publications:

  • TTD: HLA class II antigen DR10

    • Version: 2020.06.01

    Alternate Names:
    HLA-DRB1 TTD Gene Abbreviation
    T99532 TTD Target ID

    Gene Info:

    Publications:

  • FDA: HLA-DRB1

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Publications:

  • GO: HLA-DRB1

    • Version: 01-February-2022

    Alternate Names:

    Gene Info:

    Gene Categories:
    CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21