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HRH4 Gene Record

  • Summary
  • Interactions
  • Claims
  • HRH4 59340 Druggable Genome

    Alternate Names:

    59340
    HISTAMINE RECEPTOR H4
    HRH4
    AXOR35
    BG26
    GPCR105
    GPRv53
    H4
    H4R
    HH4R
    606792
    17383
    ENSG00000134489
    OTTHUMG00000131945
    Q9H3N8
    HRH4_HUMAN
    HISTAMINE H4 RECEPTOR (HH4R) (GPRV53) (G-PROTEIN COUPLED RECEPTOR 105) (GPCR105) (SP9144) (AXOR35). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9H3N8]
    SP9144
    Pfi-013
    G-protein coupled receptor 105
    Histamine H4 receptor
    PA134982275
    T26500

    Gene Info:

    Target Main Class Receptors
    Target Subclass GPCR
    Transmembrane Helix Count 7
    Target Subclass Rhodopsin
    Human Readable Name DRUGGABLE GENOME
    Human Readable Name G PROTEIN COUPLED RECEPTOR
    Uniprot Evidence 1: Evidence at protein level
    Interpro Name GPCR, rhodopsin-like, 7TM
    Uniprot Status Swiss-Prot
    Interpro Acc IPR000276
    Interpro Short Name 7TM_GPCR_Rhodpsn
    Interpro Type Family
    Target Class Receptors
    Gene Biotype PROTEIN_CODING
    (8 More Sources)

    Gene Categories: Category Details

    G PROTEIN COUPLED RECEPTOR
    DRUGGABLE GENOME

    Publications:

    Blaya et al., 2010, Histamine and histamine receptor antagonists in cancer biology., Inflamm Allergy Drug Targets
    Cowden et al., 2010, Histamine H4 receptor antagonism diminishes existing airway inflammation and dysfunction via modulation of Th2 cytokines., Respir. Res.
    Yu et al., 2010, Copy number variations of the human histamine H4 receptor gene are associated with systemic lupus erythematosus., Br. J. Dermatol.
    Smits RA et al., 2008, Discovery of quinazolines as histamine H4 receptor inverse agonists using a scaffold hopping approach., J Med Chem
    Smits RA et al., 2010, Synthesis and QSAR of quinazoline sulfonamides as highly potent human histamine H4 receptor inverse agonists., J Med Chem
    Thurmond RL, 2015, The histamine H4 receptor: from orphan to the clinic., Front Pharmacol
    Mowbray CE et al., 2011, Challenges of drug discovery in novel target space. The discovery and evaluation of PF-3893787: a novel histamine H4 receptor antagonist., Bioorg Med Chem Lett
    Wei Z et al., 2013, Histamine H4 receptor polymorphism: a potential predictor of risperidone efficacy., J Clin Psychopharmacol
    Smits et al., 2006, Characterization of the histamine H4 receptor binding site. Part 1. Synthesis and pharmacological evaluation of dibenzodiazepine derivatives., J. Med. Chem.
    Sugata et al., 2007, Histamine H4 receptor agonists have more activities than H4 agonism in antigen-specific human T-cell responses., Immunology
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Adachi et al., 2006, Suppression of ischemia/reperfusion liver injury by histamine H4 receptor stimulation in rats., Eur. J. Pharmacol.
  • PF-03893787   HRH4

    Interaction Score: 24.73

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Histamine H4 receptor antagonist
    Direct Interaction yes

    PMIDs:
    21920751


    Sources:
    DTC ChemblInteractions TTD

  • TOREFORANT   HRH4

    Interaction Score: 18.55

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Histamine H4 receptor antagonist

    PMIDs:
    25873897


    Sources:
    ChemblInteractions TTD

  • UR-63325   HRH4

    Interaction Score: 12.37

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Histamine H4 receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • CHEMBL454890   HRH4

    Interaction Score: 12.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19053770


    Sources:
    DTC

  • CHEMBL452847   HRH4

    Interaction Score: 12.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19053770


    Sources:
    DTC

  • JNJ-7777120   HRH4

    Interaction Score: 12.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21920751


    Sources:
    DTC

  • HISTAMINE   HRH4

    Interaction Score: 6.18

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    20632959 20573261 20618322 19053770 20192225


    Sources:
    DTC

  • THIOPERAMIDE   HRH4

    Interaction Score: 3.09

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    20192225 19053770


    Sources:
    DTC

  • CLOZAPINE   HRH4

    Interaction Score: 0.63

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    16854056 17346280 11752352 16860312


    Sources:
    TdgClinicalTrial TEND

  • RISPERIDONE   HRH4

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23422377


    Sources:
    PharmGKB

  • Ensembl: ENSG00000134489

    • Version: 101_38

    Alternate Names:
    HRH4 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000134489

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000134489 Ensembl Gene Id
    HISTAMINE H4 RECEPTOR (HH4R) (GPRV53) (G-PROTEIN COUPLED RECEPTOR 105) (GPCR105) (SP9144) (AXOR35). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9H3N8] Description
    HRH4 Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TEND: Q9H3N8

    • Version: 01-August-2011

    Alternate Names:
    59340 Entrez Gene Id
    Q9H3N8 Uniprot Accession
    HRH4_HUMAN Uniprot Id

    Gene Info:
    Target Main Class Receptors
    Target Subclass GPCR
    Transmembrane Helix Count 7

    Publications:

  • HopkinsGroom: Q9H3N8

    • Version: 11-September-2012

    Alternate Names:
    Q9H3N8 Uniprot Accession
    HISTAMINE H4 RECEPTOR Uniprot Protein Name
    59340 Entrez Gene Id

    Gene Info:
    Human Readable Name G PROTEIN COUPLED RECEPTOR
    Uniprot Evidence 1: Evidence at protein level
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: Q9H3N8

    • Version: January-2014

    Alternate Names:
    HRH4 Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass GPCR
    Target Subclass Rhodopsin

    Publications:

  • PharmGKB: HRH4

    • Version: 18-August-2020

    Alternate Names:
    PA134982275 PharmGKB ID

    Gene Info:

    Publications:
    Wei Z et al., 2013, Histamine H4 receptor polymorphism: a potential predictor of risperidone efficacy., J Clin Psychopharmacol

  • TTD: Histamine H4 receptor

    • Version: 2020.06.01

    Alternate Names:
    H4R TTD Gene Abbreviation
    T26500 TTD Target ID

    Gene Info:

    Publications:
    Thurmond RL, 2015, The histamine H4 receptor: from orphan to the clinic., Front Pharmacol

  • DTC: HRH4

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Smits RA et al., 2008, Discovery of quinazolines as histamine H4 receptor inverse agonists using a scaffold hopping approach., J Med Chem
    Smits RA et al., 2010, Synthesis and QSAR of quinazoline sulfonamides as highly potent human histamine H4 receptor inverse agonists., J Med Chem
    Mowbray CE et al., 2011, Challenges of drug discovery in novel target space. The discovery and evaluation of PF-3893787: a novel histamine H4 receptor antagonist., Bioorg Med Chem Lett

  • ChemblInteractions: GPCR105

    • Version: chembl_23

    Alternate Names:
    GPCR105 GENE_SYMBOL
    HRH4 GENE_SYMBOL
    Histamine H4 receptor UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000134489

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000134489 Gene Symbol
    HRH4 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • dGene: HRH4

    • Version: 27-Jun-2013

    Alternate Names:
    59340 Gene ID
    AXOR35 dGene Synonym
    BG26 dGene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • Pharos: HRH4

    • Version: 01-February-2022

    Alternate Names:
    Histamine H4 receptor Gene Name
    Q9H3N8 UniProt ID

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21