DGIdb - HSPA4 Gene Record

HSPA4 3308

Alternate Names:

3308
HEAT SHOCK PROTEIN FAMILY A (HSP70) MEMBER 4
HSPA4
APG-2
HEL-S-5a
HS24/P52
HSPH2
RY
hsp70
hsp70RY
601113
5237
ENSG00000170606
OTTHUMG00000129012
Heat shock protein 70
T49639

Gene Info:

Gene Biotype	PROTEIN_CODING

(0 More Sources)

Gene Categories: Category Details

Publications:

Hansen et al., 1995, Identification of a homologous heparin binding peptide sequence present in fibronectin and the 70 kDa family of heat-shock proteins., Biochim. Biophys. Acta
Benz et al., 1990, Biochemical correlates of the antitumor and antimitochondrial properties of gossypol enantiomers., Mol. Pharmacol.
Wu et al., 1998, Inhibition of prostaglandin production by nimesulide is accompanied by changes in expression of the cassette of uterine labor-related genes in pregnant sheep., Endocrinology
O'Neill et al., 1998, Effects of 5-hydroxytryptamine2 receptor antagonism on the behavioral activation and immediate early gene expression induced by dizocilpine., J. Pharmacol. Exp. Ther.
Gehrmann et al., 2002, Effects of antineoplastic agents on cytoplasmic and membrane-bound heat shock protein 70 (Hsp70) levels., Biol. Chem.
Brozovic et al., 2001, Induction of heat shock protein 70 in drug-resistant cells by anticancer drugs and hyperthermia., Neoplasma
Skuta et al., 1999, Molecular mechanism of the short-term cardiotoxicity caused by 2',3'-dideoxycytidine (ddC): modulation of reactive oxygen species levels and ADP-ribosylation reactions., Biochem. Pharmacol.
Sharkey et al., 2007, PKC412 demonstrates JNK-dependent activity against human multiple myeloma cells., Blood
Lee et al., 1987, Effect of cycloheximide or puromycin on induction of thermotolerance by heat in Chinese hamster ovary cells: dose fractionation at 45.5 degrees C1., Cancer Res.
Theodorakis et al., 1988, HSP70 mRNA translation in chicken reticulocytes is regulated at the level of elongation., J. Biol. Chem.
Hayashi et al., 1991, Translocation of hsp-70 and protein synthesis during continuous heating at mild temperatures in HeLa cells., Radiat. Res.
Delescluse et al., 2001, Induction of cytochrome P450 1A1 gene expression, oxidative stress, and genotoxicity by carbaryl and thiabendazole in transfected human HepG2 and lymphoblastoid cells., Biochem. Pharmacol.
Udelsman et al., 1994, Adrenergic regulation of adrenal and aortic heat shock protein., Surgery
Xu et al., 2005, Recombinant human erythropoietin pretreatment attenuates myocardial infarct size: a possible mechanism involves heat shock Protein 70 and attenuation of nuclear factor-kappaB., Ann. Clin. Lab. Sci.
Sharp et al., 1994, Neuronal injury produced by NMDA antagonists can be detected using heat shock proteins and can be blocked with antipsychotics., Psychopharmacol Bull
Wang et al., 2006, HSP70 enhances macrophage phagocytosis by interaction with lipid raft-associated TLR-7 and upregulating p38 MAPK and PI3K pathways., J. Surg. Res.
Tao et al., 2001, Effect of jianpiyiqi prescription on the expression of heat shock proteins in acetic acid-induced chronic gastric ulcer rats., J. Tongji Med. Univ.
Konturek et al., 2003, Pioglitazone, a specific ligand of peroxisome proliferator-activated receptor-gamma, accelerates gastric ulcer healing in rat., Eur. J. Pharmacol.
Matz et al., 1996, Heme-oxygenase-1 induction in glia throughout rat brain following experimental subarachnoid hemorrhage., Brain Res.
Shringarpure et al., 2006, Gene expression analysis of B-lymphoma cells resistant and sensitive to bortezomib., Br. J. Haematol.
Okuda et al., 2002, Analyses of differential gene expression in genetic hypertensive rats by microarray., Hypertens. Res.
Liu et al., 2003, Calmodulin is involved in heat shock signal transduction in wheat., Plant Physiol.
Goldbaum et al., 2001, Stress proteins in oligodendrocytes: differential effects of heat shock and oxidative stress., J. Neurochem.
Narayanan et al., 2006, Docosahexaenoic acid in combination with celecoxib modulates HSP70 and p53 proteins in prostate cancer cells., Int. J. Cancer
Gomer et al., 1996, Photodynamic therapy-mediated oxidative stress can induce expression of heat shock proteins., Cancer Res.
Xu et al., 2006, Enhancement of neuroprotection and heat shock protein induction by combined prostaglandin A1 and lithium in rodent models of focal ischemia., Brain Res.
Chuang, 2005, The antiapoptotic actions of mood stabilizers: molecular mechanisms and therapeutic potentials., Ann. N. Y. Acad. Sci.
Ren et al., 2003, Postinsult treatment with lithium reduces brain damage and facilitates neurological recovery in a rat ischemia/reperfusion model., Proc. Natl. Acad. Sci. U.S.A.

PHOTOFRIN HSPA4

Interaction Score: 3.99

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8625311

Sources:
NCI
MINNELIDE HSPA4

Interaction Score: 1.99

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
PUROMYCIN HSPA4

Interaction Score: 1.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3664499 3170555 1986403

Sources:
NCI
ZALCITABINE HSPA4

Interaction Score: 1.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10591146

Sources:
NCI
THIABENDAZOLE HSPA4

Interaction Score: 0.66

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11226373

Sources:
NCI
KETANSERIN HSPA4

Interaction Score: 0.5

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9864262

Sources:
NCI
IFOSFAMIDE HSPA4

Interaction Score: 0.44

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12530536

Sources:
NCI
UREA HSPA4

Interaction Score: 0.44

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7548155

Sources:
NCI
NIMESULIDE HSPA4

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9645681

Sources:
NCI
PHENYLEPHRINE HSPA4

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8047983

Sources:
NCI
DEFEROXAMINE HSPA4

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11579132

Sources:
NCI
SODIUM CHLORIDE HSPA4

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8724993

Sources:
NCI
RANITIDINE HSPA4

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11523209

Sources:
NCI
HYDRALAZINE HSPA4

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12047041

Sources:
NCI
PIOGLITAZONE HSPA4

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12871756

Sources:
NCI
EPOETIN ALFA HSPA4

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15943180

Sources:
NCI
ENALAPRIL HSPA4

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12047041

Sources:
NCI
CHLORPROMAZINE HSPA4

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12857801

Sources:
NCI
LITHIUM HSPA4

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16797496 16179524 12732732

Sources:
NCI
MIDOSTAURIN HSPA4

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17032922

Sources:
NCI
WORTMANNIN HSPA4

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16979664

Sources:
NCI
ISOPROTERENOL HSPA4

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8047983

Sources:
NCI
HEPARIN HSPA4

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7548155

Sources:
NCI
VERAPAMIL HSPA4

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12857801

Sources:
NCI
CYTARABINE HSPA4

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12530536

Sources:
NCI
NIFEDIPINE HSPA4

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7770620

Sources:
NCI
GOSSYPOL HSPA4

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2193225

Sources:
NCI
CELECOXIB HSPA4

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16646082

Sources:
NCI
HALOPERIDOL HSPA4

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9864262

Sources:
NCI
BORTEZOMIB HSPA4

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16846475

Sources:
NCI
CISPLATIN HSPA4

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11478701

Sources:
NCI

Ensembl: ENSG00000170606
- Version: 101_38
Alternate Names:

HSPA4 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TTD: Heat shock protein 70
- Version: 2020.06.01
Alternate Names:

HSP70 TTD Gene Abbreviation

T49639 TTD Target ID

Gene Info:

Publications:

Weng D et al., 2011, Preparation of a heat-shock protein 70-based vaccine from DC-tumor fusion cells., Methods Mol Biol

NCI: HSPA4

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Wu et al., 1998, Inhibition of prostaglandin production by nimesulide is accompanied by changes in expression of the cassette of uterine labor-related genes in pregnant sheep., Endocrinology

Brozovic et al., 2001, Induction of heat shock protein 70 in drug-resistant cells by anticancer drugs and hyperthermia., Neoplasma

O'Neill et al., 1998, Effects of 5-hydroxytryptamine2 receptor antagonism on the behavioral activation and immediate early gene expression induced by dizocilpine., J. Pharmacol. Exp. Ther.

HSPA4 Gene Record

HSPA4 3308

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8625311

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 3664499 3170555 1986403

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10591146

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11226373

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9864262

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12530536

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7548155

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9645681

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8047983

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11579132

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8724993

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11523209

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12047041

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12871756

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15943180

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12047041

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12857801

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
8625311

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
3664499 3170555 1986403

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10591146

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11226373

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9864262

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12530536

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7548155

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9645681

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8047983

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11579132

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8724993

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11523209

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12047041

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12871756

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15943180

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12047041

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12857801

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16797496 16179524 12732732

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17032922

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16979664

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8047983

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7548155

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12857801

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12530536

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7770620

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
2193225