DGIdb - HTR2B Gene Record

HTR2B 3357 Druggable Genome

Alternate Names:

3357
5-HYDROXYTRYPTAMINE RECEPTOR 2B
HTR2B
5-HT(2B)
5-HT-2B
5-HT2B
601122
5294
ENSG00000135914
OTTHUMG00000133222
P41595
5HT2B_HUMAN
Serotonin receptor 2B
5-HYDROXYTRYPTAMINE 2B RECEPTOR (5-HT-2B) (SEROTONIN RECEPTOR 2B). [SOURCE:UNIPROT/SWISSPROT;ACC:P41595]
5-HT 2B receptor
T31204

Gene Info:

Human Readable Name	G PROTEIN COUPLED RECEPTOR
Target Class	Receptors
Target Subclass	GPCR
Target Subclass	Rhodopsin
Human Readable Name	DRUGGABLE GENOME
Uniprot Status	Swiss-Prot
Uniprot Evidence	1: Evidence at protein level
Interpro Acc	IPR000276
Interpro Type	Family
Interpro Name	GPCR, rhodopsin-like, 7TM
Interpro Short Name	7TM_GPCR_Rhodpsn
Transmembrane Helix Count	7
Target Main Class	Receptors
Gene Biotype	PROTEIN_CODING

(7 More Sources)

Gene Categories: Category Details

KINASE
G PROTEIN COUPLED RECEPTOR
DRUGGABLE GENOME

Publications:

Muramatsu et al., 1988, 5-HT2 antagonists and minaprine block the 5-HT-induced inhibition of dopamine release from rat brain striatal slices., Eur. J. Pharmacol.
Kodama et al., 1992, Protective effect of minaprine against the abnormal changes of 2-deoxyglucose uptake by rat hippocampal slices induced by hypoxia/hypoglycemia., Jpn. J. Pharmacol.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Shahid et al., 2009, Asenapine: a novel psychopharmacologic agent with a unique human receptor signature., J. Psychopharmacol. (Oxford)
Citrome, 2011, Role of sublingual asenapine in treatment of schizophrenia., Neuropsychiatr Dis Treat
Lyon et al., 1986, 3,4-Methylenedioxymethamphetamine (MDMA): stereoselective interactions at brain 5-HT1 and 5-HT2 receptors., Psychopharmacology (Berl.)
Cooper et al., 1979, Some properties of 5-hydroxytryptamine receptors in the hindquarters of the rat., Br. J. Pharmacol.
Cusack et al., 1994, Binding of antidepressants to human brain receptors: focus on newer generation compounds., Psychopharmacology (Berl.)
Maj et al., 1977, Doxepin as a blocker of central serotonin receptors., Pharmakopsychiatr Neuropsychopharmakol
Porvasnik SL et al., 2010, PRX-08066, a novel 5-hydroxytryptamine receptor 2B antagonist, reduces monocrotaline-induced pulmonary arterial hypertension and right ventricular hypertrophy in rats., J Pharmacol Exp Ther
Semple G et al., 2009, Pyrimidine-based antagonists of h-MCH-R1 derived from ATC0175: in vitro profiling and in vivo evaluation., Bioorg Med Chem Lett

PRX-08066 HTR2B

Interaction Score: 10.91

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name PRX-08066

Novel drug target Established target

PMIDs:
20430844

Sources:
TdgClinicalTrial TTD
CHEMBL182150 HTR2B

Interaction Score: 7.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19773162

Sources:
DTC
MINAPRINE HTR2B

Interaction Score: 4.85

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
2975224 1361012 17016423 17139284 11752352

Sources:
TdgClinicalTrial TEND TTD
TRIFLUPROMAZINE HTR2B

Interaction Score: 3.18

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
497523 17016423 17139284 11752352

Sources:
TdgClinicalTrial TEND TTD
CHLORPROTHIXENE HTR2B

Interaction Score: 2.08

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
17016423 17139284

Sources:
TdgClinicalTrial TEND
TERGURIDE HTR2B

Interaction Score: 1.82

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name terguride

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
VABICASERIN HTR2B

Interaction Score: 1.82

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
MIDOMAFETAMINE HTR2B

Interaction Score: 1.45

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
2871581

Sources:
TTD
METHYLERGONOVINE MALEATE HTR2B

Interaction Score: 1.21

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serotonin 2b (5-HT2b) receptor partial agonist

PMIDs:
None found

Sources:
ChemblInteractions
VABICASERIN HYDROCHLORIDE HTR2B

Interaction Score: 1.21

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serotonin 2b (5-HT2b) receptor antagonist

PMIDs:
None found

Sources:
ChemblInteractions
AGOMELATINE HTR2B

Interaction Score: 0.73

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name agomelatine, AGO178C, S-20098,Valdoxan, Thymanax

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
RENZAPRIDE HTR2B

Interaction Score: 0.73

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name renzapride

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
DOXEPIN HTR2B

Interaction Score: 0.61

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Silenor (SO-101)

Novel drug target Established target

PMIDs:
7855217 309138

Sources:
TdgClinicalTrial
ASENAPINE HTR2B

Interaction Score: 0.61

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name Asenapine

PMIDs:
18308814 21655346

Sources:
TdgClinicalTrial
LEVOMEPROMAZINE HTR2B

Interaction Score: 0.52

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
QUETIAPINE HTR2B

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name Seroquel

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
SUMATRIPTAN HTR2B

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TEND

Ensembl: ENSG00000135914
- Version: 101_38
Alternate Names:

HTR2B Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TEND: P41595
- Version: 01-August-2011
Alternate Names:

P41595 Uniprot Accession

HTR2B Gene Symbol

3357 Entrez Gene Id

Gene Info:

Target Subclass Rhodopsin

Transmembrane Helix Count 7

Target Subclass GPCR

Publications:
HopkinsGroom: P41595
- Version: 11-September-2012
Alternate Names:

5-HYDROXYTRYPTAMINE RECEPTOR 2B Uniprot Protein Name

P41595 Uniprot Accession

5HT2B_HUMAN Uniprot Id

Gene Info:

Human Readable Name G PROTEIN COUPLED RECEPTOR

Human Readable Name DRUGGABLE GENOME

Uniprot Status Swiss-Prot

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:
RussLampel: ENSG00000135914
- Version: 26-July-2011
Alternate Names:

ENSG00000135914 Ensembl Gene Id

HTR2B Display Id

5-HYDROXYTRYPTAMINE 2B RECEPTOR (5-HT-2B) (SEROTONIN RECEPTOR 2B). [SOURCE:UNIPROT/SWISSPROT;ACC:P41595] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
TdgClinicalTrial: P41595
- Version: January-2014
Alternate Names:

HTR2B Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass GPCR

Target Subclass Rhodopsin

Publications:
DTC: HTR2B
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Semple G et al., 2009, Pyrimidine-based antagonists of h-MCH-R1 derived from ATC0175: in vitro profiling and in vivo evaluation., Bioorg Med Chem Lett
ChemblInteractions: HTR2B
- Version: chembl_23
Alternate Names:

HTR2B GENE_SYMBOL

5-hydroxytryptamine receptor 2B UNIPROT

Serotonin receptor 2B UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000135914
- Version: 31-May-2017
Alternate Names:

ENSG00000135914 Gene Symbol

HTR2B Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
dGene: HTR2B
- Version: 27-Jun-2013
Alternate Names:

3357 Gene ID

5-HT(2B) dGene Synonym

5-HT2B dGene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
TTD: 5-HT 2B receptor
- Version: 2020.06.01
Alternate Names:

HTR2B TTD Gene Abbreviation

T31204 TTD Target ID

Gene Info:

Publications:
Pharos: HTR2B
- Version: 01-February-2022
Alternate Names:

5-hydroxytryptamine receptor 2B Gene Name

P41595 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:

Direct Interaction	yes
Mechanism of Interaction	Serotonin 2b (5-HT2b) receptor partial agonist

Direct Interaction	yes
Mechanism of Interaction	Serotonin 2b (5-HT2b) receptor antagonist

Trial Name	agomelatine, AGO178C, S-20098,Valdoxan, Thymanax
Novel drug target	Established target

Trial Name	Silenor (SO-101)
Novel drug target	Established target

5-HYDROXYTRYPTAMINE RECEPTOR 2B	Uniprot Protein Name
P41595	Uniprot Accession
5HT2B_HUMAN	Uniprot Id

ENSG00000135914	Ensembl Gene Id
HTR2B	Display Id
5-HYDROXYTRYPTAMINE 2B RECEPTOR (5-HT-2B) (SEROTONIN RECEPTOR 2B). [SOURCE:UNIPROT/SWISSPROT;ACC:P41595]	Description

HTR2B	GENE_SYMBOL
5-hydroxytryptamine receptor 2B	UNIPROT
Serotonin receptor 2B	UNIPROT

HTR2B Gene Record

HTR2B 3357 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name PRX-08066 Novel drug target Established target

PMIDs: 20430844

Sources: TdgClinicalTrial TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19773162

Sources: DTC

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 2975224 1361012 17016423 17139284 11752352

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 497523 17016423 17139284 11752352

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 17016423 17139284

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name terguride Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 2871581

Sources: TTD

Interaction Types & Directionality: partial agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Serotonin 2b (5-HT2b) receptor partial agonist

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Serotonin 2b (5-HT2b) receptor antagonist

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name agomelatine, AGO178C, S-20098,Valdoxan, Thymanax Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info: Trial Name renzapride Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name Silenor (SO-101) Novel drug target Established target

PMIDs: 7855217 309138

Sources: TdgClinicalTrial

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name Asenapine

PMIDs: 18308814 21655346

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info: Novel drug target Established target Trial Name Seroquel

PMIDs: None found

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TEND

Ensembl: ENSG00000135914

Alternate Names: HTR2B Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TEND: P41595

Alternate Names: P41595 Uniprot Accession HTR2B Gene Symbol 3357 Entrez Gene Id

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name PRX-08066

Novel drug target Established target

PMIDs:
20430844

Sources:
TdgClinicalTrial TTD

Interaction Types & Directionality:

n/a

PMIDs:
19773162

Sources:
DTC

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
2975224 1361012 17016423 17139284 11752352

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
497523 17016423 17139284 11752352

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
17016423 17139284

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name terguride

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

agonist (activating)

PMIDs:
2871581

Sources:
TTD

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serotonin 2b (5-HT2b) receptor partial agonist

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serotonin 2b (5-HT2b) receptor antagonist

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name agomelatine, AGO178C, S-20098,Valdoxan, Thymanax

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name renzapride

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Silenor (SO-101)

Novel drug target Established target

PMIDs:
7855217 309138

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name Asenapine

PMIDs:
18308814 21655346

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name Seroquel

PMIDs:
None found

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TEND

Alternate Names:

HTR2B Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

P41595 Uniprot Accession

HTR2B Gene Symbol

3357 Entrez Gene Id

Gene Info:

Target Subclass Rhodopsin

Transmembrane Helix Count 7

Target Subclass GPCR

Alternate Names:

5-HYDROXYTRYPTAMINE RECEPTOR 2B Uniprot Protein Name

P41595 Uniprot Accession

5HT2B_HUMAN Uniprot Id

Gene Info:

Human Readable Name G PROTEIN COUPLED RECEPTOR

Human Readable Name DRUGGABLE GENOME

Uniprot Status Swiss-Prot

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Alternate Names:

ENSG00000135914 Ensembl Gene Id

HTR2B Display Id

5-HYDROXYTRYPTAMINE 2B RECEPTOR (5-HT-2B) (SEROTONIN RECEPTOR 2B). [SOURCE:UNIPROT/SWISSPROT;ACC:P41595] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

HTR2B Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass GPCR

Target Subclass Rhodopsin

Publications:

Semple G et al., 2009, Pyrimidine-based antagonists of h-MCH-R1 derived from ATC0175: in vitro profiling and in vivo evaluation., Bioorg Med Chem Lett

Alternate Names:

HTR2B GENE_SYMBOL

5-hydroxytryptamine receptor 2B UNIPROT

Serotonin receptor 2B UNIPROT

Alternate Names:

ENSG00000135914 Gene Symbol

HTR2B Ensembl Id

Gene Categories:

DRUGGABLE GENOME