3356 |
5-HYDROXYTRYPTAMINE RECEPTOR 2A |
HTR2A |
5-HT2A |
HTR2 |
182135 |
5293 |
ENSG00000102468 |
OTTHUMG00000016881 |
Serotonin receptor 2A |
5-HT-2 |
5-HT-2A |
P28223 |
5HT2A_HUMAN |
PA193 |
5-HYDROXYTRYPTAMINE 2A RECEPTOR (5-HT-2A) (SEROTONIN RECEPTOR 2A) (5- HT-2). [SOURCE:UNIPROT/SWISSPROT;ACC:P28223] |
5-HT 2A receptor |
T32060 |
Target Main Class | Receptors |
Target Subclass | Rhodopsin |
Transmembrane Helix Count | 7 |
Target Subclass | GPCR |
Human Readable Name | G PROTEIN COUPLED RECEPTOR |
Interpro Acc | IPR000276 |
Uniprot Status | Swiss-Prot |
Uniprot Evidence | 1: Evidence at protein level |
Interpro Name | GPCR, rhodopsin-like, 7TM |
Interpro Type | Family |
Human Readable Name | DRUGGABLE GENOME |
Interpro Short Name | 7TM_GPCR_Rhodpsn |
Target Class | Receptors |
Gene Biotype | PROTEIN_CODING |
KINASE |
G PROTEIN COUPLED RECEPTOR |
DRUGGABLE GENOME |
inverse agonist (inhibitory) |
antagonist (inhibitory) |
Novel drug target | Established target |
Trial Name | Pimavanserin |
antagonist (inhibitory) |
Trial Name | volinanserin |
Novel drug target | Established target |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
inverse agonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor inverse agonist |
Direct Interaction | yes |
inverse agonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor inverse agonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Trial Name | iferanserin ointment |
Novel drug target | Established target |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
antagonist (inhibitory) |
Trial Name | - |
Novel drug target | Established target |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Direct Interaction | yes |
inverse agonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor inverse agonist |
antagonist (inhibitory) |
Trial Name | paliperidone ER, paliperidone palmitate |
Novel drug target | Established target |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
n/a |
Trial Name | INN-00835, nemifitide |
Novel drug target | Established target |
antagonist (inhibitory) |
antagonist (inhibitory) |
Novel drug target | Established target |
Trial Name | ITI-007, ITI-722 |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Trial Name | - |
Novel drug target | Established target |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
inverse agonist (inhibitory) |
Trial Name | esmirtazapine, ORG-4420 |
Novel drug target | Established target |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Direct Interaction | yes |
Trial Name | trelanserin, SL 65.0472 |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Direct Interaction | yes |
Trial Name | OPC-34712 |
partial agonist (activating) |
agonist (activating) |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Trial Name | Abilify |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Direct Interaction | yes |
Trial Name | mirtazapine,Remeron, Remeron SolTab, Reflex |
antagonist (inhibitory) |
Trial Name | Flibanserin |
Novel drug target | Established target |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Direct Interaction | yes |
Trial Name | - |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Trial Name | AZ-004 |
Novel drug target | Established target |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Direct Interaction | yes |
n/a |
Trial Name | Risperdal |
Novel drug target | Established target |
agonist (activating) |
Trial Name | terguride |
Novel drug target | Established target |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
antagonist (inhibitory) |
Trial Name | Serdolect |
Novel drug target | Established target |
antagonist (inhibitory) |
Trial Name | lurasidone, SM-13496,Latuda |
Novel drug target | Established target |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Novel drug target | Established target |
antagonist (inhibitory) |
Trial Name | - |
Novel drug target | Established target |
antagonist (inhibitory) |
Trial Name | olanzapine,Zyprexa, Zypadhera, Zyprexa Relprevv |
Novel drug target | Established target |
Trial Name | Olanzapine/fluoxetine combination,Symbyax (Zyprexa/Prozac) |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Trial Name | - |
Novel drug target | Established target |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
antagonist (inhibitory) |
Trial Name | - |
Novel drug target | Established target |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
antagonist (inhibitory) |
Trial Name | OMS-103HP |
Novel drug target | Established target |
antagonist (inhibitory) |
Trial Name | Silenor (SO-101) |
Novel drug target | Established target |
antagonist (inhibitory) |
Trial Name | Asenapine |
Novel drug target | Established target |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Direct Interaction | yes |
agonist (activating) |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Direct Interaction | yes |
n/a |
Novel drug target | Established target |
Trial Name | renzapride |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
binder |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Direct Interaction | yes |
n/a |
Trial Name | - |
Novel drug target | Established target |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Direct Interaction | yes |
n/a |
Trial Name | bifeprunox, DU127090 |
Novel drug target | Established target |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
other/unknown |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
n/a |
Trial Name | NPL-2008, Fluoxetine |
Novel drug target | Established target |
HTR2A | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
P28223 | Uniprot Accession |
5HT2A_HUMAN | Uniprot Id |
HTR2A | Gene Symbol |
Target Main Class | Receptors |
Target Subclass | Rhodopsin |
Transmembrane Helix Count | 7 |
HTR2A | Display Id |
5-HYDROXYTRYPTAMINE 2A RECEPTOR (5-HT-2A) (SEROTONIN RECEPTOR 2A) (5- HT-2). [SOURCE:UNIPROT/SWISSPROT;ACC:P28223] | Description |
ENSG00000102468 | Ensembl Gene Id |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
3356 | Entrez Gene Id |
5-HYDROXYTRYPTAMINE RECEPTOR 2A | Uniprot Protein Name |
HTR2A | Uniprot Gene Name |
Human Readable Name | G PROTEIN COUPLED RECEPTOR |
Interpro Acc | IPR000276 |
Uniprot Status | Swiss-Prot |
G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME |
HTR2A | Gene Symbol |
Target Class | Receptors |
Target Subclass | GPCR |
Target Subclass | Rhodopsin |
PA193 | PharmGKB ID |
HTR2A | TTD Gene Abbreviation |
T32060 | TTD Target ID |
ENSG00000102468 | Gene Symbol |
HTR2A | Ensembl Id |
DRUGGABLE GENOME |
HTR2 | GENE_SYMBOL |
HTR2A | GENE_SYMBOL |
5-hydroxytryptamine receptor 2A | UNIPROT |
3356 | Gene ID |
5-HT2A | dGene Synonym |
HTR2 | dGene Synonym |
G PROTEIN COUPLED RECEPTOR |
5-hydroxytryptamine receptor 2A | Gene Name |
P28223 | UniProt ID |
KINASE |