DGIdb - HMOX1 Gene Record

HMOX1 3162 Druggable GenomeDrug Resistance

Alternate Names:

3162
HEME OXYGENASE 1
HMOX1
HMOX1D
HO-1
HSP32
bK286B10
141250
5013
ENSG00000100292
OTTHUMG00000150960
P09601
1441
Haem oxygenase 1
2657
T25703
HO
HO1

Gene Info:

Target Class	Enzymes
Target Subclass	EC:1.14.99
Gene Biotype	PROTEIN_CODING
GuideToPharmacology Gene Category Name	Haem oxygenase
GuideToPharmacology Gene Category ID	278

(6 More Sources)

Gene Categories: Category Details

DRUG RESISTANCE
DRUGGABLE GENOME
ENZYME

Publications:

Zheng et al., 2015, Heme oxygenase-1 is a predictive biomarker for therapeutic targeting of advanced clear cell renal cell carcinoma treated with sorafenib or sunitinib., Onco Targets Ther
Wagner et al., 2000, Tin-mesoporphyrin, a potent heme oxygenase inhibitor, for treatment of intracerebral hemorrhage: in vivo and in vitro studies., Cell. Mol. Biol. (Noisy-le-grand)
Cannon et al., 1993, Targeted delivery of a heme oxygenase inhibitor with a lyophilized liposomal tin mesoporphyrin formulation., Pharm. Res.
Drummond et al., 2004, Chemoprevention of severe neonatal hyperbilirubinemia., Semin. Perinatol.
Böni et al., 1993, Tin-mesoporphyrin inhibits heme oxygenase activity and heme-iron absorption in the intestine., Pharmacology
Nalos et al., 2003, Tin-mesoporphyrin for inhibition of heme oxygenase during long-term hyperdynamic porcine endotoxemia., Shock
Grosser et al., 2003, Heme oxygenase-1 induction may explain the antioxidant profile of aspirin., Biochem. Biophys. Res. Commun.

STANNSOPORFIN HMOX1

Interaction Score: 55.82

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name stannsoporfin,Stanate

Novel drug target Novel Target

PMIDs:
10872746 8321837 15686268 8265722 12785007

Sources:
TdgClinicalTrial TTD
SUNITINIB HMOX1

Interaction Score: 0.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26309414

Sources:
CIViC
ASPIRIN HMOX1

Interaction Score: 0.44

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12927812

Sources:
NCI
SORAFENIB HMOX1

Interaction Score: 0.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26309414

Sources:
CIViC

Ensembl: ENSG00000100292
- Version: 101_38
Alternate Names:

HMOX1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P09601
- Version: January-2014
Alternate Names:

HMOX1 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:1.14.99

Publications:
GuideToPharmacology: 3162
- Version: 29-September-2020
Alternate Names:

5013 HUGO Gene ID

5013 HUGO Gene Symbol

heme oxygenase 1 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Haem oxygenase

GuideToPharmacology Gene Category ID 278

Gene Categories:

ENZYME

Publications:
CIViC: HMOX1
- Version: 14-September-2020
Alternate Names:

3162 Entrez Gene ID

2657 CIViC Gene ID

Gene Info:

Gene Categories:

DRUG RESISTANCE

Publications:

Zheng et al., 2015, Heme oxygenase-1 is a predictive biomarker for therapeutic targeting of advanced clear cell renal cell carcinoma treated with sorafenib or sunitinib., Onco Targets Ther

NCI: HMOX1

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Saavedra et al., 2005, GDNF modulates HO-1 expression in substantia nigra postnatal cell cultures., Free Radic. Biol. Med.

Mostert et al., 2003, Selective induction of liver parenchymal cell heme oxygenase-1 in selenium-deficient rats., Biol. Chem.

Losem-Heinrichs et al., 2004, A combined treatment with 1alpha,25-dihydroxy-vitamin D3 and 17beta-estradiol reduces the expression of heat shock protein-32 (HSP-32) following cerebral cortical ischemia., J. Steroid Biochem. Mol. Biol.

HingoraniCasas: ENSG00000100292
- Version: 31-May-2017
Alternate Names:

ENSG00000100292 Gene Symbol

HMOX1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
HumanProteinAtlas: HMOX1
- Version: 19.3
Alternate Names:

ENSG00000100292 Ensembl Gene ID

bK286B10 Human Protein Atlas Gene Synonym

HO-1 Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories:

ENZYME

Publications:
TTD: Heme oxygenase 1
- Version: 2020.06.01
Alternate Names:

HMOX1 TTD Gene Abbreviation

T25703 TTD Target ID

Gene Info:

Publications:
GO: HMOX1
- Version: 01-May-2021
Alternate Names:

HO GO Gene Synonym

HO1 GO Gene Synonym

Gene Info:

Gene Categories:

DRUG RESISTANCE

Publications:
Pharos: HMOX1
- Version: 01-May-2021
Alternate Names:

Heme oxygenase 1 Gene Name

P09601 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:

Trial Name	stannsoporfin,Stanate
Novel drug target	Novel Target

5013	HUGO Gene ID
5013	HUGO Gene Symbol
heme oxygenase 1	HUGO Gene Name

ENSG00000100292	Ensembl Gene ID
bK286B10	Human Protein Atlas Gene Synonym
HO-1	Human Protein Atlas Gene Synonym

HMOX1 Gene Record

HMOX1 3162 Druggable GenomeDrug Resistance

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

STANNSOPORFIN HMOX1

Interaction Types & Directionality: n/a

Interaction Info: Trial Name stannsoporfin,Stanate Novel drug target Novel Target

PMIDs: 10872746 8321837 15686268 8265722 12785007

Sources: TdgClinicalTrial TTD

SUNITINIB HMOX1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26309414

Sources: CIViC

ASPIRIN HMOX1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12927812

Sources: NCI

SORAFENIB HMOX1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26309414

Sources: CIViC

Ensembl: ENSG00000100292

Alternate Names: HMOX1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: P09601

Alternate Names: HMOX1 Gene Symbol

Gene Info: Target Class Enzymes Target Subclass EC:1.14.99

Publications:

GuideToPharmacology: 3162

Alternate Names: 5013 HUGO Gene ID 5013 HUGO Gene Symbol heme oxygenase 1 HUGO Gene Name

Gene Info: GuideToPharmacology Gene Category Name Haem oxygenase GuideToPharmacology Gene Category ID 278

Gene Categories: ENZYME

Publications:

CIViC: HMOX1

Alternate Names: 3162 Entrez Gene ID 2657 CIViC Gene ID

Gene Info:

Gene Categories: DRUG RESISTANCE

Publications: Zheng et al., 2015, Heme oxygenase-1 is a predictive biomarker for therapeutic targeting of advanced clear cell renal cell carcinoma treated with sorafenib or sunitinib., Onco Targets Ther

NCI: HMOX1

Alternate Names:

Gene Info:

HingoraniCasas: ENSG00000100292

Alternate Names: ENSG00000100292 Gene Symbol HMOX1 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

HumanProteinAtlas: HMOX1

Alternate Names: ENSG00000100292 Ensembl Gene ID bK286B10 Human Protein Atlas Gene Synonym HO-1 Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories: ENZYME

Publications:

TTD: Heme oxygenase 1

Alternate Names: HMOX1 TTD Gene Abbreviation T25703 TTD Target ID

Gene Info:

Publications:

GO: HMOX1

Alternate Names: HO GO Gene Synonym HO1 GO Gene Synonym

Gene Info:

Gene Categories: DRUG RESISTANCE

Publications:

Pharos: HMOX1

Alternate Names: Heme oxygenase 1 Gene Name P09601 UniProt ID

Gene Info:

Gene Categories: ENZYME

Publications:

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name stannsoporfin,Stanate

Novel drug target Novel Target

PMIDs:
10872746 8321837 15686268 8265722 12785007

Sources:
TdgClinicalTrial TTD

Interaction Types & Directionality:

n/a

PMIDs:
26309414

Sources:
CIViC

Interaction Types & Directionality:

n/a

PMIDs:
12927812

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
26309414

Sources:
CIViC

Alternate Names:

HMOX1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

HMOX1 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:1.14.99

Alternate Names:

5013 HUGO Gene ID

5013 HUGO Gene Symbol

heme oxygenase 1 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Haem oxygenase

GuideToPharmacology Gene Category ID 278

Gene Categories:

ENZYME

Alternate Names:

3162 Entrez Gene ID

2657 CIViC Gene ID

Gene Categories:

DRUG RESISTANCE

Publications:

Zheng et al., 2015, Heme oxygenase-1 is a predictive biomarker for therapeutic targeting of advanced clear cell renal cell carcinoma treated with sorafenib or sunitinib., Onco Targets Ther

Alternate Names:

ENSG00000100292 Gene Symbol

HMOX1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ENSG00000100292 Ensembl Gene ID

bK286B10 Human Protein Atlas Gene Synonym

HO-1 Human Protein Atlas Gene Synonym

Gene Categories:

ENZYME

Alternate Names:

HMOX1 TTD Gene Abbreviation

T25703 TTD Target ID

Alternate Names:

HO GO Gene Synonym

HO1 GO Gene Synonym

Gene Categories:

DRUG RESISTANCE

Alternate Names:

Heme oxygenase 1 Gene Name

P09601 UniProt ID

Gene Categories:

ENZYME