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HNF4A Gene Record

  • Summary
  • Interactions
  • Claims
  • HNF4A 3172 Druggable Genome

    Alternate Names:

    3172
    HEPATOCYTE NUCLEAR FACTOR 4 ALPHA
    HNF4A
    FRTS4
    HNF4
    HNF4a7
    HNF4a8
    HNF4a9
    HNF4alpha
    MODY
    MODY1
    NR2A1
    NR2A21
    TCF
    TCF14
    600281
    5024
    ENSG00000101076
    OTTHUMG00000032531
    P41235
    HNF4A_HUMAN
    HEPATOCYTE NUCLEAR FACTOR 4-ALPHA
    HEPATOCYTE NUCLEAR FACTOR 4-ALPHA (HNF-4-ALPHA) (TRANSCRIPTION FACTOR HNF-4) (TRANSCRIPTION FACTOR 14). [SOURCE:UNIPROT/SWISSPROT;ACC:P41235]
    PA29349
    TCF-14

    Gene Info:

    Interpro Type Domain
    Interpro Short Name Nucl_hrmn_rcpt_lig-bd_core
    Uniprot Evidence 1: Evidence at protein level
    Interpro Acc IPR000536
    Uniprot Status Swiss-Prot
    Interpro Name Nuclear hormone receptor, ligand-binding, core
    Human Readable Name DRUGGABLE GENOME
    Human Readable Name NUCLEAR HORMONE RECEPTOR
    Initial Gene Query NR2A1
    Counted Citations from 1950-2000 456
    Gene Biotype PROTEIN_CODING
    (7 More Sources)

    Gene Categories: Category Details

    NUCLEAR HORMONE RECEPTOR
    DRUGGABLE GENOME
    TRANSCRIPTION FACTOR

    Publications:

    Sladek, 1993, Orphan receptor HNF-4 and liver-specific gene expression., Receptor
    Skowsky et al., A pilot study of chronic recombinant interferon-alfa 2a for diabetic proliferative retinopathy: metabolic effects and opthalmologic effects., J. Diabetes Complicat.
    Courjault-Gautier et al., 1997, Activity and inducibility of drug-metabolizing enzymes in immortalized hepatocyte-like cells (mhPKT) derived from a L-PK/Tag1 transgenic mouse., Exp. Cell Res.
    Yamagata et al., 1996, Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1), Nature
    Kahn et al., 1996, Genetics of non-insulin-dependent (type-II) diabetes mellitus., Annu. Rev. Med.
    Sanguino et al., 2005, Different response of senescent female Sprague-Dawley rats to gemfibrozil and rosiglitazone administration., Exp. Gerontol.
    Shen CH et al., 2016, Specific OCT1 and ABCG2 polymorphisms are associated with Lamotrigine concentrations in Chinese patients with epilepsy., Epilepsy Res
    Zhou Y et al., 2015, Polymorphisms of ABCG2, ABCB1 and HNF4α are associated with Lamotrigine trough concentrations in epilepsy patients., Drug Metab Pharmacokinet
    Wu et al., 1996, Retroviral vector sequences may interact with some internal promoters and influence expression., Hum. Gene Ther.
    Shen C et al., 2017, Effects of ABCB1, ABCC2, UGT2B7 and HNF4α genetic polymorphisms on oxcarbazepine concentrations and therapeutic efficacy in patients with epilepsy., Seizure
    Saruwatari J et al., 2014, Pregnane X receptor and hepatocyte nuclear factor 4α polymorphisms are cooperatively associated with carbamazepine autoinduction., Pharmacogenet Genomics
    Moon JY et al., 2015, Combined effects of hepatocyte nuclear factor 4α and constitutive androstane receptor on stable warfarin doses., Pharmacogenet Genomics
    Chew SC et al., 2014, Pharmacogenetic effects of regulatory nuclear receptors (PXR, CAR, RXRα and HNF4α) on docetaxel disposition in Chinese nasopharyngeal cancer patients., Eur J Clin Pharmacol
    Cusato J et al., 2016, Efavirenz pharmacogenetics in a cohort of Italian patients., Int J Antimicrob Agents
  • CHEMBL482792   HNF4A

    Interaction Score: 2.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ANDROSTENEDIONE   HNF4A

    Interaction Score: 0.92

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9260906


    Sources:
    NCI

  • UREA   HNF4A

    Interaction Score: 0.92

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8167573


    Sources:
    NCI

  • TOREMIFENE CITRATE   HNF4A

    Interaction Score: 0.59

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ALBUMIN HUMAN   HNF4A

    Interaction Score: 0.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8788167


    Sources:
    NCI

  • LAMOTRIGINE   HNF4A

    Interaction Score: 0.48

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27610747 26213157


    Sources:
    PharmGKB

  • EFAVIRENZ   HNF4A

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26774523


    Sources:
    PharmGKB

  • ROSIGLITAZONE   HNF4A

    Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15998575


    Sources:
    NCI

  • CARBAMAZEPINE   HNF4A

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28837897 24384557


    Sources:
    PharmGKB

  • INSULIN   HNF4A

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8945471 8712800


    Sources:
    NCI

  • WARFARIN   HNF4A

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25356900


    Sources:
    PharmGKB

  • TESTOSTERONE   HNF4A

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9260906


    Sources:
    NCI

  • CETUXIMAB   HNF4A

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8777337


    Sources:
    NCI

  • CHEMBL585591   HNF4A

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DOCETAXEL   HNF4A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24193570


    Sources:
    PharmGKB

  • Ensembl: ENSG00000101076

    • Version: 101_38

    Alternate Names:
    HNF4A Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: P41235

    • Version: 11-September-2012

    Alternate Names:
    P41235 Uniprot Accession
    HNF4A_HUMAN Uniprot Id
    ENSG00000101076 Ensembl Gene Id

    Gene Info:
    Interpro Type Domain
    Interpro Short Name Nucl_hrmn_rcpt_lig-bd_core
    Uniprot Evidence 1: Evidence at protein level

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME

    Publications:

  • BaderLabGenes: HNF4A

    • Version: February-2014

    Alternate Names:
    3172 Entrez Gene ID

    Gene Info:
    Initial Gene Query NR2A1
    Counted Citations from 1950-2000 456

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

  • RussLampel: ENSG00000101076

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000101076 Ensembl Gene Id
    HEPATOCYTE NUCLEAR FACTOR 4-ALPHA (HNF-4-ALPHA) (TRANSCRIPTION FACTOR HNF-4) (TRANSCRIPTION FACTOR 14). [SOURCE:UNIPROT/SWISSPROT;ACC:P41235] Description
    HNF4A Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • PharmGKB: HNF4A

    • Version: 18-August-2020

    Alternate Names:
    PA29349 PharmGKB ID

    Gene Info:

    Publications:
    Shen CH et al., 2016, Specific OCT1 and ABCG2 polymorphisms are associated with Lamotrigine concentrations in Chinese patients with epilepsy., Epilepsy Res
    Zhou Y et al., 2015, Polymorphisms of ABCG2, ABCB1 and HNF4α are associated with Lamotrigine trough concentrations in epilepsy patients., Drug Metab Pharmacokinet
    Saruwatari J et al., 2014, Pregnane X receptor and hepatocyte nuclear factor 4α polymorphisms are cooperatively associated with carbamazepine autoinduction., Pharmacogenet Genomics

  • NCI: HNF4A

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Sladek, 1993, Orphan receptor HNF-4 and liver-specific gene expression., Receptor
    Skowsky et al., A pilot study of chronic recombinant interferon-alfa 2a for diabetic proliferative retinopathy: metabolic effects and opthalmologic effects., J. Diabetes Complicat.
    Carter et al., 1993, Hepatocyte nuclear factor-4 activates medium chain acyl-CoA dehydrogenase gene transcription by interacting with a complex regulatory element., J. Biol. Chem.

  • HingoraniCasas: ENSG00000101076

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000101076 Gene Symbol
    HNF4A Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: HNF4A

    • Version: 01-February-2022

    Alternate Names:
    HNF4 GO Gene Synonym
    NR2A1 GO Gene Synonym
    TCF14 GO Gene Synonym

    Gene Info:

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

  • dGene: HNF4A

    • Version: 27-Jun-2013

    Alternate Names:
    3172 Gene ID
    HNF4 dGene Synonym
    HNF4a7 dGene Synonym

    Gene Info:

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

  • Pharos: HNF4A

    • Version: 01-February-2022

    Alternate Names:
    Hepatocyte nuclear factor 4-alpha Gene Name
    P41235 UniProt ID

    Gene Info:

    Gene Categories:
    TRANSCRIPTION FACTOR

    Publications:

  • DTC: HNF4A

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21