• Interaction Score: 2.99

    Interaction Types & Directionality:
    n/a

    Interaction Info:

  • Interaction Score: 1.99

    Interaction Types & Directionality:
    n/a

    Interaction Info:

  • Interaction Score: 0.6

    Interaction Types & Directionality:
    n/a

    Interaction Info:

  • Interaction Score: 0.5

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Drug family Farnesyltransferase inhibitor
    Alteration HRAS:.

    PMIDs:
    None found


    Sources:
    CGI OncoKB

  • Interaction Score: 0.5

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name Reolysin
    Novel drug target Novel Target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • Interaction Score: 0.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Indication/Tumor Type melanoma
    Response Type sensitive
    Approval Status Preclinical

    PMIDs:
    23039341


    Sources:
    JAX-CKB

  • Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Indication/Tumor Type Advanced Solid Tumor
    Response Type sensitive
    Approval Status Preclinical - Cell culture

    PMIDs:
    27104980


    Sources:
    JAX-CKB

  • Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9422737


    Sources:
    NCI

  • Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8968066


    Sources:
    NCI

  • Interaction Score: 0.21

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction Measuring inhibition of farnesylation of HRAS by human farnesyltransferase
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9104820


    Sources:
    NCI

  • Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12041671


    Sources:
    NCI

  • Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    combination therapy Sirolimus + Trametinib
    Indication/Tumor Type head and neck squamous cell carcinoma
    Response Type sensitive

  • Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Indication/Tumor Type urinary bladder cancer
    Response Type predicted – sensitive
    Indication/Tumor Type Advanced Solid Tumor

    PMIDs:
    26544513


    Sources:
    JAX-CKB CIViC

  • Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    combination therapy AZD8055 + Binimetinib
    Indication/Tumor Type lung squamous cell carcinoma
    Response Type sensitive

    PMIDs:
    26544513


    Sources:
    JAX-CKB

  • Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Indication/Tumor Type thyroid medullary carcinoma
    Response Type sensitive
    Approval Status Phase III

    PMIDs:
    27525386


    Sources:
    JAX-CKB

  • Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Evidence Type Actionable
    Approval Status Preclinical - Cell culture
    Response Type sensitive

    PMIDs:
    21289267


    Sources:
    JAX-CKB

  • Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Indication/Tumor Type lung squamous cell carcinoma
    Response Type sensitive
    Approval Status Preclinical - Cell line xenograft


    Sources:
    JAX-CKB CIViC

  • Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

  • Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Indication/Tumor Type Advanced Solid Tumor
    Response Type resistant
    Approval Status Preclinical

    PMIDs:
    22797062


    Sources:
    JAX-CKB

  • Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Indication/Tumor Type melanoma
    Response Type sensitive
    Approval Status Preclinical

    PMIDs:
    26267534


    Sources:
    JAX-CKB

  • Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Indication/Tumor Type lung squamous cell carcinoma
    Response Type no benefit
    Approval Status Preclinical - Cell culture

    PMIDs:
    26544513


    Sources:
    JAX-CKB

  • Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Indication/Tumor Type urinary bladder cancer
    Response Type sensitive
    Approval Status Preclinical


    Sources:
    JAX-CKB

  • Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Indication/Tumor Type urinary bladder cancer
    Response Type predicted – sensitive
    Indication/Tumor Type Advanced Solid Tumor

    PMIDs:
    26544513


    Sources:
    JAX-CKB CIViC

  • Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1980008


    Sources:
    NCI

  • Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12883735


    Sources:
    NCI

  • Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15998951


    Sources:
    NCI

  • Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Indication/Tumor Type thyroid cancer
    Response Type sensitive
    Approval Status Preclinical

    PMIDs:
    21831957


    Sources:
    JAX-CKB

  • Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8171758


    Sources:
    NCI

  • Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Indication/Tumor Type Advanced Solid Tumor
    Response Type resistant
    Approval Status Preclinical

    PMIDs:
    22797062


    Sources:
    JAX-CKB

  • Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8389451


    Sources:
    NCI

  • Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    combination therapy Sirolimus + Trametinib
    Indication/Tumor Type head and neck squamous cell carcinoma
    Response Type sensitive

    PMIDs:
    26882569


    Sources:
    JAX-CKB

  • Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    combination therapy BYL719 + MEK162
    Indication/Tumor Type ovarian cancer
    Response Type predicted – sensitive

    PMIDs:
    None found


    Sources:
    JAX-CKB

  • Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Approval Status Preclinical - Cell line xenograft
    Response Type resistant
    combination therapy Dasatinib + SCH772984

    PMIDs:
    27222538


    Sources:
    JAX-CKB

  • Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16818479


    Sources:
    NCI

  • Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16983095


    Sources:
    NCI