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HSPG2 Gene Record

  • Summary
  • Interactions
  • Claims
  • HSPG2 3339 Druggable Genome

    Alternate Names:

    3339
    HEPARAN SULFATE PROTEOGLYCAN 2
    HSPG2
    HSPG
    PLC
    PRCAN
    SJA
    SJS
    SJS1
    142461
    5273
    ENSG00000142798
    OTTHUMG00000002674
    P98160
    PA29537
    Phospholipase C
    T77534
    Basement membrane-specific heparan sulfate proteoglycan core protein

    Gene Info:

    Target Class Miscellaneous
    Target Subclass Miscellaneous
    Target Subclass mebrane protein
    Gene Biotype PROTEIN_CODING
    (3 More Sources)

    Gene Categories: Category Details

    KINASE
    DRUGGABLE GENOME

    Publications:

    Porcelli S et al., 2016, Possible biomarkers modulating haloperidol efficacy and/or tolerability., Pharmacogenomics
    Gnoatto et al., 2003, Gene expression of extracellular matrix proteoglycans in human cyclosporin-induced gingival overgrowth., J. Periodontol.
    Iwabuchi et al., 2006, Syndecan-4 dependent FGF stimulation of mouse vibrissae growth., Mech. Dev.
    Sharma et al., 1998, Antisense targeting of perlecan blocks tumor growth and angiogenesis in vivo., J. Clin. Invest.
    Asada et al., Expression of fibroblast growth factor receptor genes in human hepatoma-derived cell lines., In Vitro Cell. Dev. Biol. Anim.
    Berman et al., 1999, Similarities and differences between the effects of heparin and glypican-1 on the bioactivity of acidic fibroblast growth factor and the keratinocyte growth factor., J. Biol. Chem.
  • PALIFERMIN   HSPG2

    Interaction Score: 17.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name rHu-KGF, keratinocyte growth factor (KGF),Kepivance
    Novel drug target Established target

    PMIDs:
    16989989 9788974 14753849 10593896


    Sources:
    TdgClinicalTrial

  • CYCLOSPORINE   HSPG2

    Interaction Score: 0.66

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14974815


    Sources:
    NCI

  • HALOPERIDOL   HSPG2

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27023437


    Sources:
    PharmGKB

  • Ensembl: ENSG00000142798

    • Version: 101_38

    Alternate Names:
    HSPG2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P98160

    • Version: January-2014

    Alternate Names:
    HSPG2 Gene Symbol

    Gene Info:
    Target Class Miscellaneous
    Target Subclass Miscellaneous
    Target Subclass mebrane protein

    Publications:

  • PharmGKB: HSPG2

    • Version: 18-August-2020

    Alternate Names:
    PA29537 PharmGKB ID

    Gene Info:

    Publications:
    Greenbaum L et al., 2012, Support for association of HSPG2 with tardive dyskinesia in Caucasian populations., Pharmacogenomics J
    Porcelli S et al., 2016, Possible biomarkers modulating haloperidol efficacy and/or tolerability., Pharmacogenomics

  • TTD: Phospholipase C

    • Version: 2020.06.01

    Alternate Names:
    PLC TTD Gene Abbreviation
    T77534 TTD Target ID

    Gene Info:

    Publications:
    Meuillet EJ, 2011, Novel inhibitors of AKT: assessment of a different approach targeting the pleckstrin homology domain., Curr Med Chem

  • NCI: HSPG2

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Gnoatto et al., 2003, Gene expression of extracellular matrix proteoglycans in human cyclosporin-induced gingival overgrowth., J. Periodontol.

  • HingoraniCasas: ENSG00000142798

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000142798 Gene Symbol
    HSPG2 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • Pharos: HSPG2

    • Version: 01-February-2022

    Alternate Names:
    Basement membrane-specific heparan sulfate proteoglycan core protein Gene Name
    P98160 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21