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HMOX2 Gene Record

  • Summary
  • Interactions
  • Claims
  • HMOX2 3163

    Alternate Names:

    3163
    HEME OXYGENASE 2
    HMOX2
    HO-2
    141251
    5014
    ENSG00000103415
    OTTHUMG00000129473
    P30519

    Gene Info:

    Target Class Enzymes
    Target Subclass EC:1.14.99
    Gene Biotype PROTEIN_CODING
    (0 More Sources)

    Gene Categories: Category Details

    ENZYME

    Publications:

    Wagner et al., 2000, Tin-mesoporphyrin, a potent heme oxygenase inhibitor, for treatment of intracerebral hemorrhage: in vivo and in vitro studies., Cell. Mol. Biol. (Noisy-le-grand)
    Cannon et al., 1993, Targeted delivery of a heme oxygenase inhibitor with a lyophilized liposomal tin mesoporphyrin formulation., Pharm. Res.
    Drummond et al., 2004, Chemoprevention of severe neonatal hyperbilirubinemia., Semin. Perinatol.
    Böni et al., 1993, Tin-mesoporphyrin inhibits heme oxygenase activity and heme-iron absorption in the intestine., Pharmacology
    Nalos et al., 2003, Tin-mesoporphyrin for inhibition of heme oxygenase during long-term hyperdynamic porcine endotoxemia., Shock
    Liang et al., 2003, Heme oxygenase type 2 modulates behavioral and molecular changes during chronic exposure to morphine., Neuroscience
    Li et al., 2000, Chronic morphine exposure and the expression of heme oxygenase type 2., Brain Res. Mol. Brain Res.
    Parfenova et al., 2001, Cerebral vascular endothelial heme oxygenase: expression, localization, and activation by glutamate., Am. J. Physiol., Cell Physiol.
  • STANNSOPORFIN   HMOX2

    Interaction Score: 61.83

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name stannsoporfin,Stanate
    Novel drug target Novel Target

    PMIDs:
    10872746 8321837 15686268 8265722 12785007


    Sources:
    TdgClinicalTrial

  • BETAMETHASONE   HMOX2

    Interaction Score: 4.58

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11698254


    Sources:
    NCI

  • MORPHINE   HMOX2

    Interaction Score: 1.99

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14580950 10686338


    Sources:
    NCI

  • Ensembl: ENSG00000103415

    • Version: 101_38

    Alternate Names:
    HMOX2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P30519

    • Version: January-2014

    Alternate Names:
    HMOX2 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:1.14.99

    Publications:

  • NCI: HMOX2

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Sharma et al., 2000, A new antioxidant compound H-290/51 attenuates upregulation of constitutive isoform of heme oxygenase (HO-2) following trauma to the rat spinal cord., Acta Neurochir. Suppl.
    Tian et al., 2004, [Effect of sex hormones on heme oxygenase expression in rat ventral prostate]., Sheng Li Xue Bao
    Liang et al., 2003, Heme oxygenase type 2 modulates behavioral and molecular changes during chronic exposure to morphine., Neuroscience

  • Pharos: HMOX2

    • Version: 01-February-2022

    Alternate Names:
    Heme oxygenase 2 Gene Name
    P30519 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21