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HSP90AB1 Gene Record

  • Summary
  • Interactions
  • Claims
  • HSP90AB1 3326 Druggable GenomeClinically Actionable

    Alternate Names:

    3326
    HEAT SHOCK PROTEIN 90 ALPHA FAMILY CLASS B MEMBER 1
    HSP90AB1
    D6S182
    HSP84
    HSP90B
    HSPC2
    HSPCB
    140572
    5258
    ENSG00000096384
    OTTHUMG00000014761
    P08238
    HEAT SHOCK PROTEIN HSP 90-BETA
    HS90B_HUMAN
    Heat shock 84 kDa
    HSP 90
    HSP 84
    HSP90
    HEAT SHOCK PROTEIN HSP 90-BETA (HSP 84) (HSP 90). [SOURCE:UNIPROT/SWISSPROT;ACC:P08238]
    PA29524
    Heat shock protein 90 beta
    T96623

    Gene Info:

    Target Class Miscellaneous
    Target Subclass HSP90-like_chaperon
    Human Readable Name DRUGGABLE GENOME
    Interpro Short Name ATPase-like_ATP-bd
    Interpro Name ATPase-like, ATP-binding domain
    Interpro Type Domain
    Uniprot Status Swiss-Prot
    Interpro Acc IPR003594
    Uniprot Evidence 1: Evidence at protein level
    Gene Biotype PROTEIN_CODING
    (11 More Sources)

    Gene Categories: Category Details

    CELL SURFACE
    TUMOR SUPPRESSOR
    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE
    TRANSCRIPTION FACTOR

    Publications:

    Wang M et al., 2006, Radanamycin, a macrocyclic chimera of radicicol and geldanamycin., Bioorg Med Chem Lett
    Davenport J et al., 2011, Gambogic acid, a natural product inhibitor of Hsp90., J Nat Prod
    Matts RL et al., 2011, A systematic protocol for the characterization of Hsp90 modulators., Bioorg Med Chem
    Hall JA et al., 2015, Cucurbitacin D Is a Disruptor of the HSP90 Chaperone Machinery., J Nat Prod
    Li Z et al., 2014, Discovery of diamine-linked 17-aroylamido-17-demethoxygeldanamycins as potent Hsp90 inhibitors., Eur J Med Chem
    Lauria A et al., 2013, Synthesis and biological activities of a new class of heat shock protein 90 inhibitors, designed by energy-based pharmacophore virtual screening., J Med Chem
    Ramsey DM et al., 2012, An Hsp90 modulator that exhibits a unique mechanistic profile., Bioorg Med Chem Lett
    Li Z et al., 2014, Design, synthesis and biological evaluation of 17-arylmethylamine-17-demethoxygeldanamycin derivatives as potent Hsp90 inhibitors., Eur J Med Chem
    Rodina A et al., 2007, Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer., Nat Chem Biol
    Kunicki JB et al., 2011, Synthesis and evaluation of biotinylated sansalvamide A analogs and their modulation of Hsp90., Bioorg Med Chem Lett
    Turbyville TJ et al., 2006, Search for Hsp90 inhibitors with potential anticancer activity: isolation and SAR studies of radicicol and monocillin I from two plant-associated fungi of the Sonoran desert., J Nat Prod
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Zhao H et al., 2011, Identification and initial SAR of silybin: an Hsp90 inhibitor., Bioorg Med Chem Lett
    Degterev A et al., 2008, Identification of RIP1 kinase as a specific cellular target of necrostatins., Nat Chem Biol
    Gavenonis J et al., 2014, Potential C-terminal-domain inhibitors of heat shock protein 90 derived from a C-terminal peptide helix., Bioorg Med Chem
    Chen CY et al., 2014, The antitumor agent PBT-1 directly targets HSP90 and hnRNP A2/B1 and inhibits lung adenocarcinoma growth and metastasis., J Med Chem
    Hadden MK et al., 2007, Derrubone, an inhibitor of the Hsp90 protein folding machinery., J Nat Prod
    Kusuma BR et al., 2011, Targeting the heat shock protein 90 dimer with dimeric inhibitors., J Med Chem
    Gunaherath GM et al., 2013, Synthesis and biological evaluation of novobiocin analogues as potential heat shock protein 90 inhibitors., Bioorg Med Chem
    McConnell JR et al., 2014, A heat shock protein 90 inhibitor that modulates the immunophilins and regulates hormone receptors without inducing the heat shock response., Bioorg Med Chem Lett
    Li M et al., 2018, Identification of a Genomic Region between <i>SLC29A1</i> and <i>HSP90AB1</i> Associated with Risk of Bevacizumab-Induced Hypertension: CALGB 80405 (Alliance)., Clin Cancer Res
  • CYCLOPROPARADICICOL   HSP90AB1

    Interaction Score: 3.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17603540


    Sources:
    DTC

  • COUMERMYCIN A1   HSP90AB1

    Interaction Score: 3.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24360559


    Sources:
    DTC

  • RADICICOL   HSP90AB1

    Interaction Score: 2.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16499313 24984936 17603540 10592235


    Sources:
    DTC

  • PU-H71   HSP90AB1

    Interaction Score: 1.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CUCURBITACIN D   HSP90AB1

    Interaction Score: 1.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25756299


    Sources:
    DTC

  • CHEMBL192264   HSP90AB1

    Interaction Score: 1.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21764310


    Sources:
    DTC

  • TAS-116   HSP90AB1

    Interaction Score: 1.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • GELDANAMYCIN   HSP90AB1

    Interaction Score: 1.67

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    10592235 17016423 17139284 21273068 18408713 24984936 24428777 18020309 25277067 25105924 21861487 23859777 25756299


    Sources:
    DTC

  • MONOCILLIN I   HSP90AB1

    Interaction Score: 1.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16499313


    Sources:
    DTC

  • CHEMBL2022241   HSP90AB1

    Interaction Score: 1.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25756299


    Sources:
    DTC

  • CHEMBL553939   HSP90AB1

    Interaction Score: 1.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name SNX-5422
    Novel drug target Novel Target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TTD

  • RADANAMYCIN   HSP90AB1

    Interaction Score: 1.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16464590


    Sources:
    DTC

  • TANESPIMYCIN   HSP90AB1

    Interaction Score: 1.39

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Heat shock protein HSP90 inhibitor
    Direct Interaction yes
    Trial Name CNF1010

    PMIDs:
    25277067 23520985 22480433 25105924 17603540 21764310


    Sources:
    DTC MyCancerGenome TdgClinicalTrial ChemblInteractions

  • ALVESPIMYCIN   HSP90AB1

    Interaction Score: 1.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name alvespimycin hydrochloride, KOS-1022 (DMAG), NSC-707545
    Novel drug target Novel Target

    PMIDs:
    17603540


    Sources:
    DTC TdgClinicalTrial

  • CELASTROL   HSP90AB1

    Interaction Score: 1.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21129982 25756299


    Sources:
    DTC

  • RETASPIMYCIN   HSP90AB1

    Interaction Score: 1.11

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name IPI-493, oral retaspimycin
    Novel drug target Novel Target

    PMIDs:
    None found


    Sources:
    MyCancerGenome TdgClinicalTrial

  • RETASPIMYCIN HYDROCHLORIDE   HSP90AB1

    Interaction Score: 1.11

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name IPI-504
    Novel drug target Novel Target
    Mechanism of Interaction Heat shock protein HSP90 inhibitor

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions

  • ZEARALANONE   HSP90AB1

    Interaction Score: 0.84

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GEDUNIN   HSP90AB1

    Interaction Score: 0.84

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21129982 25756299


    Sources:
    DTC

  • NOVOBIOCIN   HSP90AB1

    Interaction Score: 0.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23859777


    Sources:
    DTC

  • DERRUBONE   HSP90AB1

    Interaction Score: 0.56

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18020309


    Sources:
    DTC

  • GANETESPIB   HSP90AB1

    Interaction Score: 0.56

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name STA-9090
    Novel drug target Novel Target
    Mechanism of Interaction Heat shock protein HSP90 inhibitor

    PMIDs:
    None found


    Sources:
    MyCancerGenome TdgClinicalTrial ChemblInteractions

  • XL-888   HSP90AB1

    Interaction Score: 0.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Novel Target
    Trial Name XL888

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • GAMBOGIC ACID   HSP90AB1

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21486005


    Sources:
    DTC

  • SILIBININ   HSP90AB1

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21273068


    Sources:
    DTC

  • ZERANOL   HSP90AB1

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DIACEREIN   HSP90AB1

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ZEARALENONE   HSP90AB1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TETRACYCLINE   HSP90AB1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • BEVACIZUMAB   HSP90AB1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29871907


    Sources:
    PharmGKB

  • CHEMBL53898   HSP90AB1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • RHEIN   HSP90AB1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL578512   HSP90AB1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DAUNORUBICIN HYDROCHLORIDE   HSP90AB1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DOXORUBICIN HYDROCHLORIDE   HSP90AB1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NORDIHYDROGUAIARETIC ACID   HSP90AB1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DIPYRIDAMOLE   HSP90AB1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Ensembl: ENSG00000096384

    • Version: 101_38

    Alternate Names:
    HSP90AB1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P08238

    • Version: January-2014

    Alternate Names:
    HSP90AB1 Gene Symbol

    Gene Info:
    Target Class Miscellaneous
    Target Subclass HSP90-like_chaperon

    Publications:

  • RussLampel: ENSG00000096384

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000096384 Ensembl Gene Id
    HEAT SHOCK PROTEIN HSP 90-BETA (HSP 84) (HSP 90). [SOURCE:UNIPROT/SWISSPROT;ACC:P08238] Description
    HSPCB Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: P08238

    • Version: 11-September-2012

    Alternate Names:
    3326 Entrez Gene Id
    ENSG00000096384 Ensembl Gene Id
    HEAT SHOCK PROTEIN HSP 90-BETA Uniprot Protein Name

    Gene Info:
    Human Readable Name DRUGGABLE GENOME
    Interpro Short Name ATPase-like_ATP-bd
    Interpro Name ATPase-like, ATP-binding domain

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • PharmGKB: HSP90AB1

    • Version: 18-August-2020

    Alternate Names:
    PA29524 PharmGKB ID

    Gene Info:

    Publications:
    Li M et al., 2018, Identification of a Genomic Region between <i>SLC29A1</i> and <i>HSP90AB1</i> Associated with Risk of Bevacizumab-Induced Hypertension: CALGB 80405 (Alliance)., Clin Cancer Res

  • DTC: HSP90AB1

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Hall JA et al., 2015, Cucurbitacin D Is a Disruptor of the HSP90 Chaperone Machinery., J Nat Prod
    Turbyville TJ et al., 2006, Search for Hsp90 inhibitors with potential anticancer activity: isolation and SAR studies of radicicol and monocillin I from two plant-associated fungi of the Sonoran desert., J Nat Prod
    Hadden MK et al., 2007, Derrubone, an inhibitor of the Hsp90 protein folding machinery., J Nat Prod

  • HingoraniCasas: ENSG00000096384

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000096384 Gene Symbol
    HSP90AB1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • MyCancerGenome: HSP90AB1

    • Version: 20-Jun-2017

    Alternate Names:
    3326 Entrez Gene Id
    HSP90AB1 MyCancerGenome Gene Symbol
    HSP90 MyCancerGenome Reported Gene Name

    Gene Info:

    Publications:

  • ChemblInteractions: HSP90B

    • Version: chembl_23

    Alternate Names:
    HSPC2 GENE_SYMBOL
    HSPCB GENE_SYMBOL
    HSP90AB1 GENE_SYMBOL

    Gene Info:

    Publications:

  • GO: HSP90AB1

    • Version: 01-February-2022

    Alternate Names:
    HSP90B GO Gene Synonym
    HSPC2 GO Gene Synonym
    HSPCB GO Gene Synonym

    Gene Info:

    Gene Categories:
    CELL SURFACE, TUMOR SUPPRESSOR

    Publications:

  • TTD: Heat shock protein 90 beta

    • Version: 2020.06.01

    Alternate Names:
    HSP90B TTD Gene Abbreviation
    T96623 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: HSP90AB1

    • Version: 01-February-2022

    Alternate Names:
    Heat shock protein HSP 90-beta Gene Name
    P08238 UniProt ID

    Gene Info:

    Gene Categories:
    TRANSCRIPTION FACTOR

    Publications:

  • MyCancerGenomeClinicalTrial: HSP90AB1

    • Version: 30-February-2014

    Alternate Names:

    Gene Info:

    Publications:

  • FoundationOneGenes: HSP90AB1

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • CarisMolecularIntelligence: HSP90AB1

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21