DGIdb - HSPG2 Gene Record

HSPG2 3339 Druggable Genome

Alternate Names:

3339
HEPARAN SULFATE PROTEOGLYCAN 2
HSPG2
HSPG
PLC
PRCAN
SJA
SJS
SJS1
142461
5273
ENSG00000142798
OTTHUMG00000002674
P98160
PA29537
Phospholipase C
T77534
Basement membrane-specific heparan sulfate proteoglycan core protein

Gene Info:

Target Class	Miscellaneous
Target Subclass	Miscellaneous
Target Subclass	mebrane protein
Gene Biotype	PROTEIN_CODING

(3 More Sources)

Gene Categories: Category Details

KINASE
DRUGGABLE GENOME

Publications:

Porcelli S et al., 2016, Possible biomarkers modulating haloperidol efficacy and/or tolerability., Pharmacogenomics
Gnoatto et al., 2003, Gene expression of extracellular matrix proteoglycans in human cyclosporin-induced gingival overgrowth., J. Periodontol.
Iwabuchi et al., 2006, Syndecan-4 dependent FGF stimulation of mouse vibrissae growth., Mech. Dev.
Sharma et al., 1998, Antisense targeting of perlecan blocks tumor growth and angiogenesis in vivo., J. Clin. Invest.
Asada et al., Expression of fibroblast growth factor receptor genes in human hepatoma-derived cell lines., In Vitro Cell. Dev. Biol. Anim.
Berman et al., 1999, Similarities and differences between the effects of heparin and glypican-1 on the bioactivity of acidic fibroblast growth factor and the keratinocyte growth factor., J. Biol. Chem.

PALIFERMIN HSPG2

Interaction Score: 17.17

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name rHu-KGF, keratinocyte growth factor (KGF),Kepivance

Novel drug target Established target

PMIDs:
16989989 9788974 14753849 10593896

Sources:
TdgClinicalTrial
CYCLOSPORINE HSPG2

Interaction Score: 0.66

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14974815

Sources:
NCI
HALOPERIDOL HSPG2

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27023437

Sources:
PharmGKB

Ensembl: ENSG00000142798
- Version: 101_38
Alternate Names:

HSPG2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P98160
- Version: January-2014
Alternate Names:

HSPG2 Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass Miscellaneous

Target Subclass mebrane protein

Publications:

PharmGKB: HSPG2

Version: 18-August-2020

Alternate Names:

PA29537 PharmGKB ID

Gene Info:

Publications:

Greenbaum L et al., 2012, Support for association of HSPG2 with tardive dyskinesia in Caucasian populations., Pharmacogenomics J

Porcelli S et al., 2016, Possible biomarkers modulating haloperidol efficacy and/or tolerability., Pharmacogenomics

TTD: Phospholipase C
- Version: 2020.06.01
Alternate Names:

PLC TTD Gene Abbreviation

T77534 TTD Target ID

Gene Info:

Publications:

Meuillet EJ, 2011, Novel inhibitors of AKT: assessment of a different approach targeting the pleckstrin homology domain., Curr Med Chem
NCI: HSPG2
- Version: 14-September-2017
Alternate Names:

Gene Info:

Publications:

Gnoatto et al., 2003, Gene expression of extracellular matrix proteoglycans in human cyclosporin-induced gingival overgrowth., J. Periodontol.
HingoraniCasas: ENSG00000142798
- Version: 31-May-2017
Alternate Names:

ENSG00000142798 Gene Symbol

HSPG2 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
Pharos: HSPG2
- Version: 01-February-2022
Alternate Names:

Basement membrane-specific heparan sulfate proteoglycan core protein Gene Name

P98160 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:

Trial Name	rHu-KGF, keratinocyte growth factor (KGF),Kepivance
Novel drug target	Established target

Basement membrane-specific heparan sulfate proteoglycan core protein	Gene Name
P98160	UniProt ID

HSPG2 Gene Record

HSPG2 3339 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

PALIFERMIN HSPG2

Interaction Types & Directionality: n/a

Interaction Info: Trial Name rHu-KGF, keratinocyte growth factor (KGF),Kepivance Novel drug target Established target

PMIDs: 16989989 9788974 14753849 10593896

Sources: TdgClinicalTrial

CYCLOSPORINE HSPG2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14974815

Sources: NCI

HALOPERIDOL HSPG2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27023437

Sources: PharmGKB

Ensembl: ENSG00000142798

Alternate Names: HSPG2 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: P98160

Alternate Names: HSPG2 Gene Symbol

Gene Info: Target Class Miscellaneous Target Subclass Miscellaneous Target Subclass mebrane protein

Publications:

PharmGKB: HSPG2

Alternate Names: PA29537 PharmGKB ID

Gene Info:

Publications: Greenbaum L et al., 2012, Support for association of HSPG2 with tardive dyskinesia in Caucasian populations., Pharmacogenomics J Porcelli S et al., 2016, Possible biomarkers modulating haloperidol efficacy and/or tolerability., Pharmacogenomics

TTD: Phospholipase C

Alternate Names: PLC TTD Gene Abbreviation T77534 TTD Target ID

Gene Info:

Publications: Meuillet EJ, 2011, Novel inhibitors of AKT: assessment of a different approach targeting the pleckstrin homology domain., Curr Med Chem

NCI: HSPG2

Alternate Names:

Gene Info:

Publications: Gnoatto et al., 2003, Gene expression of extracellular matrix proteoglycans in human cyclosporin-induced gingival overgrowth., J. Periodontol.

HingoraniCasas: ENSG00000142798

Alternate Names: ENSG00000142798 Gene Symbol HSPG2 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

Pharos: HSPG2

Alternate Names: Basement membrane-specific heparan sulfate proteoglycan core protein Gene Name P98160 UniProt ID

Gene Info:

Gene Categories: KINASE

Publications:

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name rHu-KGF, keratinocyte growth factor (KGF),Kepivance

Novel drug target Established target

PMIDs:
16989989 9788974 14753849 10593896

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
14974815

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
27023437

Sources:
PharmGKB

Alternate Names:

HSPG2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

HSPG2 Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass Miscellaneous

Target Subclass mebrane protein

Alternate Names:

PA29537 PharmGKB ID

Publications:

Greenbaum L et al., 2012, Support for association of HSPG2 with tardive dyskinesia in Caucasian populations., Pharmacogenomics J

Porcelli S et al., 2016, Possible biomarkers modulating haloperidol efficacy and/or tolerability., Pharmacogenomics

Alternate Names:

PLC TTD Gene Abbreviation

T77534 TTD Target ID

Publications:

Meuillet EJ, 2011, Novel inhibitors of AKT: assessment of a different approach targeting the pleckstrin homology domain., Curr Med Chem

Publications:

Gnoatto et al., 2003, Gene expression of extracellular matrix proteoglycans in human cyclosporin-induced gingival overgrowth., J. Periodontol.

Alternate Names:

ENSG00000142798 Gene Symbol

HSPG2 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

Basement membrane-specific heparan sulfate proteoglycan core protein Gene Name

P98160 UniProt ID

Gene Categories:

KINASE