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HSPA4 Gene Record

  • Summary
  • Interactions
  • Claims
  • HSPA4 3308

    Alternate Names:

    3308
    HEAT SHOCK PROTEIN FAMILY A (HSP70) MEMBER 4
    HSPA4
    APG-2
    HEL-S-5a
    HS24/P52
    HSPH2
    RY
    hsp70
    hsp70RY
    601113
    5237
    ENSG00000170606
    OTTHUMG00000129012
    Heat shock protein 70
    T49639

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (0 More Sources)

    Gene Categories: Category Details

    Publications:

    Hansen et al., 1995, Identification of a homologous heparin binding peptide sequence present in fibronectin and the 70 kDa family of heat-shock proteins., Biochim. Biophys. Acta
    Benz et al., 1990, Biochemical correlates of the antitumor and antimitochondrial properties of gossypol enantiomers., Mol. Pharmacol.
    Wu et al., 1998, Inhibition of prostaglandin production by nimesulide is accompanied by changes in expression of the cassette of uterine labor-related genes in pregnant sheep., Endocrinology
    O'Neill et al., 1998, Effects of 5-hydroxytryptamine2 receptor antagonism on the behavioral activation and immediate early gene expression induced by dizocilpine., J. Pharmacol. Exp. Ther.
    Gehrmann et al., 2002, Effects of antineoplastic agents on cytoplasmic and membrane-bound heat shock protein 70 (Hsp70) levels., Biol. Chem.
    Brozovic et al., 2001, Induction of heat shock protein 70 in drug-resistant cells by anticancer drugs and hyperthermia., Neoplasma
    Skuta et al., 1999, Molecular mechanism of the short-term cardiotoxicity caused by 2',3'-dideoxycytidine (ddC): modulation of reactive oxygen species levels and ADP-ribosylation reactions., Biochem. Pharmacol.
    Sharkey et al., 2007, PKC412 demonstrates JNK-dependent activity against human multiple myeloma cells., Blood
    Lee et al., 1987, Effect of cycloheximide or puromycin on induction of thermotolerance by heat in Chinese hamster ovary cells: dose fractionation at 45.5 degrees C1., Cancer Res.
    Theodorakis et al., 1988, HSP70 mRNA translation in chicken reticulocytes is regulated at the level of elongation., J. Biol. Chem.
    Hayashi et al., 1991, Translocation of hsp-70 and protein synthesis during continuous heating at mild temperatures in HeLa cells., Radiat. Res.
    Delescluse et al., 2001, Induction of cytochrome P450 1A1 gene expression, oxidative stress, and genotoxicity by carbaryl and thiabendazole in transfected human HepG2 and lymphoblastoid cells., Biochem. Pharmacol.
    Udelsman et al., 1994, Adrenergic regulation of adrenal and aortic heat shock protein., Surgery
    Xu et al., 2005, Recombinant human erythropoietin pretreatment attenuates myocardial infarct size: a possible mechanism involves heat shock Protein 70 and attenuation of nuclear factor-kappaB., Ann. Clin. Lab. Sci.
    Sharp et al., 1994, Neuronal injury produced by NMDA antagonists can be detected using heat shock proteins and can be blocked with antipsychotics., Psychopharmacol Bull
    Wang et al., 2006, HSP70 enhances macrophage phagocytosis by interaction with lipid raft-associated TLR-7 and upregulating p38 MAPK and PI3K pathways., J. Surg. Res.
    Tao et al., 2001, Effect of jianpiyiqi prescription on the expression of heat shock proteins in acetic acid-induced chronic gastric ulcer rats., J. Tongji Med. Univ.
    Konturek et al., 2003, Pioglitazone, a specific ligand of peroxisome proliferator-activated receptor-gamma, accelerates gastric ulcer healing in rat., Eur. J. Pharmacol.
    Matz et al., 1996, Heme-oxygenase-1 induction in glia throughout rat brain following experimental subarachnoid hemorrhage., Brain Res.
    Shringarpure et al., 2006, Gene expression analysis of B-lymphoma cells resistant and sensitive to bortezomib., Br. J. Haematol.
    Okuda et al., 2002, Analyses of differential gene expression in genetic hypertensive rats by microarray., Hypertens. Res.
    Liu et al., 2003, Calmodulin is involved in heat shock signal transduction in wheat., Plant Physiol.
    Goldbaum et al., 2001, Stress proteins in oligodendrocytes: differential effects of heat shock and oxidative stress., J. Neurochem.
    Narayanan et al., 2006, Docosahexaenoic acid in combination with celecoxib modulates HSP70 and p53 proteins in prostate cancer cells., Int. J. Cancer
    Gomer et al., 1996, Photodynamic therapy-mediated oxidative stress can induce expression of heat shock proteins., Cancer Res.
    Xu et al., 2006, Enhancement of neuroprotection and heat shock protein induction by combined prostaglandin A1 and lithium in rodent models of focal ischemia., Brain Res.
    Chuang, 2005, The antiapoptotic actions of mood stabilizers: molecular mechanisms and therapeutic potentials., Ann. N. Y. Acad. Sci.
    Ren et al., 2003, Postinsult treatment with lithium reduces brain damage and facilitates neurological recovery in a rat ischemia/reperfusion model., Proc. Natl. Acad. Sci. U.S.A.
  • PHOTOFRIN   HSPA4

    Interaction Score: 3.99

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8625311


    Sources:
    NCI

  • MINNELIDE   HSPA4

    Interaction Score: 1.99

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • PUROMYCIN   HSPA4

    Interaction Score: 1.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3664499 3170555 1986403


    Sources:
    NCI

  • ZALCITABINE   HSPA4

    Interaction Score: 1.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10591146


    Sources:
    NCI

  • THIABENDAZOLE   HSPA4

    Interaction Score: 0.66

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11226373


    Sources:
    NCI

  • KETANSERIN   HSPA4

    Interaction Score: 0.5

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9864262


    Sources:
    NCI

  • IFOSFAMIDE   HSPA4

    Interaction Score: 0.44

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12530536


    Sources:
    NCI

  • UREA   HSPA4

    Interaction Score: 0.44

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7548155


    Sources:
    NCI

  • NIMESULIDE   HSPA4

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9645681


    Sources:
    NCI

  • PHENYLEPHRINE   HSPA4

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8047983


    Sources:
    NCI

  • DEFEROXAMINE   HSPA4

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11579132


    Sources:
    NCI

  • SODIUM CHLORIDE   HSPA4

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8724993


    Sources:
    NCI

  • RANITIDINE   HSPA4

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11523209


    Sources:
    NCI

  • HYDRALAZINE   HSPA4

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12047041


    Sources:
    NCI

  • PIOGLITAZONE   HSPA4

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12871756


    Sources:
    NCI

  • EPOETIN ALFA   HSPA4

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15943180


    Sources:
    NCI

  • ENALAPRIL   HSPA4

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12047041


    Sources:
    NCI

  • CHLORPROMAZINE   HSPA4

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12857801


    Sources:
    NCI

  • LITHIUM   HSPA4

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16797496 16179524 12732732


    Sources:
    NCI

  • MIDOSTAURIN   HSPA4

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17032922


    Sources:
    NCI

  • WORTMANNIN   HSPA4

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16979664


    Sources:
    NCI

  • ISOPROTERENOL   HSPA4

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8047983


    Sources:
    NCI

  • HEPARIN   HSPA4

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7548155


    Sources:
    NCI

  • VERAPAMIL   HSPA4

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12857801


    Sources:
    NCI

  • CYTARABINE   HSPA4

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12530536


    Sources:
    NCI

  • NIFEDIPINE   HSPA4

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7770620


    Sources:
    NCI

  • GOSSYPOL   HSPA4

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2193225


    Sources:
    NCI

  • CELECOXIB   HSPA4

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16646082


    Sources:
    NCI

  • HALOPERIDOL   HSPA4

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9864262


    Sources:
    NCI

  • BORTEZOMIB   HSPA4

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16846475


    Sources:
    NCI

  • CISPLATIN   HSPA4

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11478701


    Sources:
    NCI

  • Ensembl: ENSG00000170606

    • Version: 101_38

    Alternate Names:
    HSPA4 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TTD: Heat shock protein 70

    • Version: 2020.06.01

    Alternate Names:
    HSP70 TTD Gene Abbreviation
    T49639 TTD Target ID

    Gene Info:

    Publications:
    Weng D et al., 2011, Preparation of a heat-shock protein 70-based vaccine from DC-tumor fusion cells., Methods Mol Biol

  • NCI: HSPA4

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Wu et al., 1998, Inhibition of prostaglandin production by nimesulide is accompanied by changes in expression of the cassette of uterine labor-related genes in pregnant sheep., Endocrinology
    Brozovic et al., 2001, Induction of heat shock protein 70 in drug-resistant cells by anticancer drugs and hyperthermia., Neoplasma
    O'Neill et al., 1998, Effects of 5-hydroxytryptamine2 receptor antagonism on the behavioral activation and immediate early gene expression induced by dizocilpine., J. Pharmacol. Exp. Ther.

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21