• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

HMOX1 Gene Record

  • Summary
  • Interactions
  • Claims
  • HMOX1 3162 Druggable GenomeDrug Resistance

    Alternate Names:

    3162
    HEME OXYGENASE 1
    HMOX1
    HMOX1D
    HO-1
    HSP32
    bK286B10
    141250
    5013
    ENSG00000100292
    OTTHUMG00000150960
    P09601
    2657
    T25703

    Gene Info:

    Target Class Enzymes
    Target Subclass EC:1.14.99
    Gene Biotype PROTEIN_CODING
    (4 More Sources)

    Gene Categories: Category Details

    DRUG RESISTANCE
    DRUGGABLE GENOME
    ENZYME

    Publications:

    Zheng et al., 2015, Heme oxygenase-1 is a predictive biomarker for therapeutic targeting of advanced clear cell renal cell carcinoma treated with sorafenib or sunitinib., Onco Targets Ther
    Wagner et al., 2000, Tin-mesoporphyrin, a potent heme oxygenase inhibitor, for treatment of intracerebral hemorrhage: in vivo and in vitro studies., Cell. Mol. Biol. (Noisy-le-grand)
    Cannon et al., 1993, Targeted delivery of a heme oxygenase inhibitor with a lyophilized liposomal tin mesoporphyrin formulation., Pharm. Res.
    Drummond et al., 2004, Chemoprevention of severe neonatal hyperbilirubinemia., Semin. Perinatol.
    Böni et al., 1993, Tin-mesoporphyrin inhibits heme oxygenase activity and heme-iron absorption in the intestine., Pharmacology
    Nalos et al., 2003, Tin-mesoporphyrin for inhibition of heme oxygenase during long-term hyperdynamic porcine endotoxemia., Shock
    Grosser et al., 2003, Heme oxygenase-1 induction may explain the antioxidant profile of aspirin., Biochem. Biophys. Res. Commun.
  • STANNSOPORFIN   HMOX1

    Interaction Score: 54.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name stannsoporfin,Stanate
    Novel drug target Novel Target

    PMIDs:
    10872746 8321837 15686268 8265722 12785007


    Sources:
    TdgClinicalTrial TTD

  • SUNITINIB   HMOX1

    Interaction Score: 0.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26309414


    Sources:
    CIViC

  • ASPIRIN   HMOX1

    Interaction Score: 0.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12927812


    Sources:
    NCI

  • SORAFENIB   HMOX1

    Interaction Score: 0.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26309414


    Sources:
    CIViC

  • Ensembl: ENSG00000100292

    • Version: 101_38

    Alternate Names:
    HMOX1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P09601

    • Version: January-2014

    Alternate Names:
    HMOX1 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:1.14.99

    Publications:

  • CIViC: HMOX1

    • Version: 14-September-2020

    Alternate Names:
    3162 Entrez Gene ID
    2657 CIViC Gene ID

    Gene Info:

    Gene Categories:
    DRUG RESISTANCE

    Publications:
    Zheng et al., 2015, Heme oxygenase-1 is a predictive biomarker for therapeutic targeting of advanced clear cell renal cell carcinoma treated with sorafenib or sunitinib., Onco Targets Ther

  • NCI: HMOX1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Saavedra et al., 2005, GDNF modulates HO-1 expression in substantia nigra postnatal cell cultures., Free Radic. Biol. Med.
    Mostert et al., 2003, Selective induction of liver parenchymal cell heme oxygenase-1 in selenium-deficient rats., Biol. Chem.
    Losem-Heinrichs et al., 2004, A combined treatment with 1alpha,25-dihydroxy-vitamin D3 and 17beta-estradiol reduces the expression of heat shock protein-32 (HSP-32) following cerebral cortical ischemia., J. Steroid Biochem. Mol. Biol.

  • HingoraniCasas: ENSG00000100292

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000100292 Gene Symbol
    HMOX1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HumanProteinAtlas: HMOX1

    • Version: 19.3

    Alternate Names:
    ENSG00000100292 Ensembl Gene ID
    bK286B10 Human Protein Atlas Gene Synonym
    HO-1 Human Protein Atlas Gene Synonym

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • TTD: Heme oxygenase 1

    • Version: 2020.06.01

    Alternate Names:
    HMOX1 TTD Gene Abbreviation
    T25703 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: HMOX1

    • Version: 01-February-2022

    Alternate Names:
    Heme oxygenase 1 Gene Name
    P09601 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21