DGIdb - HSP90AB1 Gene Record

HSP90AB1 3326 Druggable GenomeClinically Actionable

Alternate Names:

3326
HEAT SHOCK PROTEIN 90 ALPHA FAMILY CLASS B MEMBER 1
HSP90AB1
D6S182
HSP84
HSP90B
HSPC2
HSPCB
140572
5258
ENSG00000096384
OTTHUMG00000014761
P08238
HEAT SHOCK PROTEIN HSP 90-BETA
HS90B_HUMAN
Heat shock 84 kDa
HSP 90
HSP 84
HSP90
HEAT SHOCK PROTEIN HSP 90-BETA (HSP 84) (HSP 90). [SOURCE:UNIPROT/SWISSPROT;ACC:P08238]
PA29524
Heat shock protein 90 beta
T96623

Gene Info:

Target Class	Miscellaneous
Target Subclass	HSP90-like_chaperon
Human Readable Name	DRUGGABLE GENOME
Interpro Short Name	ATPase-like_ATP-bd
Interpro Name	ATPase-like, ATP-binding domain
Interpro Type	Domain
Uniprot Status	Swiss-Prot
Interpro Acc	IPR003594
Uniprot Evidence	1: Evidence at protein level
Gene Biotype	PROTEIN_CODING

(11 More Sources)

Gene Categories: Category Details

CELL SURFACE
TUMOR SUPPRESSOR
DRUGGABLE GENOME
CLINICALLY ACTIONABLE
TRANSCRIPTION FACTOR

Publications:

Wang M et al., 2006, Radanamycin, a macrocyclic chimera of radicicol and geldanamycin., Bioorg Med Chem Lett
Davenport J et al., 2011, Gambogic acid, a natural product inhibitor of Hsp90., J Nat Prod
Matts RL et al., 2011, A systematic protocol for the characterization of Hsp90 modulators., Bioorg Med Chem
Hall JA et al., 2015, Cucurbitacin D Is a Disruptor of the HSP90 Chaperone Machinery., J Nat Prod
Li Z et al., 2014, Discovery of diamine-linked 17-aroylamido-17-demethoxygeldanamycins as potent Hsp90 inhibitors., Eur J Med Chem
Lauria A et al., 2013, Synthesis and biological activities of a new class of heat shock protein 90 inhibitors, designed by energy-based pharmacophore virtual screening., J Med Chem
Ramsey DM et al., 2012, An Hsp90 modulator that exhibits a unique mechanistic profile., Bioorg Med Chem Lett
Li Z et al., 2014, Design, synthesis and biological evaluation of 17-arylmethylamine-17-demethoxygeldanamycin derivatives as potent Hsp90 inhibitors., Eur J Med Chem
Rodina A et al., 2007, Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer., Nat Chem Biol
Kunicki JB et al., 2011, Synthesis and evaluation of biotinylated sansalvamide A analogs and their modulation of Hsp90., Bioorg Med Chem Lett
Turbyville TJ et al., 2006, Search for Hsp90 inhibitors with potential anticancer activity: isolation and SAR studies of radicicol and monocillin I from two plant-associated fungi of the Sonoran desert., J Nat Prod
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Zhao H et al., 2011, Identification and initial SAR of silybin: an Hsp90 inhibitor., Bioorg Med Chem Lett
Degterev A et al., 2008, Identification of RIP1 kinase as a specific cellular target of necrostatins., Nat Chem Biol
Gavenonis J et al., 2014, Potential C-terminal-domain inhibitors of heat shock protein 90 derived from a C-terminal peptide helix., Bioorg Med Chem
Chen CY et al., 2014, The antitumor agent PBT-1 directly targets HSP90 and hnRNP A2/B1 and inhibits lung adenocarcinoma growth and metastasis., J Med Chem
Hadden MK et al., 2007, Derrubone, an inhibitor of the Hsp90 protein folding machinery., J Nat Prod
Kusuma BR et al., 2011, Targeting the heat shock protein 90 dimer with dimeric inhibitors., J Med Chem
Gunaherath GM et al., 2013, Synthesis and biological evaluation of novobiocin analogues as potential heat shock protein 90 inhibitors., Bioorg Med Chem
McConnell JR et al., 2014, A heat shock protein 90 inhibitor that modulates the immunophilins and regulates hormone receptors without inducing the heat shock response., Bioorg Med Chem Lett
Li M et al., 2018, Identification of a Genomic Region between <i>SLC29A1</i> and <i>HSP90AB1</i> Associated with Risk of Bevacizumab-Induced Hypertension: CALGB 80405 (Alliance)., Clin Cancer Res

CYCLOPROPARADICICOL HSP90AB1

Interaction Score: 3.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17603540

Sources:
DTC
COUMERMYCIN A1 HSP90AB1

Interaction Score: 3.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24360559

Sources:
DTC
RADICICOL HSP90AB1

Interaction Score: 2.79

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16499313 24984936 17603540 10592235

Sources:
DTC
PU-H71 HSP90AB1

Interaction Score: 1.67

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CUCURBITACIN D HSP90AB1

Interaction Score: 1.67

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25756299

Sources:
DTC
CHEMBL192264 HSP90AB1

Interaction Score: 1.67

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21764310

Sources:
DTC
TAS-116 HSP90AB1

Interaction Score: 1.67

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
GELDANAMYCIN HSP90AB1

Interaction Score: 1.67

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
10592235 17016423 17139284 21273068 18408713 24984936 24428777 18020309 25277067 25105924 21861487 23859777 25756299

Sources:
DTC
MONOCILLIN I HSP90AB1

Interaction Score: 1.67

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16499313

Sources:
DTC
CHEMBL2022241 HSP90AB1

Interaction Score: 1.67

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25756299

Sources:
DTC
CHEMBL553939 HSP90AB1

Interaction Score: 1.67

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name SNX-5422

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial TTD
RADANAMYCIN HSP90AB1

Interaction Score: 1.67

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16464590

Sources:
DTC
TANESPIMYCIN HSP90AB1

Interaction Score: 1.39

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Heat shock protein HSP90 inhibitor

Direct Interaction yes

Trial Name CNF1010

PMIDs:
25277067 23520985 22480433 25105924 17603540 21764310

Sources:
DTC MyCancerGenome TdgClinicalTrial ChemblInteractions
ALVESPIMYCIN HSP90AB1

Interaction Score: 1.25

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name alvespimycin hydrochloride, KOS-1022 (DMAG), NSC-707545

Novel drug target Novel Target

PMIDs:
17603540

Sources:
DTC TdgClinicalTrial
CELASTROL HSP90AB1

Interaction Score: 1.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21129982 25756299

Sources:
DTC
RETASPIMYCIN HSP90AB1

Interaction Score: 1.11

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name IPI-493, oral retaspimycin

Novel drug target Novel Target

PMIDs:
None found

Sources:
MyCancerGenome TdgClinicalTrial
RETASPIMYCIN HYDROCHLORIDE HSP90AB1

Interaction Score: 1.11

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name IPI-504

Novel drug target Novel Target

Mechanism of Interaction Heat shock protein HSP90 inhibitor

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
ZEARALANONE HSP90AB1

Interaction Score: 0.84

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GEDUNIN HSP90AB1

Interaction Score: 0.84

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21129982 25756299

Sources:
DTC
NOVOBIOCIN HSP90AB1

Interaction Score: 0.67

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23859777

Sources:
DTC
DERRUBONE HSP90AB1

Interaction Score: 0.56

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18020309

Sources:
DTC
GANETESPIB HSP90AB1

Interaction Score: 0.56

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name STA-9090

Novel drug target Novel Target

Mechanism of Interaction Heat shock protein HSP90 inhibitor

PMIDs:
None found

Sources:
MyCancerGenome TdgClinicalTrial ChemblInteractions
XL-888 HSP90AB1

Interaction Score: 0.42

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Novel Target

Trial Name XL888

PMIDs:
None found

Sources:
TdgClinicalTrial
GAMBOGIC ACID HSP90AB1

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21486005

Sources:
DTC
SILIBININ HSP90AB1

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21273068

Sources:
DTC
ZERANOL HSP90AB1

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIACEREIN HSP90AB1

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ZEARALENONE HSP90AB1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TETRACYCLINE HSP90AB1

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BEVACIZUMAB HSP90AB1

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29871907

Sources:
PharmGKB
CHEMBL53898 HSP90AB1

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RHEIN HSP90AB1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL578512 HSP90AB1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DAUNORUBICIN HYDROCHLORIDE HSP90AB1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DOXORUBICIN HYDROCHLORIDE HSP90AB1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NORDIHYDROGUAIARETIC ACID HSP90AB1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIPYRIDAMOLE HSP90AB1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

Ensembl: ENSG00000096384
- Version: 101_38
Alternate Names:

HSP90AB1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P08238
- Version: January-2014
Alternate Names:

HSP90AB1 Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass HSP90-like_chaperon

Publications:
RussLampel: ENSG00000096384
- Version: 26-July-2011
Alternate Names:

ENSG00000096384 Ensembl Gene Id

HEAT SHOCK PROTEIN HSP 90-BETA (HSP 84) (HSP 90). [SOURCE:UNIPROT/SWISSPROT;ACC:P08238] Description

HSPCB Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
HopkinsGroom: P08238
- Version: 11-September-2012
Alternate Names:

3326 Entrez Gene Id

ENSG00000096384 Ensembl Gene Id

HEAT SHOCK PROTEIN HSP 90-BETA Uniprot Protein Name

Gene Info:

Human Readable Name DRUGGABLE GENOME

Interpro Short Name ATPase-like_ATP-bd

Interpro Name ATPase-like, ATP-binding domain

Gene Categories:

DRUGGABLE GENOME

Publications:

PharmGKB: HSP90AB1

Version: 18-August-2020

Alternate Names:

PA29524 PharmGKB ID

Gene Info:

Publications:

Li M et al., 2018, Identification of a Genomic Region between <i>SLC29A1</i> and <i>HSP90AB1</i> Associated with Risk of Bevacizumab-Induced Hypertension: CALGB 80405 (Alliance)., Clin Cancer Res

DTC: HSP90AB1

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Hall JA et al., 2015, Cucurbitacin D Is a Disruptor of the HSP90 Chaperone Machinery., J Nat Prod

Turbyville TJ et al., 2006, Search for Hsp90 inhibitors with potential anticancer activity: isolation and SAR studies of radicicol and monocillin I from two plant-associated fungi of the Sonoran desert., J Nat Prod

Hadden MK et al., 2007, Derrubone, an inhibitor of the Hsp90 protein folding machinery., J Nat Prod

HingoraniCasas: ENSG00000096384
- Version: 31-May-2017
Alternate Names:

ENSG00000096384 Gene Symbol

HSP90AB1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
MyCancerGenome: HSP90AB1
- Version: 20-Jun-2017
Alternate Names:

3326 Entrez Gene Id

HSP90AB1 MyCancerGenome Gene Symbol

HSP90 MyCancerGenome Reported Gene Name

Gene Info:

Publications:
ChemblInteractions: HSP90B
- Version: chembl_23
Alternate Names:

HSPC2 GENE_SYMBOL

HSPCB GENE_SYMBOL

HSP90AB1 GENE_SYMBOL

Gene Info:

Publications:
GO: HSP90AB1
- Version: 01-February-2022
Alternate Names:

HSP90B GO Gene Synonym

HSPC2 GO Gene Synonym

HSPCB GO Gene Synonym

Gene Info:

Gene Categories:

CELL SURFACE, TUMOR SUPPRESSOR

Publications:
TTD: Heat shock protein 90 beta
- Version: 2020.06.01
Alternate Names:

HSP90B TTD Gene Abbreviation

T96623 TTD Target ID

Gene Info:

Publications:
Pharos: HSP90AB1
- Version: 01-February-2022
Alternate Names:

Heat shock protein HSP 90-beta Gene Name

P08238 UniProt ID

Gene Info:

Gene Categories:

TRANSCRIPTION FACTOR

Publications:
MyCancerGenomeClinicalTrial: HSP90AB1
- Version: 30-February-2014
Alternate Names:

Gene Info:

Publications:
FoundationOneGenes: HSP90AB1
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
CarisMolecularIntelligence: HSP90AB1
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Mechanism of Interaction	Heat shock protein HSP90 inhibitor
Direct Interaction	yes
Trial Name	CNF1010

Trial Name	alvespimycin hydrochloride, KOS-1022 (DMAG), NSC-707545
Novel drug target	Novel Target

Trial Name	IPI-493, oral retaspimycin
Novel drug target	Novel Target

Trial Name	IPI-504
Novel drug target	Novel Target
Mechanism of Interaction	Heat shock protein HSP90 inhibitor

Trial Name	STA-9090
Novel drug target	Novel Target
Mechanism of Interaction	Heat shock protein HSP90 inhibitor

ENSG00000096384	Ensembl Gene Id
HEAT SHOCK PROTEIN HSP 90-BETA (HSP 84) (HSP 90). [SOURCE:UNIPROT/SWISSPROT;ACC:P08238]	Description
HSPCB	Display Id

3326	Entrez Gene Id
ENSG00000096384	Ensembl Gene Id
HEAT SHOCK PROTEIN HSP 90-BETA	Uniprot Protein Name

HSP90B	GO Gene Synonym
HSPC2	GO Gene Synonym
HSPCB	GO Gene Synonym

HSP90AB1 Gene Record

HSP90AB1 3326 Druggable GenomeClinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17603540

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24360559

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16499313 24984936 17603540 10592235

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25756299

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21764310

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 10592235 17016423 17139284 21273068 18408713 24984936 24428777 18020309 25277067 25105924 21861487 23859777 25756299

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16499313

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25756299

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info: Trial Name SNX-5422 Novel drug target Novel Target

PMIDs: None found

Sources: TdgClinicalTrial TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16464590

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Heat shock protein HSP90 inhibitor Direct Interaction yes Trial Name CNF1010

PMIDs: 25277067 23520985 22480433 25105924 17603540 21764310

Sources: DTC MyCancerGenome TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Trial Name alvespimycin hydrochloride, KOS-1022 (DMAG), NSC-707545 Novel drug target Novel Target

PMIDs: 17603540

Sources: DTC TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21129982 25756299

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name IPI-493, oral retaspimycin Novel drug target Novel Target

PMIDs: None found

Sources: MyCancerGenome TdgClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name IPI-504 Novel drug target Novel Target Mechanism of Interaction Heat shock protein HSP90 inhibitor

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
17603540

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
24360559

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16499313 24984936 17603540 10592235

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
25756299

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21764310

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
10592235 17016423 17139284 21273068 18408713 24984936 24428777 18020309 25277067 25105924 21861487 23859777 25756299

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16499313

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
25756299

Sources:
DTC

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name SNX-5422

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial TTD

Interaction Types & Directionality:

n/a

PMIDs:
16464590

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Heat shock protein HSP90 inhibitor

Direct Interaction yes

Trial Name CNF1010

PMIDs:
25277067 23520985 22480433 25105924 17603540 21764310

Sources:
DTC MyCancerGenome TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name alvespimycin hydrochloride, KOS-1022 (DMAG), NSC-707545

Novel drug target Novel Target

PMIDs:
17603540

Sources:
DTC TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
21129982 25756299

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name IPI-493, oral retaspimycin

Novel drug target Novel Target

PMIDs:
None found

Sources:
MyCancerGenome TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name IPI-504

Novel drug target Novel Target

Mechanism of Interaction Heat shock protein HSP90 inhibitor

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21129982 25756299

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23859777

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
18020309

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name STA-9090

Novel drug target Novel Target

Mechanism of Interaction Heat shock protein HSP90 inhibitor

PMIDs:
None found

Sources:
MyCancerGenome TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Novel Target

Trial Name XL888

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
21486005

Sources:
DTC

Interaction Types & Directionality:

n/a